Click here to switch to the map view.

The map label for this gene is tdh [H]

Identifier: 197116450

GI number: 197116450

Start: 58851

End: 59894

Strand: Reverse

Name: tdh [H]

Synonym: Gbem_0050

Alternate gene names: 197116450

Gene position: 59894-58851 (Counterclockwise)

Preceding gene: 197116454

Following gene: 197116449

Centisome position: 1.3

GC content: 62.84

Gene sequence:

>1044_bases
ATGCAGAAGACCATGCAGGCGCTGGTTAAAAAATACCCTAAGCCCGGGCTGTGGCTCGACGAAGTCCCGGTCCCGGAGGT
AGGGATCAACGACGTGCTGATCAAGGTCCACAAGACCGCGGTCTGCGGCACCGATCTGCACATCTGGGACTGGAACGACT
GGGCCCGTAAAACCATTCCGGTCCCCATGGTGGTAGGCCACGAATTCGTGGGGCGGGTGGCCGCCATGGGCAGCAACGTC
GCCGACCTGAACATCGGGGACATCGTCTCCGGCGAGGGGCACATCGTCTGCGGCAGATGCCGCAACTGCCTGGCCGGCAG
GCGCCACCTCTGCAAGGACACCAACGGGGTAGGGGTCAACCGCGCTGGCGCTTTCGCCGAGTACATCTGCATCCCGGTCA
CCAACGTCTGGCACGCCGACCCCACCATACCCATGGAAATCCTCGGGATCTTCGATCCCTTCGGCAACGCGACCCACACC
ACCCTGGCCTTTCCCATCCTGGGGGAGGACGTGCTCATCACCGGCGCCGGCCCCATCGGCATCATGGCGACGGCCATTGC
CCGCCATGCCGGGGCGCGCTACATCGTGGTAACGGACCTGAACCAGTACCGTCTCGACTTGGCGAAGAAGATGGGGGCGA
CGGTGGCCCTCAACGTCAGGGAAGGGACCTTGGCACAGGTGCGGCAGCAGTTGGGGATGAAGGAGGGATTCGACGTGGGG
CTGGAGATGTCCGGAAACGGCGACGCCTTCAAGGAGATGCTGGCCAACATGTGCCACGGCGGCAAGATCGCCATGCTGGG
GCTTCCCTCGGGGGATCTCGCCGTCGATTGGAACCAGGTGATCTTCAACATGCTGACCATCAAAGGGATCTACGGCCGGG
AGATGTACGAGACCTGGTACCTGATGCAGTCCCTGATCAAGATCGGGCTGGATCTCACGCCGGTCATCACGCACCGGATG
CACTACACGGAGTTCGAAGAGGCGTTCCGGGTGATGAGCACCGGCAACGCCGGGAAGGTGATGCTCAACTGGGTCGAGGA
GTGA

Upstream 100 bases:

>100_bases
CGCACCCATCCTTGCCTTGCGGCGTTTCCTTCCTTTACATGACCCGTTCCCCTGATAACATTAACGTAAAGTTACGTCAC
CCACATTAGAGGAGCAGGAC

Downstream 100 bases:

>100_bases
AAATCACGCCAGGAGGCAAAGGATGTCCGAGAAGTTCGAGTGGATCAATGAGGAAATGGAGGCCCTGAAACAGCAGGGGC
TGAAGACGCATATCCGCACC

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MQKTMQALVKKYPKPGLWLDEVPVPEVGINDVLIKVHKTAVCGTDLHIWDWNDWARKTIPVPMVVGHEFVGRVAAMGSNV
ADLNIGDIVSGEGHIVCGRCRNCLAGRRHLCKDTNGVGVNRAGAFAEYICIPVTNVWHADPTIPMEILGIFDPFGNATHT
TLAFPILGEDVLITGAGPIGIMATAIARHAGARYIVVTDLNQYRLDLAKKMGATVALNVREGTLAQVRQQLGMKEGFDVG
LEMSGNGDAFKEMLANMCHGGKIAMLGLPSGDLAVDWNQVIFNMLTIKGIYGREMYETWYLMQSLIKIGLDLTPVITHRM
HYTEFEEAFRVMSTGNAGKVMLNWVEE

Sequences:

>Translated_347_residues
MQKTMQALVKKYPKPGLWLDEVPVPEVGINDVLIKVHKTAVCGTDLHIWDWNDWARKTIPVPMVVGHEFVGRVAAMGSNV
ADLNIGDIVSGEGHIVCGRCRNCLAGRRHLCKDTNGVGVNRAGAFAEYICIPVTNVWHADPTIPMEILGIFDPFGNATHT
TLAFPILGEDVLITGAGPIGIMATAIARHAGARYIVVTDLNQYRLDLAKKMGATVALNVREGTLAQVRQQLGMKEGFDVG
LEMSGNGDAFKEMLANMCHGGKIAMLGLPSGDLAVDWNQVIFNMLTIKGIYGREMYETWYLMQSLIKIGLDLTPVITHRM
HYTEFEEAFRVMSTGNAGKVMLNWVEE
>Mature_347_residues
MQKTMQALVKKYPKPGLWLDEVPVPEVGINDVLIKVHKTAVCGTDLHIWDWNDWARKTIPVPMVVGHEFVGRVAAMGSNV
ADLNIGDIVSGEGHIVCGRCRNCLAGRRHLCKDTNGVGVNRAGAFAEYICIPVTNVWHADPTIPMEILGIFDPFGNATHT
TLAFPILGEDVLITGAGPIGIMATAIARHAGARYIVVTDLNQYRLDLAKKMGATVALNVREGTLAQVRQQLGMKEGFDVG
LEMSGNGDAFKEMLANMCHGGKIAMLGLPSGDLAVDWNQVIFNMLTIKGIYGREMYETWYLMQSLIKIGLDLTPVITHRM
HYTEFEEAFRVMSTGNAGKVMLNWVEE

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=337, Percent_Identity=28.486646884273, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=26.0869565217391, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4501939, Length=362, Percent_Identity=26.2430939226519, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI71565154, Length=358, Percent_Identity=25.1396648044693, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI71743840, Length=364, Percent_Identity=24.4505494505494, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI262073058, Length=364, Percent_Identity=24.4505494505494, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI71565152, Length=382, Percent_Identity=24.0837696335079, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI4501929, Length=382, Percent_Identity=23.5602094240838, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI34577061, Length=378, Percent_Identity=23.8095238095238, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4501933, Length=378, Percent_Identity=23.2804232804233, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=59.1176470588235, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI226510992, Length=333, Percent_Identity=30.6306306306306, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788073, Length=317, Percent_Identity=30.2839116719243, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788075, Length=349, Percent_Identity=27.2206303724928, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1788407, Length=336, Percent_Identity=29.1666666666667, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787863, Length=291, Percent_Identity=27.4914089347079, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1790718, Length=320, Percent_Identity=25, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082125, Length=345, Percent_Identity=29.2753623188406, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786825, Length=384, Percent_Identity=27.8645833333333, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786552, Length=375, Percent_Identity=25.6, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081918, Length=308, Percent_Identity=25.6493506493506, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=337, Percent_Identity=29.3768545994065, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17562878, Length=217, Percent_Identity=29.4930875576037, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562584, Length=134, Percent_Identity=34.3283582089552, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71988145, Length=204, Percent_Identity=28.921568627451, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=134, Percent_Identity=32.089552238806, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=342, Percent_Identity=23.9766081871345, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323099, Length=340, Percent_Identity=27.6470588235294, Blast_Score=108, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=386, Percent_Identity=26.6839378238342, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319258, Length=272, Percent_Identity=25.3676470588235, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=325, Percent_Identity=24, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=325, Percent_Identity=23.6923076923077, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=248, Percent_Identity=26.6129032258064, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=325, Percent_Identity=26.4615384615385, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=339, Percent_Identity=25.9587020648968, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=342, Percent_Identity=26.6081871345029, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=327, Percent_Identity=26.2996941896024, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17737897, Length=337, Percent_Identity=28.1899109792285, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17137530, Length=344, Percent_Identity=26.453488372093, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17737895, Length=376, Percent_Identity=24.7340425531915, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 38092; Mature: 38092

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKTMQALVKKYPKPGLWLDEVPVPEVGINDVLIKVHKTAVCGTDLHIWDWNDWARKTIP
CCHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCHHHHCCC
VPMVVGHEFVGRVAAMGSNVADLNIGDIVSGEGHIVCGRCRNCLAGRRHLCKDTNGVGVN
CCHHHCHHHHHHHHHCCCCCCCCCCCCEECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCC
RAGAFAEYICIPVTNVWHADPTIPMEILGIFDPFGNATHTTLAFPILGEDVLITGAGPIG
CCCHHHEEEEEEECCCCCCCCCCCHHHHEEECCCCCCCCEEEEEEECCCCEEEECCCCHH
IMATAIARHAGARYIVVTDLNQYRLDLAKKMGATVALNVREGTLAQVRQQLGMKEGFDVG
HHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCCC
LEMSGNGDAFKEMLANMCHGGKIAMLGLPSGDLAVDWNQVIFNMLTIKGIYGREMYETWY
EEECCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEHHHHHHHHHHHCCHHHHHHHHHHH
LMQSLIKIGLDLTPVITHRMHYTEFEEAFRVMSTGNAGKVMLNWVEE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
>Mature Secondary Structure
MQKTMQALVKKYPKPGLWLDEVPVPEVGINDVLIKVHKTAVCGTDLHIWDWNDWARKTIP
CCHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCHHHHCCC
VPMVVGHEFVGRVAAMGSNVADLNIGDIVSGEGHIVCGRCRNCLAGRRHLCKDTNGVGVN
CCHHHCHHHHHHHHHCCCCCCCCCCCCEECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCC
RAGAFAEYICIPVTNVWHADPTIPMEILGIFDPFGNATHTTLAFPILGEDVLITGAGPIG
CCCHHHEEEEEEECCCCCCCCCCCHHHHEEECCCCCCCCEEEEEEECCCCEEEECCCCHH
IMATAIARHAGARYIVVTDLNQYRLDLAKKMGATVALNVREGTLAQVRQQLGMKEGFDVG
HHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCCC
LEMSGNGDAFKEMLANMCHGGKIAMLGLPSGDLAVDWNQVIFNMLTIKGIYGREMYETWY
EEECCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEHHHHHHHHHHHCCHHHHHHHHHHH
LMQSLIKIGLDLTPVITHRMHYTEFEEAFRVMSTGNAGKVMLNWVEE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA