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The map label for this gene is fbp [H]

Identifier: 197117498

GI number: 197117498

Start: 1281556

End: 1282119

Strand: Direct

Name: fbp [H]

Synonym: Gbem_1109

Alternate gene names: 197117498

Gene position: 1281556-1282119 (Clockwise)

Preceding gene: 197117497

Following gene: 197117500

Centisome position: 27.77

GC content: 59.04

Gene sequence:

>564_bases
ATGACCCTTCCTGGGATCGGCGAGGAGGAGGCCGGCAAGATCATCGATGGGCGGCCTTACAGCGCGAAGACAGAGCTCTC
GCGGAAAAAAATCCTCCCGTCCTCGTTGCTGTATCGCATCCTCGACAAGACGACCATCGATTTCAAGGCCTTCAACGACA
CCGGCAAGACAAAGGAAAAAGAGGCCTTCCTCGCGGAGATGCGCAGCAGCAAGACGATCAGGACGGTCAAGACGGCTTCG
GGCCTTTCCTACCAGGATCTGAAGGAGGGGCACGGGGCGAAGGTCGTAAACGGCAAAAAAGTCCTGGTGCAGTATACCGG
GTGGCTTCAAGACGGCACCAAGTTCGACAGTTCCCTGGACCGCAACAAACCCATCACCTTCACGCTCGGCAAGGGGGAGG
TGATCCGCGGCTGGGATGAGGGCATAAAGACGATGAGGGCGGGCGGCAAGCGCAGGCTCATCATCCCCCCGGTGCTCGCC
TACGGAGACAAGGGGAGCGGCAGCAAGATCCCACCAAAAGCCACGTTGGTCTTTGACGTCGAAGTCCTGGACGTCGAACC
CTAA

Upstream 100 bases:

>100_bases
TTCCTGCGGGGCCGTTTGGGCGTCGACTGCGGGCACTGCGCCGGCTGCTGCTGCCGCATCCGGGCTGGTTGATCTCAACC
TGGCGAGCAAGGAGCAGTTG

Downstream 100 bases:

>100_bases
ACCCAGAGATCTGCAACCGATGCATGCGACGGGGCGCCTTTGGCTTAGCTTAAAAAGGGGGGGGAGGCGGTTCGCCTCCC
GAAGTGAGGTTGGGGGGAGC

Product: FKBP-type peptidylprolyl cis-trans isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MTLPGIGEEEAGKIIDGRPYSAKTELSRKKILPSSLLYRILDKTTIDFKAFNDTGKTKEKEAFLAEMRSSKTIRTVKTAS
GLSYQDLKEGHGAKVVNGKKVLVQYTGWLQDGTKFDSSLDRNKPITFTLGKGEVIRGWDEGIKTMRAGGKRRLIIPPVLA
YGDKGSGSKIPPKATLVFDVEVLDVEP

Sequences:

>Translated_187_residues
MTLPGIGEEEAGKIIDGRPYSAKTELSRKKILPSSLLYRILDKTTIDFKAFNDTGKTKEKEAFLAEMRSSKTIRTVKTAS
GLSYQDLKEGHGAKVVNGKKVLVQYTGWLQDGTKFDSSLDRNKPITFTLGKGEVIRGWDEGIKTMRAGGKRRLIIPPVLA
YGDKGSGSKIPPKATLVFDVEVLDVEP
>Mature_186_residues
TLPGIGEEEAGKIIDGRPYSAKTELSRKKILPSSLLYRILDKTTIDFKAFNDTGKTKEKEAFLAEMRSSKTIRTVKTASG
LSYQDLKEGHGAKVVNGKKVLVQYTGWLQDGTKFDSSLDRNKPITFTLGKGEVIRGWDEGIKTMRAGGKRRLIIPPVLAY
GDKGSGSKIPPKATLVFDVEVLDVEP

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI4503729, Length=98, Percent_Identity=54.0816326530612, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI17149836, Length=89, Percent_Identity=58.4269662921348, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI4503725, Length=89, Percent_Identity=58.4269662921348, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI206725530, Length=89, Percent_Identity=53.9325842696629, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI17149844, Length=89, Percent_Identity=53.9325842696629, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI17149842, Length=89, Percent_Identity=53.9325842696629, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI224809329, Length=87, Percent_Identity=54.0229885057471, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI224809327, Length=87, Percent_Identity=54.0229885057471, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI4758384, Length=87, Percent_Identity=54.0229885057471, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI4758380, Length=89, Percent_Identity=52.8089887640449, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI224809331, Length=87, Percent_Identity=54.0229885057471, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI8923659, Length=91, Percent_Identity=49.4505494505495, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI4503727, Length=97, Percent_Identity=48.4536082474227, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI192448443, Length=92, Percent_Identity=47.8260869565217, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI33469985, Length=81, Percent_Identity=49.3827160493827, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI206725547, Length=86, Percent_Identity=45.3488372093023, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI150010552, Length=132, Percent_Identity=37.1212121212121, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI31317231, Length=87, Percent_Identity=44.8275862068966, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI7706131, Length=86, Percent_Identity=40.6976744186046, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI206725544, Length=100, Percent_Identity=36, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI146229346, Length=119, Percent_Identity=32.7731092436975, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI87082390, Length=108, Percent_Identity=46.2962962962963, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1789745, Length=169, Percent_Identity=37.2781065088757, Blast_Score=91, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17540882, Length=89, Percent_Identity=50.561797752809, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71993519, Length=107, Percent_Identity=46.7289719626168, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17561782, Length=98, Percent_Identity=48.9795918367347, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17561778, Length=94, Percent_Identity=42.5531914893617, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17506167, Length=94, Percent_Identity=40.4255319148936, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17506169, Length=94, Percent_Identity=40.4255319148936, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71993555, Length=82, Percent_Identity=43.9024390243902, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561780, Length=83, Percent_Identity=42.1686746987952, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=94, Percent_Identity=55.3191489361702, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324194, Length=89, Percent_Identity=51.685393258427, Blast_Score=93, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323566, Length=105, Percent_Identity=40.9523809523809, Blast_Score=78, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323482, Length=105, Percent_Identity=40, Blast_Score=78, Evalue=8e-16,
Organism=Drosophila melanogaster, GI281363946, Length=90, Percent_Identity=58.8888888888889, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17352457, Length=90, Percent_Identity=58.8888888888889, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24655568, Length=90, Percent_Identity=62.2222222222222, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=49.0384615384615, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24647110, Length=118, Percent_Identity=44.9152542372881, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356629, Length=95, Percent_Identity=51.5789473684211, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20560; Mature: 20429

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPGIGEEEAGKIIDGRPYSAKTELSRKKILPSSLLYRILDKTTIDFKAFNDTGKTKEK
CCCCCCCCHHCCCEECCCCCCCHHHHHHHHCCHHHHHHHHHHCCEEEEEEECCCCCCHHH
EAFLAEMRSSKTIRTVKTASGLSYQDLKEGHGAKVVNGKKVLVQYTGWLQDGTKFDSSLD
HHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCEEECCCEEEEEEECCCCCCCCCCCCCC
RNKPITFTLGKGEVIRGWDEGIKTMRAGGKRRLIIPPVLAYGDKGSGSKIPPKATLVFDV
CCCCEEEEECCCCEEECHHHHHHHHHCCCCEEEEECCCEEECCCCCCCCCCCCEEEEEEE
EVLDVEP
EEEEECC
>Mature Secondary Structure 
TLPGIGEEEAGKIIDGRPYSAKTELSRKKILPSSLLYRILDKTTIDFKAFNDTGKTKEK
CCCCCCCHHCCCEECCCCCCCHHHHHHHHCCHHHHHHHHHHCCEEEEEEECCCCCCHHH
EAFLAEMRSSKTIRTVKTASGLSYQDLKEGHGAKVVNGKKVLVQYTGWLQDGTKFDSSLD
HHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCEEECCCEEEEEEECCCCCCCCCCCCCC
RNKPITFTLGKGEVIRGWDEGIKTMRAGGKRRLIIPPVLAYGDKGSGSKIPPKATLVFDV
CCCCEEEEECCCCEEECHHHHHHHHHCCCCEEEEECCCEEECCCCCCCCCCCCEEEEEEE
EVLDVEP
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]