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The map label for this gene is fkpA [H]

Identifier: 197116505

GI number: 197116505

Start: 127379

End: 127813

Strand: Direct

Name: fkpA [H]

Synonym: Gbem_0105

Alternate gene names: 197116505

Gene position: 127379-127813 (Clockwise)

Preceding gene: 197116504

Following gene: 197116506

Centisome position: 2.76

GC content: 50.8

Gene sequence:

>435_bases
ATGAAAAGGTTTGGACTTATTGTCGTCATGATGGCTATTGCCGCTCCGGCCTTTGCTGCAGCAGCTAATGATGTCATCGC
TAATGCAGCTAGAGAAAACGGGGCTATACAGACGGCATCAGGAATGGTGTACAAGTCCATAAAGGACGGAAGCGGTCCTT
CGCCTAAGGCATCAAGCGTGGTGGGGGTCGATTATCGGGGCACCCTCCCAAATGGCCGAGAGTTCGATAGTTCCTATAAC
AGCAAGATGGTCACAAAGTTCCCGTTGTCATCGGTTATTCCATGTTGGACTGAAGGTCTACAAATGATGAAGGTCGGAGG
TAAAGCCAAGCTCGTCTGTCCTCCTGAGCTCGCCTATGGAAGTCGCGGTGCGGGACAAGCCATACCGCCGAATGCCACTC
TCATATTTGAGGTTGAACTGCTCAGCATAGAATAG

Upstream 100 bases:

>100_bases
GAGCCGGCTGCGGTACCGCAAAGCAGAGGTCGTAGGCTCATAGACAAAGCAGAGGTAGCCCGTTGAGGTATCACACACCC
GGTTAAAGACAGGAGTAGAC

Downstream 100 bases:

>100_bases
GCATGGGGCACCCTCCCCATCTCCTACCCGTGGCGCAATGACTCCAACAAAAGCTTCTCTTGACCGCCGCTCCCAAAGGA
GCGGCGGTTTTCTGTTTTTT

Product: FKBP-type peptidylprolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MKRFGLIVVMMAIAAPAFAAAANDVIANAARENGAIQTASGMVYKSIKDGSGPSPKASSVVGVDYRGTLPNGREFDSSYN
SKMVTKFPLSSVIPCWTEGLQMMKVGGKAKLVCPPELAYGSRGAGQAIPPNATLIFEVELLSIE

Sequences:

>Translated_144_residues
MKRFGLIVVMMAIAAPAFAAAANDVIANAARENGAIQTASGMVYKSIKDGSGPSPKASSVVGVDYRGTLPNGREFDSSYN
SKMVTKFPLSSVIPCWTEGLQMMKVGGKAKLVCPPELAYGSRGAGQAIPPNATLIFEVELLSIE
>Mature_144_residues
MKRFGLIVVMMAIAAPAFAAAANDVIANAARENGAIQTASGMVYKSIKDGSGPSPKASSVVGVDYRGTLPNGREFDSSYN
SKMVTKFPLSSVIPCWTEGLQMMKVGGKAKLVCPPELAYGSRGAGQAIPPNATLIFEVELLSIE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=43.9252336448598, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=42.9906542056075, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=42.9906542056075, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI206725530, Length=91, Percent_Identity=48.3516483516484, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI17149844, Length=91, Percent_Identity=48.3516483516484, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI17149842, Length=91, Percent_Identity=48.3516483516484, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI224809329, Length=104, Percent_Identity=41.3461538461538, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI224809327, Length=104, Percent_Identity=41.3461538461538, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI4758384, Length=104, Percent_Identity=41.3461538461538, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI224809331, Length=93, Percent_Identity=44.0860215053763, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI4503729, Length=106, Percent_Identity=44.3396226415094, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI4503727, Length=100, Percent_Identity=44, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1789745, Length=115, Percent_Identity=51.304347826087, Blast_Score=110, Evalue=4e-26,
Organism=Escherichia coli, GI87082390, Length=127, Percent_Identity=44.8818897637795, Blast_Score=107, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71993519, Length=91, Percent_Identity=43.956043956044, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17540882, Length=141, Percent_Identity=34.7517730496454, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324194, Length=91, Percent_Identity=43.956043956044, Blast_Score=75, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320727, Length=87, Percent_Identity=43.6781609195402, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323482, Length=105, Percent_Identity=37.1428571428571, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24655568, Length=92, Percent_Identity=48.9130434782609, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281363946, Length=91, Percent_Identity=46.1538461538462, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17352457, Length=91, Percent_Identity=46.1538461538462, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=40.3846153846154, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24647110, Length=98, Percent_Identity=45.9183673469388, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356629, Length=92, Percent_Identity=47.8260869565217, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15070; Mature: 15070

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFGLIVVMMAIAAPAFAAAANDVIANAARENGAIQTASGMVYKSIKDGSGPSPKASSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCCCCCCCCE
VGVDYRGTLPNGREFDSSYNSKMVTKFPLSSVIPCWTEGLQMMKVGGKAKLVCPPELAYG
EECCCCCCCCCCCCCCCCCCCEEEEECCCHHCCHHHHHHHHEECCCCCEEEEECCCCCCC
SRGAGQAIPPNATLIFEVELLSIE
CCCCCCCCCCCCEEEEEEEEEEEC
>Mature Secondary Structure
MKRFGLIVVMMAIAAPAFAAAANDVIANAARENGAIQTASGMVYKSIKDGSGPSPKASSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCCCCCCCCE
VGVDYRGTLPNGREFDSSYNSKMVTKFPLSSVIPCWTEGLQMMKVGGKAKLVCPPELAYG
EECCCCCCCCCCCCCCCCCCCEEEEECCCHHCCHHHHHHHHEECCCCCEEEEECCCCCCC
SRGAGQAIPPNATLIFEVELLSIE
CCCCCCCCCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]