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The map label for this gene is acdA [H]

Identifier: 197106001

GI number: 197106001

Start: 2915418

End: 2916551

Strand: Reverse

Name: acdA [H]

Synonym: PHZ_c2540

Alternate gene names: 197106001

Gene position: 2916551-2915418 (Counterclockwise)

Preceding gene: 197106002

Following gene: 197106000

Centisome position: 72.98

GC content: 73.81

Gene sequence:

>1134_bases
ATGAACTTCCACCTTTCCGACGAGCAGGCGGCGCTGCAGGACGCCGTCCGGCGCTTCGCCGCCGAGCAGGCCGAGGCCGG
CGTGCGCCGGCGCGCATTCGAGAGCGAGGACGGGCTGGACCGCCCGTTCTGGGACGGGCTGGTGGCCCTCGGCGTCGGCG
GCGTCGGGATCGCCGAGGAGTTCGGCGGGCTCGGCCTGGACTGGATCGACGTCGCGCTGGTGGCCGAGGCGCTGGGGTAT
GAGGCCGCGCCGGGGCCGTTCCTGGGTCACGTCGTGGCCGCTCTCGCCATCCAGCGGTTCGGAACCGAGCCCCAGAAGCA
GGCGTGGCTGCCCCGCCTGGCTACGGGCGAGAAAATCGGCACGGTCGCCCTGGCGGAGGCGGGCGAGCGCTGGCGGCCCA
AGGAGTGGAGCCTGGGCCTCGACGGCCACGGCCGCCTGTCCGGCGCCAAGGCGAACGTGCCCTACGCGGCCGTCGCCGAC
GTCCTCGTCGTCGGGCTGTCCGACGGCGGTCTGGCGCTGGTCGCGTCCGAGGCAGGCGGCCTCGCCTGCGAGCCGCTCGA
CGTCGCCGACCGCACCCGCCGGCTCTGGAACGTGACGTTCCGCGACGCGCGGGCCGAGCGCCTGCCGGCGGGCGACTGCG
CTCTGCTGCGGGATGCGCTGTGTGTGCTGCTGGCGGCCGACGCCTTCGGCGGCGCGATGCGGGTGCTCCACATGACCGCC
GAATACGCCAAGACGCGGGAACAGTTCGGTCAGGCGATCGCCCGCTTCCAGGGCGTGAAGCACCAACTCGCCAACCTCGC
CGCCGAGATCGCCCCCTGCCAGGGTCTCTACTGGTATGCGGCCGTGGCCTTCGAGCAGGCCCCCGACGAGCGGGCCCAGG
CCGCCGCCATGGCCAAGGCCCACCTGGGCGACCGCTTCATGGAGGCCGGGCGCACCGCGGTCGAGCTGCACGGCGGCATC
GGCTACACCTGGGAGTACGACCTCCAGATCTGGGTGAAGCGGGCGATGTTCGACTTCGCCTTCGGCGGACCGCCGTCGCT
CCACCGGGCGCGGGCGATGTCGCTTACCGCGCCGCGGGCCGAGCCGGACCGGCCGCCCCAGGACAAGGCCCGGGCTGAAG
AGGTCCTCGCATGA

Upstream 100 bases:

>100_bases
TCGATGTCGGTGACCATCGCCGGTGGGACCTCGAACATCCAACGCAACATCATCGCCGAGCGGGGCCTGGGCCTTCCTCG
AGACCCGGGGAGCTGAGGGC

Downstream 100 bases:

>100_bases
CGGTGGCCATCCTCGGCGGCGCCGGGAACCTCGGGTACGCGCTCGCGCGGCGGTGGGCGCTCGCCGGCCGCCACGTGTTC
ATCGGCTCGCGCGACGCGGA

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MNFHLSDEQAALQDAVRRFAAEQAEAGVRRRAFESEDGLDRPFWDGLVALGVGGVGIAEEFGGLGLDWIDVALVAEALGY
EAAPGPFLGHVVAALAIQRFGTEPQKQAWLPRLATGEKIGTVALAEAGERWRPKEWSLGLDGHGRLSGAKANVPYAAVAD
VLVVGLSDGGLALVASEAGGLACEPLDVADRTRRLWNVTFRDARAERLPAGDCALLRDALCVLLAADAFGGAMRVLHMTA
EYAKTREQFGQAIARFQGVKHQLANLAAEIAPCQGLYWYAAVAFEQAPDERAQAAAMAKAHLGDRFMEAGRTAVELHGGI
GYTWEYDLQIWVKRAMFDFAFGGPPSLHRARAMSLTAPRAEPDRPPQDKARAEEVLA

Sequences:

>Translated_377_residues
MNFHLSDEQAALQDAVRRFAAEQAEAGVRRRAFESEDGLDRPFWDGLVALGVGGVGIAEEFGGLGLDWIDVALVAEALGY
EAAPGPFLGHVVAALAIQRFGTEPQKQAWLPRLATGEKIGTVALAEAGERWRPKEWSLGLDGHGRLSGAKANVPYAAVAD
VLVVGLSDGGLALVASEAGGLACEPLDVADRTRRLWNVTFRDARAERLPAGDCALLRDALCVLLAADAFGGAMRVLHMTA
EYAKTREQFGQAIARFQGVKHQLANLAAEIAPCQGLYWYAAVAFEQAPDERAQAAAMAKAHLGDRFMEAGRTAVELHGGI
GYTWEYDLQIWVKRAMFDFAFGGPPSLHRARAMSLTAPRAEPDRPPQDKARAEEVLA
>Mature_377_residues
MNFHLSDEQAALQDAVRRFAAEQAEAGVRRRAFESEDGLDRPFWDGLVALGVGGVGIAEEFGGLGLDWIDVALVAEALGY
EAAPGPFLGHVVAALAIQRFGTEPQKQAWLPRLATGEKIGTVALAEAGERWRPKEWSLGLDGHGRLSGAKANVPYAAVAD
VLVVGLSDGGLALVASEAGGLACEPLDVADRTRRLWNVTFRDARAERLPAGDCALLRDALCVLLAADAFGGAMRVLHMTA
EYAKTREQFGQAIARFQGVKHQLANLAAEIAPCQGLYWYAAVAFEQAPDERAQAAAMAKAHLGDRFMEAGRTAVELHGGI
GYTWEYDLQIWVKRAMFDFAFGGPPSLHRARAMSLTAPRAEPDRPPQDKARAEEVLA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=309, Percent_Identity=26.537216828479, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4557233, Length=328, Percent_Identity=26.5243902439024, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=359, Percent_Identity=23.6768802228412, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40524; Mature: 40524

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFHLSDEQAALQDAVRRFAAEQAEAGVRRRAFESEDGLDRPFWDGLVALGVGGVGIAEE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHH
FGGLGLDWIDVALVAEALGYEAAPGPFLGHVVAALAIQRFGTEPQKQAWLPRLATGEKIG
HCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCC
TVALAEAGERWRPKEWSLGLDGHGRLSGAKANVPYAAVADVLVVGLSDGGLALVASEAGG
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCEEEEEECCCC
LACEPLDVADRTRRLWNVTFRDARAERLPAGDCALLRDALCVLLAADAFGGAMRVLHMTA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYAKTREQFGQAIARFQGVKHQLANLAAEIAPCQGLYWYAAVAFEQAPDERAQAAAMAKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
HLGDRFMEAGRTAVELHGGIGYTWEYDLQIWVKRAMFDFAFGGPPSLHRARAMSLTAPRA
HHHHHHHHCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
EPDRPPQDKARAEEVLA
CCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MNFHLSDEQAALQDAVRRFAAEQAEAGVRRRAFESEDGLDRPFWDGLVALGVGGVGIAEE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHH
FGGLGLDWIDVALVAEALGYEAAPGPFLGHVVAALAIQRFGTEPQKQAWLPRLATGEKIG
HCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCC
TVALAEAGERWRPKEWSLGLDGHGRLSGAKANVPYAAVADVLVVGLSDGGLALVASEAGG
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCEEEEEECCCC
LACEPLDVADRTRRLWNVTFRDARAERLPAGDCALLRDALCVLLAADAFGGAMRVLHMTA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYAKTREQFGQAIARFQGVKHQLANLAAEIAPCQGLYWYAAVAFEQAPDERAQAAAMAKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
HLGDRFMEAGRTAVELHGGIGYTWEYDLQIWVKRAMFDFAFGGPPSLHRARAMSLTAPRA
HHHHHHHHCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
EPDRPPQDKARAEEVLA
CCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]