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The map label for this gene is prsA [H]

Identifier: 197106322

GI number: 197106322

Start: 3273735

End: 3274670

Strand: Direct

Name: prsA [H]

Synonym: PHZ_c2861

Alternate gene names: 197106322

Gene position: 3273735-3274670 (Clockwise)

Preceding gene: 197106321

Following gene: 197106323

Centisome position: 81.92

GC content: 67.74

Gene sequence:

>936_bases
ATGAAGCTGCTGGCCGGCAACTCGAATCGCACGCTTGCGCAGGCCGTGGCCTCCCACCTGGACCTGCCGCTCACCAAGGC
CCAGGTGAAGCGCTTCCCGGACAACGAGGTCTGGGTGACCATCGACGAGAACGTGCGCGGCGAGGACGTCTTCGTCCTGC
AGTCCACCGCCTATCCGGCCAACGACCACCTGATGGAGCTCCTGATCTGCATCGATGCGCTGAAGCGCGCGTCGGCCCGG
CGGATCACGGCGGTGATGCCCTACTTCGGCTATGCGCGGCAGGACCGGAAGACCGGCGGCCGCACGCCCATCTCTGCCAA
GCTGGTGGCCAACCTGATCACCCGCGCCGGCGCGGACCGGGTGCTGACGATGGATCTGCACTCGGGCCAGATCCAGGGCT
TCTTCGACATCCCCACCGACAACCTGCAGTCGGCGCCGCTGATGGCCCAGGACATCAAGACCAACTACGCCAAGGCCGAC
GAGCTGCTGATCGTCTCGCCGGACGTGGGCGGCGTCGTCCGGGCCCTGGCGGTCGCCAGCCGCCTGAACGCCGAGCTGGC
CATCGTCGACAAGCGCCGCTCGGGTCCCGGCAAGTCGGAAGTGGCCAACATCATCGGCGACGTCACCGGCCGCCGGCTGA
TCATCTTCGACGACATCGTGGATTCGGCCGGCACGCTCTGCTCGGCGGCCCAGTCGCTGATGGACGCCGGCGCGGCCGAG
GTCTCGGCCTACATCACCCACGGCGTTCTCTCGGGCGCGGCGGCCGAACGGGTGAAGAACTCGGTGCTCAAGGAGCTGGT
CATCACCGACTCCATCGAGGCCTCGCAGGAGGTCGCCGGGGTGGACAAGATCCGCACCGTCGGCTGCGCGGGCCTGATCG
GCGAGGCGATCCGCCGCATCGCAAATGAGGAGTCCGTGTCGAAACTGTTCGACTAG

Upstream 100 bases:

>100_bases
AGCCCGACTACGGCCGCCTCCTTTCGGCGATCGTGCTCGCCTAGCTGGACTCCGCCGCTTCCGCTGCTACAAGCCCGGCA
ACTAGCCAAATGGGGGTCCG

Downstream 100 bases:

>100_bases
GATCCTCTGCGGCCAGGCTTGCTCAGCAAGAGTTTACCAAGTTAGGGCACGGTCGCCGGGGGGCAGGTGCTAAGATTCGT
CCACTCGTAAGAGGGGGAGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKLLAGNSNRTLAQAVASHLDLPLTKAQVKRFPDNEVWVTIDENVRGEDVFVLQSTAYPANDHLMELLICIDALKRASAR
RITAVMPYFGYARQDRKTGGRTPISAKLVANLITRAGADRVLTMDLHSGQIQGFFDIPTDNLQSAPLMAQDIKTNYAKAD
ELLIVSPDVGGVVRALAVASRLNAELAIVDKRRSGPGKSEVANIIGDVTGRRLIIFDDIVDSAGTLCSAAQSLMDAGAAE
VSAYITHGVLSGAAAERVKNSVLKELVITDSIEASQEVAGVDKIRTVGCAGLIGEAIRRIANEESVSKLFD

Sequences:

>Translated_311_residues
MKLLAGNSNRTLAQAVASHLDLPLTKAQVKRFPDNEVWVTIDENVRGEDVFVLQSTAYPANDHLMELLICIDALKRASAR
RITAVMPYFGYARQDRKTGGRTPISAKLVANLITRAGADRVLTMDLHSGQIQGFFDIPTDNLQSAPLMAQDIKTNYAKAD
ELLIVSPDVGGVVRALAVASRLNAELAIVDKRRSGPGKSEVANIIGDVTGRRLIIFDDIVDSAGTLCSAAQSLMDAGAAE
VSAYITHGVLSGAAAERVKNSVLKELVITDSIEASQEVAGVDKIRTVGCAGLIGEAIRRIANEESVSKLFD
>Mature_311_residues
MKLLAGNSNRTLAQAVASHLDLPLTKAQVKRFPDNEVWVTIDENVRGEDVFVLQSTAYPANDHLMELLICIDALKRASAR
RITAVMPYFGYARQDRKTGGRTPISAKLVANLITRAGADRVLTMDLHSGQIQGFFDIPTDNLQSAPLMAQDIKTNYAKAD
ELLIVSPDVGGVVRALAVASRLNAELAIVDKRRSGPGKSEVANIIGDVTGRRLIIFDDIVDSAGTLCSAAQSLMDAGAAE
VSAYITHGVLSGAAAERVKNSVLKELVITDSIEASQEVAGVDKIRTVGCAGLIGEAIRRIANEESVSKLFD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=308, Percent_Identity=47.4025974025974, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI4506127, Length=310, Percent_Identity=46.1290322580645, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI28557709, Length=310, Percent_Identity=45.8064516129032, Blast_Score=287, Evalue=7e-78,
Organism=Homo sapiens, GI84875539, Length=311, Percent_Identity=46.9453376205788, Blast_Score=285, Evalue=3e-77,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=36.2573099415205, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI194018537, Length=329, Percent_Identity=34.6504559270517, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=36.1111111111111, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=36.1111111111111, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=36.1111111111111, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=36.1111111111111, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=52.0766773162939, Blast_Score=329, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI17554702, Length=310, Percent_Identity=44.5161290322581, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI25149168, Length=310, Percent_Identity=44.5161290322581, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71989924, Length=310, Percent_Identity=44.5161290322581, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=44.4805194805195, Blast_Score=274, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=35.9050445103858, Blast_Score=201, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=45.5128205128205, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=44.8717948717949, Blast_Score=266, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6321776, Length=311, Percent_Identity=45.3376205787781, Blast_Score=265, Evalue=6e-72,
Organism=Saccharomyces cerevisiae, GI6322667, Length=195, Percent_Identity=41.025641025641, Blast_Score=152, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6324511, Length=110, Percent_Identity=41.8181818181818, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21355239, Length=310, Percent_Identity=45.4838709677419, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI45551540, Length=333, Percent_Identity=42.3423423423423, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24651458, Length=351, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24651456, Length=351, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI281362873, Length=351, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24651454, Length=351, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24651462, Length=370, Percent_Identity=32.1621621621622, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24651464, Length=370, Percent_Identity=32.1621621621622, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI45552010, Length=370, Percent_Identity=32.1621621621622, Blast_Score=182, Evalue=3e-46,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33267; Mature: 33267

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLAGNSNRTLAQAVASHLDLPLTKAQVKRFPDNEVWVTIDENVRGEDVFVLQSTAYPA
CCEECCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCC
NDHLMELLICIDALKRASARRITAVMPYFGYARQDRKTGGRTPISAKLVANLITRAGADR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
VLTMDLHSGQIQGFFDIPTDNLQSAPLMAQDIKTNYAKADELLIVSPDVGGVVRALAVAS
EEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
RLNAELAIVDKRRSGPGKSEVANIIGDVTGRRLIIFDDIVDSAGTLCSAAQSLMDAGAAE
HCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHHH
VSAYITHGVLSGAAAERVKNSVLKELVITDSIEASQEVAGVDKIRTVGCAGLIGEAIRRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANEESVSKLFD
HCHHHHHHHCC
>Mature Secondary Structure
MKLLAGNSNRTLAQAVASHLDLPLTKAQVKRFPDNEVWVTIDENVRGEDVFVLQSTAYPA
CCEECCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCC
NDHLMELLICIDALKRASARRITAVMPYFGYARQDRKTGGRTPISAKLVANLITRAGADR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
VLTMDLHSGQIQGFFDIPTDNLQSAPLMAQDIKTNYAKADELLIVSPDVGGVVRALAVAS
EEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
RLNAELAIVDKRRSGPGKSEVANIIGDVTGRRLIIFDDIVDSAGTLCSAAQSLMDAGAAE
HCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHHH
VSAYITHGVLSGAAAERVKNSVLKELVITDSIEASQEVAGVDKIRTVGCAGLIGEAIRRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANEESVSKLFD
HCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA