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The map label for this gene is apt

Identifier: 197119057

GI number: 197119057

Start: 3106321

End: 3106836

Strand: Reverse

Name: apt

Synonym: Gbem_2682

Alternate gene names: 197119057

Gene position: 3106836-3106321 (Counterclockwise)

Preceding gene: 197119058

Following gene: 308535314

Centisome position: 67.32

GC content: 57.56

Gene sequence:

>516_bases
ATGGAAGATCTGAAAAGCATCATCAGGAACATCCCGGACTTCCCCAAGAAGGGGATACTTTTCAAGGACATCACCACGCT
CTTAGGGGATGCCAAATCGTTTCAGCGCATGGTCGACCTTCTGTCGCACCGTTACGTTGGGCAGAAGATAGACAAGGTAG
TGGGTGTTGAAGCGCGCGGCTTCATCATCGGCGCGGCCCTCGCGTACAAGCTCGGCGCCGGCATCGTGCTGGTGCGCAAG
CCCGGCAAACTTCCGTCCAAGACGCGCAGCAAGACCTATGACCTCGAGTACGGCACCGACACCCTCGAGATCCACACCGA
CGCCTTCAACAAAGGCGATCGCGTGCTCATCGCCGACGACCTGCTTGCCACCGGCGGCACCATGGCAGCCGTAGTAGATT
TGATCAGCAGCATGGACGTCGAGCTCGTCGAGTGCTGCTTCATGGCCGAGCTGGAGTTTTTGGAAGGGGGCAAGAAGCTC
CCCGAAGGCAAAGTATTCTCCCTGCTCAAGTTCTAA

Upstream 100 bases:

>100_bases
ATCGCTGGAAAAGCTGAGAAAGATAGTAGAAACGACCGATGTCATGGGGCGCGCGGCTGTCCCCCCGACAACTACAGGCA
CATAAGGAGCGGCAGGATAA

Downstream 100 bases:

>100_bases
TAAAACTTCTTGCCAAACGGGCAGGGGTAAGGTATATAGGTCGTCTCACTTGTCCCCGTAGCTCAGCAGGATAGAGCACT
TCCCTCCTAAGGAAGGGGTC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MEDLKSIIRNIPDFPKKGILFKDITTLLGDAKSFQRMVDLLSHRYVGQKIDKVVGVEARGFIIGAALAYKLGAGIVLVRK
PGKLPSKTRSKTYDLEYGTDTLEIHTDAFNKGDRVLIADDLLATGGTMAAVVDLISSMDVELVECCFMAELEFLEGGKKL
PEGKVFSLLKF

Sequences:

>Translated_171_residues
MEDLKSIIRNIPDFPKKGILFKDITTLLGDAKSFQRMVDLLSHRYVGQKIDKVVGVEARGFIIGAALAYKLGAGIVLVRK
PGKLPSKTRSKTYDLEYGTDTLEIHTDAFNKGDRVLIADDLLATGGTMAAVVDLISSMDVELVECCFMAELEFLEGGKKL
PEGKVFSLLKF
>Mature_171_residues
MEDLKSIIRNIPDFPKKGILFKDITTLLGDAKSFQRMVDLLSHRYVGQKIDKVVGVEARGFIIGAALAYKLGAGIVLVRK
PGKLPSKTRSKTYDLEYGTDTLEIHTDAFNKGDRVLIADDLLATGGTMAAVVDLISSMDVELVECCFMAELEFLEGGKKL
PEGKVFSLLKF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=45.5089820359281, Blast_Score=151, Evalue=3e-37,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=47.9338842975207, Blast_Score=117, Evalue=7e-27,
Organism=Escherichia coli, GI1786675, Length=173, Percent_Identity=52.6011560693642, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17509087, Length=166, Percent_Identity=39.7590361445783, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323619, Length=173, Percent_Identity=41.6184971098266, Blast_Score=124, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6320649, Length=172, Percent_Identity=34.8837209302326, Blast_Score=92, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=42.1965317919075, Blast_Score=120, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_GEOBB (B5EHF2)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002139484.1
- ProteinModelPortal:   B5EHF2
- SMR:   B5EHF2
- GeneID:   6782680
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_2682
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18785; Mature: 18785

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDLKSIIRNIPDFPKKGILFKDITTLLGDAKSFQRMVDLLSHRYVGQKIDKVVGVEARG
CHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
FIIGAALAYKLGAGIVLVRKPGKLPSKTRSKTYDLEYGTDTLEIHTDAFNKGDRVLIADD
HHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCEEEEECC
LLATGGTMAAVVDLISSMDVELVECCFMAELEFLEGGKKLPEGKVFSLLKF
HHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MEDLKSIIRNIPDFPKKGILFKDITTLLGDAKSFQRMVDLLSHRYVGQKIDKVVGVEARG
CHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
FIIGAALAYKLGAGIVLVRKPGKLPSKTRSKTYDLEYGTDTLEIHTDAFNKGDRVLIADD
HHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCEEEEECC
LLATGGTMAAVVDLISSMDVELVECCFMAELEFLEGGKKLPEGKVFSLLKF
HHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA