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The map label for this gene is fdh [H]

Identifier: 197117562

GI number: 197117562

Start: 1366679

End: 1367911

Strand: Reverse

Name: fdh [H]

Synonym: Gbem_1174

Alternate gene names: 197117562

Gene position: 1367911-1366679 (Counterclockwise)

Preceding gene: 197117563

Following gene: 197117552

Centisome position: 29.64

GC content: 66.26

Gene sequence:

>1233_bases
ATGAAAGCTGTCGTTTGGCACGGAGTCGGGGACATAAGGCTCGACGAGGTTCCCGATCCGCGGATAGAAGAGCCCACCGA
CGCCATCGTTCGCCTTACCACCAGCGCCATCTGCGGGACCGACCTGCACATGGTGCGCGGGACCATGCCGGGGATGAAGG
AAGGGACCATCCTCGGCCACGAGGGGGTGGGGATCGTCGACCAGATCGGCGCCTCGATACGGAACTTCATGCCGGGGGAC
CGGGTGGTGATCCCCTCCACCATAGCCTGCGGTTTCTGCTCCTACTGCCGGGCCGGGTACTACTCCCAGTGCGACAACGC
GAACCCCAACGGCCCCGACGCCGGCACCTGCTTTTTCGGCGGCCCCGAGTTGAGCGGGCCGATCAATGGACTGCAGGCGG
AGAAGGCCCGGATACCGTTCGCCGGCGTCGGGCTCGTCAAAGTTCCCGACGAGGTGACGGACGAACAGGCGCTGCTTCTA
TCCGACATCCTTCCCACGGGCTACATGGCCGCGGAGCTGGCCGAGATCAAGCCGGGGAACACGGTGGTTGTCTTTGGCTG
CGGGCCGGTCGGGCAGTGCGCCATAGCAGCGGCGAAGCTGATGCAGGCGGGGAGGATCTTCGCGGTGGACAGCGTCCCCT
TCCGGCTCGACCTGGCCCAGGAGCAGGGGGCCGAGGCGATCGACTTCTCCAGGGAGGACCCGGTCGCCATGATCCACCAG
TTCACCGGCGGCATCGGCTGCGACCGCGCCATCGACGCCGTCGGCGTGGACGCGTCCGCACCCCACTCCGGCCCCGGGAG
CCGGGAGTTCAGGGAGCACCTGCAGGAGTTCCAGCAGGAGCTCGCCCAAGTGGCGCCGCGCACCAACGTGCAGGGTGAGA
ACTGGCACCCCGGCGACGCCCCCTCCATGACGCTCGTCTGGGCGGTGCAGTCGCTGGCCAAGGCGGGCACCCTCTCCATC
GTCGGGGTCTATCCCCAGACGGTGAGCCTATTCCCCATCGGCGCCGCCATGAACAAGAACCTCACCCTGAAGATGGGGAA
CTGCGACCACCGCAGGTTTATCCCGAAGCTGATGGAACTGGTGCAGGGTAAGGCGCTGGATCCCGCGAAGATCCTGACCC
AGAAGGCCCCCTTTTCCAACGTCATCGAGGCCTACCAGGCCTTCGACCTGAGGAAGGAAGGGTGGCTCAAGGTGCAGCTG
CAGATGCAGGGGGCGATAGGCGAAGAGCGCTAG

Upstream 100 bases:

>100_bases
GCCTTTTGGGAGAGGGGAGGGGGTGAGGGATGCTTTGCCAACCCCCCTCCTCCTGCTAGACTACGGTGGGTTAAAAACCA
CCAACCAAGGAGGAATCGCC

Downstream 100 bases:

>100_bases
AAAGCGAGGCAGGAACGAGCCATGGGGCAAAGGAAGGGGGCCGGTTGGAAGCCGGCCCCCTTTTTCATTCACATCTCCAC
CCGGGTCACGACCCCCTGGA

Product: formaldehyde dehydrogenase-like protein, glutathione-dependent

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKAVVWHGVGDIRLDEVPDPRIEEPTDAIVRLTTSAICGTDLHMVRGTMPGMKEGTILGHEGVGIVDQIGASIRNFMPGD
RVVIPSTIACGFCSYCRAGYYSQCDNANPNGPDAGTCFFGGPELSGPINGLQAEKARIPFAGVGLVKVPDEVTDEQALLL
SDILPTGYMAAELAEIKPGNTVVVFGCGPVGQCAIAAAKLMQAGRIFAVDSVPFRLDLAQEQGAEAIDFSREDPVAMIHQ
FTGGIGCDRAIDAVGVDASAPHSGPGSREFREHLQEFQQELAQVAPRTNVQGENWHPGDAPSMTLVWAVQSLAKAGTLSI
VGVYPQTVSLFPIGAAMNKNLTLKMGNCDHRRFIPKLMELVQGKALDPAKILTQKAPFSNVIEAYQAFDLRKEGWLKVQL
QMQGAIGEER

Sequences:

>Translated_410_residues
MKAVVWHGVGDIRLDEVPDPRIEEPTDAIVRLTTSAICGTDLHMVRGTMPGMKEGTILGHEGVGIVDQIGASIRNFMPGD
RVVIPSTIACGFCSYCRAGYYSQCDNANPNGPDAGTCFFGGPELSGPINGLQAEKARIPFAGVGLVKVPDEVTDEQALLL
SDILPTGYMAAELAEIKPGNTVVVFGCGPVGQCAIAAAKLMQAGRIFAVDSVPFRLDLAQEQGAEAIDFSREDPVAMIHQ
FTGGIGCDRAIDAVGVDASAPHSGPGSREFREHLQEFQQELAQVAPRTNVQGENWHPGDAPSMTLVWAVQSLAKAGTLSI
VGVYPQTVSLFPIGAAMNKNLTLKMGNCDHRRFIPKLMELVQGKALDPAKILTQKAPFSNVIEAYQAFDLRKEGWLKVQL
QMQGAIGEER
>Mature_410_residues
MKAVVWHGVGDIRLDEVPDPRIEEPTDAIVRLTTSAICGTDLHMVRGTMPGMKEGTILGHEGVGIVDQIGASIRNFMPGD
RVVIPSTIACGFCSYCRAGYYSQCDNANPNGPDAGTCFFGGPELSGPINGLQAEKARIPFAGVGLVKVPDEVTDEQALLL
SDILPTGYMAAELAEIKPGNTVVVFGCGPVGQCAIAAAKLMQAGRIFAVDSVPFRLDLAQEQGAEAIDFSREDPVAMIHQ
FTGGIGCDRAIDAVGVDASAPHSGPGSREFREHLQEFQQELAQVAPRTNVQGENWHPGDAPSMTLVWAVQSLAKAGTLSI
VGVYPQTVSLFPIGAAMNKNLTLKMGNCDHRRFIPKLMELVQGKALDPAKILTQKAPFSNVIEAYQAFDLRKEGWLKVQL
QMQGAIGEER

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=263, Percent_Identity=30.0380228136882, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4501929, Length=411, Percent_Identity=26.7639902676399, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI71565154, Length=268, Percent_Identity=29.1044776119403, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI262073058, Length=401, Percent_Identity=23.9401496259352, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI71743840, Length=401, Percent_Identity=23.9401496259352, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI34577061, Length=232, Percent_Identity=31.0344827586207, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4501933, Length=233, Percent_Identity=30.9012875536481, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4501939, Length=229, Percent_Identity=27.9475982532751, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI156523966, Length=229, Percent_Identity=27.9475982532751, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786825, Length=411, Percent_Identity=36.7396593673966, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1788073, Length=252, Percent_Identity=30.5555555555556, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI87082125, Length=255, Percent_Identity=30.5882352941176, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI87081918, Length=220, Percent_Identity=31.8181818181818, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790045, Length=226, Percent_Identity=30.0884955752212, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788075, Length=250, Percent_Identity=30.4, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786552, Length=205, Percent_Identity=32.1951219512195, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1787863, Length=242, Percent_Identity=27.6859504132231, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788407, Length=229, Percent_Identity=27.9475982532751, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI226510992, Length=255, Percent_Identity=27.0588235294118, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=227, Percent_Identity=30.3964757709251, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=227, Percent_Identity=29.9559471365639, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25146526, Length=272, Percent_Identity=29.7794117647059, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=272, Percent_Identity=29.4117647058824, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=251, Percent_Identity=30.2788844621514, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323099, Length=266, Percent_Identity=30.8270676691729, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=211, Percent_Identity=30.8056872037915, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=267, Percent_Identity=29.2134831460674, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=267, Percent_Identity=29.2134831460674, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=247, Percent_Identity=27.1255060728745, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=290, Percent_Identity=25.8620689655172, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=234, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=252, Percent_Identity=25, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=249, Percent_Identity=28.5140562248996, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=240, Percent_Identity=28.3333333333333, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17137530, Length=263, Percent_Identity=31.5589353612167, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI17737897, Length=264, Percent_Identity=31.0606060606061, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI17737895, Length=232, Percent_Identity=28.448275862069, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI45551930, Length=204, Percent_Identity=26.4705882352941, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45550770, Length=204, Percent_Identity=26.4705882352941, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI221457811, Length=204, Percent_Identity=26.4705882352941, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 43853; Mature: 43853

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVWHGVGDIRLDEVPDPRIEEPTDAIVRLTTSAICGTDLHMVRGTMPGMKEGTILGH
CCEEEEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEECC
EGVGIVDQIGASIRNFMPGDRVVIPSTIACGFCSYCRAGYYSQCDNANPNGPDAGTCFFG
CCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCEEEEC
GPELSGPINGLQAEKARIPFAGVGLVKVPDEVTDEQALLLSDILPTGYMAAELAEIKPGN
CCCCCCCCCCCCHHHCCCCCCCCCEEECCHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCC
TVVVFGCGPVGQCAIAAAKLMQAGRIFAVDSVPFRLDLAQEQGAEAIDFSREDPVAMIHQ
EEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCEEEECHHHCCCCEECCCCCCCHHHHHH
FTGGIGCDRAIDAVGVDASAPHSGPGSREFREHLQEFQQELAQVAPRTNVQGENWHPGDA
HHCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PSMTLVWAVQSLAKAGTLSIVGVYPQTVSLFPIGAAMNKNLTLKMGNCDHRRFIPKLMEL
CCHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECHHCCCCEEEEECCCCHHHHHHHHHHH
VQGKALDPAKILTQKAPFSNVIEAYQAFDLRKEGWLKVQLQMQGAIGEER
HCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCC
>Mature Secondary Structure
MKAVVWHGVGDIRLDEVPDPRIEEPTDAIVRLTTSAICGTDLHMVRGTMPGMKEGTILGH
CCEEEEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEECC
EGVGIVDQIGASIRNFMPGDRVVIPSTIACGFCSYCRAGYYSQCDNANPNGPDAGTCFFG
CCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCEEEEC
GPELSGPINGLQAEKARIPFAGVGLVKVPDEVTDEQALLLSDILPTGYMAAELAEIKPGN
CCCCCCCCCCCCHHHCCCCCCCCCEEECCHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCC
TVVVFGCGPVGQCAIAAAKLMQAGRIFAVDSVPFRLDLAQEQGAEAIDFSREDPVAMIHQ
EEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCEEEECHHHCCCCEECCCCCCCHHHHHH
FTGGIGCDRAIDAVGVDASAPHSGPGSREFREHLQEFQQELAQVAPRTNVQGENWHPGDA
HHCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PSMTLVWAVQSLAKAGTLSIVGVYPQTVSLFPIGAAMNKNLTLKMGNCDHRRFIPKLMEL
CCHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECHHCCCCEEEEECCCCHHHHHHHHHHH
VQGKALDPAKILTQKAPFSNVIEAYQAFDLRKEGWLKVQLQMQGAIGEER
HCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]