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The map label for this gene is asd-2 [H]

Identifier: 197117299

GI number: 197117299

Start: 1071083

End: 1072180

Strand: Direct

Name: asd-2 [H]

Synonym: Gbem_0909

Alternate gene names: 197117299

Gene position: 1071083-1072180 (Clockwise)

Preceding gene: 197117298

Following gene: 197117300

Centisome position: 23.21

GC content: 62.93

Gene sequence:

>1098_bases
ATGAAAGTCGGACTGGTCGGTTGGCGTGGCATGGTAGGCTCCGTTCTTCTCCAGCGTATGCAGGAGGAAAACGATTTCCA
GGGAATAGAGCCGGTTTTCTTTACAACCTCGCAGGTGGGGCAGCCCGCCCCGATGAACGCCGGGACGCTCAAGGACGCCT
CTGACATAAACGAGCTGAAGAAGCTGGACGTGATCATCACCTGCCAGGGTGGCGACTACACCAAGGCGGTGCGCCCGGAA
CTGAACAAGGCGGGATGGAAAGGGTACTGGATCGATGCGGCCAGCACGCTCCGCATGGAGAAGGACGCCGTCATCATCCT
CGACCCGATCAACCGCAACGTCATCGACGCTGCCCTTGCCAAAGGGGTCAAGGACTACATCGGCGGCAACTGCACCGTGA
GCCTCATGCTCATGGGCCTGGGCGGGCTCTTCAAGGCGGGTGCTGTCGAGTGGATCACCTCCATGACCTACCAGGCAGCC
TCCGGCGCGGGCGCTCCCAACATGCGCGAACTCCTCTCCCAGATGGGCGTATTGCAGGGCTCGGTAGCCGATCTCTTGGC
CACCCCGGGCTCCGCCATCCTGGAGATCGACCGCAAGGTGACCCAGACCCTGAGGGGGGGCGATCTCCCCACCAAGGAGT
TCGGCTTTCCGCTCGCGGGTAGCGTCCTTCCCTGGATCGACCGCGAGGTCGAGGACGGGCAGAGCCGCGAGGAATGGAAA
GGGTATGCCGAGACCAACAAGATCCTCGGCACCGCGAACCCGATCCCGGTCGACGGCATCTGCGTCCGCGTGGGGGCCAT
GCGCTGCCACAGCCAGGCGCTGACCATCAAGCTGAACAAGGACATCCCCATCGGCGAGATCGAGGAGATGATCAAGAACG
ACAATCAGTGGGTCAAGTTCGTTCCCAACACCAAGGCGGAGACTTTGGCTCAGTGCACCCCGGCAGCCGTTTCCGGTTCG
CTCACCGTGCCGGTCGGCCGCGTGAGGAAGATGAAGATGGGGCCGCAGTACCTCTCCGCCTTCACCTGCGGCGATCAGCT
CCTTTGGGGTGCCGCCGAGCCGCTGCGCCGCATGCTGCAGATCCTGAAGGAGCGGTAA

Upstream 100 bases:

>100_bases
GCACCTGGCGGAGCCAGTCCCCTCGACGCGCAACACGGTAGAGGCGGGACTCTCCCGCCGGTGCATATATTTAAATACAG
ACAGAAAAGGAAGGTCGCCT

Downstream 100 bases:

>100_bases
ACTGCAATTGACAATGGATAATTGACAATTGACGATGAGCGATTGTCGACCGAAACGATGATAAACGGAGCGCGTCCCCG
GTTTCAAGGGTGGCGCGCTC

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MKVGLVGWRGMVGSVLLQRMQEENDFQGIEPVFFTTSQVGQPAPMNAGTLKDASDINELKKLDVIITCQGGDYTKAVRPE
LNKAGWKGYWIDAASTLRMEKDAVIILDPINRNVIDAALAKGVKDYIGGNCTVSLMLMGLGGLFKAGAVEWITSMTYQAA
SGAGAPNMRELLSQMGVLQGSVADLLATPGSAILEIDRKVTQTLRGGDLPTKEFGFPLAGSVLPWIDREVEDGQSREEWK
GYAETNKILGTANPIPVDGICVRVGAMRCHSQALTIKLNKDIPIGEIEEMIKNDNQWVKFVPNTKAETLAQCTPAAVSGS
LTVPVGRVRKMKMGPQYLSAFTCGDQLLWGAAEPLRRMLQILKER

Sequences:

>Translated_365_residues
MKVGLVGWRGMVGSVLLQRMQEENDFQGIEPVFFTTSQVGQPAPMNAGTLKDASDINELKKLDVIITCQGGDYTKAVRPE
LNKAGWKGYWIDAASTLRMEKDAVIILDPINRNVIDAALAKGVKDYIGGNCTVSLMLMGLGGLFKAGAVEWITSMTYQAA
SGAGAPNMRELLSQMGVLQGSVADLLATPGSAILEIDRKVTQTLRGGDLPTKEFGFPLAGSVLPWIDREVEDGQSREEWK
GYAETNKILGTANPIPVDGICVRVGAMRCHSQALTIKLNKDIPIGEIEEMIKNDNQWVKFVPNTKAETLAQCTPAAVSGS
LTVPVGRVRKMKMGPQYLSAFTCGDQLLWGAAEPLRRMLQILKER
>Mature_365_residues
MKVGLVGWRGMVGSVLLQRMQEENDFQGIEPVFFTTSQVGQPAPMNAGTLKDASDINELKKLDVIITCQGGDYTKAVRPE
LNKAGWKGYWIDAASTLRMEKDAVIILDPINRNVIDAALAKGVKDYIGGNCTVSLMLMGLGGLFKAGAVEWITSMTYQAA
SGAGAPNMRELLSQMGVLQGSVADLLATPGSAILEIDRKVTQTLRGGDLPTKEFGFPLAGSVLPWIDREVEDGQSREEWK
GYAETNKILGTANPIPVDGICVRVGAMRCHSQALTIKLNKDIPIGEIEEMIKNDNQWVKFVPNTKAETLAQCTPAAVSGS
LTVPVGRVRKMKMGPQYLSAFTCGDQLLWGAAEPLRRMLQILKER

Specific function: Second step in the common biosynthetic pathway leading from Asp to the cell wall precursor meso-diaminopimelate, to Lys, to Met, to Ile and to Thr. [C]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789841, Length=364, Percent_Identity=64.2857142857143, Blast_Score=502, Evalue=1e-143,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR011534
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 39612; Mature: 39612

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGLVGWRGMVGSVLLQRMQEENDFQGIEPVFFTTSQVGQPAPMNAGTLKDASDINELK
CCEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCCCCCCCCCCHHHHHHHH
KLDVIITCQGGDYTKAVRPELNKAGWKGYWIDAASTLRMEKDAVIILDPINRNVIDAALA
HEEEEEEECCCCCCHHHCCCHHCCCCCEEEECCHHHEEECCCCEEEECCCCCHHHHHHHH
KGVKDYIGGNCTVSLMLMGLGGLFKAGAVEWITSMTYQAASGAGAPNMRELLSQMGVLQG
HHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
SVADLLATPGSAILEIDRKVTQTLRGGDLPTKEFGFPLAGSVLPWIDREVEDGQSREEWK
HHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHCCHHCCCCCHHHHC
GYAETNKILGTANPIPVDGICVRVGAMRCHSQALTIKLNKDIPIGEIEEMIKNDNQWVKF
CHHHHCCEEECCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHCCCCCEEEE
VPNTKAETLAQCTPAAVSGSLTVPVGRVRKMKMGPQYLSAFTCGDQLLWGAAEPLRRMLQ
CCCCCHHHHHHCCCHHHCCCEECCHHHHHHHHCCHHHHHHHHCCCHHHHCCHHHHHHHHH
ILKER
HHHCC
>Mature Secondary Structure
MKVGLVGWRGMVGSVLLQRMQEENDFQGIEPVFFTTSQVGQPAPMNAGTLKDASDINELK
CCEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCCCCCCCCCCHHHHHHHH
KLDVIITCQGGDYTKAVRPELNKAGWKGYWIDAASTLRMEKDAVIILDPINRNVIDAALA
HEEEEEEECCCCCCHHHCCCHHCCCCCEEEECCHHHEEECCCCEEEECCCCCHHHHHHHH
KGVKDYIGGNCTVSLMLMGLGGLFKAGAVEWITSMTYQAASGAGAPNMRELLSQMGVLQG
HHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
SVADLLATPGSAILEIDRKVTQTLRGGDLPTKEFGFPLAGSVLPWIDREVEDGQSREEWK
HHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHCCHHCCCCCHHHHC
GYAETNKILGTANPIPVDGICVRVGAMRCHSQALTIKLNKDIPIGEIEEMIKNDNQWVKF
CHHHHCCEEECCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHCCCCCEEEE
VPNTKAETLAQCTPAAVSGSLTVPVGRVRKMKMGPQYLSAFTCGDQLLWGAAEPLRRMLQ
CCCCCHHHHHHCCCHHHCCCEECCHHHHHHHHCCHHHHHHHHCCCHHHHCCHHHHHHHHH
ILKER
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9084174; 10984043 [H]