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The map label for this gene is kdpD [H]

Identifier: 197106108

GI number: 197106108

Start: 3034554

End: 3036011

Strand: Direct

Name: kdpD [H]

Synonym: PHZ_c2647

Alternate gene names: 197106108

Gene position: 3034554-3036011 (Clockwise)

Preceding gene: 197106103

Following gene: 197106109

Centisome position: 75.93

GC content: 74.35

Gene sequence:

>1458_bases
ATGCAGCGAAGCATGGGCCGGGTGCGGCGCGAATGGCGGGACCAGCTCTCGCGCTATGGAGCGGCGCTCGCGCTCGTGGC
CGCCTCCACCGCCGTCGCCGAGGCGCTCTACAGGCTCACCGCCACCACCCGCCTGTCGATGGTGTTCCTGGCGGGGGTCC
TGCTCGCGGCCTTCCTGCTGGGCTCGGGCCCCGCGTACTTCGCCGCCGCCGTCGCCTTCCTGGTCTACAACTTCTACCTG
GTGGAGCCTCGGTTCACGATCGAGCTCACCACGCCGGAGGAGCTGCTGACGCTGCTCGTGTTCCTGGCCGTGGCCATGCT
GACCGGCAACCTCACCGGCCGGGTCCGGGACGAGGCCGCCAGGGCCGAGGCCCGCGCCCGGGCCACCACCGCCCTGTTCG
ACGCCACCCGGGAGTTCTCGGCCTCGTCCGACGAGGGCCTCATCCGCCAGCGCCTGGCCGAGCACCTCGCCGCCACCGCC
GGGGGCGAGGGGTTCGTGCGGGACGCCGGGCGCCTGCAGATGGCCCCGGCCGGGCTCCGGCGCGAGGATATCCCAGGCGG
CCTTCCCGGCGCCGCGGAGCCGGCCGGCGGCTGGACGCTCCGGCGGCTGGAGGTGGAGGGCCAGGCCCTCGGGACCGCCG
GCTGGCGCGCTCCGCCGGACCGACGGCTCAGCCGGGACGAACACGACCTGCTCGAGCTCATGTGCGACGCCGGGGCGGCC
GCCATCGCCCGGGCCCGACTCGCGGCCGGCAAGGCCGAGGCCGAGGCGCGCGCGCGCACCGAGGACCTGCGCAACGCCCT
GCTCTCGTCCATCTCGCACGACCTGCGCACGCCGCTGGCCGCGATCCTCGCCTCGGCGACCAGCCTGCGGGAGTTCGGCG
ACAGCTTCGATCCCGGGGTCCGCCGCGACCTCGCGGCCACCATCCAGGAAGAGACCGAGCGGCTCGACGCGGTGGTCGCC
AATCTCCTCAGCATGACGCGGCTGCAGGCCGGGGCGCTGGCGATCCAGAAGGCGCCCTTCAACGTGCCCGAGGTGGTCCG
CCGCACGGTCGAGCGGCGCGACCGCGCGCACCGCCGGTTCACCCTGACCTCGATTACGCCGCGGCTGCCCGAGGGCCTTG
GCGATCCCATCCTGTTCGAGCAGGCGCTCGGCAACGTGGTGGAGAACGCGCTGCGCCACACCCCCGAGGACACGCTGGTC
TTGGTGAGCATGCGGCTGGAGGACGACCGGATCGTCGTGGACGTCTGCGACCGCGGGCCGGGCGTGGGCGAAGCCGACCT
CGAGCGGATCTTCGACCGGTTCTACCGGGCGGGCGGCGCGCGGCAGACGCCGGGGACCGGCCTTGGCCTTTCCATCGCCC
GCGGGCTGATGGAGGCGATGGACGGGGCGATCGAGGCCCGCAACGATCCCGCCGCGGGCGGCCTGGTGGTCAGTCTCAGC
CTGGAGTCCGCGGCATGA

Upstream 100 bases:

>100_bases
GGAACGGCCCGGCCGGCGGCCCATAAGGCGGCCATAATTGACCGCGGCCGCGGTTCGGGGGCTTTAGTCCGGGCGCGGCC
GGTACGGCCCGGACAGGGAG

Downstream 100 bases:

>100_bases
GTTCCGGACGGCTGCTCCTCGTCGACGACGAGCCCCAGATCGTCCGGGCCCTGCTGCCCGCCCTGCAGGCGGCGGGCTAC
GCCGTGGAGGTGGCCGGGAC

Product: osmosensitive K+ channel signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MQRSMGRVRREWRDQLSRYGAALALVAASTAVAEALYRLTATTRLSMVFLAGVLLAAFLLGSGPAYFAAAVAFLVYNFYL
VEPRFTIELTTPEELLTLLVFLAVAMLTGNLTGRVRDEAARAEARARATTALFDATREFSASSDEGLIRQRLAEHLAATA
GGEGFVRDAGRLQMAPAGLRREDIPGGLPGAAEPAGGWTLRRLEVEGQALGTAGWRAPPDRRLSRDEHDLLELMCDAGAA
AIARARLAAGKAEAEARARTEDLRNALLSSISHDLRTPLAAILASATSLREFGDSFDPGVRRDLAATIQEETERLDAVVA
NLLSMTRLQAGALAIQKAPFNVPEVVRRTVERRDRAHRRFTLTSITPRLPEGLGDPILFEQALGNVVENALRHTPEDTLV
LVSMRLEDDRIVVDVCDRGPGVGEADLERIFDRFYRAGGARQTPGTGLGLSIARGLMEAMDGAIEARNDPAAGGLVVSLS
LESAA

Sequences:

>Translated_485_residues
MQRSMGRVRREWRDQLSRYGAALALVAASTAVAEALYRLTATTRLSMVFLAGVLLAAFLLGSGPAYFAAAVAFLVYNFYL
VEPRFTIELTTPEELLTLLVFLAVAMLTGNLTGRVRDEAARAEARARATTALFDATREFSASSDEGLIRQRLAEHLAATA
GGEGFVRDAGRLQMAPAGLRREDIPGGLPGAAEPAGGWTLRRLEVEGQALGTAGWRAPPDRRLSRDEHDLLELMCDAGAA
AIARARLAAGKAEAEARARTEDLRNALLSSISHDLRTPLAAILASATSLREFGDSFDPGVRRDLAATIQEETERLDAVVA
NLLSMTRLQAGALAIQKAPFNVPEVVRRTVERRDRAHRRFTLTSITPRLPEGLGDPILFEQALGNVVENALRHTPEDTLV
LVSMRLEDDRIVVDVCDRGPGVGEADLERIFDRFYRAGGARQTPGTGLGLSIARGLMEAMDGAIEARNDPAAGGLVVSLS
LESAA
>Mature_485_residues
MQRSMGRVRREWRDQLSRYGAALALVAASTAVAEALYRLTATTRLSMVFLAGVLLAAFLLGSGPAYFAAAVAFLVYNFYL
VEPRFTIELTTPEELLTLLVFLAVAMLTGNLTGRVRDEAARAEARARATTALFDATREFSASSDEGLIRQRLAEHLAATA
GGEGFVRDAGRLQMAPAGLRREDIPGGLPGAAEPAGGWTLRRLEVEGQALGTAGWRAPPDRRLSRDEHDLLELMCDAGAA
AIARARLAAGKAEAEARARTEDLRNALLSSISHDLRTPLAAILASATSLREFGDSFDPGVRRDLAATIQEETERLDAVVA
NLLSMTRLQAGALAIQKAPFNVPEVVRRTVERRDRAHRRFTLTSITPRLPEGLGDPILFEQALGNVVENALRHTPEDTLV
LVSMRLEDDRIVVDVCDRGPGVGEADLERIFDRFYRAGGARQTPGTGLGLSIARGLMEAMDGAIEARNDPAAGGLVVSLS
LESAA

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=499, Percent_Identity=28.6573146292585, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1788393, Length=229, Percent_Identity=31.8777292576419, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790861, Length=215, Percent_Identity=32.5581395348837, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790346, Length=226, Percent_Identity=35.3982300884956, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=199, Percent_Identity=31.1557788944724, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=31.6017316017316, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789149, Length=240, Percent_Identity=30.4166666666667, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1788713, Length=270, Percent_Identity=22.5925925925926, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786783, Length=239, Percent_Identity=25.9414225941423, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789808, Length=204, Percent_Identity=28.921568627451, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787374, Length=278, Percent_Identity=26.6187050359712, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788279, Length=201, Percent_Identity=22.8855721393035, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=214, Percent_Identity=24.7663551401869, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI48994928, Length=218, Percent_Identity=22.9357798165138, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=25.9433962264151, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52174; Mature: 52174

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRSMGRVRREWRDQLSRYGAALALVAASTAVAEALYRLTATTRLSMVFLAGVLLAAFLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSGPAYFAAAVAFLVYNFYLVEPRFTIELTTPEELLTLLVFLAVAMLTGNLTGRVRDEAA
CCCHHHHHHHHHHHHHHHHEECCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
RAEARARATTALFDATREFSASSDEGLIRQRLAEHLAATAGGEGFVRDAGRLQMAPAGLR
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCEEECCCCCC
REDIPGGLPGAAEPAGGWTLRRLEVEGQALGTAGWRAPPDRRLSRDEHDLLELMCDAGAA
CCCCCCCCCCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHH
AIARARLAAGKAEAEARARTEDLRNALLSSISHDLRTPLAAILASATSLREFGDSFDPGV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
RRDLAATIQEETERLDAVVANLLSMTRLQAGALAIQKAPFNVPEVVRRTVERRDRAHRRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEE
TLTSITPRLPEGLGDPILFEQALGNVVENALRHTPEDTLVLVSMRLEDDRIVVDVCDRGP
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEECCCCC
GVGEADLERIFDRFYRAGGARQTPGTGLGLSIARGLMEAMDGAIEARNDPAAGGLVVSLS
CCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
LESAA
CCCCC
>Mature Secondary Structure
MQRSMGRVRREWRDQLSRYGAALALVAASTAVAEALYRLTATTRLSMVFLAGVLLAAFLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSGPAYFAAAVAFLVYNFYLVEPRFTIELTTPEELLTLLVFLAVAMLTGNLTGRVRDEAA
CCCHHHHHHHHHHHHHHHHEECCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
RAEARARATTALFDATREFSASSDEGLIRQRLAEHLAATAGGEGFVRDAGRLQMAPAGLR
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCEEECCCCCC
REDIPGGLPGAAEPAGGWTLRRLEVEGQALGTAGWRAPPDRRLSRDEHDLLELMCDAGAA
CCCCCCCCCCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHH
AIARARLAAGKAEAEARARTEDLRNALLSSISHDLRTPLAAILASATSLREFGDSFDPGV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
RRDLAATIQEETERLDAVVANLLSMTRLQAGALAIQKAPFNVPEVVRRTVERRDRAHRRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEE
TLTSITPRLPEGLGDPILFEQALGNVVENALRHTPEDTLVLVSMRLEDDRIVVDVCDRGP
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEECCCCC
GVGEADLERIFDRFYRAGGARQTPGTGLGLSIARGLMEAMDGAIEARNDPAAGGLVVSLS
CCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
LESAA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1532388; 8905232; 9278503; 7499326 [H]