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The map label for this gene is accC [H]

Identifier: 197117949

GI number: 197117949

Start: 1810803

End: 1812143

Strand: Direct

Name: accC [H]

Synonym: Gbem_1562

Alternate gene names: 197117949

Gene position: 1810803-1812143 (Clockwise)

Preceding gene: 197117948

Following gene: 197117950

Centisome position: 39.24

GC content: 61.0

Gene sequence:

>1341_bases
ATGTTTCATAAAATTCTTATCGCCAACAGGGGTGAGATCGCCCTCAGGATCATCAGAACCTGCAAGGAGATGGGGATCAA
GACGGTCGCCGTCTACTCCACGGCCGACAGCGAGTCGCTCCACGTGAAGCTCGCCGACGAGAGCGTCTGCATCGGTCCGC
CCCCCAGCCTCTCCAGCTACCTCAACATCAACGCCATCATCTCCGCGGCGGAGCTCACCGACGCGGAAGCGATCCACCCG
GGCTACGGGTTCCTCTCCGAAAACCCGATCTTCGCCGAGATCTGCGAGAAGTGCGGCATAACCTTCATCGGACCTACCGC
GGAAAGCATGCGCATCATGGGCGACAAGATCTCCGCCCGCCAGGCTGTCATCAAGGTCGGCGTCCCCATCCTGCCCGGTA
CCAAGGAAGGGGTGCATGACGTCAACGAAGCGATTCGCGTCGCCAAGGAGATCGGCTTCCCGGTCATCATCAAGGCTACG
GCGGGGGGCGGCGGACGCGGCATGAAGATCGTCCATTCCCCGGCGGCGCTCCCGAACGCTTTCGCCACCGCTCGTGCCGA
GGCGCAGTCCGGTTTCGGCAACCCCGAGGTTTACATCGAGCGCTACTGCGAGAGTCCGCGCCACGTCGAGATCCAGATCC
TCGCCGACAAGCACGGTAACGTGGTGCACCTGGGTGAGCGCGACTGCTCGATCCAGCGTCGCCACCAGAAGGTGATCGAG
GAAGCTCCCTCCACCGTCACCACTCCGGAACTCAGGAAAGCGATGGGCGAGGCCGCCGTCGCCGCGGCCAAGGCGGTCAA
CTACTGCAGCGTCGGCACCATGGAATTCCTCGTCGACAAGAACAACAACTTCTTCTTCATGGAGATGAACACCCGCGTGC
AGGTGGAGCACCCGGTGACCGAGATGGTGACCGGCGTGGACGTCGTGAAGGAGCAGATCCGCTCCGCATACGGCCTCAAA
CTGCGCTACACCCAGGACGACATCAAGATCAAGGGTCACTCCATCGAGTGCCGCATCAACGCGGAGGACTCGGTGAAATT
CACCCCCTGCCCGGGAAAGATCACTGATCACCACACCCCCGGCGGTCTCGGCGTCAGGGTAGACTCCTTCGTCTACACCA
ACTACTCGGTCCTGCCGCACTACGACTCCCTGATCGCCAAGCTGATCGTGCATGCCGACACCAGGGAAGAGGCGATCAAG
AGGATGGCCCGCGCGCTGGACGAGTACATCGTGGAAGGGATCAAGACCACCATTCCGTTCCACAAGAGGATCATGGCCAA
CAAAGACTTCATCGAAGGGAACATAGACACCGGCTTCATCGAAAGGCTGGTACTGGAGTAA

Upstream 100 bases:

>100_bases
TAAAGATCAGGACTAGATTCAGTTGATGTGGCTTCCTGATTTAGTCTTAGTCTAAAACTTAATCTTAGTCTTAATCTTAA
TCTGTTCTCTGGAGATATAA

Downstream 100 bases:

>100_bases
ACTATGGACTTTCCCGAAGAGCTTAAATACAGCAAGGAACACGTGTGGGTGCGCATCGAAGGCGAGCGCGCCGTAATCGG
CATTACCGATTATGCCCAGA

Product: acetyl-CoA carboxylase biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MFHKILIANRGEIALRIIRTCKEMGIKTVAVYSTADSESLHVKLADESVCIGPPPSLSSYLNINAIISAAELTDAEAIHP
GYGFLSENPIFAEICEKCGITFIGPTAESMRIMGDKISARQAVIKVGVPILPGTKEGVHDVNEAIRVAKEIGFPVIIKAT
AGGGGRGMKIVHSPAALPNAFATARAEAQSGFGNPEVYIERYCESPRHVEIQILADKHGNVVHLGERDCSIQRRHQKVIE
EAPSTVTTPELRKAMGEAAVAAAKAVNYCSVGTMEFLVDKNNNFFFMEMNTRVQVEHPVTEMVTGVDVVKEQIRSAYGLK
LRYTQDDIKIKGHSIECRINAEDSVKFTPCPGKITDHHTPGGLGVRVDSFVYTNYSVLPHYDSLIAKLIVHADTREEAIK
RMARALDEYIVEGIKTTIPFHKRIMANKDFIEGNIDTGFIERLVLE

Sequences:

>Translated_446_residues
MFHKILIANRGEIALRIIRTCKEMGIKTVAVYSTADSESLHVKLADESVCIGPPPSLSSYLNINAIISAAELTDAEAIHP
GYGFLSENPIFAEICEKCGITFIGPTAESMRIMGDKISARQAVIKVGVPILPGTKEGVHDVNEAIRVAKEIGFPVIIKAT
AGGGGRGMKIVHSPAALPNAFATARAEAQSGFGNPEVYIERYCESPRHVEIQILADKHGNVVHLGERDCSIQRRHQKVIE
EAPSTVTTPELRKAMGEAAVAAAKAVNYCSVGTMEFLVDKNNNFFFMEMNTRVQVEHPVTEMVTGVDVVKEQIRSAYGLK
LRYTQDDIKIKGHSIECRINAEDSVKFTPCPGKITDHHTPGGLGVRVDSFVYTNYSVLPHYDSLIAKLIVHADTREEAIK
RMARALDEYIVEGIKTTIPFHKRIMANKDFIEGNIDTGFIERLVLE
>Mature_446_residues
MFHKILIANRGEIALRIIRTCKEMGIKTVAVYSTADSESLHVKLADESVCIGPPPSLSSYLNINAIISAAELTDAEAIHP
GYGFLSENPIFAEICEKCGITFIGPTAESMRIMGDKISARQAVIKVGVPILPGTKEGVHDVNEAIRVAKEIGFPVIIKAT
AGGGGRGMKIVHSPAALPNAFATARAEAQSGFGNPEVYIERYCESPRHVEIQILADKHGNVVHLGERDCSIQRRHQKVIE
EAPSTVTTPELRKAMGEAAVAAAKAVNYCSVGTMEFLVDKNNNFFFMEMNTRVQVEHPVTEMVTGVDVVKEQIRSAYGLK
LRYTQDDIKIKGHSIECRINAEDSVKFTPCPGKITDHHTPGGLGVRVDSFVYTNYSVLPHYDSLIAKLIVHADTREEAIK
RMARALDEYIVEGIKTTIPFHKRIMANKDFIEGNIDTGFIERLVLE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=51.3574660633484, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=51.3574660633484, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=51.3574660633484, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI116805327, Length=443, Percent_Identity=48.3069977426637, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=45.2914798206278, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=45.2914798206278, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=45.2914798206278, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI38679977, Length=511, Percent_Identity=33.2681017612524, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679967, Length=511, Percent_Identity=33.2681017612524, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679960, Length=511, Percent_Identity=33.2681017612524, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679974, Length=511, Percent_Identity=33.2681017612524, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679971, Length=511, Percent_Identity=33.2681017612524, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI134142062, Length=512, Percent_Identity=31.8359375, Blast_Score=257, Evalue=2e-68,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=56.8848758465011, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI1786216, Length=244, Percent_Identity=25.8196721311475, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=47.9638009049774, Blast_Score=430, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=47.3922902494331, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=446, Percent_Identity=43.7219730941704, Blast_Score=378, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71997163, Length=508, Percent_Identity=29.3307086614173, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=508, Percent_Identity=29.3307086614173, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI133931226, Length=493, Percent_Identity=30.4259634888438, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6319685, Length=448, Percent_Identity=43.5267857142857, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=45.8612975391499, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=46.9798657718121, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323863, Length=486, Percent_Identity=32.7160493827161, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=31.9767441860465, Blast_Score=241, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24651757, Length=442, Percent_Identity=47.2850678733032, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=443, Percent_Identity=47.4040632054176, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652210, Length=443, Percent_Identity=47.4040632054176, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652214, Length=443, Percent_Identity=47.4040632054176, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI19921944, Length=443, Percent_Identity=47.4040632054176, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652216, Length=443, Percent_Identity=47.4040632054176, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI281363050, Length=443, Percent_Identity=47.4040632054176, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652224, Length=443, Percent_Identity=47.4040632054176, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652222, Length=443, Percent_Identity=47.4040632054176, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652220, Length=443, Percent_Identity=47.4040632054176, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652218, Length=443, Percent_Identity=47.4040632054176, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=46.0591133004926, Blast_Score=357, Evalue=1e-98,
Organism=Drosophila melanogaster, GI161076409, Length=509, Percent_Identity=31.041257367387, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI161076407, Length=509, Percent_Identity=31.041257367387, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24586460, Length=509, Percent_Identity=31.041257367387, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24586458, Length=509, Percent_Identity=31.041257367387, Blast_Score=249, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48967; Mature: 48967

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHKILIANRGEIALRIIRTCKEMGIKTVAVYSTADSESLHVKLADESVCIGPPPSLSSY
CCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEECCCCCCCHHH
LNINAIISAAELTDAEAIHPGYGFLSENPIFAEICEKCGITFIGPTAESMRIMGDKISAR
EEHHHEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHHCCHHHHH
QAVIKVGVPILPGTKEGVHDVNEAIRVAKEIGFPVIIKATAGGGGRGMKIVHSPAALPNA
HHHHEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCH
FATARAEAQSGFGNPEVYIERYCESPRHVEIQILADKHGNVVHLGERDCSIQRRHQKVIE
HHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPSTVTTPELRKAMGEAAVAAAKAVNYCSVGTMEFLVDKNNNFFFMEMNTRVQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCEEEECCCHH
EMVTGVDVVKEQIRSAYGLKLRYTQDDIKIKGHSIECRINAEDSVKFTPCPGKITDHHTP
HHHHHHHHHHHHHHHHHCEEEEEECCCEEEECCEEEEEECCCCCEEEECCCCCCCCCCCC
GGLGVRVDSFVYTNYSVLPHYDSLIAKLIVHADTREEAIKRMARALDEYIVEGIKTTIPF
CCCCEEEEEEEEECCEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
HKRIMANKDFIEGNIDTGFIERLVLE
HHHHHCCCCEECCCCCHHHHHHHHCC
>Mature Secondary Structure
MFHKILIANRGEIALRIIRTCKEMGIKTVAVYSTADSESLHVKLADESVCIGPPPSLSSY
CCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEECCCCCCCHHH
LNINAIISAAELTDAEAIHPGYGFLSENPIFAEICEKCGITFIGPTAESMRIMGDKISAR
EEHHHEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHHCCHHHHH
QAVIKVGVPILPGTKEGVHDVNEAIRVAKEIGFPVIIKATAGGGGRGMKIVHSPAALPNA
HHHHEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCH
FATARAEAQSGFGNPEVYIERYCESPRHVEIQILADKHGNVVHLGERDCSIQRRHQKVIE
HHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPSTVTTPELRKAMGEAAVAAAKAVNYCSVGTMEFLVDKNNNFFFMEMNTRVQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCEEEECCCHH
EMVTGVDVVKEQIRSAYGLKLRYTQDDIKIKGHSIECRINAEDSVKFTPCPGKITDHHTP
HHHHHHHHHHHHHHHHHCEEEEEECCCEEEECCEEEEEECCCCCEEEECCCCCCCCCCCC
GGLGVRVDSFVYTNYSVLPHYDSLIAKLIVHADTREEAIKRMARALDEYIVEGIKTTIPF
CCCCEEEEEEEEECCEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
HKRIMANKDFIEGNIDTGFIERLVLE
HHHHHCCCCEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]