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The map label for this gene is nat [H]

Identifier: 197116706

GI number: 197116706

Start: 379637

End: 380434

Strand: Direct

Name: nat [H]

Synonym: Gbem_0306

Alternate gene names: 197116706

Gene position: 379637-380434 (Clockwise)

Preceding gene: 197116705

Following gene: 197116707

Centisome position: 8.23

GC content: 59.27

Gene sequence:

>798_bases
ATGGATATTGATTTATTTCTCCAACGCATTGGCCTCCAATCCCTCCCGGACTCCCCCATGAAGCGCCTTCGGGCGCTGTA
TGCTGCGATGACCAAAACGGTTCCCTTCGAAAACGTGGCGGTTATGGAAGGAAAGAGCATCAGCCTCGAACCCGGCGATA
TCTTCGCCAAGGTGGTTGAGCAGGGGAGAGGCGGCTACTGTTTCGAGTTGAACGGCCTGCTTGCCCATCTGCTTGAACAG
TTTGGTTACAGGATCGAGCGCCTGATTGGGAGGGTCTGGGCCAGCGGAGCACCGGCGCCTTTGCTGACGCATATGACGCT
GCGGGTGTTCGTGGAAGATCGGCCCTACCTTTGCGATGTCGGCTTCGGGGGAGGGACGTTGAGAGAGCCGTTGCCGTGGG
TCACCGGGGCGGTCGCCATACAAGGCCCGGACCGTTTCCGGCTGGATGCGACCGACAACGGGGAAACCATGCTGTCCCGG
CTCGTCGATGCGGAATGGAAGAATATGTACAGCCTGCTCCCTTGCCCGGTGCGTTCCCAGGACTACATCCCCGCCAATCA
TTACACCTCGACCCACCCCAACTCGCATTTCACCCAAGGTCTGGTTGCCGCTCTGGTGACCGACAGCGGGCGGGTAACGC
TACGCGATCGACTCTTTCGCACGGTCGGCGCAGAAGGAGAGACCGAACGGGAATTGACGACGTTCGATGAAGTGGTTCAG
GTCCTGGGCCAGGAATTCGGCCTGCGCAATCTCGATCTAGCCGCTTTGCAGAGCCGGCTTTCTTACCTCTTTGCCTGA

Upstream 100 bases:

>100_bases
AAAAGTATCTCCTTTCGCCAACGCCAACCAACCATACGAGCAAGACTGAGTCGACACCTGGAGACATACAGAGCTTGAAA
TAAGGAAAGCAGGATCGGTT

Downstream 100 bases:

>100_bases
GGGGAGAGATAGACCCCCGTAAAGGAGAGTATCGTGTCTCTACGCAGCCTTCGCATCCTCACCGCCATTGCCGGCAAAGG
CACCTTTGCAGCCGCCGCCG

Product: arylamine N-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MDIDLFLQRIGLQSLPDSPMKRLRALYAAMTKTVPFENVAVMEGKSISLEPGDIFAKVVEQGRGGYCFELNGLLAHLLEQ
FGYRIERLIGRVWASGAPAPLLTHMTLRVFVEDRPYLCDVGFGGGTLREPLPWVTGAVAIQGPDRFRLDATDNGETMLSR
LVDAEWKNMYSLLPCPVRSQDYIPANHYTSTHPNSHFTQGLVAALVTDSGRVTLRDRLFRTVGAEGETERELTTFDEVVQ
VLGQEFGLRNLDLAALQSRLSYLFA

Sequences:

>Translated_265_residues
MDIDLFLQRIGLQSLPDSPMKRLRALYAAMTKTVPFENVAVMEGKSISLEPGDIFAKVVEQGRGGYCFELNGLLAHLLEQ
FGYRIERLIGRVWASGAPAPLLTHMTLRVFVEDRPYLCDVGFGGGTLREPLPWVTGAVAIQGPDRFRLDATDNGETMLSR
LVDAEWKNMYSLLPCPVRSQDYIPANHYTSTHPNSHFTQGLVAALVTDSGRVTLRDRLFRTVGAEGETERELTTFDEVVQ
VLGQEFGLRNLDLAALQSRLSYLFA
>Mature_265_residues
MDIDLFLQRIGLQSLPDSPMKRLRALYAAMTKTVPFENVAVMEGKSISLEPGDIFAKVVEQGRGGYCFELNGLLAHLLEQ
FGYRIERLIGRVWASGAPAPLLTHMTLRVFVEDRPYLCDVGFGGGTLREPLPWVTGAVAIQGPDRFRLDATDNGETMLSR
LVDAEWKNMYSLLPCPVRSQDYIPANHYTSTHPNSHFTQGLVAALVTDSGRVTLRDRLFRTVGAEGETERELTTFDEVVQ
VLGQEFGLRNLDLAALQSRLSYLFA

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649128, Length=273, Percent_Identity=28.2051282051282, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI237649126, Length=273, Percent_Identity=28.2051282051282, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI237649124, Length=273, Percent_Identity=28.2051282051282, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI237649122, Length=273, Percent_Identity=28.2051282051282, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI237649119, Length=273, Percent_Identity=28.2051282051282, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI42741671, Length=273, Percent_Identity=28.2051282051282, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI237649009, Length=273, Percent_Identity=28.2051282051282, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI237649132, Length=273, Percent_Identity=28.2051282051282, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI237649130, Length=273, Percent_Identity=28.2051282051282, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI116295260, Length=234, Percent_Identity=25.6410256410256, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1787736, Length=249, Percent_Identity=30.9236947791165, Blast_Score=113, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 29537; Mature: 29537

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIDLFLQRIGLQSLPDSPMKRLRALYAAMTKTVPFENVAVMEGKSISLEPGDIFAKVVE
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHH
QGRGGYCFELNGLLAHLLEQFGYRIERLIGRVWASGAPAPLLTHMTLRVFVEDRPYLCDV
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHEEEEEECCCCEEEEE
GFGGGTLREPLPWVTGAVAIQGPDRFRLDATDNGETMLSRLVDAEWKNMYSLLPCPVRSQ
CCCCCCCCCCCCHHHCEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
DYIPANHYTSTHPNSHFTQGLVAALVTDSGRVTLRDRLFRTVGAEGETERELTTFDEVVQ
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
VLGQEFGLRNLDLAALQSRLSYLFA
HHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIDLFLQRIGLQSLPDSPMKRLRALYAAMTKTVPFENVAVMEGKSISLEPGDIFAKVVE
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHH
QGRGGYCFELNGLLAHLLEQFGYRIERLIGRVWASGAPAPLLTHMTLRVFVEDRPYLCDV
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHEEEEEECCCCEEEEE
GFGGGTLREPLPWVTGAVAIQGPDRFRLDATDNGETMLSRLVDAEWKNMYSLLPCPVRSQ
CCCCCCCCCCCCHHHCEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
DYIPANHYTSTHPNSHFTQGLVAALVTDSGRVTLRDRLFRTVGAEGETERELTTFDEVVQ
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
VLGQEFGLRNLDLAALQSRLSYLFA
HHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]