| Definition | Geobacter bemidjiensis Bem chromosome, complete genome. |
|---|---|
| Accession | NC_011146 |
| Length | 4,615,150 |
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The map label for this gene is coaBC [H]
Identifier: 197118054
GI number: 197118054
Start: 1933310
End: 1934545
Strand: Direct
Name: coaBC [H]
Synonym: Gbem_1667
Alternate gene names: 197118054
Gene position: 1933310-1934545 (Clockwise)
Preceding gene: 197118053
Following gene: 197118056
Centisome position: 41.89
GC content: 64.08
Gene sequence:
>1236_bases ATGCTGAAAGGGAAGGAGATCGTTCTCGGGGTAACCGGCGGGATTGCGGTGTACAAGGCCGTCGAACTTTTGCGCCTTTT GGTCAAGGCGGGTGCGACGGTACACGTGGTTATGACGCAGGCCGCGAAACAGTTCGTCACGCCGCTCACCTTCCAGACCC TTTCGGGTAACCCCGTGCACAGCGAGCTCTTCAACCTGATCTCGGAGCAGGAGATAGGGCACATATCGCTCGCGGAAAGG GCCGACCTCTTCATCGTCGCCCCCGCCACGGCCAACTGCATCGGGAAACTCGCCTGCGGCATCGCCGACGACCTGCTGAC CACTACCGTCATGGCCACCAAGGCGCCGGTCCTGATCGCCCCGGCCATGAACGTCAACATGTACCAGAACCCCATTTACC GCGAGAACGAAGAGCGCCTGAAAAAGCACGGCTACCTCTTCGTGGCGCCGGTCTGCGGCATGCTCGCCTGCGGCTATGAG GGGGAGGGGAAACTTCAGGCCCCCGAAGTGATCCTAGCCGAGGCGGTGGCGGCGCTCACCCCCAAAAGGCTTGCGGGGGA GCGGATCCTGGTGACGGCGGGGCCGACCCTGGAAGAGATCGATCCGGTGCGCTTCATCAGCAACCACTCCTCGGGGAAGA TGGGGTACGCCATAGCGAGGCAGGCGCAGCTAAAGGGAGCGGAGGTCACCCTGGTGACCGGGCCCACGGCGCTCGCAGCG CCGCACGGTGTGAAGGTGATCCGGGTGCAGAGCGCTGCCGAGATGCGGGACGCCGTCATGGGGCTTCTGGAGCGGACCGA CATCGTGATCAAGGCGGCGGCGGTGGCGGACTACCGCCCGAAGTCCCGCAGCGGCGAGAAGATGAAGAAGAGCGCGGCTG CCCTTTCCATTGAACTGGAGAAAAACCCGGACATCCTGGCCGAGATAGGGGGGATGAAAGGGGAAAGGCTCCTGGTCGGA TTCGCGGCAGAAACCCAGGAACTGGTGAAAAACGCCACCGCGAAGCTGAACGCGAAGAACCTGGACCTCGTGGTCGCGAA CGACGTCTCCCAGGAGGGGGCCGGCTTCAACGTCGACACCAACATCGCGAAGCTCTTGTACCGGGACGGCCGGGTGGAGG CGCTTCCCATGATGGGGAAAGAGGAGCTGGCGGGGGAGATACTGGAGCGCGTGGAACTGCTGCGCGGAGAGGGAGCCGGC AAGGCGGAAAAGCCGGGGAGCCCGTCAGCCCGATAG
Upstream 100 bases:
>100_bases GCTTCCCGACGACACCACCGTCTGGCCCGGACACGGCCCCTCCAGCACCATCGGCCGCGAGAGGCGCAGCAATCCCTACA TCAACGAATAGGAGGAGGCG
Downstream 100 bases:
>100_bases GATCTCCAAGAGGAGCTCGGGGCGGCAGATCGCCTGCTTCAGCTTCGGCTTCAGCTCCTCCAGTTCGTCTAAGGCCTGGG GCTTGGTGATCTTTCCGGTC
Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 411; Mature: 411
Protein sequence:
>411_residues MLKGKEIVLGVTGGIAVYKAVELLRLLVKAGATVHVVMTQAAKQFVTPLTFQTLSGNPVHSELFNLISEQEIGHISLAER ADLFIVAPATANCIGKLACGIADDLLTTTVMATKAPVLIAPAMNVNMYQNPIYRENEERLKKHGYLFVAPVCGMLACGYE GEGKLQAPEVILAEAVAALTPKRLAGERILVTAGPTLEEIDPVRFISNHSSGKMGYAIARQAQLKGAEVTLVTGPTALAA PHGVKVIRVQSAAEMRDAVMGLLERTDIVIKAAAVADYRPKSRSGEKMKKSAAALSIELEKNPDILAEIGGMKGERLLVG FAAETQELVKNATAKLNAKNLDLVVANDVSQEGAGFNVDTNIAKLLYRDGRVEALPMMGKEELAGEILERVELLRGEGAG KAEKPGSPSAR
Sequences:
>Translated_411_residues MLKGKEIVLGVTGGIAVYKAVELLRLLVKAGATVHVVMTQAAKQFVTPLTFQTLSGNPVHSELFNLISEQEIGHISLAER ADLFIVAPATANCIGKLACGIADDLLTTTVMATKAPVLIAPAMNVNMYQNPIYRENEERLKKHGYLFVAPVCGMLACGYE GEGKLQAPEVILAEAVAALTPKRLAGERILVTAGPTLEEIDPVRFISNHSSGKMGYAIARQAQLKGAEVTLVTGPTALAA PHGVKVIRVQSAAEMRDAVMGLLERTDIVIKAAAVADYRPKSRSGEKMKKSAAALSIELEKNPDILAEIGGMKGERLLVG FAAETQELVKNATAKLNAKNLDLVVANDVSQEGAGFNVDTNIAKLLYRDGRVEALPMMGKEELAGEILERVELLRGEGAG KAEKPGSPSAR >Mature_411_residues MLKGKEIVLGVTGGIAVYKAVELLRLLVKAGATVHVVMTQAAKQFVTPLTFQTLSGNPVHSELFNLISEQEIGHISLAER ADLFIVAPATANCIGKLACGIADDLLTTTVMATKAPVLIAPAMNVNMYQNPIYRENEERLKKHGYLFVAPVCGMLACGYE GEGKLQAPEVILAEAVAALTPKRLAGERILVTAGPTLEEIDPVRFISNHSSGKMGYAIARQAQLKGAEVTLVTGPTALAA PHGVKVIRVQSAAEMRDAVMGLLERTDIVIKAAAVADYRPKSRSGEKMKKSAAALSIELEKNPDILAEIGGMKGERLLVG FAAETQELVKNATAKLNAKNLDLVVANDVSQEGAGFNVDTNIAKLLYRDGRVEALPMMGKEELAGEILERVELLRGEGAG KAEKPGSPSAR
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=169, Percent_Identity=37.8698224852071, Blast_Score=99, Evalue=1e-20, Organism=Escherichia coli, GI87082301, Length=395, Percent_Identity=47.8481012658228, Blast_Score=320, Evalue=8e-89, Organism=Caenorhabditis elegans, GI17560194, Length=184, Percent_Identity=31.5217391304348, Blast_Score=71, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6322762, Length=179, Percent_Identity=31.2849162011173, Blast_Score=76, Evalue=9e-15, Organism=Drosophila melanogaster, GI24657262, Length=188, Percent_Identity=30.8510638297872, Blast_Score=94, Evalue=2e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 43679; Mature: 43679
Theoretical pI: Translated: 7.54; Mature: 7.54
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.1 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 4.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLKGKEIVLGVTGGIAVYKAVELLRLLVKAGATVHVVMTQAAKQFVTPLTFQTLSGNPVH CCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCCEEEECCCCCHH SELFNLISEQEIGHISLAERADLFIVAPATANCIGKLACGIADDLLTTTVMATKAPVLIA HHHHHHHHHCCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE PAMNVNMYQNPIYRENEERLKKHGYLFVAPVCGMLACGYEGEGKLQAPEVILAEAVAALT CCCCCCCCCCCCCCCCHHHHHHCCCEEEECHHHHHHCCCCCCCCCCCCHHHHHHHHHHCC PKRLAGERILVTAGPTLEEIDPVRFISNHSSGKMGYAIARQAQLKGAEVTLVTGPTALAA HHHHCCCEEEEECCCCHHHCCCHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHCC PHGVKVIRVQSAAEMRDAVMGLLERTDIVIKAAAVADYRPKSRSGEKMKKSAAALSIELE CCCEEEEEECCHHHHHHHHHHHHHHCCEEEEEEHHHCCCCCCCCCHHHHHHHEEEEEEEC KNPDILAEIGGMKGERLLVGFAAETQELVKNATAKLNAKNLDLVVANDVSQEGAGFNVDT CCCCHHHHHCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCH NIAKLLYRDGRVEALPMMGKEELAGEILERVELLRGEGAGKAEKPGSPSAR HHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC >Mature Secondary Structure MLKGKEIVLGVTGGIAVYKAVELLRLLVKAGATVHVVMTQAAKQFVTPLTFQTLSGNPVH CCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCCEEEECCCCCHH SELFNLISEQEIGHISLAERADLFIVAPATANCIGKLACGIADDLLTTTVMATKAPVLIA HHHHHHHHHCCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE PAMNVNMYQNPIYRENEERLKKHGYLFVAPVCGMLACGYEGEGKLQAPEVILAEAVAALT CCCCCCCCCCCCCCCCHHHHHHCCCEEEECHHHHHHCCCCCCCCCCCCHHHHHHHHHHCC PKRLAGERILVTAGPTLEEIDPVRFISNHSSGKMGYAIARQAQLKGAEVTLVTGPTALAA HHHHCCCEEEEECCCCHHHCCCHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHCC PHGVKVIRVQSAAEMRDAVMGLLERTDIVIKAAAVADYRPKSRSGEKMKKSAAALSIELE CCCEEEEEECCHHHHHHHHHHHHHHCCEEEEEEHHHCCCCCCCCCHHHHHHHEEEEEEEC KNPDILAEIGGMKGERLLVGFAAETQELVKNATAKLNAKNLDLVVANDVSQEGAGFNVDT CCCCHHHHHCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCH NIAKLLYRDGRVEALPMMGKEELAGEILERVELLRGEGAGKAEKPGSPSAR HHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9534248; 9384377 [H]