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The map label for this gene is moeA-3 [H]

Identifier: 197118654

GI number: 197118654

Start: 2644395

End: 2645606

Strand: Direct

Name: moeA-3 [H]

Synonym: Gbem_2273

Alternate gene names: 197118654

Gene position: 2644395-2645606 (Clockwise)

Preceding gene: 197118651

Following gene: 197118655

Centisome position: 57.3

GC content: 65.02

Gene sequence:

>1212_bases
ATGATGAACTACGAAAAAGCGCGGCGAACGATCCTTGAGAAAGTCGCCCCCGCGGGGGTTGAGCGGGTACTCCTGTTGGA
AGCCGCCGGGAGGATACTGGCCGAGGATTACTCCGCTCCCAGCGACATGCCCCGCTGGGACAACTCCGCCATGGACGGCT
TCGCCGTGAGAAGCGCCGGCTGCGCGCCCGGGACCGTCCTTAAGGTGACCGACTACATCCCTGCCGGAGTAAGCTCCGGG
GACGCCGTTCTTGAAGGGTGTGCCGCGAGGATCATGACCGGTGCCCCCATCCCCCCGGGGGCGGACACCGTGGTCCCCAT
CGAGGAGACCGAAGCGGGCGAGCAAAGCGTGAAGCTGCTGCAGCAGGTGAAAAAGGGGGACCACATCCGCTTCCAGGGCG
AGGACGTCGGCCGCGGCGACCTGATCATGCCGAAGGGGACGCTGATCGGGCCGCCGCAGGTAAGCCTGCTTGCCTCCTTC
TCCGCCGCCGTAGTCCCGGTCTACCGCCGGGTGCGGGTAGCCATTCTCTCCACCGGGGACGAACTGGTGGAGATCGGCAC
GGAACCAAAAGAGAGCCAGATCGTCAACAGTAACGCCCTGGCCCTCGCCTGCGCCATCAAGCTCTGCGGCGCCGAACCGG
TCATCCTCGGCATCGCGAGGGACAACCGCGAAAGCCACTTGGCCCTCTTAACCGAGGGTTTGAAGGCGGACGTACTGGTC
ACCTCTGCAGGCGTTTCCGCCGGGGACCGCGACCTGGTGCGCGAGATCCTGGCTGAACTCGGGGTGGTCGAGCAGTTCTG
GAAACCAGGCGTCAAGCCCGGCGGCCCTACCGCCTTCGCGCTCAGGGGGAATACGCCTGTCTTCTCGCTTCCCGGAAACC
CAGTTTCCACCATGATCACCTTCGACGAGTTCGTTCGGCCCGCGCTTTTGAGGATGATGGGGCACGAGAAGGCGCTGAGG
CGGACCGTGCGCGGTTATCTCAAGGAAGGGACGCGCAAAAAGGCGGGGAAACTGAACTTCCTGCGGGTGCAGGTCACCAT
CGAGGACGGCCGTTACCTGGCCAGCACGGCGGGCGACCAGAACACCGGAATCCTGAAGACCATGCTCCGCTGCAACGCGC
TGGCGCTGCTCCCCGCCGACCGCATCGAATTCGCCGCAGGCGAAGAGGTCGAGCTGCACCTGCTGGATCCCACCCTGGAA
ATGGAGGCCTGA

Upstream 100 bases:

>100_bases
TGGAAAGGAGAACCGCCGCCGCTTTCAGCGCACGGGGTCCTCTCCTTTTTGGGATGCAGGACCCTTTTCTATTCCCACTC
CACAGCAATAAGAGGTGACG

Downstream 100 bases:

>100_bases
GATGTCTTTTAATCATTTTGATGCCAGCGGCAACGCCATCATGGTCGATGTCAGCCAGAAGGTCCCGACGATGCGGACCG
CCATAGCCGGAGCGGTACTG

Product: molybdopterin--molybdenum ligase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MMNYEKARRTILEKVAPAGVERVLLLEAAGRILAEDYSAPSDMPRWDNSAMDGFAVRSAGCAPGTVLKVTDYIPAGVSSG
DAVLEGCAARIMTGAPIPPGADTVVPIEETEAGEQSVKLLQQVKKGDHIRFQGEDVGRGDLIMPKGTLIGPPQVSLLASF
SAAVVPVYRRVRVAILSTGDELVEIGTEPKESQIVNSNALALACAIKLCGAEPVILGIARDNRESHLALLTEGLKADVLV
TSAGVSAGDRDLVREILAELGVVEQFWKPGVKPGGPTAFALRGNTPVFSLPGNPVSTMITFDEFVRPALLRMMGHEKALR
RTVRGYLKEGTRKKAGKLNFLRVQVTIEDGRYLASTAGDQNTGILKTMLRCNALALLPADRIEFAAGEEVELHLLDPTLE
MEA

Sequences:

>Translated_403_residues
MMNYEKARRTILEKVAPAGVERVLLLEAAGRILAEDYSAPSDMPRWDNSAMDGFAVRSAGCAPGTVLKVTDYIPAGVSSG
DAVLEGCAARIMTGAPIPPGADTVVPIEETEAGEQSVKLLQQVKKGDHIRFQGEDVGRGDLIMPKGTLIGPPQVSLLASF
SAAVVPVYRRVRVAILSTGDELVEIGTEPKESQIVNSNALALACAIKLCGAEPVILGIARDNRESHLALLTEGLKADVLV
TSAGVSAGDRDLVREILAELGVVEQFWKPGVKPGGPTAFALRGNTPVFSLPGNPVSTMITFDEFVRPALLRMMGHEKALR
RTVRGYLKEGTRKKAGKLNFLRVQVTIEDGRYLASTAGDQNTGILKTMLRCNALALLPADRIEFAAGEEVELHLLDPTLE
MEA
>Mature_403_residues
MMNYEKARRTILEKVAPAGVERVLLLEAAGRILAEDYSAPSDMPRWDNSAMDGFAVRSAGCAPGTVLKVTDYIPAGVSSG
DAVLEGCAARIMTGAPIPPGADTVVPIEETEAGEQSVKLLQQVKKGDHIRFQGEDVGRGDLIMPKGTLIGPPQVSLLASF
SAAVVPVYRRVRVAILSTGDELVEIGTEPKESQIVNSNALALACAIKLCGAEPVILGIARDNRESHLALLTEGLKADVLV
TSAGVSAGDRDLVREILAELGVVEQFWKPGVKPGGPTAFALRGNTPVFSLPGNPVSTMITFDEFVRPALLRMMGHEKALR
RTVRGYLKEGTRKKAGKLNFLRVQVTIEDGRYLASTAGDQNTGILKTMLRCNALALLPADRIEFAAGEEVELHLLDPTLE
MEA

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=414, Percent_Identity=33.5748792270531, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI66932975, Length=414, Percent_Identity=33.5748792270531, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1787049, Length=387, Percent_Identity=38.2428940568475, Blast_Score=231, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI25147659, Length=328, Percent_Identity=32.9268292682927, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17562606, Length=375, Percent_Identity=24.2666666666667, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136978, Length=375, Percent_Identity=31.4666666666667, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24638841, Length=375, Percent_Identity=31.4666666666667, Blast_Score=124, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43043; Mature: 43043

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNYEKARRTILEKVAPAGVERVLLLEAAGRILAEDYSAPSDMPRWDNSAMDGFAVRSAG
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCCEEEECCC
CAPGTVLKVTDYIPAGVSSGDAVLEGCAARIMTGAPIPPGADTVVPIEETEAGEQSVKLL
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHH
QQVKKGDHIRFQGEDVGRGDLIMPKGTLIGPPQVSLLASFSAAVVPVYRRVRVAILSTGD
HHHHCCCCEEEECCCCCCCCEECCCCCEECCCHHHHHHHHHHHHHHHHHHEEEEEEECCC
ELVEIGTEPKESQIVNSNALALACAIKLCGAEPVILGIARDNRESHLALLTEGLKADVLV
HHHCCCCCCCHHHEECCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCEEEEE
TSAGVSAGDRDLVREILAELGVVEQFWKPGVKPGGPTAFALRGNTPVFSLPGNPVSTMIT
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEECCCCCHHHEEE
FDEFVRPALLRMMGHEKALRRTVRGYLKEGTRKKAGKLNFLRVQVTIEDGRYLASTAGDQ
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHCCCEEEEEEEEEECCCEEEEECCCCC
NTGILKTMLRCNALALLPADRIEFAAGEEVELHLLDPTLEMEA
CCHHHHHHHHHCEEEECCCHHHHCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MMNYEKARRTILEKVAPAGVERVLLLEAAGRILAEDYSAPSDMPRWDNSAMDGFAVRSAG
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCCEEEECCC
CAPGTVLKVTDYIPAGVSSGDAVLEGCAARIMTGAPIPPGADTVVPIEETEAGEQSVKLL
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHH
QQVKKGDHIRFQGEDVGRGDLIMPKGTLIGPPQVSLLASFSAAVVPVYRRVRVAILSTGD
HHHHCCCCEEEECCCCCCCCEECCCCCEECCCHHHHHHHHHHHHHHHHHHEEEEEEECCC
ELVEIGTEPKESQIVNSNALALACAIKLCGAEPVILGIARDNRESHLALLTEGLKADVLV
HHHCCCCCCCHHHEECCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCEEEEE
TSAGVSAGDRDLVREILAELGVVEQFWKPGVKPGGPTAFALRGNTPVFSLPGNPVSTMIT
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEECCCCCHHHEEE
FDEFVRPALLRMMGHEKALRRTVRGYLKEGTRKKAGKLNFLRVQVTIEDGRYLASTAGDQ
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHCCCEEEEEEEEEECCCEEEEECCCCC
NTGILKTMLRCNALALLPADRIEFAAGEEVELHLLDPTLEMEA
CCHHHHHHHHHCEEEECCCHHHHCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]