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The map label for this gene is dxr

Identifier: 197119123

GI number: 197119123

Start: 3180216

End: 3181373

Strand: Reverse

Name: dxr

Synonym: Gbem_2750

Alternate gene names: 197119123

Gene position: 3181373-3180216 (Counterclockwise)

Preceding gene: 308535318

Following gene: 197119122

Centisome position: 68.93

GC content: 62.09

Gene sequence:

>1158_bases
ATGAAAAACCTCACCATCCTAGGTTCCACAGGTTCCATCGGGGTCAGCACCCTCGACGTGGTCAAAGCGTATCCCGACAT
GTTCCGGGTGGTCGCGCTTACCGCAGGGAACAACCTCGAACTCTTAAAGACCCAGATAGAGACCTTCAGCCCCGACCTGG
TCTCGGTGCTGACCGCCGAGAAGGCCCAGGCCCTCAGCCGGTCGCTCACCGGCAAAAAGCCCGAGATAATGCATGGCGTG
GAGGGGATGATAGCCGCCGCGACCGCATCCGAAACCACCATGGTGGTGGCGGCCATCGTCGGTGCCGCAGGGCTTGTTCC
CACCACGGCCGCGATCATGGCGGGAAAGGACGTGGCGCTCGCCAATAAGGAGACACTGGTAACCGCAGGCCATCTGGTGA
TGCAGATGGTGCGCGAGAAGAAGGTGAATCTTTATCCGGTCGACAGCGAGCATTGCGCGGTGTTCCAGTCCATGGCGGGG
CACCGCAGCCAGGACATTGCCCGGGTGATCCTCACTGCTTCCGGCGGCCCCTTCCTCAACTGGGGAAGAGAGAAGTTGCA
AGCCGCGACGGTTGCCGACGCGCTCAACCATCCCAACTGGAGCATGGGGAGAAAGATCACCGTTGACTCGGCCACCATGA
TGAACAAGGGGCTTGAGGTGATCGAGGCCCGCTGGCTTTTCGATATCCCGGTGCAGAGAATAGGGGTGAACATCCATCCG
CAAAGCATCATCCACTCCATGGTGGAATATGTGGACGGGAGCGTGATGGCGCAACTGGGGACTCCCGACATGAAGGGGCC
CATCGCCTACGCGCTCACCTACCCGGGCCGCGTACCCTCCGGGGTCAAGGCGCTTGATCTCACCGCGCTTTCGGGGCTCA
CCTTCTTCAAGCCGGACACGGACCGCTTCCCCGCTTTGCAGCTCGCCTATCGCGCGGCTGACGCCGGGGAAAGCATGCCG
GCGGTCATGAACGCCGCCAACGAGATCGCCGTCGAGGCGTTCCTCGGTGGAAGGATCGGCTTCATGGCCATAGCCGAGGC
GATCGAGAAGGTGATGGACCTGCACGAGCCGCACGCGCTGGCATCGATCGAAGAGGTGCTGGAGGCGGACCGTTGGGGTA
GGAGAACCGCCAAGGAAGTCCTTGGCGTAGGCTGCTGA

Upstream 100 bases:

>100_bases
AAGCGGGGCGCCTTCCCGCGCCCGGCTGTCGCCGCCGCCGCTTCCGGTCCCAATCTACGAGGGCCCAGGCGTATTTGACT
TGAGATAACTGCGAGGGACA

Downstream 100 bases:

>100_bases
AACAAAGGCTTTTCTTCGGGTGCAATAGGGCACGCGAAGGCACCAGCTTTCCGGTGCGGTCCGGTTGCCGGCCGCGGTCC
GGTTGAGGAAACGTTATGAG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKNLTILGSTGSIGVSTLDVVKAYPDMFRVVALTAGNNLELLKTQIETFSPDLVSVLTAEKAQALSRSLTGKKPEIMHGV
EGMIAAATASETTMVVAAIVGAAGLVPTTAAIMAGKDVALANKETLVTAGHLVMQMVREKKVNLYPVDSEHCAVFQSMAG
HRSQDIARVILTASGGPFLNWGREKLQAATVADALNHPNWSMGRKITVDSATMMNKGLEVIEARWLFDIPVQRIGVNIHP
QSIIHSMVEYVDGSVMAQLGTPDMKGPIAYALTYPGRVPSGVKALDLTALSGLTFFKPDTDRFPALQLAYRAADAGESMP
AVMNAANEIAVEAFLGGRIGFMAIAEAIEKVMDLHEPHALASIEEVLEADRWGRRTAKEVLGVGC

Sequences:

>Translated_385_residues
MKNLTILGSTGSIGVSTLDVVKAYPDMFRVVALTAGNNLELLKTQIETFSPDLVSVLTAEKAQALSRSLTGKKPEIMHGV
EGMIAAATASETTMVVAAIVGAAGLVPTTAAIMAGKDVALANKETLVTAGHLVMQMVREKKVNLYPVDSEHCAVFQSMAG
HRSQDIARVILTASGGPFLNWGREKLQAATVADALNHPNWSMGRKITVDSATMMNKGLEVIEARWLFDIPVQRIGVNIHP
QSIIHSMVEYVDGSVMAQLGTPDMKGPIAYALTYPGRVPSGVKALDLTALSGLTFFKPDTDRFPALQLAYRAADAGESMP
AVMNAANEIAVEAFLGGRIGFMAIAEAIEKVMDLHEPHALASIEEVLEADRWGRRTAKEVLGVGC
>Mature_385_residues
MKNLTILGSTGSIGVSTLDVVKAYPDMFRVVALTAGNNLELLKTQIETFSPDLVSVLTAEKAQALSRSLTGKKPEIMHGV
EGMIAAATASETTMVVAAIVGAAGLVPTTAAIMAGKDVALANKETLVTAGHLVMQMVREKKVNLYPVDSEHCAVFQSMAG
HRSQDIARVILTASGGPFLNWGREKLQAATVADALNHPNWSMGRKITVDSATMMNKGLEVIEARWLFDIPVQRIGVNIHP
QSIIHSMVEYVDGSVMAQLGTPDMKGPIAYALTYPGRVPSGVKALDLTALSGLTFFKPDTDRFPALQLAYRAADAGESMP
AVMNAANEIAVEAFLGGRIGFMAIAEAIEKVMDLHEPHALASIEEVLEADRWGRRTAKEVLGVGC

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=399, Percent_Identity=50.125313283208, Blast_Score=349, Evalue=2e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_GEOBB (B5EHV5)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002139550.1
- ProteinModelPortal:   B5EHV5
- SMR:   B5EHV5
- GeneID:   6782748
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_2750
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41021; Mature: 41021

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: BINDING 123-123 BINDING 150-150 BINDING 174-174 BINDING 197-197 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLTILGSTGSIGVSTLDVVKAYPDMFRVVALTAGNNLELLKTQIETFSPDLVSVLTAE
CCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHH
KAQALSRSLTGKKPEIMHGVEGMIAAATASETTMVVAAIVGAAGLVPTTAAIMAGKDVAL
HHHHHHHHHCCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEE
ANKETLVTAGHLVMQMVREKKVNLYPVDSEHCAVFQSMAGHRSQDIARVILTASGGPFLN
CCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCHHHHEEEEEECCCCCCCC
WGREKLQAATVADALNHPNWSMGRKITVDSATMMNKGLEVIEARWLFDIPVQRIGVNIHP
CCHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHCCHHHHHHHHHEECCHHHHCCCCCH
QSIIHSMVEYVDGSVMAQLGTPDMKGPIAYALTYPGRVPSGVKALDLTALSGLTFFKPDT
HHHHHHHHHHHCCHHEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEECCCC
DRFPALQLAYRAADAGESMPAVMNAANEIAVEAFLGGRIGFMAIAEAIEKVMDLHEPHAL
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHH
ASIEEVLEADRWGRRTAKEVLGVGC
HHHHHHHHHHHCCHHHHHHHHCCCC
>Mature Secondary Structure
MKNLTILGSTGSIGVSTLDVVKAYPDMFRVVALTAGNNLELLKTQIETFSPDLVSVLTAE
CCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHH
KAQALSRSLTGKKPEIMHGVEGMIAAATASETTMVVAAIVGAAGLVPTTAAIMAGKDVAL
HHHHHHHHHCCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEE
ANKETLVTAGHLVMQMVREKKVNLYPVDSEHCAVFQSMAGHRSQDIARVILTASGGPFLN
CCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCHHHHEEEEEECCCCCCCC
WGREKLQAATVADALNHPNWSMGRKITVDSATMMNKGLEVIEARWLFDIPVQRIGVNIHP
CCHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHCCHHHHHHHHHEECCHHHHCCCCCH
QSIIHSMVEYVDGSVMAQLGTPDMKGPIAYALTYPGRVPSGVKALDLTALSGLTFFKPDT
HHHHHHHHHHHCCHHEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEECCCC
DRFPALQLAYRAADAGESMPAVMNAANEIAVEAFLGGRIGFMAIAEAIEKVMDLHEPHAL
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHH
ASIEEVLEADRWGRRTAKEVLGVGC
HHHHHHHHHHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA