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The map label for this gene is pyrD

Identifier: 197118778

GI number: 197118778

Start: 2778955

End: 2779872

Strand: Reverse

Name: pyrD

Synonym: Gbem_2399

Alternate gene names: 197118778

Gene position: 2779872-2778955 (Counterclockwise)

Preceding gene: 197118779

Following gene: 197118777

Centisome position: 60.23

GC content: 65.03

Gene sequence:

>918_bases
ATGCAAAGACCTGACATGTCCGTGGCTGTCGCCGGGATCAAGATGCGCAACCCCGTGATGACCGCATCCGGCACCTTCGG
ATACGGCGCCGAGTTCGCCGACTACCTCGACCTTGAGTGCATCGGGGCGATGATCAGCAAGGGGCTGTCGCTGAAGCCCA
AGGCCGGCAACCCCACCCCCCGCATCGTGGAAACCCCGGGCGGGATGCTGAACGCCATCGGCCTGCAAAACGTCGGCATC
GACGCCTTCATCGAGCAGAAACTCCCGTATCTCAAGAACGTGAACACCCCGGTGATCGTGAACCTCTACGGCAACACGCT
GGAAGAGTACGGCGAGGTCGCGGCCAGGCTGGATGGGCTTTCCGGCGTCGCCGGCATCGAGGTGAACATCTCCTGCCCCA
ACGTGAAGCAGGGGGGAATCGTTTTCGGCACCGACCCCGGCGCCGCGCAGGAGGTGGTGCGCCTGGTGAAGAAAAACACC
ACCAAGCCGATGATCGTAAAGCTCTCCCCCAACGTCACCGACGTGGTGCTGATGGCCAAGGCGTGTGCCGACGCCGGAGC
GGACGCCCTCTCGCTGATCAACACCCTCACCGGGATGGCGATCGACCTGGAGCGCCGCCGCCCGGTGCTGGCCAACGTCA
CCGGCGGGCTCTCCGGCCCGGCGATCAAGCCGGTAGCGCTCCGGATGGTCTGGCAGGTGGCCAAGGCGGTTAAGCTGCCG
CTGATCGGCATCGGCGGCATCATGAACGGCCGCGACGCCCTGGAGTTCATGCTGGCGGGGGCGACTGCGGTGCAGGTCGG
CACCGCAAGCTTCCTCGACCCCTCCGCGGCTCAGCGGATCGCCCGGGAGATGGAGCAGTACCTGGTTGACCACAAGATAG
AATCTGTCTCCTCGCTGATCGGTGCCCTAGAGCTCTGA

Upstream 100 bases:

>100_bases
TAATGAAGGGGGCCAACCACACCGAGGATACCCCCGACTACCGCTGTGTCTGCAAGGACGGCCCCGTCTTCGACAGCTTC
GAACTGCAATGGAGTTAAAC

Downstream 100 bases:

>100_bases
TGGAAGCGTGGGAGAAAAGCCTGAAAAACTGCATCACCAGCCCGGAGGAGCTTTCCGGGCTTTTTCGTCTGCAGGGGGGC
GCGTTTTCGCCGGTGGTCGA

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MQRPDMSVAVAGIKMRNPVMTASGTFGYGAEFADYLDLECIGAMISKGLSLKPKAGNPTPRIVETPGGMLNAIGLQNVGI
DAFIEQKLPYLKNVNTPVIVNLYGNTLEEYGEVAARLDGLSGVAGIEVNISCPNVKQGGIVFGTDPGAAQEVVRLVKKNT
TKPMIVKLSPNVTDVVLMAKACADAGADALSLINTLTGMAIDLERRRPVLANVTGGLSGPAIKPVALRMVWQVAKAVKLP
LIGIGGIMNGRDALEFMLAGATAVQVGTASFLDPSAAQRIAREMEQYLVDHKIESVSSLIGALEL

Sequences:

>Translated_305_residues
MQRPDMSVAVAGIKMRNPVMTASGTFGYGAEFADYLDLECIGAMISKGLSLKPKAGNPTPRIVETPGGMLNAIGLQNVGI
DAFIEQKLPYLKNVNTPVIVNLYGNTLEEYGEVAARLDGLSGVAGIEVNISCPNVKQGGIVFGTDPGAAQEVVRLVKKNT
TKPMIVKLSPNVTDVVLMAKACADAGADALSLINTLTGMAIDLERRRPVLANVTGGLSGPAIKPVALRMVWQVAKAVKLP
LIGIGGIMNGRDALEFMLAGATAVQVGTASFLDPSAAQRIAREMEQYLVDHKIESVSSLIGALEL
>Mature_305_residues
MQRPDMSVAVAGIKMRNPVMTASGTFGYGAEFADYLDLECIGAMISKGLSLKPKAGNPTPRIVETPGGMLNAIGLQNVGI
DAFIEQKLPYLKNVNTPVIVNLYGNTLEEYGEVAARLDGLSGVAGIEVNISCPNVKQGGIVFGTDPGAAQEVVRLVKKNT
TKPMIVKLSPNVTDVVLMAKACADAGADALSLINTLTGMAIDLERRRPVLANVTGGLSGPAIKPVALRMVWQVAKAVKLP
LIGIGGIMNGRDALEFMLAGATAVQVGTASFLDPSAAQRIAREMEQYLVDHKIESVSSLIGALEL

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=293, Percent_Identity=29.0102389078498, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI45006951, Length=331, Percent_Identity=29.9093655589124, Blast_Score=95, Evalue=7e-20,
Organism=Escherichia coli, GI87082059, Length=324, Percent_Identity=29.6296296296296, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71984108, Length=295, Percent_Identity=26.4406779661017, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322633, Length=300, Percent_Identity=30.3333333333333, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24640763, Length=293, Percent_Identity=31.740614334471, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18858217, Length=293, Percent_Identity=31.740614334471, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281361352, Length=321, Percent_Identity=27.7258566978193, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17137316, Length=321, Percent_Identity=27.7258566978193, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_GEOBB (B5EFU4)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002139205.1
- ProteinModelPortal:   B5EFU4
- GeneID:   6782397
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_2399
- HOGENOM:   HBG472415
- OMA:   NSIGLQN
- ProtClustDB:   PRK07259
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 32000; Mature: 32000

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRPDMSVAVAGIKMRNPVMTASGTFGYGAEFADYLDLECIGAMISKGLSLKPKAGNPTP
CCCCCCEEEEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
RIVETPGGMLNAIGLQNVGIDAFIEQKLPYLKNVNTPVIVNLYGNTLEEYGEVAARLDGL
CEEECCCCCEECCCCCCCCHHHHHHHCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCC
SGVAGIEVNISCPNVKQGGIVFGTDPGAAQEVVRLVKKNTTKPMIVKLSPNVTDVVLMAK
CCCEEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHH
ACADAGADALSLINTLTGMAIDLERRRPVLANVTGGLSGPAIKPVALRMVWQVAKAVKLP
HHHCCCHHHHHHHHHHHCCEEEHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCC
LIGIGGIMNGRDALEFMLAGATAVQVGTASFLDPSAAQRIAREMEQYLVDHKIESVSSLI
EEEECCCCCCHHHHHHHHHCCHHEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALEL
HHHCC
>Mature Secondary Structure
MQRPDMSVAVAGIKMRNPVMTASGTFGYGAEFADYLDLECIGAMISKGLSLKPKAGNPTP
CCCCCCEEEEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
RIVETPGGMLNAIGLQNVGIDAFIEQKLPYLKNVNTPVIVNLYGNTLEEYGEVAARLDGL
CEEECCCCCEECCCCCCCCHHHHHHHCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCC
SGVAGIEVNISCPNVKQGGIVFGTDPGAAQEVVRLVKKNTTKPMIVKLSPNVTDVVLMAK
CCCEEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHH
ACADAGADALSLINTLTGMAIDLERRRPVLANVTGGLSGPAIKPVALRMVWQVAKAVKLP
HHHCCCHHHHHHHHHHHCCEEEHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCC
LIGIGGIMNGRDALEFMLAGATAVQVGTASFLDPSAAQRIAREMEQYLVDHKIESVSSLI
EEEECCCCCCHHHHHHHHHCCHHEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALEL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA