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The map label for this gene is bioF [C]

Identifier: 197105840

GI number: 197105840

Start: 2697208

End: 2698368

Strand: Direct

Name: bioF [C]

Synonym: PHZ_c2379

Alternate gene names: 197105840

Gene position: 2697208-2698368 (Clockwise)

Preceding gene: 197105830

Following gene: 197105841

Centisome position: 67.49

GC content: 71.4

Gene sequence:

>1161_bases
ATGCCAGCGCCGATGGACAGCCTTGCCGCCTTCGCCACGGACAAGCTCGCGGCTCTTGAGAGCCAAAGTCTCCGGCGCAG
GCTGCGGCCGACGCGCCGGACGGACGGAGTCTGCGTGGAGCGCGGGGGCCGGCGCCTCGTCTCCTTCTCCTGCAATGACT
ATCTCGGCCTCAGCCACCACCCCGCGGTGAAGGCTGCTGCCGCGGCGGCGATTGAATCCGAAGGGCTCGGCGCGGGCGCG
TCCCGCCTGGTGACGGGGGACAATCCCCTGCTCGCCACGCTTGAACGACGGCTCGCCGCGCTGAAGGGCGCAGAGGCCGC
CTGCGTCTTCGGGTCGGGCTACCTGGCCAACCTCGGCATCATCCCGACCTTCATGGGCGCGGGCGACATTGTCCTCGTGG
ATGAGCTCGCCCATGCCTGCATCTGGGGCGGCGCGCGTCTGAGCGGGGCTCAGGTCATCAGCTTCAGGCACAACGACGTC
GACGACCTCACGGGAAAGCTGGCCGCGGCGCGGGGCTCCGCCCGGCGGGCGCTCGTGGCCACGGATGGCGTCTTTTCGAT
GGATGGCGACATCGCGCCGCTCGACGACATCTCACGGACCGCGCAGGCCTGGGACGCCTGGCTGCTCGTGGACGATGCGC
ATGGCCTGGGGGTCGTGGGGGGCGGCGTCGGCGTAGGGGCCCTTTTTCCCTCGGCCAGGATCGACCTGTCCATGGGCACG
CTCTCCAAGGCGCTCGGCGCATACGGCGCTTATGTGTGCGCTGCGCAGCCAGTCATCGATCTCATCAAGTCGCGGACGCG
GACCGTGGTCTACACAACCGCCCTGCCCCCCGCCGTGGCGGCGGGCGCGCTGGCGGCCCTCGACATCATCATCACCGAGC
CCAAGCGGGTCGCCGCGCCCCGGCTGCGGGCGCGACGCCTCACCAGATCGCTCGGCCTGCCGACGGCGGAGAGCGCGATC
GTCCCGATCGTGCTCGGCGACGCCGAAACGGCGCTGGCCGCGGCCGCGGACCTGGAGCGCCAGGGCCTGCTCGCCGTCGC
CATCCGGCCGCCGACCGTTCCGGCCAACACCGCGCGGCTGCGCATCGCCTGCAGCGCCCTGCACACCGAAAGCCAGATCG
ATGACCTGGCGGCCGCGCTTCAGCCCTGGATGCAGGCATGA

Upstream 100 bases:

>100_bases
CGCCAGACATGCGGCGCGCCGCGTTCGTACCAGCCAGGCCTGTCGTTCATGGGCTCAGGATCCTTTGGAATTGCGCTGGT
TTACGTAGGGTAAGCTCATT

Downstream 100 bases:

>100_bases
GCCGTTACTTTGTGGCCGGGTCCCATACGGATGTCGGCAAGACCTTCGTCAGCTGTCAGCTGATCCGCGCCGAACGGGCG
GCGGGCCGAAGCGCGACCGC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MPAPMDSLAAFATDKLAALESQSLRRRLRPTRRTDGVCVERGGRRLVSFSCNDYLGLSHHPAVKAAAAAAIESEGLGAGA
SRLVTGDNPLLATLERRLAALKGAEAACVFGSGYLANLGIIPTFMGAGDIVLVDELAHACIWGGARLSGAQVISFRHNDV
DDLTGKLAAARGSARRALVATDGVFSMDGDIAPLDDISRTAQAWDAWLLVDDAHGLGVVGGGVGVGALFPSARIDLSMGT
LSKALGAYGAYVCAAQPVIDLIKSRTRTVVYTTALPPAVAAGALAALDIIITEPKRVAAPRLRARRLTRSLGLPTAESAI
VPIVLGDAETALAAAADLERQGLLAVAIRPPTVPANTARLRIACSALHTESQIDDLAAALQPWMQA

Sequences:

>Translated_386_residues
MPAPMDSLAAFATDKLAALESQSLRRRLRPTRRTDGVCVERGGRRLVSFSCNDYLGLSHHPAVKAAAAAAIESEGLGAGA
SRLVTGDNPLLATLERRLAALKGAEAACVFGSGYLANLGIIPTFMGAGDIVLVDELAHACIWGGARLSGAQVISFRHNDV
DDLTGKLAAARGSARRALVATDGVFSMDGDIAPLDDISRTAQAWDAWLLVDDAHGLGVVGGGVGVGALFPSARIDLSMGT
LSKALGAYGAYVCAAQPVIDLIKSRTRTVVYTTALPPAVAAGALAALDIIITEPKRVAAPRLRARRLTRSLGLPTAESAI
VPIVLGDAETALAAAADLERQGLLAVAIRPPTVPANTARLRIACSALHTESQIDDLAAALQPWMQA
>Mature_385_residues
PAPMDSLAAFATDKLAALESQSLRRRLRPTRRTDGVCVERGGRRLVSFSCNDYLGLSHHPAVKAAAAAAIESEGLGAGAS
RLVTGDNPLLATLERRLAALKGAEAACVFGSGYLANLGIIPTFMGAGDIVLVDELAHACIWGGARLSGAQVISFRHNDVD
DLTGKLAAARGSARRALVATDGVFSMDGDIAPLDDISRTAQAWDAWLLVDDAHGLGVVGGGVGVGALFPSARIDLSMGTL
SKALGAYGAYVCAAQPVIDLIKSRTRTVVYTTALPPAVAAGALAALDIIITEPKRVAAPRLRARRLTRSLGLPTAESAIV
PIVLGDAETALAAAADLERQGLLAVAIRPPTVPANTARLRIACSALHTESQIDDLAAALQPWMQA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=362, Percent_Identity=36.4640883977901, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI284448556, Length=343, Percent_Identity=36.1516034985423, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI83977442, Length=347, Percent_Identity=33.4293948126801, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI83977444, Length=347, Percent_Identity=33.4293948126801, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI83977440, Length=347, Percent_Identity=33.4293948126801, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI4502025, Length=356, Percent_Identity=33.7078651685393, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI40316939, Length=356, Percent_Identity=33.7078651685393, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4758668, Length=367, Percent_Identity=28.0653950953678, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI119220554, Length=361, Percent_Identity=27.7008310249307, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI5454084, Length=282, Percent_Identity=27.6595744680851, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1790046, Length=340, Percent_Identity=36.7647058823529, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1786993, Length=345, Percent_Identity=38.8405797101449, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71994529, Length=379, Percent_Identity=32.9815303430079, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI32566772, Length=364, Percent_Identity=29.6703296703297, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17560912, Length=348, Percent_Identity=25.8620689655172, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17560914, Length=348, Percent_Identity=25.5747126436782, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71982617, Length=267, Percent_Identity=25.0936329588015, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982625, Length=267, Percent_Identity=25.0936329588015, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320438, Length=386, Percent_Identity=31.6062176165803, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6320267, Length=355, Percent_Identity=28.169014084507, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6323954, Length=226, Percent_Identity=26.5486725663717, Blast_Score=106, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24662918, Length=357, Percent_Identity=33.0532212885154, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17137420, Length=355, Percent_Identity=34.0845070422535, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI17136286, Length=327, Percent_Identity=30.5810397553517, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24653280, Length=289, Percent_Identity=24.9134948096886, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24653276, Length=289, Percent_Identity=24.9134948096886, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24653278, Length=289, Percent_Identity=24.9134948096886, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_PHEZH (B4RFX5)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002131217.1
- ProteinModelPortal:   B4RFX5
- GeneID:   6791900
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c2379
- HOGENOM:   HBG649839
- OMA:   GCENDID
- ProtClustDB:   CLSK2518308
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 39927; Mature: 39796

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 26-26 BINDING 138-138 BINDING 186-186 BINDING 352-352

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPMDSLAAFATDKLAALESQSLRRRLRPTRRTDGVCVERGGRRLVSFSCNDYLGLSHH
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCC
PAVKAAAAAAIESEGLGAGASRLVTGDNPLLATLERRLAALKGAEAACVFGSGYLANLGI
CHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCEECCCC
IPTFMGAGDIVLVDELAHACIWGGARLSGAQVISFRHNDVDDLTGKLAAARGSARRALVA
HHHHCCCCCEEEHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEE
TDGVFSMDGDIAPLDDISRTAQAWDAWLLVDDAHGLGVVGGGVGVGALFPSARIDLSMGT
ECCEEECCCCCCCHHHHHHHHHHCEEEEEEECCCCCEEEECCCCHHHHCCCCEEEEEHHH
LSKALGAYGAYVCAAQPVIDLIKSRTRTVVYTTALPPAVAAGALAALDIIITEPKRVAAP
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHEEEEEECCHHHHHH
RLRARRLTRSLGLPTAESAIVPIVLGDAETALAAAADLERQGLLAVAIRPPTVPANTARL
HHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCEE
RIACSALHTESQIDDLAAALQPWMQA
EEEEHHHHCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PAPMDSLAAFATDKLAALESQSLRRRLRPTRRTDGVCVERGGRRLVSFSCNDYLGLSHH
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCC
PAVKAAAAAAIESEGLGAGASRLVTGDNPLLATLERRLAALKGAEAACVFGSGYLANLGI
CHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCEECCCC
IPTFMGAGDIVLVDELAHACIWGGARLSGAQVISFRHNDVDDLTGKLAAARGSARRALVA
HHHHCCCCCEEEHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEE
TDGVFSMDGDIAPLDDISRTAQAWDAWLLVDDAHGLGVVGGGVGVGALFPSARIDLSMGT
ECCEEECCCCCCCHHHHHHHHHHCEEEEEEECCCCCEEEECCCCHHHHCCCCEEEEEHHH
LSKALGAYGAYVCAAQPVIDLIKSRTRTVVYTTALPPAVAAGALAALDIIITEPKRVAAP
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHEEEEEECCHHHHHH
RLRARRLTRSLGLPTAESAIVPIVLGDAETALAAAADLERQGLLAVAIRPPTVPANTARL
HHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCEE
RIACSALHTESQIDDLAAALQPWMQA
EEEEHHHHCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA