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The map label for this gene is rocF [H]

Identifier: 197118269

GI number: 197118269

Start: 2185370

End: 2186281

Strand: Direct

Name: rocF [H]

Synonym: Gbem_1886

Alternate gene names: 197118269

Gene position: 2185370-2186281 (Clockwise)

Preceding gene: 197118268

Following gene: 197118276

Centisome position: 47.35

GC content: 65.02

Gene sequence:

>912_bases
ATGGGAAAGGCTGGGGGGAAGATGGAAAACCGTATCAGGATGATAGGCGTGCCGCTGGACCTGGGGCAGGAGCAGCGCGG
CGTCGACCTGGGGCCGGGGGCGCTGCGCTATGCGGGGCTGTCGGCTCGCCTCACCGGTCTGGGGTACCAAGTGGAGGATA
TAGGGAACCTGGAGGTGCCGGTACGTGACGTGGTGACCGCTGAGCGGCAGCAGCATTACCTTCCCTCGATAGGGAAGGTC
TGCGAGACGGTTTATCAGGCAGGGCGCACGGCGGTGGCGCAAGGTTGCATCCCCGTCTTCATGGGGGGGGACCATTCGCT
GGCGCTTGGCTCCATAGGCGGCGTGACCCATGAACAGCCGACGGCGGTGATCTGGGTCGACGCCCACGGCGACTTCAACA
CGCCTGAGACCTCCCCCAGCGGGAACATTCACGGGATGGTTTTGGCGGCGCTTTTGGGGGAAGGGCATTCGGAACTGGTG
CACCTGGGGAGGCCGGGGCCGAAGCTTAGCGGCAGCGACGTGGTCCTGATCGGGCTGCGGGAGCTGGATCCGCAGGAGAA
GGTCAGGCTGCGGGAGAGTTCAGTCAACGTCTACACCATGAGGGACATAGACGAGCGGGGCATCGGCGCCATCGCGCGGG
AGGCGCTGGGAAAGCTCGCCCACAGGACCCGCCTGCACCTGAGCCTCGATCTCGACGGCCTGGACCCGCTGGAGGTTCCC
GGCGTCGGCACCACCTCGCCGGGAGGGATCACCTACCGCGAGGCCCAGCTCCTGATGGAGATCATCGCCGATACGAAGCT
TCTTTGCTCCATGGACATCGTGGAGATAAACCCGATCCTGGACCACGGCAACCGCACCGCAAAAATCGCCGTGGAACTGG
CCGCCTCCGCTTTCGGGGAGGCGATCATGTAA

Upstream 100 bases:

>100_bases
TGGCCAACCGCGGCTCGGCGCAGGCGGTGGGGCTTTTGACCAACGCGCAGGATTTCGTAGTGAACCTCTGGAACCACCTG
AAGCAAAAGGGATGAGCTGA

Downstream 100 bases:

>100_bases
AGGCAATCTATTTAGCTGCGGTTACGGGTGGATCAATGGAGGAATTGGACAGAGCAACGGCGGGATGTGCTTCCTGCGGA
AAAAAAGCGGCCCGCGCTCT

Product: arginase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MGKAGGKMENRIRMIGVPLDLGQEQRGVDLGPGALRYAGLSARLTGLGYQVEDIGNLEVPVRDVVTAERQQHYLPSIGKV
CETVYQAGRTAVAQGCIPVFMGGDHSLALGSIGGVTHEQPTAVIWVDAHGDFNTPETSPSGNIHGMVLAALLGEGHSELV
HLGRPGPKLSGSDVVLIGLRELDPQEKVRLRESSVNVYTMRDIDERGIGAIAREALGKLAHRTRLHLSLDLDGLDPLEVP
GVGTTSPGGITYREAQLLMEIIADTKLLCSMDIVEINPILDHGNRTAKIAVELAASAFGEAIM

Sequences:

>Translated_303_residues
MGKAGGKMENRIRMIGVPLDLGQEQRGVDLGPGALRYAGLSARLTGLGYQVEDIGNLEVPVRDVVTAERQQHYLPSIGKV
CETVYQAGRTAVAQGCIPVFMGGDHSLALGSIGGVTHEQPTAVIWVDAHGDFNTPETSPSGNIHGMVLAALLGEGHSELV
HLGRPGPKLSGSDVVLIGLRELDPQEKVRLRESSVNVYTMRDIDERGIGAIAREALGKLAHRTRLHLSLDLDGLDPLEVP
GVGTTSPGGITYREAQLLMEIIADTKLLCSMDIVEINPILDHGNRTAKIAVELAASAFGEAIM
>Mature_302_residues
GKAGGKMENRIRMIGVPLDLGQEQRGVDLGPGALRYAGLSARLTGLGYQVEDIGNLEVPVRDVVTAERQQHYLPSIGKVC
ETVYQAGRTAVAQGCIPVFMGGDHSLALGSIGGVTHEQPTAVIWVDAHGDFNTPETSPSGNIHGMVLAALLGEGHSELVH
LGRPGPKLSGSDVVLIGLRELDPQEKVRLRESSVNVYTMRDIDERGIGAIAREALGKLAHRTRLHLSLDLDGLDPLEVPG
VGTTSPGGITYREAQLLMEIIADTKLLCSMDIVEINPILDHGNRTAKIAVELAASAFGEAIM

Specific function: Controls arginine catabolism [H]

COG id: COG0010

COG function: function code E; Arginase/agmatinase/formimionoglutamate hydrolase, arginase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arginase family [H]

Homologues:

Organism=Homo sapiens, GI4502215, Length=314, Percent_Identity=38.5350318471338, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI10947139, Length=306, Percent_Identity=40.1960784313725, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71996843, Length=298, Percent_Identity=32.2147651006711, Blast_Score=121, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6325146, Length=329, Percent_Identity=31.0030395136778, Blast_Score=146, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24638886, Length=305, Percent_Identity=32.4590163934426, Blast_Score=151, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014033
- InterPro:   IPR006035
- InterPro:   IPR020855 [H]

Pfam domain/function: PF00491 Arginase [H]

EC number: =3.5.3.1 [H]

Molecular weight: Translated: 32211; Mature: 32080

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00147 ARGINASE_1 ; PS00148 ARGINASE_2 ; PS01053 ARGINASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKAGGKMENRIRMIGVPLDLGQEQRGVDLGPGALRYAGLSARLTGLGYQVEDIGNLEVP
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEEECCEEEECCCCCCCC
VRDVVTAERQQHYLPSIGKVCETVYQAGRTAVAQGCIPVFMGGDHSLALGSIGGVTHEQP
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHCCCEEEEECCCCCEEEECCCCCCCCCC
TAVIWVDAHGDFNTPETSPSGNIHGMVLAALLGEGHSELVHLGRPGPKLSGSDVVLIGLR
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHEEECCCCCCCCCCCCEEEEEEC
ELDPQEKVRLRESSVNVYTMRDIDERGIGAIAREALGKLAHRTRLHLSLDLDGLDPLEVP
CCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCC
GVGTTSPGGITYREAQLLMEIIADTKLLCSMDIVEINPILDHGNRTAKIAVELAASAFGE
CCCCCCCCCEEHHHHHHHHHHHHCCHHEEEECEEEECHHHCCCCCEEEEEEEEHHHHHHH
AIM
CCC
>Mature Secondary Structure 
GKAGGKMENRIRMIGVPLDLGQEQRGVDLGPGALRYAGLSARLTGLGYQVEDIGNLEVP
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEEECCEEEECCCCCCCC
VRDVVTAERQQHYLPSIGKVCETVYQAGRTAVAQGCIPVFMGGDHSLALGSIGGVTHEQP
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHCCCEEEEECCCCCEEEECCCCCCCCCC
TAVIWVDAHGDFNTPETSPSGNIHGMVLAALLGEGHSELVHLGRPGPKLSGSDVVLIGLR
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHEEECCCCCCCCCCCCEEEEEEC
ELDPQEKVRLRESSVNVYTMRDIDERGIGAIAREALGKLAHRTRLHLSLDLDGLDPLEVP
CCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCC
GVGTTSPGGITYREAQLLMEIIADTKLLCSMDIVEINPILDHGNRTAKIAVELAASAFGE
CCCCCCCCCEEHHHHHHHHHHHHCCHHEEEECEEEECHHHCCCCCEEEEEEEEHHHHHHH
AIM
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8647285; 10196128 [H]