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The map label for this gene is norM-2 [H]

Identifier: 197118736

GI number: 197118736

Start: 2732672

End: 2734021

Strand: Reverse

Name: norM-2 [H]

Synonym: Gbem_2355

Alternate gene names: 197118736

Gene position: 2734021-2732672 (Counterclockwise)

Preceding gene: 197118739

Following gene: 197118735

Centisome position: 59.24

GC content: 64.52

Gene sequence:

>1350_bases
ATGAGACAGAACCATATCCCGCGCCTGCTGAAACTGGCAGGCCCCATGATCCTTTCCACTTCCACCATAACCTTGATGCA
GATTATCGACGCCCTGATCCTGGCACGGCACTCCAGCGAGGCTGTGGCGGCGATCGGTCCTTCCGGTCTCGCCGTCATCC
TGTTCCAGGGCTTTCTCTTCGGGACCGCCGGCTACGCTGGAACCTTCGTCGCGCACAACCATGGGCGAGGCGACGCCCGC
GGGGTCCGCAGGTCCGCTTGGCTCGGCATCCATACCTCGCTCGCCTCCGGAATCCTGGCCCTTGCCATTGCCTGGCCGCT
GGCGCAACTTTTCCTGCTGGCGGGGCACGAGGCGCAGGTCGCACGCGACGAGCAGGTTTACTTCCTGCTTTGCATGGCCG
GCTCCTTGTTCCCGGTTCTTAGCTCGGCATTGGGGGGGTGGCTCTCGGGCATAGGGCGCCCCGCTTTGGTAACGGCGGTG
ACCTTCATCTCCCTGATTGTGAATGCGCTTCTTGCCTGGGGGCTCGTCCTCGGTGCGTGGGGCTTCCCCCGGATGGGGAT
TGCCGGCGCCGCGGTTGCCACCGTCAGCGCCCAAGGGGTTGCCGCCGCGCTTTACCTGGGCATCTTCGCCATAGGCGGTG
GGTTCACCGACCGGATCGCCCGGCGGCTGGACTGGGCGGAGTGGCACCGTTTCCTCGCGCTGGCGACCCCGATGGGGCTC
AGGATCAGCGGCGAACTCACCGCATGGACCCTTTTCCTCGTGGCGATCGGCCGCCTGGGCACGGTGGAGCTTGCCGCCTC
CAGCATCGCTTTCCGGATCAACGGGCTGGCGTTTTTCCCGGCGCTGGGGCTAGGACAGGCCGCGGGAATTCTGGTGGGCC
ATGCTCGTGGGGGAGGGGAAGACGATCAGGTACCGGCCATCGCGTGGCAATCCCTTTTGATCTGTGAGGTATGGATGCTC
GCTATGGCTATCCTCTTTGCCACGGCGTCGGCGCCTCTCATGTCCGTCTTTGCAGGGTATGGGGGCGACGCCGCGCGCAT
CGTGGCCGCAGGCTCCCTGATCATGAAGTTCGTCGCCTTCTACTGCCTCTTCGATGCCGCCAACGTCATGATAGGCTGCG
TGCTGGCCTCGGCGGGGGACACCTGCTGGATCGCCCGTACCTTCCTCTACTCATCTGCCGGATTCCTGGTTTTCTTGTGG
CTCATCGACCGCACCATGCCGGGGCTGGTTGCCGAGTGGACCCTGGCCACCTTCTTCGTATTCGTCACCGCAATCATCTG
GTCGCTGCGTTTTCGTTTCGGCGCCTGGAGGCGGACCCGAATTCTGCACGAACCCGAGCTGCCGGCTTAG

Upstream 100 bases:

>100_bases
GGATGGCAATGCAAAATCTTTATCTATGGAAATCGGCATGCTCATAGGGAACAGCCTTAGTGCTCGACAGTGCTTTACCT
CATGAGGTACATTGGCCTCT

Downstream 100 bases:

>100_bases
CCGCAGCTGGGGTTCCCTGTACAACCATTGTTTACCTCGATACAGGGGTACTCTCTTGCCTCTGCTGCACGTCTATCGCC
GCAATTCACCCCGCTTCAAG

Product: sodium-driven efflux pump MatE

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MRQNHIPRLLKLAGPMILSTSTITLMQIIDALILARHSSEAVAAIGPSGLAVILFQGFLFGTAGYAGTFVAHNHGRGDAR
GVRRSAWLGIHTSLASGILALAIAWPLAQLFLLAGHEAQVARDEQVYFLLCMAGSLFPVLSSALGGWLSGIGRPALVTAV
TFISLIVNALLAWGLVLGAWGFPRMGIAGAAVATVSAQGVAAALYLGIFAIGGGFTDRIARRLDWAEWHRFLALATPMGL
RISGELTAWTLFLVAIGRLGTVELAASSIAFRINGLAFFPALGLGQAAGILVGHARGGGEDDQVPAIAWQSLLICEVWML
AMAILFATASAPLMSVFAGYGGDAARIVAAGSLIMKFVAFYCLFDAANVMIGCVLASAGDTCWIARTFLYSSAGFLVFLW
LIDRTMPGLVAEWTLATFFVFVTAIIWSLRFRFGAWRRTRILHEPELPA

Sequences:

>Translated_449_residues
MRQNHIPRLLKLAGPMILSTSTITLMQIIDALILARHSSEAVAAIGPSGLAVILFQGFLFGTAGYAGTFVAHNHGRGDAR
GVRRSAWLGIHTSLASGILALAIAWPLAQLFLLAGHEAQVARDEQVYFLLCMAGSLFPVLSSALGGWLSGIGRPALVTAV
TFISLIVNALLAWGLVLGAWGFPRMGIAGAAVATVSAQGVAAALYLGIFAIGGGFTDRIARRLDWAEWHRFLALATPMGL
RISGELTAWTLFLVAIGRLGTVELAASSIAFRINGLAFFPALGLGQAAGILVGHARGGGEDDQVPAIAWQSLLICEVWML
AMAILFATASAPLMSVFAGYGGDAARIVAAGSLIMKFVAFYCLFDAANVMIGCVLASAGDTCWIARTFLYSSAGFLVFLW
LIDRTMPGLVAEWTLATFFVFVTAIIWSLRFRFGAWRRTRILHEPELPA
>Mature_449_residues
MRQNHIPRLLKLAGPMILSTSTITLMQIIDALILARHSSEAVAAIGPSGLAVILFQGFLFGTAGYAGTFVAHNHGRGDAR
GVRRSAWLGIHTSLASGILALAIAWPLAQLFLLAGHEAQVARDEQVYFLLCMAGSLFPVLSSALGGWLSGIGRPALVTAV
TFISLIVNALLAWGLVLGAWGFPRMGIAGAAVATVSAQGVAAALYLGIFAIGGGFTDRIARRLDWAEWHRFLALATPMGL
RISGELTAWTLFLVAIGRLGTVELAASSIAFRINGLAFFPALGLGQAAGILVGHARGGGEDDQVPAIAWQSLLICEVWML
AMAILFATASAPLMSVFAGYGGDAARIVAAGSLIMKFVAFYCLFDAANVMIGCVLASAGDTCWIARTFLYSSAGFLVFLW
LIDRTMPGLVAEWTLATFFVFVTAIIWSLRFRFGAWRRTRILHEPELPA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47694; Mature: 47694

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQNHIPRLLKLAGPMILSTSTITLMQIIDALILARHSSEAVAAIGPSGLAVILFQGFLF
CCCCCHHHHHHHCCCHHEECHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHH
GTAGYAGTFVAHNHGRGDARGVRRSAWLGIHTSLASGILALAIAWPLAQLFLLAGHEAQV
HCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ARDEQVYFLLCMAGSLFPVLSSALGGWLSGIGRPALVTAVTFISLIVNALLAWGLVLGAW
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GFPRMGIAGAAVATVSAQGVAAALYLGIFAIGGGFTDRIARRLDWAEWHRFLALATPMGL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCE
RISGELTAWTLFLVAIGRLGTVELAASSIAFRINGLAFFPALGLGQAAGILVGHARGGGE
EEECCHHHHHHHHHHHCCCCHHHHHHHHHHHEECCEEECCCCCCCCCCCEEEEECCCCCC
DDQVPAIAWQSLLICEVWMLAMAILFATASAPLMSVFAGYGGDAARIVAAGSLIMKFVAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YCLFDAANVMIGCVLASAGDTCWIARTFLYSSAGFLVFLWLIDRTMPGLVAEWTLATFFV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
FVTAIIWSLRFRFGAWRRTRILHEPELPA
HHHHHHHHHHHHHCCHHHHHCCCCCCCCC
>Mature Secondary Structure
MRQNHIPRLLKLAGPMILSTSTITLMQIIDALILARHSSEAVAAIGPSGLAVILFQGFLF
CCCCCHHHHHHHCCCHHEECHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHH
GTAGYAGTFVAHNHGRGDARGVRRSAWLGIHTSLASGILALAIAWPLAQLFLLAGHEAQV
HCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ARDEQVYFLLCMAGSLFPVLSSALGGWLSGIGRPALVTAVTFISLIVNALLAWGLVLGAW
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GFPRMGIAGAAVATVSAQGVAAALYLGIFAIGGGFTDRIARRLDWAEWHRFLALATPMGL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCE
RISGELTAWTLFLVAIGRLGTVELAASSIAFRINGLAFFPALGLGQAAGILVGHARGGGE
EEECCHHHHHHHHHHHCCCCHHHHHHHHHHHEECCEEECCCCCCCCCCCEEEEECCCCCC
DDQVPAIAWQSLLICEVWMLAMAILFATASAPLMSVFAGYGGDAARIVAAGSLIMKFVAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YCLFDAANVMIGCVLASAGDTCWIARTFLYSSAGFLVFLWLIDRTMPGLVAEWTLATFFV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
FVTAIIWSLRFRFGAWRRTRILHEPELPA
HHHHHHHHHHHHHCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]