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The map label for this gene is czcC [H]

Identifier: 197118322

GI number: 197118322

Start: 2240273

End: 2241571

Strand: Direct

Name: czcC [H]

Synonym: Gbem_1939

Alternate gene names: 197118322

Gene position: 2240273-2241571 (Clockwise)

Preceding gene: 197118321

Following gene: 197118323

Centisome position: 48.54

GC content: 63.43

Gene sequence:

>1299_bases
GTGTTTGATGTGCCGCTGATGAATAGATACGGCCTGCTGGCCGCTGCAATGTCCGTGCTGCTCTGCGCTACTGCGGGACC
GGCCCGGGGCGAGGAGATTTCGCTGCAAAAGGCAGTGGAGATCGCTGTCCAAAATAACGTGGAGCTGAACGCTTTCCGCA
AAGAAGAGGGGCTTCGCGAAGCTGCGAAGACGAAGGCGGGCCTGCTCCCCAACCCGACGCTGGAGCTCAGCCTCGAATCC
GGCGCCCTGACCGGCAACAGCGGGGAGAATGCCTTTTCCGTCGGCGTATCGCAGGAGTTTCTCCTCGCCGGAAAAAGGGA
GAAGAGGCTTGCCCTGGCGCAAAAGGAACTGGAGGTATACCGCTGGCAACTGGCCGACCGGGAAAGGCTGCTCCGCCTCG
ACGCGAAGGCGCGGTTTTATCAGGTGCTGCTGGCCGTCAGGAAGCTAAAGCTGGCCGAGGGAGGAATCGAACTGAACCGC
CACCTTTACCAGGTGGCCAAGGAGCGTCTCGCCGCCGGCGACATCCCCGAACTGGAACTGAACCTGGTGCAGGTGGAGCT
GGCCAGGAGCGAGGGGGCGAAAACCGCCGCTCTTGAGGCCGTTTTGTCCAGCCGTGCCGAGCTTTCCCTCCTCTTGGGGG
GGAGCGAGGTCGACCCGGCGCTCCCGACCGGGCCCCTGGAAGCTGGGGGGGCGGTAAAGGAGGCACAGGGTGATCTTTTC
CGACTCGCCTTGGAACGGCGCCCGGATCTCAAGGCGCTTAGGGCAGAGGCGGAGAAGGGGAGCGCGGAGCTTTCCCTGGC
CCAGGCCGAGGGGGTCCCGAACCTCACCGCCGGCCTTGGGCTCAAGCGCGACACCACCACCGTCGAGGTGGCGGGGCTGG
AAGGGAAAGACACCTCTTATACCGTCGGGATCACTCTCTCGATGCCGATACCGCTTTTCGACAAGAACCAGTCGGGCGTC
CGCGAGGCAAGCGTCAGACGCGACACCGCCGGCAGCCGGCTAGCCGTTGCAGTCAAACGGGTAGAGCGCGAGGTGGCCAC
GGCGTATGCCAGCCTCTCCAACGCCGAGCAGCTCCTTTCCCTGTACCTCAGAAACGTCATGCCCCAGCTCGAGGAGAACC
TGAAGCTGACCAGCGAGGCTTACCAACTGGGTGAAGTCCCTGTGCTGACGGTCTTCGAGGAGCAGAAGAAGTACCTCGAG
GTGAACCAGGGGTACCTGGAAGCCCTGAACCAGCGGCAGCAGGCGCTTTTCAAACTGGAAGCGGCGGCGGCAACCGAACT
TACCGGAGGTGTGCATTGA

Upstream 100 bases:

>100_bases
CTGGGTTGGTATGGTTCAACCCTGGAGGCTCAGCTGCAAAGGGATCCGTGCAGTCGGCGCCTGTCTTTGTTTCCGAAAAA
CTACTTTAGGAGGATGGTAC

Downstream 100 bases:

>100_bases
GCAAGAAAGCAAAGATCGTTGGATTAATTTTGGCCCTCGCCCTGACGGGAGCCTTTACCTATCGTTTCGTCCAGATGGGC
GCCGCCGGTTCGGAACCAGG

Product: RND family metal ion efflux pump outer membrane protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MFDVPLMNRYGLLAAAMSVLLCATAGPARGEEISLQKAVEIAVQNNVELNAFRKEEGLREAAKTKAGLLPNPTLELSLES
GALTGNSGENAFSVGVSQEFLLAGKREKRLALAQKELEVYRWQLADRERLLRLDAKARFYQVLLAVRKLKLAEGGIELNR
HLYQVAKERLAAGDIPELELNLVQVELARSEGAKTAALEAVLSSRAELSLLLGGSEVDPALPTGPLEAGGAVKEAQGDLF
RLALERRPDLKALRAEAEKGSAELSLAQAEGVPNLTAGLGLKRDTTTVEVAGLEGKDTSYTVGITLSMPIPLFDKNQSGV
REASVRRDTAGSRLAVAVKRVEREVATAYASLSNAEQLLSLYLRNVMPQLEENLKLTSEAYQLGEVPVLTVFEEQKKYLE
VNQGYLEALNQRQQALFKLEAAAATELTGGVH

Sequences:

>Translated_432_residues
MFDVPLMNRYGLLAAAMSVLLCATAGPARGEEISLQKAVEIAVQNNVELNAFRKEEGLREAAKTKAGLLPNPTLELSLES
GALTGNSGENAFSVGVSQEFLLAGKREKRLALAQKELEVYRWQLADRERLLRLDAKARFYQVLLAVRKLKLAEGGIELNR
HLYQVAKERLAAGDIPELELNLVQVELARSEGAKTAALEAVLSSRAELSLLLGGSEVDPALPTGPLEAGGAVKEAQGDLF
RLALERRPDLKALRAEAEKGSAELSLAQAEGVPNLTAGLGLKRDTTTVEVAGLEGKDTSYTVGITLSMPIPLFDKNQSGV
REASVRRDTAGSRLAVAVKRVEREVATAYASLSNAEQLLSLYLRNVMPQLEENLKLTSEAYQLGEVPVLTVFEEQKKYLE
VNQGYLEALNQRQQALFKLEAAAATELTGGVH
>Mature_432_residues
MFDVPLMNRYGLLAAAMSVLLCATAGPARGEEISLQKAVEIAVQNNVELNAFRKEEGLREAAKTKAGLLPNPTLELSLES
GALTGNSGENAFSVGVSQEFLLAGKREKRLALAQKELEVYRWQLADRERLLRLDAKARFYQVLLAVRKLKLAEGGIELNR
HLYQVAKERLAAGDIPELELNLVQVELARSEGAKTAALEAVLSSRAELSLLLGGSEVDPALPTGPLEAGGAVKEAQGDLF
RLALERRPDLKALRAEAEKGSAELSLAQAEGVPNLTAGLGLKRDTTTVEVAGLEGKDTSYTVGITLSMPIPLFDKNQSGV
REASVRRDTAGSRLAVAVKRVEREVATAYASLSNAEQLLSLYLRNVMPQLEENLKLTSEAYQLGEVPVLTVFEEQKKYLE
VNQGYLEALNQRQQALFKLEAAAATELTGGVH

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 46754; Mature: 46754

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDVPLMNRYGLLAAAMSVLLCATAGPARGEEISLQKAVEIAVQNNVELNAFRKEEGLRE
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHH
AAKTKAGLLPNPTLELSLESGALTGNSGENAFSVGVSQEFLLAGKREKRLALAQKELEVY
HHHHHCCCCCCCCEEEEECCCEECCCCCCCEEEECCCHHHHHCCCCHHHHHHHHHHHHHH
RWQLADRERLLRLDAKARFYQVLLAVRKLKLAEGGIELNRHLYQVAKERLAAGDIPELEL
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEE
NLVQVELARSEGAKTAALEAVLSSRAELSLLLGGSEVDPALPTGPLEAGGAVKEAQGDLF
EEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCHHH
RLALERRPDLKALRAEAEKGSAELSLAQAEGVPNLTAGLGLKRDTTTVEVAGLEGKDTSY
HHHHHCCCCHHHHHHHHHCCCCEEEEHHHCCCCCHHHCCCCCCCCCEEEEECCCCCCCEE
TVGITLSMPIPLFDKNQSGVREASVRRDTAGSRLAVAVKRVEREVATAYASLSNAEQLLS
EEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LYLRNVMPQLEENLKLTSEAYQLGEVPVLTVFEEQKKYLEVNQGYLEALNQRQQALFKLE
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AAAATELTGGVH
HHHHHHHCCCCC
>Mature Secondary Structure
MFDVPLMNRYGLLAAAMSVLLCATAGPARGEEISLQKAVEIAVQNNVELNAFRKEEGLRE
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHH
AAKTKAGLLPNPTLELSLESGALTGNSGENAFSVGVSQEFLLAGKREKRLALAQKELEVY
HHHHHCCCCCCCCEEEEECCCEECCCCCCCEEEECCCHHHHHCCCCHHHHHHHHHHHHHH
RWQLADRERLLRLDAKARFYQVLLAVRKLKLAEGGIELNRHLYQVAKERLAAGDIPELEL
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEE
NLVQVELARSEGAKTAALEAVLSSRAELSLLLGGSEVDPALPTGPLEAGGAVKEAQGDLF
EEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCHHH
RLALERRPDLKALRAEAEKGSAELSLAQAEGVPNLTAGLGLKRDTTTVEVAGLEGKDTSY
HHHHHCCCCHHHHHHHHHCCCCEEEEHHHCCCCCHHHCCCCCCCCCEEEEECCCCCCCEE
TVGITLSMPIPLFDKNQSGVREASVRRDTAGSRLAVAVKRVEREVATAYASLSNAEQLLS
EEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LYLRNVMPQLEENLKLTSEAYQLGEVPVLTVFEEQKKYLEVNQGYLEALNQRQQALFKLE
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AAAATELTGGVH
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]