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The map label for this gene is folK [H]

Identifier: 197105346

GI number: 197105346

Start: 2109617

End: 2110129

Strand: Reverse

Name: folK [H]

Synonym: PHZ_c1883

Alternate gene names: 197105346

Gene position: 2110129-2109617 (Counterclockwise)

Preceding gene: 197105350

Following gene: 197105345

Centisome position: 52.8

GC content: 72.51

Gene sequence:

>513_bases
TTGGCAGGGGTCCTGGATAGCGATCGGGCGGTCGTCGTCGCCCTGGGCGGCAACCTGCCGGACGGCTTCGGCTCGTCCGA
GGCGCTGCTGGAGGCGGTTCTGGCGCGCTTCCCCGACGCGGGGCTGAAAATCCTCGTTCGGTCGTCCTGGTGGCGCTCGG
CCGCCTGGCCCGACCCAATGGCGCCTGAGTACCGCAACGGCGTCGCGCTTGTCGAGGCGACGGCGCCCCCGAAAGAGGTG
CTGGAGAGGCTTCTGTCCCTCGAAGCGGCGTTCGGACGCACGAGATCGCTCAGGAATGCGGCGCGGACGGTGGATCTCGA
CCTGATCGCCTACGGGCGCGAGGTGCGGGACGCGCCCGGCCTTGTCCTGCCCCACCCGCGAGCGCACGAGCGGCTGTTCG
TCATGGGCCCGCTGGCCGAGATCGCCCCGGAGTGGCGTCATCCGGTGCTGGGCCGCACCGCCGCCGAGCTGGCCCGCGCC
GCCACCGTGGGGCTGGACGCCAGGCCTGTCTGA

Upstream 100 bases:

>100_bases
CTTGCGGTAGTCGATGTCGAAGCCGAGGTTCTTGGCCGCCGAGTAGAGGTTGGCCCCGTCGATGAACAGCGCCAGCCGGT
CCGTGGGGTAGAAGGTCATC

Downstream 100 bases:

>100_bases
TAAACTAGTCCGTCTGACGAAAATGTCGGCCCTTCCGCGCCCCGTTCGTCGTCCCGCCGAAGGGCGCGCATCGGGCCGCC
CGTATCCAGGAGTTCGACAA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MAGVLDSDRAVVVALGGNLPDGFGSSEALLEAVLARFPDAGLKILVRSSWWRSAAWPDPMAPEYRNGVALVEATAPPKEV
LERLLSLEAAFGRTRSLRNAARTVDLDLIAYGREVRDAPGLVLPHPRAHERLFVMGPLAEIAPEWRHPVLGRTAAELARA
ATVGLDARPV

Sequences:

>Translated_170_residues
MAGVLDSDRAVVVALGGNLPDGFGSSEALLEAVLARFPDAGLKILVRSSWWRSAAWPDPMAPEYRNGVALVEATAPPKEV
LERLLSLEAAFGRTRSLRNAARTVDLDLIAYGREVRDAPGLVLPHPRAHERLFVMGPLAEIAPEWRHPVLGRTAAELARA
ATVGLDARPV
>Mature_169_residues
AGVLDSDRAVVVALGGNLPDGFGSSEALLEAVLARFPDAGLKILVRSSWWRSAAWPDPMAPEYRNGVALVEATAPPKEVL
ERLLSLEAAFGRTRSLRNAARTVDLDLIAYGREVRDAPGLVLPHPRAHERLFVMGPLAEIAPEWRHPVLGRTAAELARAA
TVGLDARPV

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=137, Percent_Identity=34.3065693430657, Blast_Score=67, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18300; Mature: 18169

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGVLDSDRAVVVALGGNLPDGFGSSEALLEAVLARFPDAGLKILVRSSWWRSAAWPDPM
CCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
APEYRNGVALVEATAPPKEVLERLLSLEAAFGRTRSLRNAARTVDLDLIAYGREVRDAPG
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCC
LVLPHPRAHERLFVMGPLAEIAPEWRHPVLGRTAAELARAATVGLDARPV
EECCCCCCCCEEEEECCHHHHCHHHCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AGVLDSDRAVVVALGGNLPDGFGSSEALLEAVLARFPDAGLKILVRSSWWRSAAWPDPM
CCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
APEYRNGVALVEATAPPKEVLERLLSLEAAFGRTRSLRNAARTVDLDLIAYGREVRDAPG
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCC
LVLPHPRAHERLFVMGPLAEIAPEWRHPVLGRTAAELARAATVGLDARPV
EECCCCCCCCEEEEECCHHHHCHHHCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]