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The map label for this gene is ghrA [H]

Identifier: 197105466

GI number: 197105466

Start: 2240236

End: 2241168

Strand: Reverse

Name: ghrA [H]

Synonym: PHZ_c2003

Alternate gene names: 197105466

Gene position: 2241168-2240236 (Counterclockwise)

Preceding gene: 197105467

Following gene: 197105465

Centisome position: 56.08

GC content: 72.24

Gene sequence:

>933_bases
TTGCCCAATCCCGTGCTGCTGTTCGCCTGCCACGATGTTCCGGCGGAGCCCTGGCTCGTGGCCCTCCAGCGCGCCGCGCC
GGAGCTGGAGGTCCGCCTCTCGCCCGAGGGCCCGCCCGAGACCGTCGACTTCGGCCTGGCCTGGGCGACCCCGCCTGGCT
TCTGGAACCGGTTCCCCCGCCTGCGGGCGATCTTTTCGCTGGGCGCCGGCGTCGAGCATCTGCTGGCGTCCGGGGCGCCG
GCGCACGTTCCGCTCGTGCGAATGACCGACCCCGGCCTGGCTCGGGACATGAGCGACTTCGTGCTGATGCGCGTGCTCCA
CTACCACCGGGGCATGCACCTCTACCTGCGCCAGCAGGAGGCGCAGGTCTGGACGCCGATCCGGCCGCCCCGGCCGAACG
GGCGGACCGTAGGAGTGATGGGCCTGGGGGAACTCGGCGCGCATTGCGCCCGCACCCTAGCGGAGGTGGGATTCAGGACC
CGGGGCTGGAGCCGGAGCGCCAAGGCCGTCGAGGGCGTGGCGACCTTCGCCGGGCGCGATGAGCTCCCGCGGTTCCTGGA
AGGGTGTGAGATTCTCGTCTGCCTCCTGCCGCTCACGGCCGAGACCCGGGACATTCTGGATGCCAAGCTGTTTGCGGCGC
TACCGCAGGGGGCGTGCCTGATCCAGGTCGGCCGGGGGTTGCAACTGGTCGAGGCCGACCTGCTGGCGGCGCTCGACGCC
GGCCGCATCGCCGCGGCCACGCTCGACGTCTTCCGGCAGGAGCCGCTGCCGCAGGGCCATCCTTTCTGGAGCCGGGCGGA
CATCACCGTCGTCCCGCACGCGGCCGCCTTCACCTATCCCGAGACCGCCGCGGAGGTCGTGGCCGAGAACGTCCGTCGGT
TGCAGGCGGGCGAGGTCCCGATCGGCCTCGTGGACCGGGCGCTCGGCTATTGA

Upstream 100 bases:

>100_bases
CCGCTGGCTCGAACGAGAAGCCGCGAAGACCCCGGCCTGACGGTCGCCGCTCCTTACGAATCGCGGGAAGCGTGCCGCCC
ACCCCAGACGGAGCGCTCGT

Downstream 100 bases:

>100_bases
GCGTCAGTGGTGTGGATGGGCGTGATGACCGTCGACGCGCATGGCCTCATCAATGATCTCCAGGCGCTCCTGCCGTAGCC
GGTCCGTCAGGTCCGGGGCG

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MPNPVLLFACHDVPAEPWLVALQRAAPELEVRLSPEGPPETVDFGLAWATPPGFWNRFPRLRAIFSLGAGVEHLLASGAP
AHVPLVRMTDPGLARDMSDFVLMRVLHYHRGMHLYLRQQEAQVWTPIRPPRPNGRTVGVMGLGELGAHCARTLAEVGFRT
RGWSRSAKAVEGVATFAGRDELPRFLEGCEILVCLLPLTAETRDILDAKLFAALPQGACLIQVGRGLQLVEADLLAALDA
GRIAAATLDVFRQEPLPQGHPFWSRADITVVPHAAAFTYPETAAEVVAENVRRLQAGEVPIGLVDRALGY

Sequences:

>Translated_310_residues
MPNPVLLFACHDVPAEPWLVALQRAAPELEVRLSPEGPPETVDFGLAWATPPGFWNRFPRLRAIFSLGAGVEHLLASGAP
AHVPLVRMTDPGLARDMSDFVLMRVLHYHRGMHLYLRQQEAQVWTPIRPPRPNGRTVGVMGLGELGAHCARTLAEVGFRT
RGWSRSAKAVEGVATFAGRDELPRFLEGCEILVCLLPLTAETRDILDAKLFAALPQGACLIQVGRGLQLVEADLLAALDA
GRIAAATLDVFRQEPLPQGHPFWSRADITVVPHAAAFTYPETAAEVVAENVRRLQAGEVPIGLVDRALGY
>Mature_309_residues
PNPVLLFACHDVPAEPWLVALQRAAPELEVRLSPEGPPETVDFGLAWATPPGFWNRFPRLRAIFSLGAGVEHLLASGAPA
HVPLVRMTDPGLARDMSDFVLMRVLHYHRGMHLYLRQQEAQVWTPIRPPRPNGRTVGVMGLGELGAHCARTLAEVGFRTR
GWSRSAKAVEGVATFAGRDELPRFLEGCEILVCLLPLTAETRDILDAKLFAALPQGACLIQVGRGLQLVEADLLAALDAG
RIAAATLDVFRQEPLPQGHPFWSRADITVVPHAAAFTYPETAAEVVAENVRRLQAGEVPIGLVDRALGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=229, Percent_Identity=26.6375545851528, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI23308577, Length=258, Percent_Identity=25.5813953488372, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87081824, Length=312, Percent_Identity=39.4230769230769, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI87082289, Length=279, Percent_Identity=28.673835125448, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17532191, Length=242, Percent_Identity=24.3801652892562, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325144, Length=154, Percent_Identity=25.3246753246753, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28574286, Length=167, Percent_Identity=29.940119760479, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24585514, Length=258, Percent_Identity=26.3565891472868, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574282, Length=258, Percent_Identity=26.3565891472868, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574284, Length=258, Percent_Identity=26.3565891472868, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45551003, Length=170, Percent_Identity=31.7647058823529, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45552429, Length=258, Percent_Identity=26.3565891472868, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571528, Length=180, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33752; Mature: 33621

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNPVLLFACHDVPAEPWLVALQRAAPELEVRLSPEGPPETVDFGLAWATPPGFWNRFPR
CCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCEEECEEECCCCHHHHHHHH
LRAIFSLGAGVEHLLASGAPAHVPLVRMTDPGLARDMSDFVLMRVLHYHRGMHLYLRQQE
HHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEECC
AQVWTPIRPPRPNGRTVGVMGLGELGAHCARTLAEVGFRTRGWSRSAKAVEGVATFAGRD
CCEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHH
ELPRFLEGCEILVCLLPLTAETRDILDAKLFAALPQGACLIQVGRGLQLVEADLLAALDA
HHHHHHHHHHEEHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCC
GRIAAATLDVFRQEPLPQGHPFWSRADITVVPHAAAFTYPETAAEVVAENVRRLQAGEVP
CHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHCCCCHHHHHHHHHHHHHHHCCCCC
IGLVDRALGY
HHHHHHHHCC
>Mature Secondary Structure 
PNPVLLFACHDVPAEPWLVALQRAAPELEVRLSPEGPPETVDFGLAWATPPGFWNRFPR
CCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCEEECEEECCCCHHHHHHHH
LRAIFSLGAGVEHLLASGAPAHVPLVRMTDPGLARDMSDFVLMRVLHYHRGMHLYLRQQE
HHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEECC
AQVWTPIRPPRPNGRTVGVMGLGELGAHCARTLAEVGFRTRGWSRSAKAVEGVATFAGRD
CCEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHH
ELPRFLEGCEILVCLLPLTAETRDILDAKLFAALPQGACLIQVGRGLQLVEADLLAALDA
HHHHHHHHHHEEHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCC
GRIAAATLDVFRQEPLPQGHPFWSRADITVVPHAAAFTYPETAAEVVAENVRRLQAGEVP
CHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHCCCCHHHHHHHHHHHHHHHCCCCC
IGLVDRALGY
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]