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The map label for this gene is ethA [H]

Identifier: 197105374

GI number: 197105374

Start: 2139951

End: 2141450

Strand: Reverse

Name: ethA [H]

Synonym: PHZ_c1911

Alternate gene names: 197105374

Gene position: 2141450-2139951 (Counterclockwise)

Preceding gene: 197105375

Following gene: 197105373

Centisome position: 53.59

GC content: 67.4

Gene sequence:

>1500_bases
GTGGGAATCCAGATGGCTGTCGAACACTTCGACGTGGTGATCGTGGGCGCGGGCCTGTCCGGCGTGGGCGCCGGCTACCA
CCTGCAGACCGAGGCGCCCGACCGCAGCTACGTCATCCTCGAGGGCCGCGACGCCTCGGGCGGGACCTGGGACCTGTTCC
GCTATCCCGGCATCCGCTCGGACAGCGACATGTACACCCTGGGCTACGCCTTCAAGCCGTGGCGCGAGGCCAAGGCGATC
GCCGACGGCCCCTCGATCCTGCGGTACGTGCGCGAGACGGCCGCCGAGCACGGCATCGACCGTCACATCCGGTTCCGCCA
CCTCGTCAAGCGGGCCTCCTGGTCCACCGAGGACGCGCTCTGGACCGTCGAGGCCGAGCACTCCGGCAAGACTGTCCGCT
TCACCTGCAGCTTCCTGTTCCTGTGCGGCGGCTACTATTCCTACGAGGGCGGCTACACGCCCGAATACCCGGGCCGCGAG
CGCTTCAAGGGCGCCTTCGTCCATCCCCAGCAGTGGCCCGAGGGCCTCGACTACACGGGCAAGAAGGTCGTGGTGATCGG
CTCGGGGGCGACGGCGGTCACCCTGGTGCCCGAGATGGCCAAGGACGCCGCCCACGTCGTCATGCTGCAGCGCTCGCCGA
CCTACGTGGTCTCGCGGCCCGCCGAGGACCGGTTCGCCAACTGGCTGCGCAAGGTGCTGCCGGGCAAGCTCGCCTATGAC
ATCGTCCGTTGGCGCAACGTCCTGTTTGGCATGTACTTCTTCAAGATGGCCCGCGAGAAGCCCGAGGCGGTCAAGGCGCG
CATCCTGAAGATGGTCCGCCAGGAGCTGGGCCCGGACTACGACATCGAGACCCACTTCACCCCCAGCTACAATCCCTGGG
ACCAGCGCCTCTGCCTGGTGCCGGACTCCGACATGTTCAAGATGATCAAGTCGGGCCGCGCCTCGGTGGTCACCGACCAT
ATCGAGACGTTCACCGAGACGGGGATCCGCCTGAAGTCCGGGCAGGAGCTGGAGGCCGACGTCGTCGTCTCGGCGACCGG
CCTCGTCCTCGAGGTCTGGAACGGCGTCGAGCTCACCGTCGACGGCCGCAAGGTCGATGCGTCCCAGACGCTGTCCTACA
AGGGCATGATGTACGAGGGCGTGCCGAACCTGGCCTCGGCCTTCGGCTACACCAACGCCTCCTGGACCCTGAAGTGCGAC
CTGACGTGCGAGTACGTCAGCCGGGTCCTGAACCACATGAAGAAGACCGGCCTGCGCCAGGCGACGCCGGTGAACGACGA
TCCCACCGTGACGCACGAGCCGTGGCTGGACTTCTCGTCGGGCTACGTCCAGCGGGCGATGGCCAGGTTCCCCAAGCAGG
GGAACAAGCCGCCGTGGAAGCTCTATCAGAACTACGCCCTCGACCTGATGAGCCTGCGCTACGCCAAGCTCGACGACGGC
GTGCTGCGGTTCACCAACCCGGCCGGCCAGGCCAAGGAGCGCCCGAAGCTCGCCGCCTGA

Upstream 100 bases:

>100_bases
GAGCCGCTGGTGGACTACCTCGTGGCGCTGAGCGAGGGCGCGCCCTTTTCGGCTGGAAAGTGATCGGCGTTCAGATATCT
TCCGCCGCAAATCTCAAAGG

Downstream 100 bases:

>100_bases
GCCTTGCCGTCCGCCCGGGTTTTGGATTACACATGTAGTCTATAAATCCGGGAGGGCGCCCATGACCAGGGACCTGGGGG
TTCGCAGTCCGCCGCGGCGC

Product: flavin binding monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MGIQMAVEHFDVVIVGAGLSGVGAGYHLQTEAPDRSYVILEGRDASGGTWDLFRYPGIRSDSDMYTLGYAFKPWREAKAI
ADGPSILRYVRETAAEHGIDRHIRFRHLVKRASWSTEDALWTVEAEHSGKTVRFTCSFLFLCGGYYSYEGGYTPEYPGRE
RFKGAFVHPQQWPEGLDYTGKKVVVIGSGATAVTLVPEMAKDAAHVVMLQRSPTYVVSRPAEDRFANWLRKVLPGKLAYD
IVRWRNVLFGMYFFKMAREKPEAVKARILKMVRQELGPDYDIETHFTPSYNPWDQRLCLVPDSDMFKMIKSGRASVVTDH
IETFTETGIRLKSGQELEADVVVSATGLVLEVWNGVELTVDGRKVDASQTLSYKGMMYEGVPNLASAFGYTNASWTLKCD
LTCEYVSRVLNHMKKTGLRQATPVNDDPTVTHEPWLDFSSGYVQRAMARFPKQGNKPPWKLYQNYALDLMSLRYAKLDDG
VLRFTNPAGQAKERPKLAA

Sequences:

>Translated_499_residues
MGIQMAVEHFDVVIVGAGLSGVGAGYHLQTEAPDRSYVILEGRDASGGTWDLFRYPGIRSDSDMYTLGYAFKPWREAKAI
ADGPSILRYVRETAAEHGIDRHIRFRHLVKRASWSTEDALWTVEAEHSGKTVRFTCSFLFLCGGYYSYEGGYTPEYPGRE
RFKGAFVHPQQWPEGLDYTGKKVVVIGSGATAVTLVPEMAKDAAHVVMLQRSPTYVVSRPAEDRFANWLRKVLPGKLAYD
IVRWRNVLFGMYFFKMAREKPEAVKARILKMVRQELGPDYDIETHFTPSYNPWDQRLCLVPDSDMFKMIKSGRASVVTDH
IETFTETGIRLKSGQELEADVVVSATGLVLEVWNGVELTVDGRKVDASQTLSYKGMMYEGVPNLASAFGYTNASWTLKCD
LTCEYVSRVLNHMKKTGLRQATPVNDDPTVTHEPWLDFSSGYVQRAMARFPKQGNKPPWKLYQNYALDLMSLRYAKLDDG
VLRFTNPAGQAKERPKLAA
>Mature_498_residues
GIQMAVEHFDVVIVGAGLSGVGAGYHLQTEAPDRSYVILEGRDASGGTWDLFRYPGIRSDSDMYTLGYAFKPWREAKAIA
DGPSILRYVRETAAEHGIDRHIRFRHLVKRASWSTEDALWTVEAEHSGKTVRFTCSFLFLCGGYYSYEGGYTPEYPGRER
FKGAFVHPQQWPEGLDYTGKKVVVIGSGATAVTLVPEMAKDAAHVVMLQRSPTYVVSRPAEDRFANWLRKVLPGKLAYDI
VRWRNVLFGMYFFKMAREKPEAVKARILKMVRQELGPDYDIETHFTPSYNPWDQRLCLVPDSDMFKMIKSGRASVVTDHI
ETFTETGIRLKSGQELEADVVVSATGLVLEVWNGVELTVDGRKVDASQTLSYKGMMYEGVPNLASAFGYTNASWTLKCDL
TCEYVSRVLNHMKKTGLRQATPVNDDPTVTHEPWLDFSSGYVQRAMARFPKQGNKPPWKLYQNYALDLMSLRYAKLDDGV
LRFTNPAGQAKERPKLAA

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503757, Length=248, Percent_Identity=25.4032258064516, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4503759, Length=257, Percent_Identity=26.0700389105058, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI50541965, Length=250, Percent_Identity=23.2, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI50541961, Length=250, Percent_Identity=23.2, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25145785, Length=348, Percent_Identity=25.2873563218391, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI193202226, Length=233, Percent_Identity=26.6094420600858, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17541300, Length=375, Percent_Identity=23.2, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17561948, Length=377, Percent_Identity=23.0769230769231, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 56243; Mature: 56112

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIQMAVEHFDVVIVGAGLSGVGAGYHLQTEAPDRSYVILEGRDASGGTWDLFRYPGIRS
CCCEEEEEECCEEEEECCCCCCCCCEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCC
DSDMYTLGYAFKPWREAKAIADGPSILRYVRETAAEHGIDRHIRFRHLVKRASWSTEDAL
CCCEEEEECEECCHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCE
WTVEAEHSGKTVRFTCSFLFLCGGYYSYEGGYTPEYPGRERFKGAFVHPQQWPEGLDYTG
EEEEECCCCCEEEEEEHHHHHHCCEEECCCCCCCCCCCHHHCCCCCCCHHHCCCCCCCCC
KKVVVIGSGATAVTLVPEMAKDAAHVVMLQRSPTYVVSRPAEDRFANWLRKVLPGKLAYD
CEEEEEECCCEEEEECHHHHCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHCCCHHHHH
IVRWRNVLFGMYFFKMAREKPEAVKARILKMVRQELGPDYDIETHFTPSYNPWDQRLCLV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCEEEEC
PDSDMFKMIKSGRASVVTDHIETFTETGIRLKSGQELEADVVVSATGLVLEVWNGVELTV
CCHHHHHHHHCCCCHHHHHHHHHHHHCCEEECCCCCCCCEEEEECCCEEEEECCCEEEEE
DGRKVDASQTLSYKGMMYEGVPNLASAFGYTNASWTLKCDLTCEYVSRVLNHMKKTGLRQ
CCCEECHHHHHEECCEEECCCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCC
ATPVNDDPTVTHEPWLDFSSGYVQRAMARFPKQGNKPPWKLYQNYALDLMSLRYAKLDDG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
VLRFTNPAGQAKERPKLAA
EEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
GIQMAVEHFDVVIVGAGLSGVGAGYHLQTEAPDRSYVILEGRDASGGTWDLFRYPGIRS
CCEEEEEECCEEEEECCCCCCCCCEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCC
DSDMYTLGYAFKPWREAKAIADGPSILRYVRETAAEHGIDRHIRFRHLVKRASWSTEDAL
CCCEEEEECEECCHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCE
WTVEAEHSGKTVRFTCSFLFLCGGYYSYEGGYTPEYPGRERFKGAFVHPQQWPEGLDYTG
EEEEECCCCCEEEEEEHHHHHHCCEEECCCCCCCCCCCHHHCCCCCCCHHHCCCCCCCCC
KKVVVIGSGATAVTLVPEMAKDAAHVVMLQRSPTYVVSRPAEDRFANWLRKVLPGKLAYD
CEEEEEECCCEEEEECHHHHCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHCCCHHHHH
IVRWRNVLFGMYFFKMAREKPEAVKARILKMVRQELGPDYDIETHFTPSYNPWDQRLCLV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCEEEEC
PDSDMFKMIKSGRASVVTDHIETFTETGIRLKSGQELEADVVVSATGLVLEVWNGVELTV
CCHHHHHHHHCCCCHHHHHHHHHHHHCCEEECCCCCCCCEEEEECCCEEEEECCCEEEEE
DGRKVDASQTLSYKGMMYEGVPNLASAFGYTNASWTLKCDLTCEYVSRVLNHMKKTGLRQ
CCCEECHHHHHEECCEEECCCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCC
ATPVNDDPTVTHEPWLDFSSGYVQRAMARFPKQGNKPPWKLYQNYALDLMSLRYAKLDDG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
VLRFTNPAGQAKERPKLAA
EEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA