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The map label for this gene is kdsC [H]

Identifier: 197117990

GI number: 197117990

Start: 1858523

End: 1859038

Strand: Direct

Name: kdsC [H]

Synonym: Gbem_1603

Alternate gene names: 197117990

Gene position: 1858523-1859038 (Clockwise)

Preceding gene: 197117989

Following gene: 197117991

Centisome position: 40.27

GC content: 60.66

Gene sequence:

>516_bases
ATGGAAGAAAGACTGAAAAAGATCAAGCTCCTGATTCTCGACGTCGACGGCGTGATGACCGACGGCCGCATCATCTTCGA
TTCCAACGGGGTGGAGAGCAAGTTCTTCAACGTGAAGGACGGCCACGGCATCAAGATGCTGCAGCGCTCCGGCATCGAGG
TGGGGATCATCTCCGGCCGCGAATCCCAGGTGGTCTACAACCGTGCCGTAGAGCTCGGCATCGGGCAGGTCTACCAGAAG
TCGCTCGACAAACTGGTCCCTTACCGCCAGATGCTGGAGGCGACGGGGCTTACCGACGAACAGGTCGCCTTCATGGGGGA
CGACGTCATCGACATCCCGCTGTTGAAAAGGGTGGGATTTGCCGCCGCCCCTGCGGACGCCGTCTGCGAGGTCTACGAGT
TCGCGCAGTTCGTCGCCAAGAACAGGGGTGGGTGGGGAGCCGTGCGCGAAGTCTGCGACCTCATCCTCAAGGCCCAGGGG
AATTGGGAGACCGTCACGTCCAGGTACTACGTGTAG

Upstream 100 bases:

>100_bases
AAGAAAGGCTGAAGCGCCAAGCAGAAAGCGTTTAAAGGTTTTCTTTGCGGTCTTGGCGTCTTTGCGTGAGACCGGGGTGG
GGTTTCTTAGTGAGGTGTTT

Downstream 100 bases:

>100_bases
AAGCCGCAAAGCAAACCGTGTCACGCAAAGCCGCAAAGACGCAAAGAAAGGCTAAAGCTCCATCCCTATAAATCGGTTCT
AGAGGTTTTCTCCGCGGTCT

Product: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase

Products: NA

Alternate protein names: KDO 8-P phosphatase [H]

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MEERLKKIKLLILDVDGVMTDGRIIFDSNGVESKFFNVKDGHGIKMLQRSGIEVGIISGRESQVVYNRAVELGIGQVYQK
SLDKLVPYRQMLEATGLTDEQVAFMGDDVIDIPLLKRVGFAAAPADAVCEVYEFAQFVAKNRGGWGAVREVCDLILKAQG
NWETVTSRYYV

Sequences:

>Translated_171_residues
MEERLKKIKLLILDVDGVMTDGRIIFDSNGVESKFFNVKDGHGIKMLQRSGIEVGIISGRESQVVYNRAVELGIGQVYQK
SLDKLVPYRQMLEATGLTDEQVAFMGDDVIDIPLLKRVGFAAAPADAVCEVYEFAQFVAKNRGGWGAVREVCDLILKAQG
NWETVTSRYYV
>Mature_171_residues
MEERLKKIKLLILDVDGVMTDGRIIFDSNGVESKFFNVKDGHGIKMLQRSGIEVGIISGRESQVVYNRAVELGIGQVYQK
SLDKLVPYRQMLEATGLTDEQVAFMGDDVIDIPLLKRVGFAAAPADAVCEVYEFAQFVAKNRGGWGAVREVCDLILKAQG
NWETVTSRYYV

Specific function: Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate [H]

COG id: COG1778

COG function: function code R; Low specificity phosphatase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsC family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=154, Percent_Identity=37.012987012987, Blast_Score=95, Evalue=3e-20,
Organism=Escherichia coli, GI2367202, Length=160, Percent_Identity=46.875, Blast_Score=147, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006549
- InterPro:   IPR010023 [H]

Pfam domain/function: PF08282 Hydrolase_3 [H]

EC number: =3.1.3.45 [H]

Molecular weight: Translated: 19051; Mature: 19051

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEERLKKIKLLILDVDGVMTDGRIIFDSNGVESKFFNVKDGHGIKMLQRSGIEVGIISGR
CHHHHHHEEEEEEECCCEEECCEEEECCCCCCCCEECCCCCCCHHHHHHCCCEEEEECCC
ESQVVYNRAVELGIGQVYQKSLDKLVPYRQMLEATGLTDEQVAFMGDDVIDIPLLKRVGF
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHCCCCEECHHHHHHCCC
AAAPADAVCEVYEFAQFVAKNRGGWGAVREVCDLILKAQGNWETVTSRYYV
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MEERLKKIKLLILDVDGVMTDGRIIFDSNGVESKFFNVKDGHGIKMLQRSGIEVGIISGR
CHHHHHHEEEEEEECCCEEECCEEEECCCCCCCCEECCCCCCCHHHHHHCCCEEEEECCC
ESQVVYNRAVELGIGQVYQKSLDKLVPYRQMLEATGLTDEQVAFMGDDVIDIPLLKRVGF
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHCCCCEECHHHHHHCCC
AAAPADAVCEVYEFAQFVAKNRGGWGAVREVCDLILKAQGNWETVTSRYYV
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]