Click here to switch to the map view.

The map label for this gene is trpG [H]

Identifier: 197118338

GI number: 197118338

Start: 2259344

End: 2259913

Strand: Direct

Name: trpG [H]

Synonym: Gbem_1955

Alternate gene names: 197118338

Gene position: 2259344-2259913 (Clockwise)

Preceding gene: 197118337

Following gene: 197118339

Centisome position: 48.95

GC content: 63.51

Gene sequence:

>570_bases
ATGCTCCTGATGATAGACAACTACGACTCCTTCACCTACAACATCGTCCAATACCTGGGCGAGCTGGGCGAGGACGTCCG
GGTGTACCGCAACGACAAGATCACCCTAGACGAAATCGAGGCCCTGGCGCCGGAGCGCATCGTGATCTCCCCGGGCCCCT
GCTCCCCAGAGGAGGCAGGGATCTCGGTCGAGGTGGTGCGCCGCTTCGCCGGGCGCATTCCGATCCTGGGGGTCTGCCTC
GGGCACCAGTCGATCGGCTACGCCTTCGGCGGCAAGATCGTCAAGAGCGCCACCTTGATGCACGGCAAGACCTCCCCCAT
CCTGCACGACGGCAAGGAACTCTTCGCCGGCCTCCCCAACCCGTTTGCGGCCACGCGCTACCACTCGCTGATCGTCGAGC
GCGAGTCGCTTCCCGCCGAGCTCGAGGTGACCGCCTGGGTTACCGAGGGGGAGATAATGGGGATGCGGCACCGCACCCTC
CCGATCTGGGGCGTGCAGTTTCACCCGGAGTCCATCCTCACCGAGGGTGGGATGGAGCTTTTGCAAAACTTTCTGCAGAT
GACGAAGTAA

Upstream 100 bases:

>100_bases
CGATTCCGATTAAACACCAAACGAGTGGGGATCGGGGCCTCCCGCGTCTCCTTCCCACGCAGTGTCCGATAAAACTTCTG
TATTCCGACAGGTTATCCAT

Downstream 100 bases:

>100_bases
CCTCTGCGCTACCAGGGACCCGGATTGCATCCGCCCGGGCCCGGTTCCCTGGCCGGCGCCGCAAAATGCATGGCCAGCAA
GGAGAACGTCCCGCACCGGA

Product: anthranilate synthase component II

Products: NA

Alternate protein names: Glutamine amido-transferase [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MLLMIDNYDSFTYNIVQYLGELGEDVRVYRNDKITLDEIEALAPERIVISPGPCSPEEAGISVEVVRRFAGRIPILGVCL
GHQSIGYAFGGKIVKSATLMHGKTSPILHDGKELFAGLPNPFAATRYHSLIVERESLPAELEVTAWVTEGEIMGMRHRTL
PIWGVQFHPESILTEGGMELLQNFLQMTK

Sequences:

>Translated_189_residues
MLLMIDNYDSFTYNIVQYLGELGEDVRVYRNDKITLDEIEALAPERIVISPGPCSPEEAGISVEVVRRFAGRIPILGVCL
GHQSIGYAFGGKIVKSATLMHGKTSPILHDGKELFAGLPNPFAATRYHSLIVERESLPAELEVTAWVTEGEIMGMRHRTL
PIWGVQFHPESILTEGGMELLQNFLQMTK
>Mature_189_residues
MLLMIDNYDSFTYNIVQYLGELGEDVRVYRNDKITLDEIEALAPERIVISPGPCSPEEAGISVEVVRRFAGRIPILGVCL
GHQSIGYAFGGKIVKSATLMHGKTSPILHDGKELFAGLPNPFAATRYHSLIVERESLPAELEVTAWVTEGEIMGMRHRTL
PIWGVQFHPESILTEGGMELLQNFLQMTK

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=184, Percent_Identity=31.5217391304348, Blast_Score=70, Evalue=9e-13,
Organism=Escherichia coli, GI1789760, Length=186, Percent_Identity=63.9784946236559, Blast_Score=261, Evalue=2e-71,
Organism=Escherichia coli, GI1787517, Length=187, Percent_Identity=42.2459893048128, Blast_Score=158, Evalue=2e-40,
Organism=Escherichia coli, GI1786215, Length=141, Percent_Identity=27.6595744680851, Blast_Score=67, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322638, Length=188, Percent_Identity=48.936170212766, Blast_Score=196, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324361, Length=212, Percent_Identity=34.9056603773585, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323873, Length=145, Percent_Identity=29.6551724137931, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281365319, Length=139, Percent_Identity=33.0935251798561, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 21026; Mature: 21026

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLMIDNYDSFTYNIVQYLGELGEDVRVYRNDKITLDEIEALAPERIVISPGPCSPEEAG
CEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCEEEECCCCCCHHHCC
ISVEVVRRFAGRIPILGVCLGHQSIGYAFGGKIVKSATLMHGKTSPILHDGKELFAGLPN
CHHHHHHHHHCCCCEEEEEECCCCCCHHHCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCC
PFAATRYHSLIVERESLPAELEVTAWVTEGEIMGMRHRTLPIWGVQFHPESILTEGGMEL
CHHHHHHHHHEEECCCCCCEEEEEEEEECCEEECCCCCCCEEEEEEECCHHHHHHHHHHH
LQNFLQMTK
HHHHHHHCC
>Mature Secondary Structure
MLLMIDNYDSFTYNIVQYLGELGEDVRVYRNDKITLDEIEALAPERIVISPGPCSPEEAG
CEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCEEEECCCCCCHHHCC
ISVEVVRRFAGRIPILGVCLGHQSIGYAFGGKIVKSATLMHGKTSPILHDGKELFAGLPN
CHHHHHHHHHCCCCEEEEEECCCCCCHHHCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCC
PFAATRYHSLIVERESLPAELEVTAWVTEGEIMGMRHRTLPIWGVQFHPESILTEGGMEL
CHHHHHHHHHEEECCCCCCEEEEEEEEECCEEECCCCCCCEEEEEEECCHHHHHHHHHHH
LQNFLQMTK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2105306; 10984043 [H]