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The map label for this gene is uvrD [H]

Identifier: 197105764

GI number: 197105764

Start: 2607774

End: 2610098

Strand: Direct

Name: uvrD [H]

Synonym: PHZ_c2302

Alternate gene names: 197105764

Gene position: 2607774-2610098 (Clockwise)

Preceding gene: 197105761

Following gene: 197105766

Centisome position: 65.26

GC content: 70.06

Gene sequence:

>2325_bases
ATGTCTTCTGAGTCCTACGAGCCCCCTGCCCCCCGCGTGAGCGACCTCGCCCGCGTCGATCCGCCTGCCGCCGACTACCT
GCAAGGCCTCAATCCCGAGCAGCGCGAGGCCGTGCTCGCCACCGAGGGGCCGGTGCTGGTGCTGGCGGGCGCGGGCACGG
GCAAGACGCGGGTGCTGACCACCCGTCTCGCCCACATCCTGGCCACCGGCAAGGCCCGGCCATGGGAGCTGCTGGCGGTC
ACCTTCACCAACAAGGCCGCCCGCGAGATGCGCGAGCGGATCTCGCACATGATCGGCCCGGCGGCCGAGGGCCTGCGCTG
GCTGGGGACCTTCCACTCGGTGGCCGCCCAGATCCTGCGCCGCCACGCCGAGCTGGTGGGGCTGAAGTCGAACTACACCA
TCCTCGACGACGACGATCAGGAGCGCCTGATCAAGCAGATCCTCGAGGCCGAGAACATCGACGCCAAGCGCTGGACCCCC
AAGGCGCTGGCCGGCCTGATCGACCACTGGAAGAACCGCGGCTGGCGGCCCGACCAGCTTCCGCCGGCCGAGGCGCAGGC
CTTCGCCAACGGCCGCGGCCAGGCGCTGTACCGGCTCTACCAGGAGCGGCTGCGGGTGCTGAACGCCTGCGACTTCGGCG
ACCTGCTGCTGCACAACATCACCATCTTCACCAGCCAGCCCGACGTGCTGGCCGACTACCACGCCCGCTTCCGCTACCTG
CTGGTGGACGAGTACCAGGACACCAACGTCGCCCAGTACCTGTGGCTGCGGCTGCTGGCCCAGAAGAGCCAGAACCTCTG
CTGCGTGGGCGACGACGACCAGTCGATCTACGGCTGGCGCGGGGCCGAGGTGGACAACATCCTGCGCTTCGAGCGGGACT
TCCCGGGCGCCAAGGTCGTGCGGCTCGAGCGCAACTACCGCTCCACCAGCCACATCCTGGCCGCCGCCTCGGGCCTGATC
GCCGCCAACAAGTCCCGCCTGGGCAAGACGCTGTGGACCGAGGCCGAGGGCGGCGAGAAGGTCATCGTGCGCGGCGTCTG
GGACGGCGAGGCCGAGAGCCGGCTGATCGCCGACGAGATCGAGCGGGCCAAGCGCGCCGGCCGCCGCTACCGCGACATCG
CCATCCTGGTGCGCGCCTCGTTCCAGATGCGCGCCTTCGAAGAGCGCTTCGTCCTGCTGCAGATCCCCTACACGGTGGTC
GGCGGCCCCCGGTTCTTCGAGCGGGCCGAGATCCGCGACGCCCACGCCTACCTGCGGCTGATCCAGTCCGAGGATGACGA
CCTGGCCTTCGAGCGGATCGTCAACACGCCCAAGCGGGGCATCGGCGACACCACCGTCCAGAAGCTGCTGCAGGTCGCGC
GCCTCAACGGCGTCTCCGCCACCCGCGCGGCGCGGCAGATCGTGCTGACCGACGAGCTCGCGGCCCGGACGCGGACGTCG
CTCGCCAATTTCCTGCGGGACCTCGACCGCTGGCGCGCCGAGGCCCAGCACGTCGCCCATCCCCGCCTGATGGAGGCGGT
GCTTGAGGAGAGCGGCTACACGGACGCCCTTCGCCTCGATAAGAGCCCGACCGCCCAGACCCGGCTCGAGAACCTCAAGG
AGCTGGTCCAGTCGATGGGGAACTTCGACACGCTCCAAGCCTACCTGGAGCACGTCTCCCTGGTCATGGACCTCGACCGC
GGCCCCGCCGCCGACGCGGTGCAGATCATGACCCTGCACTCGGCCAAGGGCCTGGAGTTCCCGCTGGTCTTCCTGCCCGG
CTGGGAGGAAGGCGTCTTTCCCTCGCAGCGCTCGATGGACGAGAAGGGCGAGAAGGGCCTCGAGGAGGAGCGGCGCCTGG
CCTACGTCGGCATCACCCGGGCGCGGGAGGAGGCGCGGATCAGCTTCGCCGCCAACCGGCAGGTCTACGGCCGCTGGACC
AGCCAGCTGCCCTCGCGCTTCGTCGACGAGTTGCCCCTGGCCAACGTCGAGGCCAGCTCCGAAACCGGCTACTACGGCGG
CGGCCCGGGCATGCAGCAGCACGGCAGCCGCTGGGACGAGAGCCCCTCGTTCGGCGCCGGCTATTCCTCGCCCGGCTGGC
GGCGGGCGCAGGCGTCCAACTACCGCGGCAGCCATCCCGGCCGCCAGCAGGTGATCGAGGGCGACGGCCGGCTGGTCGTC
ACCGGCTCTGAGGCCAAGAGCGACTACAGCCGCGGCGACCGCGTCTTCCACCTCAAGTTCGGCTACGGCACGGTGAAGGG
CATCGAGGGCAACAAGCTGACCGTCGCCTTCGACAAGGCCGGCGAGAAGAAGGTCATCGACAGCTTCGTGGAGAAGCAGT
CCTAG

Upstream 100 bases:

>100_bases
GGAGGGCGATACCGGGCGGGGCGGCGCACGTCCAGCGGCGGGAACGCAGCGCGAACACCGGGGTGCCCTGGCGCGCCCGG
CGTGCTAAGGGCTCCCGGAA

Downstream 100 bases:

>100_bases
GCCTCGGGTCCCCGCCGCCGCATCAGCCGCCGCGCAGCGAAGGTCGCAAGTCCGGCCACCACCGCCGCGCCGGCCGCCAT
CAGCGGGGCCGCCTTGCGGA

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 774; Mature: 773

Protein sequence:

>774_residues
MSSESYEPPAPRVSDLARVDPPAADYLQGLNPEQREAVLATEGPVLVLAGAGTGKTRVLTTRLAHILATGKARPWELLAV
TFTNKAAREMRERISHMIGPAAEGLRWLGTFHSVAAQILRRHAELVGLKSNYTILDDDDQERLIKQILEAENIDAKRWTP
KALAGLIDHWKNRGWRPDQLPPAEAQAFANGRGQALYRLYQERLRVLNACDFGDLLLHNITIFTSQPDVLADYHARFRYL
LVDEYQDTNVAQYLWLRLLAQKSQNLCCVGDDDQSIYGWRGAEVDNILRFERDFPGAKVVRLERNYRSTSHILAAASGLI
AANKSRLGKTLWTEAEGGEKVIVRGVWDGEAESRLIADEIERAKRAGRRYRDIAILVRASFQMRAFEERFVLLQIPYTVV
GGPRFFERAEIRDAHAYLRLIQSEDDDLAFERIVNTPKRGIGDTTVQKLLQVARLNGVSATRAARQIVLTDELAARTRTS
LANFLRDLDRWRAEAQHVAHPRLMEAVLEESGYTDALRLDKSPTAQTRLENLKELVQSMGNFDTLQAYLEHVSLVMDLDR
GPAADAVQIMTLHSAKGLEFPLVFLPGWEEGVFPSQRSMDEKGEKGLEEERRLAYVGITRAREEARISFAANRQVYGRWT
SQLPSRFVDELPLANVEASSETGYYGGGPGMQQHGSRWDESPSFGAGYSSPGWRRAQASNYRGSHPGRQQVIEGDGRLVV
TGSEAKSDYSRGDRVFHLKFGYGTVKGIEGNKLTVAFDKAGEKKVIDSFVEKQS

Sequences:

>Translated_774_residues
MSSESYEPPAPRVSDLARVDPPAADYLQGLNPEQREAVLATEGPVLVLAGAGTGKTRVLTTRLAHILATGKARPWELLAV
TFTNKAAREMRERISHMIGPAAEGLRWLGTFHSVAAQILRRHAELVGLKSNYTILDDDDQERLIKQILEAENIDAKRWTP
KALAGLIDHWKNRGWRPDQLPPAEAQAFANGRGQALYRLYQERLRVLNACDFGDLLLHNITIFTSQPDVLADYHARFRYL
LVDEYQDTNVAQYLWLRLLAQKSQNLCCVGDDDQSIYGWRGAEVDNILRFERDFPGAKVVRLERNYRSTSHILAAASGLI
AANKSRLGKTLWTEAEGGEKVIVRGVWDGEAESRLIADEIERAKRAGRRYRDIAILVRASFQMRAFEERFVLLQIPYTVV
GGPRFFERAEIRDAHAYLRLIQSEDDDLAFERIVNTPKRGIGDTTVQKLLQVARLNGVSATRAARQIVLTDELAARTRTS
LANFLRDLDRWRAEAQHVAHPRLMEAVLEESGYTDALRLDKSPTAQTRLENLKELVQSMGNFDTLQAYLEHVSLVMDLDR
GPAADAVQIMTLHSAKGLEFPLVFLPGWEEGVFPSQRSMDEKGEKGLEEERRLAYVGITRAREEARISFAANRQVYGRWT
SQLPSRFVDELPLANVEASSETGYYGGGPGMQQHGSRWDESPSFGAGYSSPGWRRAQASNYRGSHPGRQQVIEGDGRLVV
TGSEAKSDYSRGDRVFHLKFGYGTVKGIEGNKLTVAFDKAGEKKVIDSFVEKQS
>Mature_773_residues
SSESYEPPAPRVSDLARVDPPAADYLQGLNPEQREAVLATEGPVLVLAGAGTGKTRVLTTRLAHILATGKARPWELLAVT
FTNKAAREMRERISHMIGPAAEGLRWLGTFHSVAAQILRRHAELVGLKSNYTILDDDDQERLIKQILEAENIDAKRWTPK
ALAGLIDHWKNRGWRPDQLPPAEAQAFANGRGQALYRLYQERLRVLNACDFGDLLLHNITIFTSQPDVLADYHARFRYLL
VDEYQDTNVAQYLWLRLLAQKSQNLCCVGDDDQSIYGWRGAEVDNILRFERDFPGAKVVRLERNYRSTSHILAAASGLIA
ANKSRLGKTLWTEAEGGEKVIVRGVWDGEAESRLIADEIERAKRAGRRYRDIAILVRASFQMRAFEERFVLLQIPYTVVG
GPRFFERAEIRDAHAYLRLIQSEDDDLAFERIVNTPKRGIGDTTVQKLLQVARLNGVSATRAARQIVLTDELAARTRTSL
ANFLRDLDRWRAEAQHVAHPRLMEAVLEESGYTDALRLDKSPTAQTRLENLKELVQSMGNFDTLQAYLEHVSLVMDLDRG
PAADAVQIMTLHSAKGLEFPLVFLPGWEEGVFPSQRSMDEKGEKGLEEERRLAYVGITRAREEARISFAANRQVYGRWTS
QLPSRFVDELPLANVEASSETGYYGGGPGMQQHGSRWDESPSFGAGYSSPGWRRAQASNYRGSHPGRQQVIEGDGRLVVT
GSEAKSDYSRGDRVFHLKFGYGTVKGIEGNKLTVAFDKAGEKKVIDSFVEKQS

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=767, Percent_Identity=41.0691003911343, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI48994965, Length=646, Percent_Identity=39.3188854489164, Blast_Score=400, Evalue=1e-112,
Organism=Escherichia coli, GI1787196, Length=354, Percent_Identity=29.6610169491525, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322369, Length=455, Percent_Identity=31.6483516483516, Blast_Score=173, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324477, Length=687, Percent_Identity=23.2896652110626, Blast_Score=111, Evalue=4e-25,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 86844; Mature: 86713

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSESYEPPAPRVSDLARVDPPAADYLQGLNPEQREAVLATEGPVLVLAGAGTGKTRVLT
CCCCCCCCCCCCHHHHHHCCCCHHHHHHCCCCHHHCEEEEECCCEEEEECCCCCCHHHHH
TRLAHILATGKARPWELLAVTFTNKAAREMRERISHMIGPAAEGLRWLGTFHSVAAQILR
HHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RHAELVGLKSNYTILDDDDQERLIKQILEAENIDAKRWTPKALAGLIDHWKNRGWRPDQL
HHHHHEECCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
PPAEAQAFANGRGQALYRLYQERLRVLNACDFGDLLLHNITIFTSQPDVLADYHARFRYL
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEEECCCHHHHHHHHHEEEE
LVDEYQDTNVAQYLWLRLLAQKSQNLCCVGDDDQSIYGWRGAEVDNILRFERDFPGAKVV
EEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCEEE
RLERNYRSTSHILAAASGLIAANKSRLGKTLWTEAEGGEKVIVRGVWDGEAESRLIADEI
EEECCCCHHHHHHHHHHHHHCCCHHHHCHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHH
ERAKRAGRRYRDIAILVRASFQMRAFEERFVLLQIPYTVVGGPRFFERAEIRDAHAYLRL
HHHHHHCCHHHHEEEEEEHHHHHHHHHCCEEEEEECCEEECCCHHHHHHHHHHHHHHHHH
IQSEDDDLAFERIVNTPKRGIGDTTVQKLLQVARLNGVSATRAARQIVLTDELAARTRTS
HHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHEEEEHHHHHHHHHHH
LANFLRDLDRWRAEAQHVAHPRLMEAVLEESGYTDALRLDKSPTAQTRLENLKELVQSMG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHC
NFDTLQAYLEHVSLVMDLDRGPAADAVQIMTLHSAKGLEFPLVFLPGWEEGVFPSQRSMD
CHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCC
EKGEKGLEEERRLAYVGITRAREEARISFAANRQVYGRWTSQLPSRFVDELPLANVEASS
HHHHCCCHHHHHEEEEEHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCC
ETGYYGGGPGMQQHGSRWDESPSFGAGYSSPGWRRAQASNYRGSHPGRQQVIEGDGRLVV
CCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEE
TGSEAKSDYSRGDRVFHLKFGYGTVKGIEGNKLTVAFDKAGEKKVIDSFVEKQS
ECCCCCCHHCCCCEEEEEEECCCEEECCCCCEEEEEECCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SSESYEPPAPRVSDLARVDPPAADYLQGLNPEQREAVLATEGPVLVLAGAGTGKTRVLT
CCCCCCCCCCCHHHHHHCCCCHHHHHHCCCCHHHCEEEEECCCEEEEECCCCCCHHHHH
TRLAHILATGKARPWELLAVTFTNKAAREMRERISHMIGPAAEGLRWLGTFHSVAAQILR
HHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RHAELVGLKSNYTILDDDDQERLIKQILEAENIDAKRWTPKALAGLIDHWKNRGWRPDQL
HHHHHEECCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
PPAEAQAFANGRGQALYRLYQERLRVLNACDFGDLLLHNITIFTSQPDVLADYHARFRYL
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEEECCCHHHHHHHHHEEEE
LVDEYQDTNVAQYLWLRLLAQKSQNLCCVGDDDQSIYGWRGAEVDNILRFERDFPGAKVV
EEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCEEE
RLERNYRSTSHILAAASGLIAANKSRLGKTLWTEAEGGEKVIVRGVWDGEAESRLIADEI
EEECCCCHHHHHHHHHHHHHCCCHHHHCHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHH
ERAKRAGRRYRDIAILVRASFQMRAFEERFVLLQIPYTVVGGPRFFERAEIRDAHAYLRL
HHHHHHCCHHHHEEEEEEHHHHHHHHHCCEEEEEECCEEECCCHHHHHHHHHHHHHHHHH
IQSEDDDLAFERIVNTPKRGIGDTTVQKLLQVARLNGVSATRAARQIVLTDELAARTRTS
HHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHEEEEHHHHHHHHHHH
LANFLRDLDRWRAEAQHVAHPRLMEAVLEESGYTDALRLDKSPTAQTRLENLKELVQSMG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHC
NFDTLQAYLEHVSLVMDLDRGPAADAVQIMTLHSAKGLEFPLVFLPGWEEGVFPSQRSMD
CHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCC
EKGEKGLEEERRLAYVGITRAREEARISFAANRQVYGRWTSQLPSRFVDELPLANVEASS
HHHHCCCHHHHHEEEEEHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCC
ETGYYGGGPGMQQHGSRWDESPSFGAGYSSPGWRRAQASNYRGSHPGRQQVIEGDGRLVV
CCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEE
TGSEAKSDYSRGDRVFHLKFGYGTVKGIEGNKLTVAFDKAGEKKVIDSFVEKQS
ECCCCCCHHCCCCEEEEEEECCCEEECCCCCEEEEEECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA