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The map label for this gene is kbl [C]

Identifier: 197116449

GI number: 197116449

Start: 57638

End: 58828

Strand: Reverse

Name: kbl [C]

Synonym: Gbem_0049

Alternate gene names: 197116449

Gene position: 58828-57638 (Counterclockwise)

Preceding gene: 197116450

Following gene: 197116441

Centisome position: 1.27

GC content: 64.82

Gene sequence:

>1191_bases
ATGTCCGAGAAGTTCGAGTGGATCAATGAGGAAATGGAGGCCCTGAAACAGCAGGGGCTGAAGACGCATATCCGCACCAT
CGGTTCGGCCTGCGGCCCCTGGATGGTGGTCGACGGCAAGAAGGTGCTCAATTTCTGCACCAACAACTACCTGGGGCTCG
CCAACCACCCGCGGCTCAAGGAGGCGGCCCGGGCCGCGGTACAGATCTGGGGAGTGGGGCCGGCGGCGGTCAGAAGCATC
GCCGGGACCCTGGAGTTGCACCGGTTGCTGGAGGAGCGGCTGGCCGCCTTCAAGGGGGTCGAGGACGCCCTCTACGTCCA
GTCCGGGTTTTGCGCCAACCAGGCGGCCATCCCCTCCATGGTGGGGAAGGGGGACGTCATCTTCACCGACCGGCTGAACC
ACGCCAGCATCATCGACGGCTGCAGGCTTTCCTCCGCCCGGGTCGTGGTGTACGAGCACTGCGACGTAGAGGATTGCGAA
CGTGCCATCAAGGAGAACCTGGGGGAGTACCGGCGGGCCCTTTTGATCACCGACGGGGTCTTTTCCATGGACGGCGACAT
AGCCCCCTTGGACCGGCTCTTCGAGCTCTGCGAGCGCCACGGCATCATCACCATGGTGGACGACGCCCACGGCGAGGGGG
TCCTTGGGCGCGGCGGGCGCGGCATCGTGGACCACTTCCAGCTGAACGGGAAGTTCGACCTGGAGATAGGGACCCTCTCC
AAGGCCTTCGGCGTCATGGGCGGGGTCATTGCCGGGAGCAGCACGGTCATCGAGTGGATCCGGCAGAAGGCGCGCCCTTT
CCTCTTTTCGAGCGCGGTAACCGCCGCCGACACGGCGGCGTGCCTCGCTGCGGTCGACCTGTTGGAGGAGGGGACCGAGC
TGGTAGAGCGGCTCTGGGAAAACACGCGCTACTTCAAGGAGGGGATGCGGGGAGCTGGGTTCGACATCGGCGCCAGCGTC
ACTCCAATCACGCCGGTGATGATCGGGGACGCGACGCTCGCCCAAAATTTTTCGCGCATGCTCTTCGATTCCGACCCCGG
AATCTTCGCCATGCCGATCGGCTACCCGACCGTCCCGCAAGGGAAGGCGCGCATCAGGGTCATGATCAGCGCCTCCCACT
CCCGTGAAGATCTCGACCTTGGGCTGGACATCTTCACCCGGATCGGGAAGTCCGTGGGGGTCATCGGCTGA

Upstream 100 bases:

>100_bases
ACGGAGTTCGAAGAGGCGTTCCGGGTGATGAGCACCGGCAACGCCGGGAAGGTGATGCTCAACTGGGTCGAGGAGTGAAA
ATCACGCCAGGAGGCAAAGG

Downstream 100 bases:

>100_bases
CCTCAGCGGGTGTCTACCGAGCCGAACAGAAAGCCCCCTCCTCCCGGAAACCGATGGGAAAAAGAGGGGGCTTTTTTAGT
CCCTGGTTCCCAATCTCCAG

Product: 2-amino-3-ketobutyrate--coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSEKFEWINEEMEALKQQGLKTHIRTIGSACGPWMVVDGKKVLNFCTNNYLGLANHPRLKEAARAAVQIWGVGPAAVRSI
AGTLELHRLLEERLAAFKGVEDALYVQSGFCANQAAIPSMVGKGDVIFTDRLNHASIIDGCRLSSARVVVYEHCDVEDCE
RAIKENLGEYRRALLITDGVFSMDGDIAPLDRLFELCERHGIITMVDDAHGEGVLGRGGRGIVDHFQLNGKFDLEIGTLS
KAFGVMGGVIAGSSTVIEWIRQKARPFLFSSAVTAADTAACLAAVDLLEEGTELVERLWENTRYFKEGMRGAGFDIGASV
TPITPVMIGDATLAQNFSRMLFDSDPGIFAMPIGYPTVPQGKARIRVMISASHSREDLDLGLDIFTRIGKSVGVIG

Sequences:

>Translated_396_residues
MSEKFEWINEEMEALKQQGLKTHIRTIGSACGPWMVVDGKKVLNFCTNNYLGLANHPRLKEAARAAVQIWGVGPAAVRSI
AGTLELHRLLEERLAAFKGVEDALYVQSGFCANQAAIPSMVGKGDVIFTDRLNHASIIDGCRLSSARVVVYEHCDVEDCE
RAIKENLGEYRRALLITDGVFSMDGDIAPLDRLFELCERHGIITMVDDAHGEGVLGRGGRGIVDHFQLNGKFDLEIGTLS
KAFGVMGGVIAGSSTVIEWIRQKARPFLFSSAVTAADTAACLAAVDLLEEGTELVERLWENTRYFKEGMRGAGFDIGASV
TPITPVMIGDATLAQNFSRMLFDSDPGIFAMPIGYPTVPQGKARIRVMISASHSREDLDLGLDIFTRIGKSVGVIG
>Mature_395_residues
SEKFEWINEEMEALKQQGLKTHIRTIGSACGPWMVVDGKKVLNFCTNNYLGLANHPRLKEAARAAVQIWGVGPAAVRSIA
GTLELHRLLEERLAAFKGVEDALYVQSGFCANQAAIPSMVGKGDVIFTDRLNHASIIDGCRLSSARVVVYEHCDVEDCER
AIKENLGEYRRALLITDGVFSMDGDIAPLDRLFELCERHGIITMVDDAHGEGVLGRGGRGIVDHFQLNGKFDLEIGTLSK
AFGVMGGVIAGSSTVIEWIRQKARPFLFSSAVTAADTAACLAAVDLLEEGTELVERLWENTRYFKEGMRGAGFDIGASVT
PITPVMIGDATLAQNFSRMLFDSDPGIFAMPIGYPTVPQGKARIRVMISASHSREDLDLGLDIFTRIGKSVGVIG

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=389, Percent_Identity=40.3598971722365, Blast_Score=272, Evalue=4e-73,
Organism=Homo sapiens, GI284448556, Length=415, Percent_Identity=37.8313253012048, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI4758668, Length=367, Percent_Identity=32.1525885558583, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI119220554, Length=372, Percent_Identity=31.1827956989247, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI83977440, Length=347, Percent_Identity=31.700288184438, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI83977442, Length=347, Percent_Identity=31.700288184438, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI83977444, Length=347, Percent_Identity=31.700288184438, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI4502025, Length=363, Percent_Identity=31.129476584022, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI40316939, Length=363, Percent_Identity=31.129476584022, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI5454084, Length=309, Percent_Identity=30.42071197411, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1790046, Length=396, Percent_Identity=43.6868686868687, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI1786993, Length=361, Percent_Identity=34.6260387811634, Blast_Score=208, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI71994529, Length=393, Percent_Identity=38.676844783715, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI32566772, Length=372, Percent_Identity=34.1397849462366, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17560914, Length=365, Percent_Identity=29.3150684931507, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17560912, Length=365, Percent_Identity=29.3150684931507, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71982625, Length=305, Percent_Identity=27.2131147540984, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI71982617, Length=305, Percent_Identity=27.2131147540984, Blast_Score=137, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6320267, Length=369, Percent_Identity=29.5392953929539, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6320438, Length=380, Percent_Identity=28.1578947368421, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323954, Length=267, Percent_Identity=27.7153558052434, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24662918, Length=393, Percent_Identity=40.7124681933842, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI17137420, Length=344, Percent_Identity=32.2674418604651, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI17136286, Length=372, Percent_Identity=28.7634408602151, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24653280, Length=333, Percent_Identity=29.4294294294294, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24653276, Length=333, Percent_Identity=29.4294294294294, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24653278, Length=333, Percent_Identity=29.4294294294294, Blast_Score=157, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43050; Mature: 42919

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKFEWINEEMEALKQQGLKTHIRTIGSACGPWMVVDGKKVLNFCTNNYLGLANHPRLK
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCCCCCCHHH
EAARAAVQIWGVGPAAVRSIAGTLELHRLLEERLAAFKGVEDALYVQSGFCANQAAIPSM
HHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHH
VGKGDVIFTDRLNHASIIDGCRLSSARVVVYEHCDVEDCERAIKENLGEYRRALLITDGV
CCCCCEEEECCCCCCHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEEECCC
FSMDGDIAPLDRLFELCERHGIITMVDDAHGEGVLGRGGRGIVDHFQLNGKFDLEIGTLS
CCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCEECCCCCCCCCEEEECCEEEEEEHHHH
KAFGVMGGVIAGSSTVIEWIRQKARPFLFSSAVTAADTAACLAAVDLLEEGTELVERLWE
HHHHHHHHHHCCCHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTRYFKEGMRGAGFDIGASVTPITPVMIGDATLAQNFSRMLFDSDPGIFAMPIGYPTVPQ
HHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
GKARIRVMISASHSREDLDLGLDIFTRIGKSVGVIG
CCCEEEEEEECCCCCCHHHHHHHHHHHCCHHCCCCC
>Mature Secondary Structure 
SEKFEWINEEMEALKQQGLKTHIRTIGSACGPWMVVDGKKVLNFCTNNYLGLANHPRLK
CCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCCCCCCHHH
EAARAAVQIWGVGPAAVRSIAGTLELHRLLEERLAAFKGVEDALYVQSGFCANQAAIPSM
HHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHH
VGKGDVIFTDRLNHASIIDGCRLSSARVVVYEHCDVEDCERAIKENLGEYRRALLITDGV
CCCCCEEEECCCCCCHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEEECCC
FSMDGDIAPLDRLFELCERHGIITMVDDAHGEGVLGRGGRGIVDHFQLNGKFDLEIGTLS
CCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCEECCCCCCCCCEEEECCEEEEEEHHHH
KAFGVMGGVIAGSSTVIEWIRQKARPFLFSSAVTAADTAACLAAVDLLEEGTELVERLWE
HHHHHHHHHHCCCHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTRYFKEGMRGAGFDIGASVTPITPVMIGDATLAQNFSRMLFDSDPGIFAMPIGYPTVPQ
HHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
GKARIRVMISASHSREDLDLGLDIFTRIGKSVGVIG
CCCEEEEEEECCCCCCHHHHHHHHHHHCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA