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The map label for this gene is guaC [H]

Identifier: 197116496

GI number: 197116496

Start: 120264

End: 121301

Strand: Reverse

Name: guaC [H]

Synonym: Gbem_0096

Alternate gene names: 197116496

Gene position: 121301-120264 (Counterclockwise)

Preceding gene: 197116498

Following gene: 197116491

Centisome position: 2.63

GC content: 62.91

Gene sequence:

>1038_bases
ATGTTCCTGGAAAGCGACATAAAGCTCGGTTTCAGCGATGTCCTCATCAGACCCAAGCGGTCCAATCTCAAGAGCCGTTC
GCAGGTGGACCTGCAGCGGCACTTCAAGTTCCTGCATAGCCGGCACGAATGGACCGGGGTGCCGGTCATCGCAGCGAACA
TGGATACCACCGGCACCTTCGAGGTCGCCGACCGGCTGGCGTCCCACGAGATGCTCACCGCCATCCACAAGCACTACTCC
ATTGCCGAGTGGGACGCCTACCTCGCCAGCCGCAACGACGACATCTACCCCCGCATCATGGTAAGCACCGGAACCTCCGA
GGCCGATTTCGAGAAGGTCTCCGCCATCCTGGGAAAACACCCCAAGCTCGAATTCATCTGCATCGACGTCGCCAACGGCT
ATGCCGAGAGCTTTGTTGAGTTCGTGGCGAAGATGAGGGAGGCGTACGCGGAGAAGACCATTGTGGCGGGGAACGTGGTC
ACCGGCGAGATGGTAGAGGAACTGCTCTTGTCCGGCGCCGACATCGTCAAGGTCGGCATAGGTCCGGGCTCGGTCTGCAC
CACCCGGGTCAAGGCGGGAGTCGGTTACCCGCAACTCTCCGCGGTGATCGAATGCGCCGACGCGGCGCACGGTCTAGGGG
GGAGGATCATCTCCGACGGCGGCTGCACCTGCCCCGGCGACGTCGCCAAGGCGTTCGGAGGGGGAGCCGACTTCGTCATG
CTAGGGGGGATGTTCGCCGGGCACGACGAATGCGGGGGGCAGCTCCTTGAACGCGGGGGGAGGCAGTTCAAGCTTTTCTA
CGGCATGAGCTCCACCACAGCCATGGACAAGCACGCAGGCGGCGTCGCCTCCTACCGCGCTTCGGAAGGAAAGACCGTGG
AGGTCCCCTACCGCGGCCCCATCGACGAAACGGTGCGCGACGTCCTGGGGGGGGTACGTTCCGCCTGCACCTACGTAGGC
GCCTCAGCCCTTAAGGAGCTCACCAAGCGGACCACCTTCATCAGGGTTCAGGAACAGGAGAACAGGATCTTCGGGTAA

Upstream 100 bases:

>100_bases
TTGCAATCATCAATGCCGTTACCGATTGCACCCGATCCAGTGTTTGGGCAAATGATACCGGCATTGTGAGACACACCCGA
CGGTTCAAAGGAGAAATAAG

Downstream 100 bases:

>100_bases
AGAACAAAGAAACCCCGCTTCCGGAAAAGCGGGGTTGGCGGTTCAAATAAAAAAGGGCCTCCCATTCGGGAGGCCCTTTT
TAGTTGTTGCTTCAGCAGCC

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MFLESDIKLGFSDVLIRPKRSNLKSRSQVDLQRHFKFLHSRHEWTGVPVIAANMDTTGTFEVADRLASHEMLTAIHKHYS
IAEWDAYLASRNDDIYPRIMVSTGTSEADFEKVSAILGKHPKLEFICIDVANGYAESFVEFVAKMREAYAEKTIVAGNVV
TGEMVEELLLSGADIVKVGIGPGSVCTTRVKAGVGYPQLSAVIECADAAHGLGGRIISDGGCTCPGDVAKAFGGGADFVM
LGGMFAGHDECGGQLLERGGRQFKLFYGMSSTTAMDKHAGGVASYRASEGKTVEVPYRGPIDETVRDVLGGVRSACTYVG
ASALKELTKRTTFIRVQEQENRIFG

Sequences:

>Translated_345_residues
MFLESDIKLGFSDVLIRPKRSNLKSRSQVDLQRHFKFLHSRHEWTGVPVIAANMDTTGTFEVADRLASHEMLTAIHKHYS
IAEWDAYLASRNDDIYPRIMVSTGTSEADFEKVSAILGKHPKLEFICIDVANGYAESFVEFVAKMREAYAEKTIVAGNVV
TGEMVEELLLSGADIVKVGIGPGSVCTTRVKAGVGYPQLSAVIECADAAHGLGGRIISDGGCTCPGDVAKAFGGGADFVM
LGGMFAGHDECGGQLLERGGRQFKLFYGMSSTTAMDKHAGGVASYRASEGKTVEVPYRGPIDETVRDVLGGVRSACTYVG
ASALKELTKRTTFIRVQEQENRIFG
>Mature_345_residues
MFLESDIKLGFSDVLIRPKRSNLKSRSQVDLQRHFKFLHSRHEWTGVPVIAANMDTTGTFEVADRLASHEMLTAIHKHYS
IAEWDAYLASRNDDIYPRIMVSTGTSEADFEKVSAILGKHPKLEFICIDVANGYAESFVEFVAKMREAYAEKTIVAGNVV
TGEMVEELLLSGADIVKVGIGPGSVCTTRVKAGVGYPQLSAVIECADAAHGLGGRIISDGGCTCPGDVAKAFGGGADFVM
LGGMFAGHDECGGQLLERGGRQFKLFYGMSSTTAMDKHAGGVASYRASEGKTVEVPYRGPIDETVRDVLGGVRSACTYVG
ASALKELTKRTTFIRVQEQENRIFG

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI156104880, Length=342, Percent_Identity=65.4970760233918, Blast_Score=491, Evalue=1e-139,
Organism=Homo sapiens, GI50541956, Length=342, Percent_Identity=65.7894736842105, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI50541954, Length=342, Percent_Identity=65.7894736842105, Blast_Score=484, Evalue=1e-137,
Organism=Homo sapiens, GI50541952, Length=342, Percent_Identity=65.7894736842105, Blast_Score=484, Evalue=1e-137,
Organism=Homo sapiens, GI50541948, Length=342, Percent_Identity=65.7894736842105, Blast_Score=484, Evalue=1e-137,
Organism=Homo sapiens, GI66933016, Length=250, Percent_Identity=28.4, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI217035148, Length=251, Percent_Identity=30.2788844621514, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI217035152, Length=251, Percent_Identity=30.2788844621514, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI217035146, Length=251, Percent_Identity=30.2788844621514, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI217035150, Length=251, Percent_Identity=30.2788844621514, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI34328930, Length=251, Percent_Identity=30.2788844621514, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI156616279, Length=251, Percent_Identity=30.2788844621514, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI34328928, Length=251, Percent_Identity=30.2788844621514, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786293, Length=344, Percent_Identity=72.9651162790698, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI1788855, Length=233, Percent_Identity=35.6223175965665, Blast_Score=129, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17560440, Length=342, Percent_Identity=64.9122807017544, Blast_Score=483, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI71994385, Length=217, Percent_Identity=29.4930875576037, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994389, Length=164, Percent_Identity=34.1463414634146, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323585, Length=235, Percent_Identity=29.3617021276596, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322012, Length=237, Percent_Identity=29.1139240506329, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323464, Length=235, Percent_Identity=28.936170212766, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319352, Length=120, Percent_Identity=31.6666666666667, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24641071, Length=250, Percent_Identity=27.6, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24641073, Length=250, Percent_Identity=27.6, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28571163, Length=250, Percent_Identity=27.6, Blast_Score=101, Evalue=7e-22,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 37277; Mature: 37277

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLESDIKLGFSDVLIRPKRSNLKSRSQVDLQRHFKFLHSRHEWTGVPVIAANMDTTGTF
CCCCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHH
EVADRLASHEMLTAIHKHYSIAEWDAYLASRNDDIYPRIMVSTGTSEADFEKVSAILGKH
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCC
PKLEFICIDVANGYAESFVEFVAKMREAYAEKTIVAGNVVTGEMVEELLLSGADIVKVGI
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHCCCCEEEEEC
GPGSVCTTRVKAGVGYPQLSAVIECADAAHGLGGRIISDGGCTCPGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCEEE
LGGMFAGHDECGGQLLERGGRQFKLFYGMSSTTAMDKHAGGVASYRASEGKTVEVPYRGP
ECCEECCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCCHHEECCCCCEEEECCCCC
IDETVRDVLGGVRSACTYVGASALKELTKRTTFIRVQEQENRIFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCC
>Mature Secondary Structure
MFLESDIKLGFSDVLIRPKRSNLKSRSQVDLQRHFKFLHSRHEWTGVPVIAANMDTTGTF
CCCCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHH
EVADRLASHEMLTAIHKHYSIAEWDAYLASRNDDIYPRIMVSTGTSEADFEKVSAILGKH
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCC
PKLEFICIDVANGYAESFVEFVAKMREAYAEKTIVAGNVVTGEMVEELLLSGADIVKVGI
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHCCCCEEEEEC
GPGSVCTTRVKAGVGYPQLSAVIECADAAHGLGGRIISDGGCTCPGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCEEE
LGGMFAGHDECGGQLLERGGRQFKLFYGMSSTTAMDKHAGGVASYRASEGKTVEVPYRGP
ECCEECCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCCHHEECCCCCEEEECCCCC
IDETVRDVLGGVRSACTYVGASALKELTKRTTFIRVQEQENRIFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA