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The map label for this gene is zraR [H]

Identifier: 197117814

GI number: 197117814

Start: 1645152

End: 1646486

Strand: Direct

Name: zraR [H]

Synonym: Gbem_1426

Alternate gene names: 197117814

Gene position: 1645152-1646486 (Clockwise)

Preceding gene: 197117813

Following gene: 197117817

Centisome position: 35.65

GC content: 61.87

Gene sequence:

>1335_bases
GTGAACACCATTTTGATAGCTGACGATGACATCGCCATCCGGCGCACGCTGGAGCTGCACCTGACCGAAGAAGGTTATTC
GGTGGTGACGGCCGCGAACGGTCCCAATGCGGTCGAGGTTGCGCTGGAGAAGGAAATCGACCTGATGCTCCTCGATCTTA
GGCTCTCCGGGATGGATGGTTTCGAGGTGCTGGGGCGGGTAAAGGAGCGCCGCCCCGATCTCCCCGTCGTGATGATCACC
GCGTACGACGACATGCAGACCGCCATCGAGGCGATACGCCTGGGGGCCATCGACCATTTGGGCAAGCCGGTCGATCTCGA
TCACCTGGACCAGGTCATCGCCAAGATTTTCGACATGAGCGCCCTGGCCCGCAAAGGGGTCACCTTCTGCGACTCGGCCG
ATCCACCCTTCGAGCAGAACATCATGGTTGGCCGCTCGCGCAGCATGAAGGAGGTGTACAAGACCATCGGCGCGGTGGCA
GACTCCCGCGCCACCGTGCTGATCCAGGGGGAGAGCGGAACGGGGAAGGAAATGGTGGCGCGAGCGCTTCATTTCAACAG
TTCCTTCAGGAATCGCCCCTTCATTGCGGTTGCCTGCGCCTCGCTCGCGCCGTCGCTTCTGGAGAGCGAGCTCTTCGGCC
ACGAACGGGGCGCCTTCACGGGGGCCCACCGGACCAAGCCGGGGAAGTTCGAACTGGCGCAGGGGGGGACGCTCTTTCTC
GACGAGATCTCGGAGACGAGCCCGGAGATCCAGGTGAAGCTCTTGCGCTTTCTCCAGGAGAGGGAATTCGAGCGAGTGGG
GGGTGTAGAGACCCTGAAGGCCGACGTGCGGGTCATCGCCGCCAGCAACAAGGAACTCTCGGCGCTCGCCAATGCGGGCG
AATTCCGCAAGGACCTCTATTACCGCCTGAACGTGGTGACCCTTTTCCTCCCGCCGTTGCGCGAGCGAAAGGACGACATC
CTGCTCCTTGTCAAGTTCTTCTTGGGGAAGATGCGCGAGGAGACCGGCAAGAGCGTGGATATCGTCACCCAGGAAACGCT
CACCATGATCCAGGAGCACTCCTGGCCGGGAAACGTGCGCGAACTGGAGAACACGATCAGGCGTGCCGTGCTCCTCTCGC
ACGGGAACGTGCTGCTTCCGGAATCCCTGCACCTGGAAGGAGAGAAGGAGCAGGAGCGGCTGGCGCTGACGATCAGGCCG
CTGCACGAGGTGGAGCGCGAGCATATCGAGAACGTGCTCATCTACACGGGGTACGAGAAGAAGAGGACCGCAGAGATTCT
AGGCATCTCGCGGCCGACGCTGGATAGGAGGCTCAAGGAGTACGGATTGGAGTGA

Upstream 100 bases:

>100_bases
ATGGCGGGTCCGTTTCCGTGACGGGCGGGACCGGCGCCGGCGCTACCTTTACCGTCGTACTTCCCCTCGCGGGGCCTTCA
GGAACTGGAGAAAAAACACC

Downstream 100 bases:

>100_bases
GATGAGGGGGACTGGCTCCGCAGGTGCCTGTCCCCCTGGTCCCCCTGGCCCACAGAGCGAAGGTACTCCGTCCATCCCCT
CTCCCAAAGGGCGAGGGGAG

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MNTILIADDDIAIRRTLELHLTEEGYSVVTAANGPNAVEVALEKEIDLMLLDLRLSGMDGFEVLGRVKERRPDLPVVMIT
AYDDMQTAIEAIRLGAIDHLGKPVDLDHLDQVIAKIFDMSALARKGVTFCDSADPPFEQNIMVGRSRSMKEVYKTIGAVA
DSRATVLIQGESGTGKEMVARALHFNSSFRNRPFIAVACASLAPSLLESELFGHERGAFTGAHRTKPGKFELAQGGTLFL
DEISETSPEIQVKLLRFLQEREFERVGGVETLKADVRVIAASNKELSALANAGEFRKDLYYRLNVVTLFLPPLRERKDDI
LLLVKFFLGKMREETGKSVDIVTQETLTMIQEHSWPGNVRELENTIRRAVLLSHGNVLLPESLHLEGEKEQERLALTIRP
LHEVEREHIENVLIYTGYEKKRTAEILGISRPTLDRRLKEYGLE

Sequences:

>Translated_444_residues
MNTILIADDDIAIRRTLELHLTEEGYSVVTAANGPNAVEVALEKEIDLMLLDLRLSGMDGFEVLGRVKERRPDLPVVMIT
AYDDMQTAIEAIRLGAIDHLGKPVDLDHLDQVIAKIFDMSALARKGVTFCDSADPPFEQNIMVGRSRSMKEVYKTIGAVA
DSRATVLIQGESGTGKEMVARALHFNSSFRNRPFIAVACASLAPSLLESELFGHERGAFTGAHRTKPGKFELAQGGTLFL
DEISETSPEIQVKLLRFLQEREFERVGGVETLKADVRVIAASNKELSALANAGEFRKDLYYRLNVVTLFLPPLRERKDDI
LLLVKFFLGKMREETGKSVDIVTQETLTMIQEHSWPGNVRELENTIRRAVLLSHGNVLLPESLHLEGEKEQERLALTIRP
LHEVEREHIENVLIYTGYEKKRTAEILGISRPTLDRRLKEYGLE
>Mature_444_residues
MNTILIADDDIAIRRTLELHLTEEGYSVVTAANGPNAVEVALEKEIDLMLLDLRLSGMDGFEVLGRVKERRPDLPVVMIT
AYDDMQTAIEAIRLGAIDHLGKPVDLDHLDQVIAKIFDMSALARKGVTFCDSADPPFEQNIMVGRSRSMKEVYKTIGAVA
DSRATVLIQGESGTGKEMVARALHFNSSFRNRPFIAVACASLAPSLLESELFGHERGAFTGAHRTKPGKFELAQGGTLFL
DEISETSPEIQVKLLRFLQEREFERVGGVETLKADVRVIAASNKELSALANAGEFRKDLYYRLNVVTLFLPPLRERKDDI
LLLVKFFLGKMREETGKSVDIVTQETLTMIQEHSWPGNVRELENTIRRAVLLSHGNVLLPESLHLEGEKEQERLALTIRP
LHEVEREHIENVLIYTGYEKKRTAEILGISRPTLDRRLKEYGLE

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=454, Percent_Identity=41.4096916299559, Blast_Score=353, Evalue=1e-98,
Organism=Escherichia coli, GI1790437, Length=438, Percent_Identity=44.9771689497717, Blast_Score=353, Evalue=2e-98,
Organism=Escherichia coli, GI1790299, Length=474, Percent_Identity=37.9746835443038, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1788905, Length=441, Percent_Identity=38.0952380952381, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1789087, Length=319, Percent_Identity=47.0219435736677, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI87082117, Length=323, Percent_Identity=45.8204334365325, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789233, Length=330, Percent_Identity=40.9090909090909, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI87082152, Length=241, Percent_Identity=49.3775933609959, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1786524, Length=322, Percent_Identity=41.6149068322981, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI87081872, Length=317, Percent_Identity=38.801261829653, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1787583, Length=314, Percent_Identity=39.4904458598726, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI1789828, Length=227, Percent_Identity=35.2422907488987, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87081858, Length=293, Percent_Identity=31.740614334471, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789809, Length=102, Percent_Identity=34.3137254901961, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789402, Length=103, Percent_Identity=35.9223300970874, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=111, Percent_Identity=34.2342342342342, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49797; Mature: 49797

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTILIADDDIAIRRTLELHLTEEGYSVVTAANGPNAVEVALEKEIDLMLLDLRLSGMDG
CCEEEEECCCEEEEEEEEEEEECCCCEEEEECCCCCEEEEEEECCCCEEEEEEEECCCCH
FEVLGRVKERRPDLPVVMITAYDDMQTAIEAIRLGAIDHLGKPVDLDHLDQVIAKIFDMS
HHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ALARKGVTFCDSADPPFEQNIMVGRSRSMKEVYKTIGAVADSRATVLIQGESGTGKEMVA
HHHHCCCEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH
RALHFNSSFRNRPFIAVACASLAPSLLESELFGHERGAFTGAHRTKPGKFELAQGGTLFL
HHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEE
DEISETSPEIQVKLLRFLQEREFERVGGVETLKADVRVIAASNKELSALANAGEFRKDLY
ECCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEECCEEEEEECCCHHHHHHCCHHHHHHHH
YRLNVVTLFLPPLRERKDDILLLVKFFLGKMREETGKSVDIVTQETLTMIQEHSWPGNVR
HHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHCCCCCCHH
ELENTIRRAVLLSHGNVLLPESLHLEGEKEQERLALTIRPLHEVEREHIENVLIYTGYEK
HHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEEEEECHHHHHHHHHHCEEEEEECCCH
KRTAEILGISRPTLDRRLKEYGLE
HHHHHHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNTILIADDDIAIRRTLELHLTEEGYSVVTAANGPNAVEVALEKEIDLMLLDLRLSGMDG
CCEEEEECCCEEEEEEEEEEEECCCCEEEEECCCCCEEEEEEECCCCEEEEEEEECCCCH
FEVLGRVKERRPDLPVVMITAYDDMQTAIEAIRLGAIDHLGKPVDLDHLDQVIAKIFDMS
HHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ALARKGVTFCDSADPPFEQNIMVGRSRSMKEVYKTIGAVADSRATVLIQGESGTGKEMVA
HHHHCCCEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH
RALHFNSSFRNRPFIAVACASLAPSLLESELFGHERGAFTGAHRTKPGKFELAQGGTLFL
HHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEE
DEISETSPEIQVKLLRFLQEREFERVGGVETLKADVRVIAASNKELSALANAGEFRKDLY
ECCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEECCEEEEEECCCHHHHHHCCHHHHHHHH
YRLNVVTLFLPPLRERKDDILLLVKFFLGKMREETGKSVDIVTQETLTMIQEHSWPGNVR
HHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHCCCCCCHH
ELENTIRRAVLLSHGNVLLPESLHLEGEKEQERLALTIRPLHEVEREHIENVLIYTGYEK
HHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEEEEECHHHHHHHHHHCEEEEEECCCH
KRTAEILGISRPTLDRRLKEYGLE
HHHHHHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]