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The map label for this gene is pdhA [H]

Identifier: 197118638

GI number: 197118638

Start: 2625778

End: 2626755

Strand: Reverse

Name: pdhA [H]

Synonym: Gbem_2257

Alternate gene names: 197118638

Gene position: 2626755-2625778 (Counterclockwise)

Preceding gene: 197118639

Following gene: 308535294

Centisome position: 56.92

GC content: 63.09

Gene sequence:

>978_bases
ATGGCGGACAATCTTAACGACCTGCTTCCCGAGGAGGATCTGCTGAAATTCTACGAGCAGATGGTGCTTTGCCGCGAGTT
CGAGGAGAGCTGTGCCGAGCAGTACTCCAAGGGGCATATCACCGGCTTCCTGCATCTCTATAGTGGCCAGGAAGCGGTCG
CCGTCGGCTGCACCGCCGGGCTGCAGCCTGCCGACTACGTGCTGTCGGCCTACCGCGACCATGCCCAAGCCATCGTAAGG
GGGGCCGATCCCAAGAGGGTCATGGCAGAACTCTTCGGCAAGGCGACCGGCCTTTGCAAGGGTAAAGGGGGGTCGATGCA
CCTGTTCGCGCCCGAGCTGAACTTCATGGGGGGGTACGCCATCGTGGGTGGGCAGTTCCCCATCGCCATCGGGCTTGCCT
GGGGGAGCCAGCTCCAGGAACAGGACCGCATCACCGCCTGTTTCTTCGGCGACGGCTCGATGAACCAGGGGACCTTCCAC
GAGTCGCTTAACTGGGCGCGGCTTTGGGACCTCCCAGTACTCTTCATCTGCGAGAACAACTTCTACGGCATAGGGACCGA
GGTGCACCGCGCCTCCGCCCAGGCAGCACTGCACCGGCGTACCTGTGGCTATGACATACCGAGCGAGAAGGTGGACGGCA
TGGACGTGGTAGCCATGTACCAGGCGACCAAGAGGGCGGCGGAGTGGGTGAGGGAGCACCAGCGCCCCTACTTCATAGAG
GCGGTCACCTACCGGTTCCGCGGCCACTCCATGTCTGACCCCGCCAAGTACCGTAGTTCCTCCGAGGCCGAGGTCTGGAA
AAGCCGCGACCCGATACCGAACCTCTCGCGCCGCCTGCAGGAGGAGGGAATCGCCGATCAGGCGCGCCTGGACGAGATAA
ACAGGAATGCCCTGGCCCAGGTCCAGGAGGCCGTCCGCTTCGCCGAGGATTCCCCCTGGCCTGAGGACTCCGAAATCTGG
AGCGATATCTACGTGTGA

Upstream 100 bases:

>100_bases
TTCAACGGAGGCGAGATCCTTACCCAGCTCACTGTTTCGGAGCGGGAGCGGGAGGAACTTCTGGCCGGGGGGCTTTTGAA
CAAGGTGAAGGAGGAGACCA

Downstream 100 bases:

>100_bases
AAAGGCCTGGCGAATACGGAGGGCCCCTCCTGATACAATATCCATCCATTACTTCGTAAAGGCCAGCCAATCAAGCTGGT
CTTTTTTTATACACATACTT

Product: pyruvate dehydrogenase complex, E1 protein subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MADNLNDLLPEEDLLKFYEQMVLCREFEESCAEQYSKGHITGFLHLYSGQEAVAVGCTAGLQPADYVLSAYRDHAQAIVR
GADPKRVMAELFGKATGLCKGKGGSMHLFAPELNFMGGYAIVGGQFPIAIGLAWGSQLQEQDRITACFFGDGSMNQGTFH
ESLNWARLWDLPVLFICENNFYGIGTEVHRASAQAALHRRTCGYDIPSEKVDGMDVVAMYQATKRAAEWVREHQRPYFIE
AVTYRFRGHSMSDPAKYRSSSEAEVWKSRDPIPNLSRRLQEEGIADQARLDEINRNALAQVQEAVRFAEDSPWPEDSEIW
SDIYV

Sequences:

>Translated_325_residues
MADNLNDLLPEEDLLKFYEQMVLCREFEESCAEQYSKGHITGFLHLYSGQEAVAVGCTAGLQPADYVLSAYRDHAQAIVR
GADPKRVMAELFGKATGLCKGKGGSMHLFAPELNFMGGYAIVGGQFPIAIGLAWGSQLQEQDRITACFFGDGSMNQGTFH
ESLNWARLWDLPVLFICENNFYGIGTEVHRASAQAALHRRTCGYDIPSEKVDGMDVVAMYQATKRAAEWVREHQRPYFIE
AVTYRFRGHSMSDPAKYRSSSEAEVWKSRDPIPNLSRRLQEEGIADQARLDEINRNALAQVQEAVRFAEDSPWPEDSEIW
SDIYV
>Mature_324_residues
ADNLNDLLPEEDLLKFYEQMVLCREFEESCAEQYSKGHITGFLHLYSGQEAVAVGCTAGLQPADYVLSAYRDHAQAIVRG
ADPKRVMAELFGKATGLCKGKGGSMHLFAPELNFMGGYAIVGGQFPIAIGLAWGSQLQEQDRITACFFGDGSMNQGTFHE
SLNWARLWDLPVLFICENNFYGIGTEVHRASAQAALHRRTCGYDIPSEKVDGMDVVAMYQATKRAAEWVREHQRPYFIEA
VTYRFRGHSMSDPAKYRSSSEAEVWKSRDPIPNLSRRLQEEGIADQARLDEINRNALAQVQEAVRFAEDSPWPEDSEIWS
DIYV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=322, Percent_Identity=41.304347826087, Blast_Score=251, Evalue=6e-67,
Organism=Homo sapiens, GI4505685, Length=322, Percent_Identity=40.9937888198758, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI291084742, Length=322, Percent_Identity=40.9937888198758, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI291084744, Length=329, Percent_Identity=40.1215805471125, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI291084757, Length=322, Percent_Identity=38.1987577639752, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI11386135, Length=318, Percent_Identity=32.3899371069182, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI258645172, Length=321, Percent_Identity=33.0218068535826, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17536047, Length=324, Percent_Identity=41.9753086419753, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI32564172, Length=324, Percent_Identity=41.9753086419753, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI86563355, Length=317, Percent_Identity=29.9684542586751, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI86563357, Length=317, Percent_Identity=29.9684542586751, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321026, Length=316, Percent_Identity=43.6708860759494, Blast_Score=259, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24639744, Length=318, Percent_Identity=41.1949685534591, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI28571106, Length=318, Percent_Identity=41.1949685534591, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24639740, Length=318, Percent_Identity=41.1949685534591, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24639748, Length=318, Percent_Identity=40.8805031446541, Blast_Score=230, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=41.1764705882353, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI21355903, Length=329, Percent_Identity=29.483282674772, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36537; Mature: 36406

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNLNDLLPEEDLLKFYEQMVLCREFEESCAEQYSKGHITGFLHLYSGQEAVAVGCTAG
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCC
LQPADYVLSAYRDHAQAIVRGADPKRVMAELFGKATGLCKGKGGSMHLFAPELNFMGGYA
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEECCCCEEEEECCCCCCCCCEE
IVGGQFPIAIGLAWGSQLQEQDRITACFFGDGSMNQGTFHESLNWARLWDLPVLFICENN
EECCCCCEEEEEHHCHHHHHCCCEEEEEECCCCCCCCCHHHCCCCEEEECCCEEEEECCC
FYGIGTEVHRASAQAALHRRTCGYDIPSEKVDGMDVVAMYQATKRAAEWVREHQRPYFIE
CEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
AVTYRFRGHSMSDPAKYRSSSEAEVWKSRDPIPNLSRRLQEEGIADQARLDEINRNALAQ
EEEHEECCCCCCCHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VQEAVRFAEDSPWPEDSEIWSDIYV
HHHHHHHHCCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
ADNLNDLLPEEDLLKFYEQMVLCREFEESCAEQYSKGHITGFLHLYSGQEAVAVGCTAG
CCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCC
LQPADYVLSAYRDHAQAIVRGADPKRVMAELFGKATGLCKGKGGSMHLFAPELNFMGGYA
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEECCCCEEEEECCCCCCCCCEE
IVGGQFPIAIGLAWGSQLQEQDRITACFFGDGSMNQGTFHESLNWARLWDLPVLFICENN
EECCCCCEEEEEHHCHHHHHCCCEEEEEECCCCCCCCCHHHCCCCEEEECCCEEEEECCC
FYGIGTEVHRASAQAALHRRTCGYDIPSEKVDGMDVVAMYQATKRAAEWVREHQRPYFIE
CEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
AVTYRFRGHSMSDPAKYRSSSEAEVWKSRDPIPNLSRRLQEEGIADQARLDEINRNALAQ
EEEHEECCCCCCCHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VQEAVRFAEDSPWPEDSEIWSDIYV
HHHHHHHHCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA