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The map label for this gene is lpxC

Identifier: 197105774

GI number: 197105774

Start: 2621185

End: 2622066

Strand: Reverse

Name: lpxC

Synonym: PHZ_c2312

Alternate gene names: 197105774

Gene position: 2622066-2621185 (Counterclockwise)

Preceding gene: 197105775

Following gene: 197105773

Centisome position: 65.61

GC content: 73.13

Gene sequence:

>882_bases
GTGTTCCAGCACACCGTCAAGGCGCCGGCCCTGTTCGCGGGCGTGGGCGTCCACACCGGCGCGTACACGCGCGTGGCGGT
GCGTCCGGCCGCGGCCGACACGGGGATCGTCTTCGTGCGGACCGACGTCTCCGGGAGCGACAACCGCATCGCCGTCTCGC
CCGAGGCGGTCTGCAAGACCCAGCTCGGCACGGTGGTCGGCAACGCCGCTGGCGTCACGGTCTCGACCATCGAGCACCTG
ATGGCGGCCCTCGTCATGCTCGGCGTCGACAACGCCGTCGTCGAGGTGGACGGCCCCGAGATGCCGATCATGGACGGCTC
GGCCCTGCCCTTCGTGCGGGTGCTGGACCGCGCCGGCCGCCGCGAGCAGCAGGCCCCGCGCCGCTACATCGAAATCCTGG
CGCCCGTCGAGGTGATCGACGGCGACAAGCGCGCCGCGCTCCGCCCCGCGGAAGCCTTCGAGGTGGCCTTCGAGATCCGC
TTCGGCTCCCAGGCCATCGGAACCCAGGCCATCGACCTGCCCATGGACGAGGCCGCCTTCCGCGACGAGCTCGCCGACTG
CCGCACCTTCGGCTTCCTGCACGAGGTCGAGGCCCTGCGCGCCATGGGCCTGGCCCGCGGCGGCTCGATGGAGAACGCCG
TGGTGATCGACGGCGACCGCATCCTCAATCCCGAGGGCCTGCGCCGGCCCGACGAGTTCGTCCGCCACAAGGCGCTGGAC
GCCATCGGCGACCTGTTCGTCCTGGGCGCGCCGGTGGTGGGCCGCTTCGAGGGCGTGCTGGCCGGCCACGGCCTGAACAA
CGCCCTGGTCCGCGCCCTGGCCGCGCGGCCCGACGCCTGGCGGGTCCGCACCTTCGCCGAGGATCTGGCCGAGGCGGTCT
GA

Upstream 100 bases:

>100_bases
CTATGCACGAGTTGAGGGCGAAGGCTCGGTCGCTGTCCCGGTGTCACGGGAAGGGGCCGGACCGGTTGTGTTTGTGGAAG
GTCCCGGTTTGTCCGCACCC

Downstream 100 bases:

>100_bases
CGCGCCGCCGTTTGCTCGCCACAGTCGGTGGTGTAGAAGCGACTCTCTCGCGTGGGGGCGCGCGTGTTGGTCTTGAGGTG
AAGGTGTCTTCGGTTCGAAC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MFQHTVKAPALFAGVGVHTGAYTRVAVRPAAADTGIVFVRTDVSGSDNRIAVSPEAVCKTQLGTVVGNAAGVTVSTIEHL
MAALVMLGVDNAVVEVDGPEMPIMDGSALPFVRVLDRAGRREQQAPRRYIEILAPVEVIDGDKRAALRPAEAFEVAFEIR
FGSQAIGTQAIDLPMDEAAFRDELADCRTFGFLHEVEALRAMGLARGGSMENAVVIDGDRILNPEGLRRPDEFVRHKALD
AIGDLFVLGAPVVGRFEGVLAGHGLNNALVRALAARPDAWRVRTFAEDLAEAV

Sequences:

>Translated_293_residues
MFQHTVKAPALFAGVGVHTGAYTRVAVRPAAADTGIVFVRTDVSGSDNRIAVSPEAVCKTQLGTVVGNAAGVTVSTIEHL
MAALVMLGVDNAVVEVDGPEMPIMDGSALPFVRVLDRAGRREQQAPRRYIEILAPVEVIDGDKRAALRPAEAFEVAFEIR
FGSQAIGTQAIDLPMDEAAFRDELADCRTFGFLHEVEALRAMGLARGGSMENAVVIDGDRILNPEGLRRPDEFVRHKALD
AIGDLFVLGAPVVGRFEGVLAGHGLNNALVRALAARPDAWRVRTFAEDLAEAV
>Mature_293_residues
MFQHTVKAPALFAGVGVHTGAYTRVAVRPAAADTGIVFVRTDVSGSDNRIAVSPEAVCKTQLGTVVGNAAGVTVSTIEHL
MAALVMLGVDNAVVEVDGPEMPIMDGSALPFVRVLDRAGRREQQAPRRYIEILAPVEVIDGDKRAALRPAEAFEVAFEIR
FGSQAIGTQAIDLPMDEAAFRDELADCRTFGFLHEVEALRAMGLARGGSMENAVVIDGDRILNPEGLRRPDEFVRHKALD
AIGDLFVLGAPVVGRFEGVLAGHGLNNALVRALAARPDAWRVRTFAEDLAEAV

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=288, Percent_Identity=43.4027777777778, Blast_Score=237, Evalue=8e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_PHEZH (B4RFF2)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002131151.1
- GeneID:   6791833
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c2312
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- ProtClustDB:   PRK13186
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 31273; Mature: 31273

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQHTVKAPALFAGVGVHTGAYTRVAVRPAAADTGIVFVRTDVSGSDNRIAVSPEAVCKT
CCCCCCCCCHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCEEEECHHHHHHH
QLGTVVGNAAGVTVSTIEHLMAALVMLGVDNAVVEVDGPEMPIMDGSALPFVRVLDRAGR
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCC
REQQAPRRYIEILAPVEVIDGDKRAALRPAEAFEVAFEIRFGSQAIGTQAIDLPMDEAAF
HHHHHHHHHHHHHCCHHEECCCCHHHCCCHHHEEEEEEEEECCHHHCCEEECCCCHHHHH
RDELADCRTFGFLHEVEALRAMGLARGGSMENAVVIDGDRILNPEGLRRPDEFVRHKALD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEECCCCCCCHHHHHHHHHHH
AIGDLFVLGAPVVGRFEGVLAGHGLNNALVRALAARPDAWRVRTFAEDLAEAV
HHHHHHHHCCCHHHHHHHEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MFQHTVKAPALFAGVGVHTGAYTRVAVRPAAADTGIVFVRTDVSGSDNRIAVSPEAVCKT
CCCCCCCCCHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCEEEECHHHHHHH
QLGTVVGNAAGVTVSTIEHLMAALVMLGVDNAVVEVDGPEMPIMDGSALPFVRVLDRAGR
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCC
REQQAPRRYIEILAPVEVIDGDKRAALRPAEAFEVAFEIRFGSQAIGTQAIDLPMDEAAF
HHHHHHHHHHHHHCCHHEECCCCHHHCCCHHHEEEEEEEEECCHHHCCEEECCCCHHHHH
RDELADCRTFGFLHEVEALRAMGLARGGSMENAVVIDGDRILNPEGLRRPDEFVRHKALD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEECCCCCCCHHHHHHHHHHH
AIGDLFVLGAPVVGRFEGVLAGHGLNNALVRALAARPDAWRVRTFAEDLAEAV
HHHHHHHHCCCHHHHHHHEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA