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The map label for this gene is atoC [H]

Identifier: 197118047

GI number: 197118047

Start: 1927184

End: 1927564

Strand: Direct

Name: atoC [H]

Synonym: Gbem_1660

Alternate gene names: 197118047

Gene position: 1927184-1927564 (Clockwise)

Preceding gene: 308535257

Following gene: 197118048

Centisome position: 41.76

GC content: 53.54

Gene sequence:

>381_bases
TTGCCAAAGCAGCCCAAGCGAATATTGGTGGTGGATGACGAGGAGAACGCGCGCATCGGTCTCTCCCGCTTGCTGGCCAA
GGAAGGGTTCCTGGTTGACAGCGTTGCCAACGGTTTCGAAGCGCTTAACTACCTGCGCGAGCAGGAGGTTAACCTGATCG
TTACCGACATCAACATGCCCGAGATGAACGGCATCACCTTCCTCAAGGAACTCAACCGGAGCTACCCCTCCAGCAACGTG
ATCATGATCACCGCTTACGGCGGTGTCGAGTCTTATATCGAAGCCATGAACCTCGGGGCTTTCGAATATATCAACAAGCC
GGTGAAGATAGACGAGCTGAAGTCGATCCTGAAGAAGATCTTCAAGGAAACCAGCCACTGA

Upstream 100 bases:

>100_bases
TACGTAAAAGATTCGCTCTTGGGGGAAAACCCCCGTTGACACCCCGGGGGGCGGTGCTAGAATCAAAGCTGCTTTTCTAA
TAAACGAATCGGAGCCTATC

Downstream 100 bases:

>100_bases
CTCTGAACACCGGTTCGCAGGGGGGCGAGATGAGAAGCTTCGACAAGATTCTGTTTGCCACCGATTTTTCCGAGAGCTCG
GACCATGCCTTCGAGTACGC

Product: response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 126; Mature: 125

Protein sequence:

>126_residues
MPKQPKRILVVDDEENARIGLSRLLAKEGFLVDSVANGFEALNYLREQEVNLIVTDINMPEMNGITFLKELNRSYPSSNV
IMITAYGGVESYIEAMNLGAFEYINKPVKIDELKSILKKIFKETSH

Sequences:

>Translated_126_residues
MPKQPKRILVVDDEENARIGLSRLLAKEGFLVDSVANGFEALNYLREQEVNLIVTDINMPEMNGITFLKELNRSYPSSNV
IMITAYGGVESYIEAMNLGAFEYINKPVKIDELKSILKKIFKETSH
>Mature_125_residues
PKQPKRILVVDDEENARIGLSRLLAKEGFLVDSVANGFEALNYLREQEVNLIVTDINMPEMNGITFLKELNRSYPSSNVI
MITAYGGVESYIEAMNLGAFEYINKPVKIDELKSILKKIFKETSH

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=41.1764705882353, Blast_Score=93, Evalue=4e-21,
Organism=Escherichia coli, GI1790437, Length=117, Percent_Identity=39.3162393162393, Blast_Score=83, Evalue=5e-18,
Organism=Escherichia coli, GI1790299, Length=112, Percent_Identity=33.9285714285714, Blast_Score=80, Evalue=3e-17,
Organism=Escherichia coli, GI1788905, Length=125, Percent_Identity=29.6, Blast_Score=74, Evalue=3e-15,
Organism=Escherichia coli, GI1789809, Length=120, Percent_Identity=31.6666666666667, Blast_Score=66, Evalue=6e-13,
Organism=Escherichia coli, GI1786784, Length=119, Percent_Identity=26.890756302521, Blast_Score=65, Evalue=1e-12,
Organism=Escherichia coli, GI1786599, Length=122, Percent_Identity=33.6065573770492, Blast_Score=64, Evalue=2e-12,
Organism=Escherichia coli, GI1787229, Length=120, Percent_Identity=30, Blast_Score=63, Evalue=6e-12,
Organism=Escherichia coli, GI87082012, Length=117, Percent_Identity=26.4957264957265, Blast_Score=61, Evalue=2e-11,
Organism=Escherichia coli, GI1788191, Length=126, Percent_Identity=34.1269841269841, Blast_Score=61, Evalue=2e-11,
Organism=Escherichia coli, GI1789402, Length=119, Percent_Identity=26.890756302521, Blast_Score=59, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 14282; Mature: 14151

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKQPKRILVVDDEENARIGLSRLLAKEGFLVDSVANGFEALNYLREQEVNLIVTDINMP
CCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
EMNGITFLKELNRSYPSSNVIMITAYGGVESYIEAMNLGAFEYINKPVKIDELKSILKKI
CCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHH
FKETSH
HHHCCC
>Mature Secondary Structure 
PKQPKRILVVDDEENARIGLSRLLAKEGFLVDSVANGFEALNYLREQEVNLIVTDINMP
CCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
EMNGITFLKELNRSYPSSNVIMITAYGGVESYIEAMNLGAFEYINKPVKIDELKSILKKI
CCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHH
FKETSH
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]