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The map label for this gene is ilvB [H]

Identifier: 197105598

GI number: 197105598

Start: 2402699

End: 2404432

Strand: Direct

Name: ilvB [H]

Synonym: PHZ_c2135

Alternate gene names: 197105598

Gene position: 2402699-2404432 (Clockwise)

Preceding gene: 197105595

Following gene: 197105599

Centisome position: 60.12

GC content: 73.47

Gene sequence:

>1734_bases
ATGACCAAAAAGCGCGCAGCGGGCGAGTTGGCGGCCGCCGCCCTGGCGGGCCTCGGCGTCACGGAGGTGTTCGCGCTGCA
CGGCAGCCACCTCGATCCCCTGTTCATGGCCTGCGAGGAGTTCGGCATCCGGCTGACCGACACCCGCCACGAGGCGTCGG
CGGGCCACGCGGCCGACGCCTACGCCCGCGCCTCCAACGGCAAGCTCGGCGTCTGCGCCGTCACGGCCGGGCCGGGCTTC
ACCAACGCCCTGACGGCGATGGCCAACGCGCACCTCGACCGGATCCCCACGCTGTTCATCGCCGGCGCCGCGCCGCTCCG
GGAAGCGGAGGCCAACACCCTGCAGGGCGGCTTCGACGCCGTCGCCATGGCCCGGCCCGTCACCAAGTGGGCGCAGCGGG
TCAGCGAGCCCGACCGCATCGTCGAGTTCATCCGCCGGGCGGGCGAGATCGCCCTCAGCGGCGCACCCGGGCCGGTGTTC
CTCGAAATCCCCATCGACGTGATGTTCTGGCCGATCGACCAGGCGCCGCCGGACGTCTCCACCTGGAAGCGGCCGCCGCG
CCCGGCGCCGGCCCCGGACGTCGTCGAGGCCGTGGTCGAGATGTTCCGCAAGGCCGAGCGGCCGGTGATCATCGCCGGCG
GCGGAGCGGTCCTGACCAACTCCGGCGAGCGCCTGCGGCGGCTGGCCGAACTGGTCGGCGCGCCGGTGATCGCCAGCCAG
AAGGCGCTGGGCGCCCTCCCCGACGACCACCCCTACTACGCCGGCGCCGCCGCAGGCCTGGCCGCGGCGGCCGCCTCGGG
CGAGCCGGCCGACGCCGTGCTCCTCGTGGGCGCCCGGATGGGCATGTTCCTCGGCGGGGCCATGGGCGCGATCATCCCCG
AGGGCGCCTATGTCGCCCAGATCGAGTCGAACCCGGAGGAGATCGGCCGGGTGCGCATGGCCGACCTGCCCATCGTGGCG
GACGCGGGGGCGACCCTGGACGCCCTGATCCAGCGGGCGGGCGGCGAGGACTGGCCCAAGCGGGAGGCCTGGGCGGCCAA
ACTGCGCAGCTTCCGCGGCAATGTCCGCAAGGCTTTCGCCGACGCGCCGGTCAATTCCCGGCCGGGCGCCATCCATCCCG
GCCACGCGGTGGCGGCGATCATGGACGCCCTGCCCGAGGGGACCACCGTGGTGGCCGACGGCGGCGAGGCGGGCAACTGG
GTGGGCGACCTGGTGCGCTCGCCGGGCGCCGGCCGGTTCCTGCGCTGCGGCTATCTCGGCTGCCTGGGCATCTCGCCGGG
CTTCGCGATCGGGGCGGCCCGGGCCACCCCCGGCCAGCCCGTGGTCTGCTTCGCCGGCGACGGCGGGGCGGGTTTCCACA
TCCAGGAACTCGACACCATGGTGCGGCACAAGCTGCCGATCGTCACGGTGATCCTGAACAACGCCGAATGGGGCATGTCG
CGGAACGCCCAGAACCTCCTCTACGGCAAGAACCGGGAGGTGATCGTGGCCTTGCAGGACACCCGCTATGAGGACGTGGC
TCGCGGCTTCGGCGTCGAGGCGGTGCGCATCGACCGCTACGAGGACCTCGAGCCGGCGGTGAAGGCCGCCTTCGCCGCGG
GCGAGCCCCGCTGCCTGAACGTCATCATCGACGCCGGCGTCATGCATCCGCGGACCCGGATGATGGTGGGCGACGTCAGC
GGCGCGGACGGGGTTCCGATCCCCTACTACGCCAACATCCCGACGGGCCGGTGA

Upstream 100 bases:

>100_bases
CGAGGATATTGGATGCAGATTTTGCACCCTGCATCCGCGCGAGCCATCCGCCGGACAGCCTAAGCCGGCGAACCGAGTCT
AAGAACAGTTTGGGGGAAAC

Downstream 100 bases:

>100_bases
GCGAGCCCTGGCCCGGGGCCGCGGCGGCGCTGGCGGCCGCGGAGCGGCTGTTCTGGACGGTGGAGCACGGCGACCTGGAG
GCGCTGCGCGACATCTTCGC

Product: acetolactate synthase, large subunit

Products: NA

Alternate protein names: Benzoin aldolase; BL; BZL [H]

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MTKKRAAGELAAAALAGLGVTEVFALHGSHLDPLFMACEEFGIRLTDTRHEASAGHAADAYARASNGKLGVCAVTAGPGF
TNALTAMANAHLDRIPTLFIAGAAPLREAEANTLQGGFDAVAMARPVTKWAQRVSEPDRIVEFIRRAGEIALSGAPGPVF
LEIPIDVMFWPIDQAPPDVSTWKRPPRPAPAPDVVEAVVEMFRKAERPVIIAGGGAVLTNSGERLRRLAELVGAPVIASQ
KALGALPDDHPYYAGAAAGLAAAAASGEPADAVLLVGARMGMFLGGAMGAIIPEGAYVAQIESNPEEIGRVRMADLPIVA
DAGATLDALIQRAGGEDWPKREAWAAKLRSFRGNVRKAFADAPVNSRPGAIHPGHAVAAIMDALPEGTTVVADGGEAGNW
VGDLVRSPGAGRFLRCGYLGCLGISPGFAIGAARATPGQPVVCFAGDGGAGFHIQELDTMVRHKLPIVTVILNNAEWGMS
RNAQNLLYGKNREVIVALQDTRYEDVARGFGVEAVRIDRYEDLEPAVKAAFAAGEPRCLNVIIDAGVMHPRTRMMVGDVS
GADGVPIPYYANIPTGR

Sequences:

>Translated_577_residues
MTKKRAAGELAAAALAGLGVTEVFALHGSHLDPLFMACEEFGIRLTDTRHEASAGHAADAYARASNGKLGVCAVTAGPGF
TNALTAMANAHLDRIPTLFIAGAAPLREAEANTLQGGFDAVAMARPVTKWAQRVSEPDRIVEFIRRAGEIALSGAPGPVF
LEIPIDVMFWPIDQAPPDVSTWKRPPRPAPAPDVVEAVVEMFRKAERPVIIAGGGAVLTNSGERLRRLAELVGAPVIASQ
KALGALPDDHPYYAGAAAGLAAAAASGEPADAVLLVGARMGMFLGGAMGAIIPEGAYVAQIESNPEEIGRVRMADLPIVA
DAGATLDALIQRAGGEDWPKREAWAAKLRSFRGNVRKAFADAPVNSRPGAIHPGHAVAAIMDALPEGTTVVADGGEAGNW
VGDLVRSPGAGRFLRCGYLGCLGISPGFAIGAARATPGQPVVCFAGDGGAGFHIQELDTMVRHKLPIVTVILNNAEWGMS
RNAQNLLYGKNREVIVALQDTRYEDVARGFGVEAVRIDRYEDLEPAVKAAFAAGEPRCLNVIIDAGVMHPRTRMMVGDVS
GADGVPIPYYANIPTGR
>Mature_576_residues
TKKRAAGELAAAALAGLGVTEVFALHGSHLDPLFMACEEFGIRLTDTRHEASAGHAADAYARASNGKLGVCAVTAGPGFT
NALTAMANAHLDRIPTLFIAGAAPLREAEANTLQGGFDAVAMARPVTKWAQRVSEPDRIVEFIRRAGEIALSGAPGPVFL
EIPIDVMFWPIDQAPPDVSTWKRPPRPAPAPDVVEAVVEMFRKAERPVIIAGGGAVLTNSGERLRRLAELVGAPVIASQK
ALGALPDDHPYYAGAAAGLAAAAASGEPADAVLLVGARMGMFLGGAMGAIIPEGAYVAQIESNPEEIGRVRMADLPIVAD
AGATLDALIQRAGGEDWPKREAWAAKLRSFRGNVRKAFADAPVNSRPGAIHPGHAVAAIMDALPEGTTVVADGGEAGNWV
GDLVRSPGAGRFLRCGYLGCLGISPGFAIGAARATPGQPVVCFAGDGGAGFHIQELDTMVRHKLPIVTVILNNAEWGMSR
NAQNLLYGKNREVIVALQDTRYEDVARGFGVEAVRIDRYEDLEPAVKAAFAAGEPRCLNVIIDAGVMHPRTRMMVGDVSG
ADGVPIPYYANIPTGR

Specific function: Cleavage of benzoin-anisoin acyloin linkage [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=585, Percent_Identity=30.9401709401709, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI93004078, Length=558, Percent_Identity=24.910394265233, Blast_Score=178, Evalue=1e-44,
Organism=Escherichia coli, GI1786717, Length=555, Percent_Identity=31.8918918918919, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI87081685, Length=539, Percent_Identity=27.4582560296846, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1788716, Length=513, Percent_Identity=29.8245614035088, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1790104, Length=551, Percent_Identity=29.2196007259528, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1787096, Length=546, Percent_Identity=25.2747252747253, Blast_Score=138, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17542570, Length=559, Percent_Identity=30.7692307692308, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17531299, Length=558, Percent_Identity=26.7025089605735, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17531301, Length=558, Percent_Identity=26.7025089605735, Blast_Score=156, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323755, Length=568, Percent_Identity=26.9366197183099, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6320816, Length=574, Percent_Identity=25.7839721254355, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321524, Length=509, Percent_Identity=22.5933202357564, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323163, Length=518, Percent_Identity=24.5173745173745, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922626, Length=579, Percent_Identity=27.979274611399, Blast_Score=184, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.2.38 [H]

Molecular weight: Translated: 60329; Mature: 60198

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00187 TPP_ENZYMES ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKRAAGELAAAALAGLGVTEVFALHGSHLDPLFMACEEFGIRLTDTRHEASAGHAADA
CCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCHHH
YARASNGKLGVCAVTAGPGFTNALTAMANAHLDRIPTLFIAGAAPLREAEANTLQGGFDA
HHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCCCCCHHH
VAMARPVTKWAQRVSEPDRIVEFIRRAGEIALSGAPGPVFLEIPIDVMFWPIDQAPPDVS
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCEEEEECCEEEEEECCCCCCCHH
TWKRPPRPAPAPDVVEAVVEMFRKAERPVIIAGGGAVLTNSGERLRRLAELVGAPVIASQ
HCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEEECCCHHHHHHHHHHCCCCEECC
KALGALPDDHPYYAGAAAGLAAAAASGEPADAVLLVGARMGMFLGGAMGAIIPEGAYVAQ
HHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEE
IESNPEEIGRVRMADLPIVADAGATLDALIQRAGGEDWPKREAWAAKLRSFRGNVRKAFA
ECCCHHHHCCEEECCCCEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DAPVNSRPGAIHPGHAVAAIMDALPEGTTVVADGGEAGNWVGDLVRSPGAGRFLRCGYLG
CCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHCCCCCCCEEEECEEE
CLGISPGFAIGAARATPGQPVVCFAGDGGAGFHIQELDTMVRHKLPIVTVILNNAEWGMS
EECCCCCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCC
RNAQNLLYGKNREVIVALQDTRYEDVARGFGVEAVRIDRYEDLEPAVKAAFAAGEPRCLN
CCCCHHEECCCCCEEEEECCCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEE
VIIDAGVMHPRTRMMVGDVSGADGVPIPYYANIPTGR
EEEECCCCCCCCEEEEECCCCCCCCCCCEEECCCCCC
>Mature Secondary Structure 
TKKRAAGELAAAALAGLGVTEVFALHGSHLDPLFMACEEFGIRLTDTRHEASAGHAADA
CCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCHHH
YARASNGKLGVCAVTAGPGFTNALTAMANAHLDRIPTLFIAGAAPLREAEANTLQGGFDA
HHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCCCCCHHH
VAMARPVTKWAQRVSEPDRIVEFIRRAGEIALSGAPGPVFLEIPIDVMFWPIDQAPPDVS
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCEEEEECCEEEEEECCCCCCCHH
TWKRPPRPAPAPDVVEAVVEMFRKAERPVIIAGGGAVLTNSGERLRRLAELVGAPVIASQ
HCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEEECCCHHHHHHHHHHCCCCEECC
KALGALPDDHPYYAGAAAGLAAAAASGEPADAVLLVGARMGMFLGGAMGAIIPEGAYVAQ
HHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEE
IESNPEEIGRVRMADLPIVADAGATLDALIQRAGGEDWPKREAWAAKLRSFRGNVRKAFA
ECCCHHHHCCEEECCCCEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DAPVNSRPGAIHPGHAVAAIMDALPEGTTVVADGGEAGNWVGDLVRSPGAGRFLRCGYLG
CCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHCCCCCCCEEEECEEE
CLGISPGFAIGAARATPGQPVVCFAGDGGAGFHIQELDTMVRHKLPIVTVILNNAEWGMS
EECCCCCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCC
RNAQNLLYGKNREVIVALQDTRYEDVARGFGVEAVRIDRYEDLEPAVKAAFAAGEPRCLN
CCCCHHEECCCCCEEEEECCCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEE
VIIDAGVMHPRTRMMVGDVSGADGVPIPYYANIPTGR
EEEECCCCCCCCEEEEECCCCCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8026749 [H]