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The map label for this gene is phoR [H]

Identifier: 197116412

GI number: 197116412

Start: 17567

End: 19714

Strand: Direct

Name: phoR [H]

Synonym: Gbem_0012

Alternate gene names: 197116412

Gene position: 17567-19714 (Clockwise)

Preceding gene: 308535145

Following gene: 197116413

Centisome position: 0.38

GC content: 62.29

Gene sequence:

>2148_bases
ATGTCCAAAGAGCTGAGGGTCCTTTTGGTCGAGGACTCGGAAGAAGACAGCCTGCTTCTGATCAGGGAGCTGCGCCGCGG
CGGCTACAAACTGATACACATGCGAGTGGAGACTGCGGAGAGCATGCGCCGGGCCCTGCATGACGGGGAGTGGGACGTGG
TGATCTCCGACTACCGCATGCCCTCTTTCGACGCCCTCGGGGCCCTGCAGGTGCTGCACGAGACCGGGCGCGACATCCCA
TTCATCATCGTCTCAGGCAAGATCGGCGAGGACCTAGCCGTCGAGGCCATGAAATCGGGTGCCAGCGACTACCTAATGAA
AGGGAACCTGGCCCGCCTGGTACCGGTTATGGTGCGGGAACTGAGGGAGGCTGAGGAGCGCAGGACGCACCGGCTCACCC
AGGATGCGGTGCGCCGCGGCAAGGCGGAGTGGGAAAGCGTCTTCGACGCGGTCTCGGACCTGATCATCATCACCGACGCC
GACGGCGTCGTGTTGCGCTGCAACGGCCGGGTGAGCGCCTACTTTCCCGGCGGGTACGGCGCCATCATCGGCCGCAGGAT
CGACGAGATATTTTTCGGATCGCAGCAACCCGAGGGAAAGCTGTTCCGCTTCCTGCACAGCGTCCAGAGCGAGGCCGACG
AGGACATCCGCTTCCCCAACCTGAGCGGCTGGTACAACGTCGCCAGCTACCCCATGCGCACCGAGGGGAGCAACCGCCCG
AACCTGGTCTTCATCATCAAGGACATCACCAAAAGGCGCGAGGTCGAGGAGGAGAAACGGACCAGCGACCGCGAACTCCT
CACCCTGTACGCGGTCGCCTTCCGCCTGCAGTACACGAAGGGGGTCGACAAGGTGATGGGGGACCTCCTCTTCCAGCTGC
ACAACATGCTGCAGATGGATTTCTCCTGCATCCACCTTTTCGAGGACGACAAACTCAAGATGCGCGCCTCGCTGGGTGTT
TCCCCCGCGTTCGAGAAGGCGATGAAGACGCTCCCCCGGGAGACCCAGTGGGCGACCCTGGCGCAGGCGGGGCGCCCTTT
TCTGGGAGAGGAGCCAGACGCAAGGTTTCCGGCCAGAGCCAAAAGCGCCGCCATAGAGATGGGGCTGCACTCCTGGTGCA
CAGTGCCGCTCAAGATAGGACAGGAGGTGATGGGGGTGATGACGGTGGGGACCGTCTCCGGGCGCAGCTACAGCGACCGC
GACGTCTTCCTGCTCTGTGCCATTGCAGGTCAGCTCGCGGTCCTCATCGACAACTACGGCCTCTACGACAAGATGAAGGA
GAAGGCGGAGGAACTCTACCGCAGCAAAGAAGAGCTCAAAGAGAACCTGCACAAGGTGAAGCGCGCCAACATCGAGCTGG
GGCGCCTCAACACGGCGAAGAACAACTTCATCGGCATCGCCTCGCACGAGTTGAAGACCCCGATCACCTCGATCATGGGG
GGGGTCGAGTTCCTGCTGAAATATTCCGGCATCCAGATGAGCCCCGAGCAGCACAACATCTTCGTCTCGGTGTACGAAGG
GACCATTCAGCTCAGGAAACTGGTGGAGGACCTCCTCTCCATCTCCCGCATCGAGGCGCAAGGGCCGCTGGCCCAGAAAA
AGCCGGCGAGCCTGATGCGGGTCTGCCGCGAAGTGCACGACCTCTTCGCGCTGCCGCTATCCGAGCGGCACATAAAGGTG
GAGATCACGGGGGACGACGTCCTCGTGCCGGTGGACGAGGCCTTCGCCATGCTCGCGGTGCGCAACCTTTTAGAGAACGC
CATCAAGTTCACCCGCGACGGAGGGTGCGTCCGATTAACCGGACGGGTGCTGAAGCAGGCGCAGCTCAAGGAGATGACGC
AGACGCTGCATACCTTCTATCCCTCCTTCCCCGGTAACGTCGCGGCGACCGAAAAATACTATCTGCTCCAGGTGCGCGAC
AACGGAATCGGCATCCCGCCGGACGAGAGAGTCCGCGTCTTCGAAAAGTTCTACGGCGTCGGGGATATCGACCACCACAG
CTCGGGAGCCACCGCCTTCATGTCCAAGGGCTCGGGGCTCGGACTCTCCATCGTGCGCGGCATCATGGACGCCCATGAAG
GGGCGGTCTGGGTCGAAGAGGCCGAGGGGGGAGGAAGCACCTTCTCGCTCCTTTTCCCCATCGAATAA

Upstream 100 bases:

>100_bases
TATCCATTGTCAGTTGTCCATTGGGGTAAGGGTTTTAGTTGTCAATTGTCAATCGTCAATTGTCAATTGGTTTAAAAGCT
TTTTAAGTTTGGGGTAAAGC

Downstream 100 bases:

>100_bases
ATTATTTCCCAGGATCCAGACGGGAGCCATCGATGCCGCACGCGATCAGGCTGCATGAAATAACCAAGAGCTACGGCGGG
TTCAAGGCGGTGGACCGTTT

Product: response receiver histidine kinase PAS_4/GAF domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 715; Mature: 714

Protein sequence:

>715_residues
MSKELRVLLVEDSEEDSLLLIRELRRGGYKLIHMRVETAESMRRALHDGEWDVVISDYRMPSFDALGALQVLHETGRDIP
FIIVSGKIGEDLAVEAMKSGASDYLMKGNLARLVPVMVRELREAEERRTHRLTQDAVRRGKAEWESVFDAVSDLIIITDA
DGVVLRCNGRVSAYFPGGYGAIIGRRIDEIFFGSQQPEGKLFRFLHSVQSEADEDIRFPNLSGWYNVASYPMRTEGSNRP
NLVFIIKDITKRREVEEEKRTSDRELLTLYAVAFRLQYTKGVDKVMGDLLFQLHNMLQMDFSCIHLFEDDKLKMRASLGV
SPAFEKAMKTLPRETQWATLAQAGRPFLGEEPDARFPARAKSAAIEMGLHSWCTVPLKIGQEVMGVMTVGTVSGRSYSDR
DVFLLCAIAGQLAVLIDNYGLYDKMKEKAEELYRSKEELKENLHKVKRANIELGRLNTAKNNFIGIASHELKTPITSIMG
GVEFLLKYSGIQMSPEQHNIFVSVYEGTIQLRKLVEDLLSISRIEAQGPLAQKKPASLMRVCREVHDLFALPLSERHIKV
EITGDDVLVPVDEAFAMLAVRNLLENAIKFTRDGGCVRLTGRVLKQAQLKEMTQTLHTFYPSFPGNVAATEKYYLLQVRD
NGIGIPPDERVRVFEKFYGVGDIDHHSSGATAFMSKGSGLGLSIVRGIMDAHEGAVWVEEAEGGGSTFSLLFPIE

Sequences:

>Translated_715_residues
MSKELRVLLVEDSEEDSLLLIRELRRGGYKLIHMRVETAESMRRALHDGEWDVVISDYRMPSFDALGALQVLHETGRDIP
FIIVSGKIGEDLAVEAMKSGASDYLMKGNLARLVPVMVRELREAEERRTHRLTQDAVRRGKAEWESVFDAVSDLIIITDA
DGVVLRCNGRVSAYFPGGYGAIIGRRIDEIFFGSQQPEGKLFRFLHSVQSEADEDIRFPNLSGWYNVASYPMRTEGSNRP
NLVFIIKDITKRREVEEEKRTSDRELLTLYAVAFRLQYTKGVDKVMGDLLFQLHNMLQMDFSCIHLFEDDKLKMRASLGV
SPAFEKAMKTLPRETQWATLAQAGRPFLGEEPDARFPARAKSAAIEMGLHSWCTVPLKIGQEVMGVMTVGTVSGRSYSDR
DVFLLCAIAGQLAVLIDNYGLYDKMKEKAEELYRSKEELKENLHKVKRANIELGRLNTAKNNFIGIASHELKTPITSIMG
GVEFLLKYSGIQMSPEQHNIFVSVYEGTIQLRKLVEDLLSISRIEAQGPLAQKKPASLMRVCREVHDLFALPLSERHIKV
EITGDDVLVPVDEAFAMLAVRNLLENAIKFTRDGGCVRLTGRVLKQAQLKEMTQTLHTFYPSFPGNVAATEKYYLLQVRD
NGIGIPPDERVRVFEKFYGVGDIDHHSSGATAFMSKGSGLGLSIVRGIMDAHEGAVWVEEAEGGGSTFSLLFPIE
>Mature_714_residues
SKELRVLLVEDSEEDSLLLIRELRRGGYKLIHMRVETAESMRRALHDGEWDVVISDYRMPSFDALGALQVLHETGRDIPF
IIVSGKIGEDLAVEAMKSGASDYLMKGNLARLVPVMVRELREAEERRTHRLTQDAVRRGKAEWESVFDAVSDLIIITDAD
GVVLRCNGRVSAYFPGGYGAIIGRRIDEIFFGSQQPEGKLFRFLHSVQSEADEDIRFPNLSGWYNVASYPMRTEGSNRPN
LVFIIKDITKRREVEEEKRTSDRELLTLYAVAFRLQYTKGVDKVMGDLLFQLHNMLQMDFSCIHLFEDDKLKMRASLGVS
PAFEKAMKTLPRETQWATLAQAGRPFLGEEPDARFPARAKSAAIEMGLHSWCTVPLKIGQEVMGVMTVGTVSGRSYSDRD
VFLLCAIAGQLAVLIDNYGLYDKMKEKAEELYRSKEELKENLHKVKRANIELGRLNTAKNNFIGIASHELKTPITSIMGG
VEFLLKYSGIQMSPEQHNIFVSVYEGTIQLRKLVEDLLSISRIEAQGPLAQKKPASLMRVCREVHDLFALPLSERHIKVE
ITGDDVLVPVDEAFAMLAVRNLLENAIKFTRDGGCVRLTGRVLKQAQLKEMTQTLHTFYPSFPGNVAATEKYYLLQVRDN
GIGIPPDERVRVFEKFYGVGDIDHHSSGATAFMSKGSGLGLSIVRGIMDAHEGAVWVEEAEGGGSTFSLLFPIE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0784

COG function: function code T; FOG: CheY-like receiver

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=287, Percent_Identity=27.1777003484321, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI48994928, Length=270, Percent_Identity=25.9259259259259, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786783, Length=256, Percent_Identity=26.5625, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790861, Length=410, Percent_Identity=23.9024390243902, Blast_Score=83, Evalue=8e-17,
Organism=Escherichia coli, GI1788713, Length=265, Percent_Identity=25.2830188679245, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788393, Length=284, Percent_Identity=25.3521126760563, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1789149, Length=295, Percent_Identity=24.7457627118644, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 80274; Mature: 80143

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKELRVLLVEDSEEDSLLLIRELRRGGYKLIHMRVETAESMRRALHDGEWDVVISDYRM
CCCCEEEEEEECCCCCCHHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCCCEEEEECCCC
PSFDALGALQVLHETGRDIPFIIVSGKIGEDLAVEAMKSGASDYLMKGNLARLVPVMVRE
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHH
LREAEERRTHRLTQDAVRRGKAEWESVFDAVSDLIIITDADGVVLRCNGRVSAYFPGGYG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEEEECCCCEEEEECCEEEEEECCCHH
AIIGRRIDEIFFGSQQPEGKLFRFLHSVQSEADEDIRFPNLSGWYNVASYPMRTEGSNRP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCCC
NLVFIIKDITKRREVEEEKRTSDRELLTLYAVAFRLQYTKGVDKVMGDLLFQLHNMLQMD
CEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
FSCIHLFEDDKLKMRASLGVSPAFEKAMKTLPRETQWATLAQAGRPFLGEEPDARFPARA
HHEEEEECCCCEEEHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCHH
KSAAIEMGLHSWCTVPLKIGQEVMGVMTVGTVSGRSYSDRDVFLLCAIAGQLAVLIDNYG
HHHHHHHCHHHHEEEHHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEHHCCCEEEEECCC
LYDKMKEKAEELYRSKEELKENLHKVKRANIELGRLNTAKNNFIGIASHELKTPITSIMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEECHHHHCHHHHHHH
GVEFLLKYSGIQMSPEQHNIFVSVYEGTIQLRKLVEDLLSISRIEAQGPLAQKKPASLMR
HHHHHHHHCCCEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
VCREVHDLFALPLSERHIKVEITGDDVLVPVDEAFAMLAVRNLLENAIKFTRDGGCVRLT
HHHHHHHHHHCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEH
GRVLKQAQLKEMTQTLHTFYPSFPGNVAATEKYYLLQVRDNGIGIPPDERVRVFEKFYGV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCC
GDIDHHSSGATAFMSKGSGLGLSIVRGIMDAHEGAVWVEEAEGGGSTFSLLFPIE
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECC
>Mature Secondary Structure 
SKELRVLLVEDSEEDSLLLIRELRRGGYKLIHMRVETAESMRRALHDGEWDVVISDYRM
CCCEEEEEEECCCCCCHHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCCCEEEEECCCC
PSFDALGALQVLHETGRDIPFIIVSGKIGEDLAVEAMKSGASDYLMKGNLARLVPVMVRE
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHH
LREAEERRTHRLTQDAVRRGKAEWESVFDAVSDLIIITDADGVVLRCNGRVSAYFPGGYG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEEEECCCCEEEEECCEEEEEECCCHH
AIIGRRIDEIFFGSQQPEGKLFRFLHSVQSEADEDIRFPNLSGWYNVASYPMRTEGSNRP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCCC
NLVFIIKDITKRREVEEEKRTSDRELLTLYAVAFRLQYTKGVDKVMGDLLFQLHNMLQMD
CEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
FSCIHLFEDDKLKMRASLGVSPAFEKAMKTLPRETQWATLAQAGRPFLGEEPDARFPARA
HHEEEEECCCCEEEHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCHH
KSAAIEMGLHSWCTVPLKIGQEVMGVMTVGTVSGRSYSDRDVFLLCAIAGQLAVLIDNYG
HHHHHHHCHHHHEEEHHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEHHCCCEEEEECCC
LYDKMKEKAEELYRSKEELKENLHKVKRANIELGRLNTAKNNFIGIASHELKTPITSIMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEECHHHHCHHHHHHH
GVEFLLKYSGIQMSPEQHNIFVSVYEGTIQLRKLVEDLLSISRIEAQGPLAQKKPASLMR
HHHHHHHHCCCEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
VCREVHDLFALPLSERHIKVEITGDDVLVPVDEAFAMLAVRNLLENAIKFTRDGGCVRLT
HHHHHHHHHHCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEH
GRVLKQAQLKEMTQTLHTFYPSFPGNVAATEKYYLLQVRDNGIGIPPDERVRVFEKFYGV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCC
GDIDHHSSGATAFMSKGSGLGLSIVRGIMDAHEGAVWVEEAEGGGSTFSLLFPIE
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]