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The map label for this gene is pyrR

Identifier: 197118278

GI number: 197118278

Start: 2194498

End: 2195031

Strand: Direct

Name: pyrR

Synonym: Gbem_1895

Alternate gene names: 197118278

Gene position: 2194498-2195031 (Clockwise)

Preceding gene: 197118276

Following gene: 197118279

Centisome position: 47.55

GC content: 64.61

Gene sequence:

>534_bases
ATGGCTGACAACACGGTAATTCTGGACGGCAGCGGCGTCAAAAGGGCGCTCACCAGGATAGCCCACGAGGTGCTTGAGAA
GAACAAGGGGGTCGAAGGGCTCGTCCTGGTCGGGATCCGGACCGGCGGCGTCTTCCTGGCACAGGAACTCGCCGAGCGCC
TGGTCGAGATCGAGGGGGTCGAGGTCCCCTGCGGAGCGGTGGACATCACCATGTACCGCGACGACATCAAGGGGCACGCC
GAGCACCTGCCGGTCGGCAAAACCGAGCTTCCTTTCTCCATCGAGGGGAAGAAGGTGGTGCTGGTCGACGACGTGCTCTT
CACCGGGCGCACCATCCGCGCCGCCATGGACGCGCTGATGGACCAAGGGCGTGCCTCCTGCATCCAGCTCGCCGTCCTGG
TGGACCGCGGGCACCGCGACCTCCCGATCCGCGCCGACTTCGTGGGACGAAACGTCCCGACCAGCAGGAGCGAGAACATC
GTCGTCGCTTTCGATGCCGGCAACAAGCCGACGGAAGTGATCCTGCAGAAATAA

Upstream 100 bases:

>100_bases
CTTTTCGCCCCTACGCGCGGAAAGGCTCTTTTTAGTTGAAACTAGGTCGGACCCGAAACTGCTTCAGAACAGGCTCTTAT
GCCGATAACAGGGGGTTATT

Downstream 100 bases:

>100_bases
AAACTTCCTCCTCTACGGGGGGAAAGCCATAAATTGATATCGTTTTGCTTTAACGCTGGAGCGCGCCGGTGCGCTCCGCA
AACCGAGGGGGGGACCATGG

Product: bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase

Products: NA

Alternate protein names: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase; UPRTase

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MADNTVILDGSGVKRALTRIAHEVLEKNKGVEGLVLVGIRTGGVFLAQELAERLVEIEGVEVPCGAVDITMYRDDIKGHA
EHLPVGKTELPFSIEGKKVVLVDDVLFTGRTIRAAMDALMDQGRASCIQLAVLVDRGHRDLPIRADFVGRNVPTSRSENI
VVAFDAGNKPTEVILQK

Sequences:

>Translated_177_residues
MADNTVILDGSGVKRALTRIAHEVLEKNKGVEGLVLVGIRTGGVFLAQELAERLVEIEGVEVPCGAVDITMYRDDIKGHA
EHLPVGKTELPFSIEGKKVVLVDDVLFTGRTIRAAMDALMDQGRASCIQLAVLVDRGHRDLPIRADFVGRNVPTSRSENI
VVAFDAGNKPTEVILQK
>Mature_176_residues
ADNTVILDGSGVKRALTRIAHEVLEKNKGVEGLVLVGIRTGGVFLAQELAERLVEIEGVEVPCGAVDITMYRDDIKGHAE
HLPVGKTELPFSIEGKKVVLVDDVLFTGRTIRAAMDALMDQGRASCIQLAVLVDRGHRDLPIRADFVGRNVPTSRSENIV
VAFDAGNKPTEVILQK

Specific function: Displays also a weak uracil phosphoribosyltransferase activity which is not physiologically significant

COG id: COG2065

COG function: function code F; Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRR_GEOBB (B5EB48)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002138705.1
- ProteinModelPortal:   B5EB48
- SMR:   B5EB48
- GeneID:   6781885
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_1895
- HOGENOM:   HBG641958
- OMA:   IAHEVLE
- ProtClustDB:   PRK05205
- GO:   GO:0006350
- HAMAP:   MF_01219
- InterPro:   IPR000836
- InterPro:   IPR023050

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 19164; Mature: 19033

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNTVILDGSGVKRALTRIAHEVLEKNKGVEGLVLVGIRTGGVFLAQELAERLVEIEGV
CCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCC
EVPCGAVDITMYRDDIKGHAEHLPVGKTELPFSIEGKKVVLVDDVLFTGRTIRAAMDALM
CCCCCEEEEEEEECCCCCHHHHCCCCCCCCCEEECCCEEEEEECEECCCCHHHHHHHHHH
DQGRASCIQLAVLVDRGHRDLPIRADFVGRNVPTSRSENIVVAFDAGNKPTEVILQK
HCCCHHHHEEEEEEECCCCCCCEEEHCCCCCCCCCCCCCEEEEECCCCCCCEEEEEC
>Mature Secondary Structure 
ADNTVILDGSGVKRALTRIAHEVLEKNKGVEGLVLVGIRTGGVFLAQELAERLVEIEGV
CCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCC
EVPCGAVDITMYRDDIKGHAEHLPVGKTELPFSIEGKKVVLVDDVLFTGRTIRAAMDALM
CCCCCEEEEEEEECCCCCHHHHCCCCCCCCCEEECCCEEEEEECEECCCCHHHHHHHHHH
DQGRASCIQLAVLVDRGHRDLPIRADFVGRNVPTSRSENIVVAFDAGNKPTEVILQK
HCCCHHHHEEEEEEECCCCCCCEEEHCCCCCCCCCCCCCEEEEECCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA