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The map label for this gene is tldD [H]

Identifier: 197119094

GI number: 197119094

Start: 3145690

End: 3147072

Strand: Direct

Name: tldD [H]

Synonym: Gbem_2721

Alternate gene names: 197119094

Gene position: 3145690-3147072 (Clockwise)

Preceding gene: 197119093

Following gene: 197119096

Centisome position: 68.16

GC content: 66.45

Gene sequence:

>1383_bases
GTGCTCGAAACCATAGACGCCGCAGCCATACTGCGCCGCTCCCTCTCCGCCGGCGGCGAGTTCGCCGAGATCTATTACGA
GGCCGGCGCCTCTACCGTGGTCGTCTGCGAGGACGGCAAGGTGGAAAGGGTCCTCTCCTCCGCCGACCGAGGCATCGGCA
TCAGGGTGATCTCCGGCTTCTCCACCGCCTACGCCTATACCAACCAGTTGGACCAGGAGTCGCTGCTGCGCCTGGCCGCC
ACGGTAAGCCGCGGGGTGCGCGGCGGCGTGCCCCACGCCGAGTTCAACCTCTGCGAGCGCAGGGTCGCGCCGGGCTTTGC
CATCGGCATTGCTCCGGACAGCATCGAACTGGCCGAGAAGGTTGCGCTGGTGAACCGGGCCGACAGGGCGGCGCGGGGTT
TCGACAAGAGGGTGCGCCAGGTCATGGCGATGTACCGGGATGCGCAGACGAAGGTCCAGACGGTGAACTCGCTGGGGGAA
TTTCACGAGGACAACAGCACCGCGACCGTCTTCATCGTGCAGGCGGTGGCGCAGGAAGGAAAGGTGACCCAGACCGGCTA
CGAGCCGGTGGGCGCTGCGCGCGGCTTCGAGCTTTTCGACGCCACTTCCCCGGAGGATCTGGCGCTAAAGGCGGCCGCGC
GCGGGGTGATGATGCTGGGAGCGCAGAAAGCCCCCTCGGGCCCTCTGCCGGTGGTGCTCTCAAGCGAGGCAGGGGGGACC
ATGGTGCACGAGGCGATAGGGCACGGACTGGAAGCGGATCTGGTGCAGGCGGGGACCTCCGTCTACCGCGGCAGGATCGG
TGAAATGGTCGCCTCGGAACTGGTCACGGTGATAGACGACGCCACCATACCAAACGCACGCGGCTCCTTCGCCTTCGACG
GCGAGGGTACCGCGGCGCAAAGGACCGTGCTGGTGGAAAACGGCGTCCTCAAGGGTTACATGTACGACCGGCTCTCGGCC
ATGAAAGACGGCTGCGCCTCCACCGGCAACGGCAGGCGGGAGTCGTACCGCTCGCGCCCCATCGTCCGCATGACCAACAC
GCTCATCGCCCCGGGGAAAAGCGACCCGGCGCAGATCGTCAGGAGCGTAGACCGCGGCCTTTTCGTGAAGCGGATGGGTG
GGGGACAGGTGAACACGGTGACCGGTGACTTCGTCTTCGAGGTGTCGGAGGGGTTCCTGATAGAAAACGGCGCGGTGGGA
GAGCCGGTTCGGGGCGCTACGCTCACCGGTAACGGCCCCGAGGTGCTCAGGAAGATAACCATGGTGGGAAATGACTTGGG
TTTCGGAATCGGCACCTGCGGCAAGGACGGCCAGGGGGTCCCGGTCTCCGACGCACAGCCGACCCTGCTCATCTCGGGGA
TCACCGTCGGCGGCGCCGGGTAA

Upstream 100 bases:

>100_bases
GCGTCAGCTTTCCGCTTTGCTTCGCCGGCGACGTAGAGGCGCTGATGCAGGAGATCGCCAAGGAGATCGAGATCGCCGAG
GTGACAAAGGAGGGTGAGCC

Downstream 100 bases:

>100_bases
GACAAAAAAACGTTTAACAGGGATAAAGGGGATGACCTTCATCCCTGTTAAGTTGCCTTTATGGTTCCTTGGATTTCCCC
TCCCTCAGTACCCTCTCCAG

Product: zinc protease TldD modulator of DNA gyrase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MLETIDAAAILRRSLSAGGEFAEIYYEAGASTVVVCEDGKVERVLSSADRGIGIRVISGFSTAYAYTNQLDQESLLRLAA
TVSRGVRGGVPHAEFNLCERRVAPGFAIGIAPDSIELAEKVALVNRADRAARGFDKRVRQVMAMYRDAQTKVQTVNSLGE
FHEDNSTATVFIVQAVAQEGKVTQTGYEPVGAARGFELFDATSPEDLALKAAARGVMMLGAQKAPSGPLPVVLSSEAGGT
MVHEAIGHGLEADLVQAGTSVYRGRIGEMVASELVTVIDDATIPNARGSFAFDGEGTAAQRTVLVENGVLKGYMYDRLSA
MKDGCASTGNGRRESYRSRPIVRMTNTLIAPGKSDPAQIVRSVDRGLFVKRMGGGQVNTVTGDFVFEVSEGFLIENGAVG
EPVRGATLTGNGPEVLRKITMVGNDLGFGIGTCGKDGQGVPVSDAQPTLLISGITVGGAG

Sequences:

>Translated_460_residues
MLETIDAAAILRRSLSAGGEFAEIYYEAGASTVVVCEDGKVERVLSSADRGIGIRVISGFSTAYAYTNQLDQESLLRLAA
TVSRGVRGGVPHAEFNLCERRVAPGFAIGIAPDSIELAEKVALVNRADRAARGFDKRVRQVMAMYRDAQTKVQTVNSLGE
FHEDNSTATVFIVQAVAQEGKVTQTGYEPVGAARGFELFDATSPEDLALKAAARGVMMLGAQKAPSGPLPVVLSSEAGGT
MVHEAIGHGLEADLVQAGTSVYRGRIGEMVASELVTVIDDATIPNARGSFAFDGEGTAAQRTVLVENGVLKGYMYDRLSA
MKDGCASTGNGRRESYRSRPIVRMTNTLIAPGKSDPAQIVRSVDRGLFVKRMGGGQVNTVTGDFVFEVSEGFLIENGAVG
EPVRGATLTGNGPEVLRKITMVGNDLGFGIGTCGKDGQGVPVSDAQPTLLISGITVGGAG
>Mature_460_residues
MLETIDAAAILRRSLSAGGEFAEIYYEAGASTVVVCEDGKVERVLSSADRGIGIRVISGFSTAYAYTNQLDQESLLRLAA
TVSRGVRGGVPHAEFNLCERRVAPGFAIGIAPDSIELAEKVALVNRADRAARGFDKRVRQVMAMYRDAQTKVQTVNSLGE
FHEDNSTATVFIVQAVAQEGKVTQTGYEPVGAARGFELFDATSPEDLALKAAARGVMMLGAQKAPSGPLPVVLSSEAGGT
MVHEAIGHGLEADLVQAGTSVYRGRIGEMVASELVTVIDDATIPNARGSFAFDGEGTAAQRTVLVENGVLKGYMYDRLSA
MKDGCASTGNGRRESYRSRPIVRMTNTLIAPGKSDPAQIVRSVDRGLFVKRMGGGQVNTVTGDFVFEVSEGFLIENGAVG
EPVRGATLTGNGPEVLRKITMVGNDLGFGIGTCGKDGQGVPVSDAQPTLLISGITVGGAG

Specific function: Suppresses the inhibitory activity of the carbon storage regulator (CsrA) [H]

COG id: COG0312

COG function: function code R; Predicted Zn-dependent proteases and their inactivated homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase U62 family [H]

Homologues:

Organism=Escherichia coli, GI1789640, Length=464, Percent_Identity=40.0862068965517, Blast_Score=311, Evalue=7e-86,
Organism=Escherichia coli, GI1790682, Length=400, Percent_Identity=24.5, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002510 [H]

Pfam domain/function: PF01523 PmbA_TldD [H]

EC number: NA

Molecular weight: Translated: 48213; Mature: 48213

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLETIDAAAILRRSLSAGGEFAEIYYEAGASTVVVCEDGKVERVLSSADRGIGIRVISGF
CCCCHHHHHHHHHHHHCCCCEEEHEEECCCCEEEEECCCCHHHHHHHCCCCCEEEEEECC
STAYAYTNQLDQESLLRLAATVSRGVRGGVPHAEFNLCERRVAPGFAIGIAPDSIELAEK
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHH
VALVNRADRAARGFDKRVRQVMAMYRDAQTKVQTVNSLGEFHEDNSTATVFIVQAVAQEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHCC
KVTQTGYEPVGAARGFELFDATSPEDLALKAAARGVMMLGAQKAPSGPLPVVLSSEAGGT
CEEECCCCCCCCCCCCEEECCCCCHHHHHHHHHCCEEEECCCCCCCCCCCEEEECCCCCH
MVHEAIGHGLEADLVQAGTSVYRGRIGEMVASELVTVIDDATIPNARGSFAFDGEGTAAQ
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHH
RTVLVENGVLKGYMYDRLSAMKDGCASTGNGRRESYRSRPIVRMTNTLIAPGKSDPAQIV
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEECCEEECCCCCCHHHHH
RSVDRGLFVKRMGGGQVNTVTGDFVFEVSEGFLIENGAVGEPVRGATLTGNGPEVLRKIT
HHHHHCEEEEECCCCEEEEEECCEEEEECCCEEEECCCCCCCCCCCEECCCCHHHHHHHH
MVGNDLGFGIGTCGKDGQGVPVSDAQPTLLISGITVGGAG
HHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCC
>Mature Secondary Structure
MLETIDAAAILRRSLSAGGEFAEIYYEAGASTVVVCEDGKVERVLSSADRGIGIRVISGF
CCCCHHHHHHHHHHHHCCCCEEEHEEECCCCEEEEECCCCHHHHHHHCCCCCEEEEEECC
STAYAYTNQLDQESLLRLAATVSRGVRGGVPHAEFNLCERRVAPGFAIGIAPDSIELAEK
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHH
VALVNRADRAARGFDKRVRQVMAMYRDAQTKVQTVNSLGEFHEDNSTATVFIVQAVAQEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHCC
KVTQTGYEPVGAARGFELFDATSPEDLALKAAARGVMMLGAQKAPSGPLPVVLSSEAGGT
CEEECCCCCCCCCCCCEEECCCCCHHHHHHHHHCCEEEECCCCCCCCCCCEEEECCCCCH
MVHEAIGHGLEADLVQAGTSVYRGRIGEMVASELVTVIDDATIPNARGSFAFDGEGTAAQ
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHH
RTVLVENGVLKGYMYDRLSAMKDGCASTGNGRRESYRSRPIVRMTNTLIAPGKSDPAQIV
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEECCEEECCCCCCHHHHH
RSVDRGLFVKRMGGGQVNTVTGDFVFEVSEGFLIENGAVGEPVRGATLTGNGPEVLRKIT
HHHHHCEEEEECCCCEEEEEECCEEEEECCCEEEECCCCCCCCCCCEECCCCHHHHHHHH
MVGNDLGFGIGTCGKDGQGVPVSDAQPTLLISGITVGGAG
HHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]