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The map label for this gene is serS

Identifier: 197116508

GI number: 197116508

Start: 130066

End: 131334

Strand: Direct

Name: serS

Synonym: Gbem_0108

Alternate gene names: 197116508

Gene position: 130066-131334 (Clockwise)

Preceding gene: 197116506

Following gene: 197116509

Centisome position: 2.82

GC content: 59.02

Gene sequence:

>1269_bases
ATGCTCGACGCGAGATACATACGCGAAAACCTGGAAACTGTAGAGGCGCGGCTCAAAACCAGAGGCGAAGGCGTTGATAT
TGCGCTCTTCAAGGAACTGGACGGCCGTCGTCGCGAACTTCTGCAGCAAAGCGAGACCCTCAAGGCACTGCGCAACAAGG
TGACCGAAGAGATCGCGCGACTGCAGGACAAGAGCCAGGCGGCGGAGCGCAAGACCGAGATGCGCGAGGTCTCGCAACAG
ATCAAGGGGATCGACGAGTCGCTCAGGAGCGTCGAAGAGGAACTGCAGAACTTCCTGCTCACCGTTCCCAACGTACCCAA
TGAGACCACCCCGATAGGTAAGTCCGAAGAGGACAACGTCGTGGTGCGGACTTGGGGCGAGGTCCCGACGCTTTCCTTCG
AGCCGAAACCGCACTGGGAGATCGGCGAGGGACTCGGCATCCTCGACTTCGAGCGCGGCGCCAAGCTCGCCGGAGCACGC
TTCACCCTCTACCGTGGGGCTGGAGCGAGGCTCGAACGCGCTCTCATTAATTACATGCTGGATCTGCATACTGACGAGCA
TAAATATATTGAAATGCTCCCGCCCTTTATGGTAAACAGGGAATGCATGACCGGGACCGGGCAGCTGCCCAAGTTTGAGG
AAGATCTCTTCCATATGGAAGGGGTCGATTTTTTTCTCATCCCCACGGCTGAAGTACCGGTAACCAACATACACCGCGGC
GAGATCCTGAAGGGTTCCGATCTCCCGATTTCTTATGTTGCCTACACGCCCTGCTTCCGCAAGGAGGCTGGTTCTTACGG
CAAGGACACGCGTGGGCTGATCAGGCAGCACCAGTTCAACAAGGTGGAACTGGTCAAGTTCACCTCCCCCGAGGATTCCT
ACCAGCAATTGCAGAAGCTGCTTGGCCACGCCGAGGAAGTGCTGCGCAGGTTGCAGATACCTTACCGGGTGGTGGAGCTT
TGCACCGGCGACATAGGTTTTTCCGCCGCCAAGACCTTCGATATCGAGGTCTGGCTGCCGGGACAGAACTGCTACCGGGA
GATTTCCTCCTGCAGCTGCTTCGAAGATTTCCAGGCCCGTCGCGCCGGGATTCGGTTCCGCCCGGAAGAGAAGGCCAAGC
CCGAGTTCGTGCACACGCTGAACGGCTCCGGCCTCGCCGTCGGCAGGACCCTGGTGGCGGTGCTGGAAAACTACCAGCAG
GCAGACGGCTCGGTGCTGATCCCCGAGGTGCTCAGGCCTTACATGGGCGGGGCAGAGAGAATCAGCTAG

Upstream 100 bases:

>100_bases
TGCAGGAAGAGTATCTGGGAGTGCAAAAAACGGTTGACTAACTGAAATTTGAGTGTTAGACAGTATAGCTTTGGTGATCT
GAATGTAAAGGCGCTGACAC

Downstream 100 bases:

>100_bases
GCTTTGGAGGAATGGCCGAGTGGTTGAAGGCGGCGGTCTTGAAAACCGTTGAACGAAAGTTCCGTGGGTTCGAATCCTAC
TTCCTCCGCCATCGCTTTTG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLDARYIRENLETVEARLKTRGEGVDIALFKELDGRRRELLQQSETLKALRNKVTEEIARLQDKSQAAERKTEMREVSQQ
IKGIDESLRSVEEELQNFLLTVPNVPNETTPIGKSEEDNVVVRTWGEVPTLSFEPKPHWEIGEGLGILDFERGAKLAGAR
FTLYRGAGARLERALINYMLDLHTDEHKYIEMLPPFMVNRECMTGTGQLPKFEEDLFHMEGVDFFLIPTAEVPVTNIHRG
EILKGSDLPISYVAYTPCFRKEAGSYGKDTRGLIRQHQFNKVELVKFTSPEDSYQQLQKLLGHAEEVLRRLQIPYRVVEL
CTGDIGFSAAKTFDIEVWLPGQNCYREISSCSCFEDFQARRAGIRFRPEEKAKPEFVHTLNGSGLAVGRTLVAVLENYQQ
ADGSVLIPEVLRPYMGGAERIS

Sequences:

>Translated_422_residues
MLDARYIRENLETVEARLKTRGEGVDIALFKELDGRRRELLQQSETLKALRNKVTEEIARLQDKSQAAERKTEMREVSQQ
IKGIDESLRSVEEELQNFLLTVPNVPNETTPIGKSEEDNVVVRTWGEVPTLSFEPKPHWEIGEGLGILDFERGAKLAGAR
FTLYRGAGARLERALINYMLDLHTDEHKYIEMLPPFMVNRECMTGTGQLPKFEEDLFHMEGVDFFLIPTAEVPVTNIHRG
EILKGSDLPISYVAYTPCFRKEAGSYGKDTRGLIRQHQFNKVELVKFTSPEDSYQQLQKLLGHAEEVLRRLQIPYRVVEL
CTGDIGFSAAKTFDIEVWLPGQNCYREISSCSCFEDFQARRAGIRFRPEEKAKPEFVHTLNGSGLAVGRTLVAVLENYQQ
ADGSVLIPEVLRPYMGGAERIS
>Mature_422_residues
MLDARYIRENLETVEARLKTRGEGVDIALFKELDGRRRELLQQSETLKALRNKVTEEIARLQDKSQAAERKTEMREVSQQ
IKGIDESLRSVEEELQNFLLTVPNVPNETTPIGKSEEDNVVVRTWGEVPTLSFEPKPHWEIGEGLGILDFERGAKLAGAR
FTLYRGAGARLERALINYMLDLHTDEHKYIEMLPPFMVNRECMTGTGQLPKFEEDLFHMEGVDFFLIPTAEVPVTNIHRG
EILKGSDLPISYVAYTPCFRKEAGSYGKDTRGLIRQHQFNKVELVKFTSPEDSYQQLQKLLGHAEEVLRRLQIPYRVVEL
CTGDIGFSAAKTFDIEVWLPGQNCYREISSCSCFEDFQARRAGIRFRPEEKAKPEFVHTLNGSGLAVGRTLVAVLENYQQ
ADGSVLIPEVLRPYMGGAERIS

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=355, Percent_Identity=35.7746478873239, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI8923421, Length=427, Percent_Identity=31.615925058548, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI225579074, Length=338, Percent_Identity=34.6153846153846, Blast_Score=188, Evalue=8e-48,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=49.1841491841492, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17539260, Length=332, Percent_Identity=34.9397590361446, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=369, Percent_Identity=29.2682926829268, Blast_Score=139, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=432, Percent_Identity=34.9537037037037, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6321799, Length=380, Percent_Identity=31.5789473684211, Blast_Score=196, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24581334, Length=345, Percent_Identity=36.231884057971, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI17737985, Length=361, Percent_Identity=29.6398891966759, Blast_Score=149, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_GEOBB (B5E8F6)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002136935.1
- ProteinModelPortal:   B5E8F6
- SMR:   B5E8F6
- GeneID:   6782926
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0108
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47998; Mature: 47998

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 283-283 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDARYIRENLETVEARLKTRGEGVDIALFKELDGRRRELLQQSETLKALRNKVTEEIAR
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LQDKSQAAERKTEMREVSQQIKGIDESLRSVEEELQNFLLTVPNVPNETTPIGKSEEDNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCE
VVRTWGEVPTLSFEPKPHWEIGEGLGILDFERGAKLAGARFTLYRGAGARLERALINYML
EEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
DLHTDEHKYIEMLPPFMVNRECMTGTGQLPKFEEDLFHMEGVDFFLIPTAEVPVTNIHRG
HCCCCCHHHHHHCCCHHHCCHHCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCC
EILKGSDLPISYVAYTPCFRKEAGSYGKDTRGLIRQHQFNKVELVKFTSPEDSYQQLQKL
CEECCCCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
LGHAEEVLRRLQIPYRVVELCTGDIGFSAAKTFDIEVWLPGQNCYREISSCSCFEDFQAR
HHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEEEEECCHHHHHHHHCCHHHHHHHHH
RAGIRFRPEEKAKPEFVHTLNGSGLAVGRTLVAVLENYQQADGSVLIPEVLRPYMGGAER
HCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHCCCHHC
IS
CC
>Mature Secondary Structure
MLDARYIRENLETVEARLKTRGEGVDIALFKELDGRRRELLQQSETLKALRNKVTEEIAR
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LQDKSQAAERKTEMREVSQQIKGIDESLRSVEEELQNFLLTVPNVPNETTPIGKSEEDNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCE
VVRTWGEVPTLSFEPKPHWEIGEGLGILDFERGAKLAGARFTLYRGAGARLERALINYML
EEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
DLHTDEHKYIEMLPPFMVNRECMTGTGQLPKFEEDLFHMEGVDFFLIPTAEVPVTNIHRG
HCCCCCHHHHHHCCCHHHCCHHCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCC
EILKGSDLPISYVAYTPCFRKEAGSYGKDTRGLIRQHQFNKVELVKFTSPEDSYQQLQKL
CEECCCCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
LGHAEEVLRRLQIPYRVVELCTGDIGFSAAKTFDIEVWLPGQNCYREISSCSCFEDFQAR
HHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEEEEECCHHHHHHHHCCHHHHHHHHH
RAGIRFRPEEKAKPEFVHTLNGSGLAVGRTLVAVLENYQQADGSVLIPEVLRPYMGGAER
HCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHCCCHHC
IS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA