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The map label for this gene is cysK [H]

Identifier: 197118365

GI number: 197118365

Start: 2285825

End: 2286778

Strand: Direct

Name: cysK [H]

Synonym: Gbem_1983

Alternate gene names: 197118365

Gene position: 2285825-2286778 (Clockwise)

Preceding gene: 197118357

Following gene: 197118366

Centisome position: 49.53

GC content: 64.78

Gene sequence:

>954_bases
ATGTCCCGTATCTACCTAGACAACTCCCAGTCCATTGGCAACACGCCGCTGGTGCGGCTGAACCATGTAACCAAGGGGGC
CAAGGCGACCGTGCTCGCCAAGGTCGAGGGGCGCAACCCCGCCTACTCGGTAAAGTGCCGCATCGGTGCCAACATGATCT
GGGATGCCGAGGAGCGTGGCGTACTGAAGCCTGGGGTGGAGATCGTCGAGCCGACCAGCGGCAACACCGGCATAGCGCTT
GCCTACGTGGCGGCGGCCCGCGGTTACAAGCTGACCCTCACCATGCCCGAGACCATGAGCATCGAGCGCCGCAGGGTGCT
GGCGGCATTGGGAGCGAACCTGATCCTTACCCCGGGTTCCGCCGGGATGAAAGGGGCCGTGGCCAAGGCCGAGGAGATCG
CGGCTTCCGATCCGGCGCGCTACTTCCTGCCGCAGCAGTTCAAGAACCCTGCTAACCCCGCCATTCACGAGAAAACGACC
GGCCCGGAAATCTGGGCCGACACCGACGGCGCCGTAGACGTCGTCGTAGCCGGCGTAGGTACCGGCGGCACCATCTCCGG
GATCGCCCGCTACCTCAAGCAGACCAAGGGGAAGCAGGTCGTCGCGGTTGCGGTCGAGCCCAAGGAAAGCCCGGTAATCA
GCCAGAAGCTTGCCGGCCAGGAACTCAAGCCCGGCCCGCACAAGATCCAGGGGATCGGCGCCGGTTTCATTCCCGATACC
CTCGACCTCTCCGTCATCGACCGGGTCGAGCAGATCGACAGCAACGAGGCCTTGGAGTTCGCCAAGCGCCTTACCAAGGA
AGAGGGCCTTTTGGTCGGCATCTCCAGCGGCGCCGCGGTTGCCGCCGCCGTGCGGCTGGCCAACCTGCAGGAATTTGCCG
GCAAGACCATCGTGGTGGTGCTCCCCGACCTCGCCGAGCGCTATCTCTCCACCGCACTCTTCGAAGAAGCCTGA

Upstream 100 bases:

>100_bases
TGACAGTGTTGCAGGATAAATATAAAAATACGAACCATGTTACCATCCGCCGTCAGATATTGAGGCGTTACGCAAATCAC
GACCGAAAGGAGAATTCGCC

Downstream 100 bases:

>100_bases
TACTTTCCTGGCTGAAAAGCATCGATAGAGGCCCCGGTTTCCCCGGGGCCTTTTTACGTCCGGGGTCCGTTTTCCCGGAA
GATGTTGACACCCCGCACGC

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine sulfhydrylase A; Sulfate starvation-induced protein 5; SSI5 [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSRIYLDNSQSIGNTPLVRLNHVTKGAKATVLAKVEGRNPAYSVKCRIGANMIWDAEERGVLKPGVEIVEPTSGNTGIAL
AYVAAARGYKLTLTMPETMSIERRRVLAALGANLILTPGSAGMKGAVAKAEEIAASDPARYFLPQQFKNPANPAIHEKTT
GPEIWADTDGAVDVVVAGVGTGGTISGIARYLKQTKGKQVVAVAVEPKESPVISQKLAGQELKPGPHKIQGIGAGFIPDT
LDLSVIDRVEQIDSNEALEFAKRLTKEEGLLVGISSGAAVAAAVRLANLQEFAGKTIVVVLPDLAERYLSTALFEEA

Sequences:

>Translated_317_residues
MSRIYLDNSQSIGNTPLVRLNHVTKGAKATVLAKVEGRNPAYSVKCRIGANMIWDAEERGVLKPGVEIVEPTSGNTGIAL
AYVAAARGYKLTLTMPETMSIERRRVLAALGANLILTPGSAGMKGAVAKAEEIAASDPARYFLPQQFKNPANPAIHEKTT
GPEIWADTDGAVDVVVAGVGTGGTISGIARYLKQTKGKQVVAVAVEPKESPVISQKLAGQELKPGPHKIQGIGAGFIPDT
LDLSVIDRVEQIDSNEALEFAKRLTKEEGLLVGISSGAAVAAAVRLANLQEFAGKTIVVVLPDLAERYLSTALFEEA
>Mature_316_residues
SRIYLDNSQSIGNTPLVRLNHVTKGAKATVLAKVEGRNPAYSVKCRIGANMIWDAEERGVLKPGVEIVEPTSGNTGIALA
YVAAARGYKLTLTMPETMSIERRRVLAALGANLILTPGSAGMKGAVAKAEEIAASDPARYFLPQQFKNPANPAIHEKTTG
PEIWADTDGAVDVVVAGVGTGGTISGIARYLKQTKGKQVVAVAVEPKESPVISQKLAGQELKPGPHKIQGIGAGFIPDTL
DLSVIDRVEQIDSNEALEFAKRLTKEEGLLVGISSGAAVAAAVRLANLQEFAGKTIVVVLPDLAERYLSTALFEEA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=317, Percent_Identity=43.217665615142, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI295821200, Length=317, Percent_Identity=43.217665615142, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI4557415, Length=317, Percent_Identity=43.217665615142, Blast_Score=221, Evalue=6e-58,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=71.1111111111111, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI2367138, Length=307, Percent_Identity=41.6938110749186, Blast_Score=215, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=52.6143790849673, Blast_Score=290, Evalue=7e-79,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=53.5947712418301, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17562970, Length=319, Percent_Identity=47.3354231974922, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI32566674, Length=312, Percent_Identity=48.0769230769231, Blast_Score=266, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17561720, Length=317, Percent_Identity=48.2649842271293, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI32566672, Length=222, Percent_Identity=46.8468468468468, Blast_Score=193, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=324, Percent_Identity=38.8888888888889, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI25147552, Length=322, Percent_Identity=37.888198757764, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17561716, Length=125, Percent_Identity=45.6, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321594, Length=320, Percent_Identity=37.1875, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6321449, Length=329, Percent_Identity=34.0425531914894, Blast_Score=136, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24643623, Length=305, Percent_Identity=40.327868852459, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI20129101, Length=305, Percent_Identity=40.327868852459, Blast_Score=181, Evalue=8e-46,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33418; Mature: 33287

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIYLDNSQSIGNTPLVRLNHVTKGAKATVLAKVEGRNPAYSVKCRIGANMIWDAEERG
CCEEEECCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCEEECCCCCC
VLKPGVEIVEPTSGNTGIALAYVAAARGYKLTLTMPETMSIERRRVLAALGANLILTPGS
CCCCCCEEECCCCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCC
AGMKGAVAKAEEIAASDPARYFLPQQFKNPANPAIHEKTTGPEIWADTDGAVDVVVAGVG
CCCCCHHHHHHHHHCCCCHHHCCCHHHCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECC
TGGTISGIARYLKQTKGKQVVAVAVEPKESPVISQKLAGQELKPGPHKIQGIGAGFIPDT
CCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCCC
LDLSVIDRVEQIDSNEALEFAKRLTKEEGLLVGISSGAAVAAAVRLANLQEFAGKTIVVV
CCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEEE
LPDLAERYLSTALFEEA
CCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRIYLDNSQSIGNTPLVRLNHVTKGAKATVLAKVEGRNPAYSVKCRIGANMIWDAEERG
CEEEECCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCEEECCCCCC
VLKPGVEIVEPTSGNTGIALAYVAAARGYKLTLTMPETMSIERRRVLAALGANLILTPGS
CCCCCCEEECCCCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCC
AGMKGAVAKAEEIAASDPARYFLPQQFKNPANPAIHEKTTGPEIWADTDGAVDVVVAGVG
CCCCCHHHHHHHHHCCCCHHHCCCHHHCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECC
TGGTISGIARYLKQTKGKQVVAVAVEPKESPVISQKLAGQELKPGPHKIQGIGAGFIPDT
CCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCCC
LDLSVIDRVEQIDSNEALEFAKRLTKEEGLLVGISSGAAVAAAVRLANLQEFAGKTIVVV
CCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEEE
LPDLAERYLSTALFEEA
CCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]