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The map label for this gene is msrA [H]

Identifier: 197116664

GI number: 197116664

Start: 312382

End: 313017

Strand: Direct

Name: msrA [H]

Synonym: Gbem_0264

Alternate gene names: 197116664

Gene position: 312382-313017 (Clockwise)

Preceding gene: 197116663

Following gene: 197116665

Centisome position: 6.77

GC content: 61.01

Gene sequence:

>636_bases
ATGAAACGTATTCGATTCGCAATTCTTACCCTAACTGCGCTTTTCTGCGCGGCGGGACCAACCCTGGCAGCAAGCGCCAC
GGCGCCTGGGGGCAAGGGTACCCAGTCCGCCGGGCACCTGGAGAAGGCGACCTTTGCCGGGGGGTGCTTCTGGTGCATGG
AGCACCCCTTTGACGAGCTGCCCGGTGTCGTCTCCGTCACCTCAGGCTATACCGGCGGCCATAAGATAAACCCCACTTAC
GAGGAGGTCTCCTCCGGGACCACCGGGCATGCAGAATCAATCCAGGTGGTGTACGACCCGGCGAAGATAGGTTACGACAA
GCTCCTCGACGTCTTCTGGCACAACATCGACCCGCTGGCCAAGGACCGGCAGTTCTGCGACAGCGGCGAGCAGTACCGGA
GTGCCATTTTTTACCATAACGAGGAGCAGCAACGCCTGGCCCTCCAGTCCAAGAAGGCGCTGGAGTCAAGCAAGAGGTTC
AAAGAACCCATCGCCACCCAGATCGTGGCGGCGGGGGTGTTCTACCCCGCCGAGGAGTACCATCAGCACTACTACAAGAA
GAACCCGATCCGCTACTTCTACTACCGCTCGAGCTGCGGGCGCGACCGGCGGCTGAAGGAGCTGTGGGGGCGTTAA

Upstream 100 bases:

>100_bases
CGAAGTAGCTGCGGCTCCCCAGCCCACCTGCCGCGCCGGAAGGAATCCGATGCCGGGGGGGGGCAGGAGCTACGGCGGGG
TCTGGCAGAGGAGAAGAGTG

Downstream 100 bases:

>100_bases
CGAGAGAGGCTATGAAAAACAGGGAAATCGCACGGATCTTTGCCGAGATCGCCGACATCCTGGAGATCAAGGAAGGGAAC
GTCTTCAAGATAAGGGCCTA

Product: peptide methionine sulfoxide reductase (S-isomer-specific)

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MKRIRFAILTLTALFCAAGPTLAASATAPGGKGTQSAGHLEKATFAGGCFWCMEHPFDELPGVVSVTSGYTGGHKINPTY
EEVSSGTTGHAESIQVVYDPAKIGYDKLLDVFWHNIDPLAKDRQFCDSGEQYRSAIFYHNEEQQRLALQSKKALESSKRF
KEPIATQIVAAGVFYPAEEYHQHYYKKNPIRYFYYRSSCGRDRRLKELWGR

Sequences:

>Translated_211_residues
MKRIRFAILTLTALFCAAGPTLAASATAPGGKGTQSAGHLEKATFAGGCFWCMEHPFDELPGVVSVTSGYTGGHKINPTY
EEVSSGTTGHAESIQVVYDPAKIGYDKLLDVFWHNIDPLAKDRQFCDSGEQYRSAIFYHNEEQQRLALQSKKALESSKRF
KEPIATQIVAAGVFYPAEEYHQHYYKKNPIRYFYYRSSCGRDRRLKELWGR
>Mature_211_residues
MKRIRFAILTLTALFCAAGPTLAASATAPGGKGTQSAGHLEKATFAGGCFWCMEHPFDELPGVVSVTSGYTGGHKINPTY
EEVSSGTTGHAESIQVVYDPAKIGYDKLLDVFWHNIDPLAKDRQFCDSGEQYRSAIFYHNEEQQRLALQSKKALESSKRF
KEPIATQIVAAGVFYPAEEYHQHYYKKNPIRYFYYRSSCGRDRRLKELWGR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=154, Percent_Identity=46.1038961038961, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI208609995, Length=154, Percent_Identity=46.1038961038961, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI208609993, Length=147, Percent_Identity=40.8163265306122, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1790665, Length=163, Percent_Identity=47.8527607361963, Blast_Score=142, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=35.8108108108108, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=36.9426751592357, Blast_Score=85, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24664627, Length=147, Percent_Identity=38.7755102040816, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24664631, Length=147, Percent_Identity=38.0952380952381, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45553131, Length=142, Percent_Identity=38.0281690140845, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23730; Mature: 23730

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIRFAILTLTALFCAAGPTLAASATAPGGKGTQSAGHLEKATFAGGCFWCMEHPFDEL
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHCCCHHHC
PGVVSVTSGYTGGHKINPTYEEVSSGTTGHAESIQVVYDPAKIGYDKLLDVFWHNIDPLA
CCEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEECHHHHCHHHHHHHHHCCCCCHH
KDRQFCDSGEQYRSAIFYHNEEQQRLALQSKKALESSKRFKEPIATQIVAAGVFYPAEEY
HHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
HQHYYKKNPIRYFYYRSSCGRDRRLKELWGR
HHHHHHCCCEEEEEEECCCCCCHHHHHHHCC
>Mature Secondary Structure
MKRIRFAILTLTALFCAAGPTLAASATAPGGKGTQSAGHLEKATFAGGCFWCMEHPFDEL
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHCCCHHHC
PGVVSVTSGYTGGHKINPTYEEVSSGTTGHAESIQVVYDPAKIGYDKLLDVFWHNIDPLA
CCEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEECHHHHCHHHHHHHHHCCCCCHH
KDRQFCDSGEQYRSAIFYHNEEQQRLALQSKKALESSKRFKEPIATQIVAAGVFYPAEEY
HHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
HQHYYKKNPIRYFYYRSSCGRDRRLKELWGR
HHHHHHCCCEEEEEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA