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The map label for this gene is zraR [H]

Identifier: 197118650

GI number: 197118650

Start: 2639054

End: 2640424

Strand: Direct

Name: zraR [H]

Synonym: Gbem_2269

Alternate gene names: 197118650

Gene position: 2639054-2640424 (Clockwise)

Preceding gene: 197118642

Following gene: 197118651

Centisome position: 57.18

GC content: 61.42

Gene sequence:

>1371_bases
ATGAGACAGGAAAAGATTCTTATCTGCGACGACGAGGAAGGGATCCTCATCTATCTGAAGAAGCTGCTGCAGACCCAGGG
CTACCAGGTGGAGACCTTCAACGGGGGCGCGGCGCTCCTGCGCCGCCTTAAGGAGGGGGACCCCTCGGACGCGGACCTCC
TTTTGCAGGACGTAAGGATGCCGGACATGGACGGCATCACCGTGCTCAAGGAGGTCAAGGCGCTCCGCCCCTCGCTTCCC
ATCGTCATCATGACCGCCTTCGGGACCATAGACGCGGCGGTCGAGGCGATCAAGATGGGCGCCTACGACTACGTCACCAA
GCCCTTTCCCAAGGAGAAGATCCTGAGCGTCCTCAAAAACGCCCTGGAAAAGGAGCAGCTCTTGCAGGAGAACCGGGCGC
TCAAGAGCGAGCTGGAGAAGCCGATCCTGCAGGAATCGATCATCTTCAGAAGCGCCGCCTTCCAGGAGATCTACGACCTC
ACCCTGCAGGTCGCGGCCAGCGAAGCCAACATCCTGGTCCTGGGCGAATCGGGGACCGGCAAGGAGCTCATTGCCGGCGC
CATCCACTACAACAGCTTAAGGCGCGACCGGCGCTTTCTCTCCATCAACTGCGCGGCCCTCACCGATACGCTCCTGGAGA
GCCAGCTCTTCGGGCACGTCCGGGGCGCCTTCACCGGCGCGGTCGCAGCGCAGAAGGGACTCTTGGAGGAGGCCGACGGC
GGCACCCTCTTCATGGACGAGATCGGCGACATGACCCTCCCCATCCAGGCAAAGCTTTTGCGCGTGATCCAGGAGCGTGA
TTTCATCCCGGTTGGGTCGACCCGCCCGAAAAGCGCCGATATCCGCTTCGTGGCAGCCACCAACAAGAATCTGGAGCAGG
AGGTTCAGGAGGGGCGATTCCGCGAGGACCTCTTCTACCGTCTGAACGTGATCAACATCCCGCTGCCGCCGCTTAGGGAG
AGAAAGGACGACGTGGAACCCCTGGCGCTGCATTTCCTGAAGAAGTACAGCCTGAAGATGAAGAAGCAGGTAACCACCTT
GGCACCCGAGGCGCTGCAGCTCCTTTACGGCTACGACTGGCCCGGCAACATCAGGGAGCTGGAAAACGTCATGGAGCGCG
CAGTCATCCTGGCCCGGACCCAGACGGTCACCGCGAAGGAGCTTCCCATCTGGCGCAAACAGCCCCAAAAGGTTGAAGCG
CCGCGCGGCGAGGCGCAGTTCGTCTCGCTGGAAAACGTGGAGAAGGAAGCCATCGAGCGGACCCTGTCCGGAACCGGGTA
CCACAAGAGCAGGTCGGCCGAGATCCTGGGCATCTCCAGAAAAACCCTGGACCGCAAGATCGTCGAATACCGCATCACCA
TTCCCTCATGA

Upstream 100 bases:

>100_bases
AACAACGCTTAAAGATGTGCCGTTTTGTCGTGATGTGTGACATTTTGACCAGGTCACACAGGTAGCGCCGTGGCAGGAGC
AGCATGAGGAACACCGGGAA

Downstream 100 bases:

>100_bases
CTCTTCCCAAGCTGCGCTTTCCCATAAAGACCAAGCTCACCGTGGCGACGCTCATCCCGCTGGGGATAGCGATCCTCATC
TGCTGGATGGCCGGGGTCTT

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MRQEKILICDDEEGILIYLKKLLQTQGYQVETFNGGAALLRRLKEGDPSDADLLLQDVRMPDMDGITVLKEVKALRPSLP
IVIMTAFGTIDAAVEAIKMGAYDYVTKPFPKEKILSVLKNALEKEQLLQENRALKSELEKPILQESIIFRSAAFQEIYDL
TLQVAASEANILVLGESGTGKELIAGAIHYNSLRRDRRFLSINCAALTDTLLESQLFGHVRGAFTGAVAAQKGLLEEADG
GTLFMDEIGDMTLPIQAKLLRVIQERDFIPVGSTRPKSADIRFVAATNKNLEQEVQEGRFREDLFYRLNVINIPLPPLRE
RKDDVEPLALHFLKKYSLKMKKQVTTLAPEALQLLYGYDWPGNIRELENVMERAVILARTQTVTAKELPIWRKQPQKVEA
PRGEAQFVSLENVEKEAIERTLSGTGYHKSRSAEILGISRKTLDRKIVEYRITIPS

Sequences:

>Translated_456_residues
MRQEKILICDDEEGILIYLKKLLQTQGYQVETFNGGAALLRRLKEGDPSDADLLLQDVRMPDMDGITVLKEVKALRPSLP
IVIMTAFGTIDAAVEAIKMGAYDYVTKPFPKEKILSVLKNALEKEQLLQENRALKSELEKPILQESIIFRSAAFQEIYDL
TLQVAASEANILVLGESGTGKELIAGAIHYNSLRRDRRFLSINCAALTDTLLESQLFGHVRGAFTGAVAAQKGLLEEADG
GTLFMDEIGDMTLPIQAKLLRVIQERDFIPVGSTRPKSADIRFVAATNKNLEQEVQEGRFREDLFYRLNVINIPLPPLRE
RKDDVEPLALHFLKKYSLKMKKQVTTLAPEALQLLYGYDWPGNIRELENVMERAVILARTQTVTAKELPIWRKQPQKVEA
PRGEAQFVSLENVEKEAIERTLSGTGYHKSRSAEILGISRKTLDRKIVEYRITIPS
>Mature_456_residues
MRQEKILICDDEEGILIYLKKLLQTQGYQVETFNGGAALLRRLKEGDPSDADLLLQDVRMPDMDGITVLKEVKALRPSLP
IVIMTAFGTIDAAVEAIKMGAYDYVTKPFPKEKILSVLKNALEKEQLLQENRALKSELEKPILQESIIFRSAAFQEIYDL
TLQVAASEANILVLGESGTGKELIAGAIHYNSLRRDRRFLSINCAALTDTLLESQLFGHVRGAFTGAVAAQKGLLEEADG
GTLFMDEIGDMTLPIQAKLLRVIQERDFIPVGSTRPKSADIRFVAATNKNLEQEVQEGRFREDLFYRLNVINIPLPPLRE
RKDDVEPLALHFLKKYSLKMKKQVTTLAPEALQLLYGYDWPGNIRELENVMERAVILARTQTVTAKELPIWRKQPQKVEA
PRGEAQFVSLENVEKEAIERTLSGTGYHKSRSAEILGISRKTLDRKIVEYRITIPS

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=454, Percent_Identity=43.8325991189427, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1790437, Length=446, Percent_Identity=44.8430493273543, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1790299, Length=472, Percent_Identity=40.2542372881356, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1788905, Length=380, Percent_Identity=40.5263157894737, Blast_Score=298, Evalue=7e-82,
Organism=Escherichia coli, GI87082117, Length=261, Percent_Identity=49.0421455938697, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI1789233, Length=321, Percent_Identity=43.613707165109, Blast_Score=254, Evalue=8e-69,
Organism=Escherichia coli, GI1789087, Length=345, Percent_Identity=42.6086956521739, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI87082152, Length=217, Percent_Identity=52.073732718894, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1786524, Length=321, Percent_Identity=40.1869158878505, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI87081872, Length=308, Percent_Identity=37.987012987013, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787583, Length=322, Percent_Identity=33.5403726708075, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789828, Length=255, Percent_Identity=36.4705882352941, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87081858, Length=297, Percent_Identity=30.976430976431, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=124, Percent_Identity=30.6451612903226, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786784, Length=120, Percent_Identity=30.8333333333333, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787375, Length=134, Percent_Identity=29.1044776119403, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51332; Mature: 51332

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQEKILICDDEEGILIYLKKLLQTQGYQVETFNGGAALLRRLKEGDPSDADLLLQDVRM
CCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCHHHHHHHHCCC
PDMDGITVLKEVKALRPSLPIVIMTAFGTIDAAVEAIKMGAYDYVTKPFPKEKILSVLKN
CCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHH
ALEKEQLLQENRALKSELEKPILQESIIFRSAAFQEIYDLTLQVAASEANILVLGESGTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCC
KELIAGAIHYNSLRRDRRFLSINCAALTDTLLESQLFGHVRGAFTGAVAAQKGLLEEADG
HHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GTLFMDEIGDMTLPIQAKLLRVIQERDFIPVGSTRPKSADIRFVAATNKNLEQEVQEGRF
CEEEHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCCH
REDLFYRLNVINIPLPPLRERKDDVEPLALHFLKKYSLKMKKQVTTLAPEALQLLYGYDW
HHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PGNIRELENVMERAVILARTQTVTAKELPIWRKQPQKVEAPRGEAQFVSLENVEKEAIER
CCCHHHHHHHHHHHHHHHHCCCCCHHHCCCHHCCCCCCCCCCCCEEEEEHHHHHHHHHHH
TLSGTGYHKSRSAEILGISRKTLDRKIVEYRITIPS
HHCCCCCCCCCCCEEEECHHHHHHHEEEEEEEECCC
>Mature Secondary Structure
MRQEKILICDDEEGILIYLKKLLQTQGYQVETFNGGAALLRRLKEGDPSDADLLLQDVRM
CCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCHHHHHHHHCCC
PDMDGITVLKEVKALRPSLPIVIMTAFGTIDAAVEAIKMGAYDYVTKPFPKEKILSVLKN
CCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHH
ALEKEQLLQENRALKSELEKPILQESIIFRSAAFQEIYDLTLQVAASEANILVLGESGTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCC
KELIAGAIHYNSLRRDRRFLSINCAALTDTLLESQLFGHVRGAFTGAVAAQKGLLEEADG
HHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GTLFMDEIGDMTLPIQAKLLRVIQERDFIPVGSTRPKSADIRFVAATNKNLEQEVQEGRF
CEEEHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCCH
REDLFYRLNVINIPLPPLRERKDDVEPLALHFLKKYSLKMKKQVTTLAPEALQLLYGYDW
HHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PGNIRELENVMERAVILARTQTVTAKELPIWRKQPQKVEAPRGEAQFVSLENVEKEAIER
CCCHHHHHHHHHHHHHHHHCCCCCHHHCCCHHCCCCCCCCCCCCEEEEEHHHHHHHHHHH
TLSGTGYHKSRSAEILGISRKTLDRKIVEYRITIPS
HHCCCCCCCCCCCEEEECHHHHHHHEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]