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The map label for this gene is uvrB [H]

Identifier: 197116550

GI number: 197116550

Start: 180127

End: 182115

Strand: Direct

Name: uvrB [H]

Synonym: Gbem_0150

Alternate gene names: 197116550

Gene position: 180127-182115 (Clockwise)

Preceding gene: 197116549

Following gene: 308535149

Centisome position: 3.9

GC content: 62.9

Gene sequence:

>1989_bases
ATGGACAAATTCGAACTGGTAACAAGTTTCGAGCCCCGCGGCGACCAACCCAGGGCCATCGCAGAACTGGCGGACGGAGT
GCTGCGGGGCGATCCGCACCAGGTGCTCCTCGGGGTCACCGGGTCGGGCAAGACCTTCACCATGGCCCAGGTGATCGCAC
GCTGCAACTGCCCCACCCTGGTCCTTGCGCCCAACAAGACGCTGGCCGCCCAGCTCTACGGCGAGTTCAAGGAACTGTTC
CCCAACAACGCCGTCGAGTATTTCGTTTCCTACTACGACTATTACCAGCCTGAAGCCTACATCCCCTCCTCCGATACCTT
CATCGAGAAGGACTCCTCGATAAACGACGAGATCGACAAGTTCAGGCACTCCGCCACCAGGAGCCTTTTGACCCGCCGCG
ACGTCATCATCGTCGCCTCGGTTTCCTGCATTTACGGCATAGGCTCCCCCGAGTCGTACCAGGAGATGCAGATCCGCTTC
CGGGAAGGGGACGAGGTAGGGCGCGACGAAATGCTGCAGCGTCTGGTGGCGATCCAGTATCAGAGAAACGACGTCGATTT
CCACCGCGGCTCCTTCCGGGTCCGTGGGGACACGGTCGAGGTCTTCCCCGCCCACGACGACGAGCGGGCGCTCAGGATCG
AGTTCTTCGGGGACACGGTGGATGCCATCTCCGAGATAGACCCTTTGCGCGGGGTGCAGCTGCAGAAGCTTTCCCGCTGC
GCCATCTACCCTGCCTCCCATTACGTCGCCAGCCGCCAGACCCTGGAGCGGGCCGTGGAGCAGATCCGACTCGAACTGGA
GGAACGGCTCCGCTACTTCAACTCGCAGAACATGCTGCTTGAGGCGCAGCGCATTGAGCAGAGGACCTTTTTCGACATCG
AGATGATGGAGGAGATGGGTTTTTGCCAGGGGATCGAAAACTACTCGCGCCACTTCGACGGCCGCGCCGCCGGCGAGCCC
CCTTATACGCTGATCGACTATTTCCCCAAGGACTTCCTGCTGGTGATCGACGAGTCCCACATCACCGTTTCGCAGGTGGG
GGGGATGTACCGCGGCGACCGCAGCCGGAAAGAGACCCTGGTGAACTACGGTTTCAGGCTCCCCTCCGCCCTGGACAACC
GCCCGCTCACCTTCCAGGAGTTCCAGAAGAAGCTGCACCAGACCATCTACGTTTCCGCGACACCGGCGGACTACGAGCTG
AAGCTGGCGGAAGGGGTCGTGGTCGAGCAGCTGATCCGCCCCACCGGTCTTATCGACCCGGCCATCGAGGTGCGCCCGGC
CGCCGGGCAGGTGGACGACCTGCTGCACGAGGCGCGCGAGACGGCGGCCAGGGGAGAACGGGTGCTGGTCACGACCCTTA
CCAAGCGCATGGCCGAGGAGCTCACCGACTACTACCGCGAGCTTGGGATCCGCGTCCGTTACCTCCACTCCGACATCGAC
ACCTTCCAGCGCATGGAGATCCTCAGGGACTTAAGGCTCGGCGAGTTCGACCTGCTGGTCGGGATCAACCTGCTCAGGGA
AGGGCTCGACCTCCCCGAGGTCTCGCTGGTGGCGATCCTCGATGCGGACAAGGAAGGGTTCCTCCGCTCCACGAGGTCGC
TGATCCAGACCTGCGGCCGCGCGGCGAGGAACGTGTCGGGGCGTGTCCTCATGTATGCGGACAAGGTGACCGGTTCCATG
CAGGCCGCCATCGACGAAACCCTCAGGAGGCGCGCTTTGCAGACGGCCTACAACGAGGAGCACGGCATCACACCGGAGAG
CGTGCGGAGGATGATCGGGAACGTGCTTCAGGCGCCTGAGGAGAAGGACTGGGTCACGGTGCCGGCATCGGCCGAGGAGT
TCTTGAGCGTCAAGGAGCTGGAGAAGACGCTGAAGAGGCTGCGAAAGGAGATGCTGGCGGCGGCCAAGGCTCAGGAATTC
GAAAGGGCCGCGGAGCTGAGGGACAAGATCAAGCGGCTGGAGGTTGCGGAAATCACCAGGGGAAGCTGA

Upstream 100 bases:

>100_bases
CTATTGGCTGAGTGTCAACCAGCTCCCCCCCCAGAGAAATTGCGCGGCGGCCTGATCACCCTGTTGCCAAGGCGCGCCGA
GGCCTGCTAATATCCCCGGC

Downstream 100 bases:

>100_bases
GAAGCAATTGACAATTGACGATTGACGATTGACAACGAAACCCCCTCGGGCTTGGTGCGCGAGGGGGTTCTTGTTTGGAT
CCACTAGCTCGGCATGGGGG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MDKFELVTSFEPRGDQPRAIAELADGVLRGDPHQVLLGVTGSGKTFTMAQVIARCNCPTLVLAPNKTLAAQLYGEFKELF
PNNAVEYFVSYYDYYQPEAYIPSSDTFIEKDSSINDEIDKFRHSATRSLLTRRDVIIVASVSCIYGIGSPESYQEMQIRF
REGDEVGRDEMLQRLVAIQYQRNDVDFHRGSFRVRGDTVEVFPAHDDERALRIEFFGDTVDAISEIDPLRGVQLQKLSRC
AIYPASHYVASRQTLERAVEQIRLELEERLRYFNSQNMLLEAQRIEQRTFFDIEMMEEMGFCQGIENYSRHFDGRAAGEP
PYTLIDYFPKDFLLVIDESHITVSQVGGMYRGDRSRKETLVNYGFRLPSALDNRPLTFQEFQKKLHQTIYVSATPADYEL
KLAEGVVVEQLIRPTGLIDPAIEVRPAAGQVDDLLHEARETAARGERVLVTTLTKRMAEELTDYYRELGIRVRYLHSDID
TFQRMEILRDLRLGEFDLLVGINLLREGLDLPEVSLVAILDADKEGFLRSTRSLIQTCGRAARNVSGRVLMYADKVTGSM
QAAIDETLRRRALQTAYNEEHGITPESVRRMIGNVLQAPEEKDWVTVPASAEEFLSVKELEKTLKRLRKEMLAAAKAQEF
ERAAELRDKIKRLEVAEITRGS

Sequences:

>Translated_662_residues
MDKFELVTSFEPRGDQPRAIAELADGVLRGDPHQVLLGVTGSGKTFTMAQVIARCNCPTLVLAPNKTLAAQLYGEFKELF
PNNAVEYFVSYYDYYQPEAYIPSSDTFIEKDSSINDEIDKFRHSATRSLLTRRDVIIVASVSCIYGIGSPESYQEMQIRF
REGDEVGRDEMLQRLVAIQYQRNDVDFHRGSFRVRGDTVEVFPAHDDERALRIEFFGDTVDAISEIDPLRGVQLQKLSRC
AIYPASHYVASRQTLERAVEQIRLELEERLRYFNSQNMLLEAQRIEQRTFFDIEMMEEMGFCQGIENYSRHFDGRAAGEP
PYTLIDYFPKDFLLVIDESHITVSQVGGMYRGDRSRKETLVNYGFRLPSALDNRPLTFQEFQKKLHQTIYVSATPADYEL
KLAEGVVVEQLIRPTGLIDPAIEVRPAAGQVDDLLHEARETAARGERVLVTTLTKRMAEELTDYYRELGIRVRYLHSDID
TFQRMEILRDLRLGEFDLLVGINLLREGLDLPEVSLVAILDADKEGFLRSTRSLIQTCGRAARNVSGRVLMYADKVTGSM
QAAIDETLRRRALQTAYNEEHGITPESVRRMIGNVLQAPEEKDWVTVPASAEEFLSVKELEKTLKRLRKEMLAAAKAQEF
ERAAELRDKIKRLEVAEITRGS
>Mature_662_residues
MDKFELVTSFEPRGDQPRAIAELADGVLRGDPHQVLLGVTGSGKTFTMAQVIARCNCPTLVLAPNKTLAAQLYGEFKELF
PNNAVEYFVSYYDYYQPEAYIPSSDTFIEKDSSINDEIDKFRHSATRSLLTRRDVIIVASVSCIYGIGSPESYQEMQIRF
REGDEVGRDEMLQRLVAIQYQRNDVDFHRGSFRVRGDTVEVFPAHDDERALRIEFFGDTVDAISEIDPLRGVQLQKLSRC
AIYPASHYVASRQTLERAVEQIRLELEERLRYFNSQNMLLEAQRIEQRTFFDIEMMEEMGFCQGIENYSRHFDGRAAGEP
PYTLIDYFPKDFLLVIDESHITVSQVGGMYRGDRSRKETLVNYGFRLPSALDNRPLTFQEFQKKLHQTIYVSATPADYEL
KLAEGVVVEQLIRPTGLIDPAIEVRPAAGQVDDLLHEARETAARGERVLVTTLTKRMAEELTDYYRELGIRVRYLHSDID
TFQRMEILRDLRLGEFDLLVGINLLREGLDLPEVSLVAILDADKEGFLRSTRSLIQTCGRAARNVSGRVLMYADKVTGSM
QAAIDETLRRRALQTAYNEEHGITPESVRRMIGNVLQAPEEKDWVTVPASAEEFLSVKELEKTLKRLRKEMLAAAKAQEF
ERAAELRDKIKRLEVAEITRGS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=661, Percent_Identity=59.304084720121, Blast_Score=777, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75595; Mature: 75595

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKFELVTSFEPRGDQPRAIAELADGVLRGDPHQVLLGVTGSGKTFTMAQVIARCNCPTL
CCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEE
VLAPNKTLAAQLYGEFKELFPNNAVEYFVSYYDYYQPEAYIPSSDTFIEKDSSINDEIDK
EECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCHHHHHH
FRHSATRSLLTRRDVIIVASVSCIYGIGSPESYQEMQIRFREGDEVGRDEMLQRLVAIQY
HHHHHHHHHHHHCCEEEEEEHHHHEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
QRNDVDFHRGSFRVRGDTVEVFPAHDDERALRIEFFGDTVDAISEIDPLRGVQLQKLSRC
CCCCCCEECCCEEEECCEEEEEECCCCCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHH
AIYPASHYVASRQTLERAVEQIRLELEERLRYFNSQNMLLEAQRIEQRTFFDIEMMEEMG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHH
FCQGIENYSRHFDGRAAGEPPYTLIDYFPKDFLLVIDESHITVSQVGGMYRGDRSRKETL
HHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCEEHHHHCCCCCCCCHHHHHH
VNYGFRLPSALDNRPLTFQEFQKKLHQTIYVSATPADYELKLAEGVVVEQLIRPTGLIDP
HHHCCCCCCCCCCCCCCHHHHHHHHHHEEEEEECCCCCEEEHHHHHHHHHHHCCCCCCCC
AIEVRPAAGQVDDLLHEARETAARGERVLVTTLTKRMAEELTDYYRELGIRVRYLHSDID
CCEEECCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHH
TFQRMEILRDLRLGEFDLLVGINLLREGLDLPEVSLVAILDADKEGFLRSTRSLIQTCGR
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
AARNVSGRVLMYADKVTGSMQAAIDETLRRRALQTAYNEEHGITPESVRRMIGNVLQAPE
HHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
EKDWVTVPASAEEFLSVKELEKTLKRLRKEMLAAAKAQEFERAAELRDKIKRLEVAEITR
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GS
CC
>Mature Secondary Structure
MDKFELVTSFEPRGDQPRAIAELADGVLRGDPHQVLLGVTGSGKTFTMAQVIARCNCPTL
CCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEE
VLAPNKTLAAQLYGEFKELFPNNAVEYFVSYYDYYQPEAYIPSSDTFIEKDSSINDEIDK
EECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCHHHHHH
FRHSATRSLLTRRDVIIVASVSCIYGIGSPESYQEMQIRFREGDEVGRDEMLQRLVAIQY
HHHHHHHHHHHHCCEEEEEEHHHHEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
QRNDVDFHRGSFRVRGDTVEVFPAHDDERALRIEFFGDTVDAISEIDPLRGVQLQKLSRC
CCCCCCEECCCEEEECCEEEEEECCCCCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHH
AIYPASHYVASRQTLERAVEQIRLELEERLRYFNSQNMLLEAQRIEQRTFFDIEMMEEMG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHH
FCQGIENYSRHFDGRAAGEPPYTLIDYFPKDFLLVIDESHITVSQVGGMYRGDRSRKETL
HHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCEEHHHHCCCCCCCCHHHHHH
VNYGFRLPSALDNRPLTFQEFQKKLHQTIYVSATPADYELKLAEGVVVEQLIRPTGLIDP
HHHCCCCCCCCCCCCCCHHHHHHHHHHEEEEEECCCCCEEEHHHHHHHHHHHCCCCCCCC
AIEVRPAAGQVDDLLHEARETAARGERVLVTTLTKRMAEELTDYYRELGIRVRYLHSDID
CCEEECCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHH
TFQRMEILRDLRLGEFDLLVGINLLREGLDLPEVSLVAILDADKEGFLRSTRSLIQTCGR
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
AARNVSGRVLMYADKVTGSMQAAIDETLRRRALQTAYNEEHGITPESVRRMIGNVLQAPE
HHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
EKDWVTVPASAEEFLSVKELEKTLKRLRKEMLAAAKAQEFERAAELRDKIKRLEVAEITR
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA