Click here to switch to the map view.

The map label for this gene is pyrE

Identifier: 197105340

GI number: 197105340

Start: 2103461

End: 2104045

Strand: Reverse

Name: pyrE

Synonym: PHZ_c1877

Alternate gene names: 197105340

Gene position: 2104045-2103461 (Counterclockwise)

Preceding gene: 197105343

Following gene: 197105339

Centisome position: 52.65

GC content: 71.79

Gene sequence:

>585_bases
ATGAACACCGAAGACGTCCTCAACGAGTTCCGCGGCGCCGGCGCCCTGCGCGAAGGCCACTTCGTCCTGTCGTCGGGGCT
GCACTCGCCGGTCTTCCTGCAGAAGAACCTGGTCTTCCAGTATCCCGACCGCACCGAGCGCCTGTGCAAGGCGCTGGCGG
CGAAGATCACCGAGGCCGTGGGGCCGGTGGACCTCTGCGTCTCCCCGGCGGTGGGCGGCATCATTCCGGGCTACGAGACG
GCCCGGCACCTGGGCTGCCCGTCGGTCTACGTCGAGCGCGAAGGGGGCGAGTTCAAGCTGCGCCGAGCCTTCTCCATCCC
CGAGGGCGCCCGCATCGCCATGGTCGAGGACATCGTCACCACGGGCCTCTCGTCCCGCGAATGCGTGGAGGCGATCCGCA
AGGCCGGCGGCAACGTCGTCGTCGCCGCCTGCATCGTCGACCGCTCGGGCGGCCGGGCCGACCCCGGCGCGCCGCTGGTG
GCCCTGGCGCGGCTGGACGTGCCCGCCTATCCCGCCGACCAGCTCCCGCCCGAGCTCGCCGCCATCCCCATCGAGGACCC
CGGCAGCCGGAGACTGAAGGGATGA

Upstream 100 bases:

>100_bases
TCAGCACCTTCACCATCCGTCCGTCGTAGCGGGGGCAGGGGCCAGCCTGCAACGGCTGGCATCTTCCGCCTCTGGCGAAA
CGCGACTATCTCCCGGGTCC

Downstream 100 bases:

>100_bases
GCAAGCTCAGGCTGGGCGTGAACATCGACCACGTGGCGACCGTCCGGAACGCCCGCGGCGAGAGCTACCCCGATCCCGTG
CGCGCCGCAGAGCTGGCGCT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MNTEDVLNEFRGAGALREGHFVLSSGLHSPVFLQKNLVFQYPDRTERLCKALAAKITEAVGPVDLCVSPAVGGIIPGYET
ARHLGCPSVYVEREGGEFKLRRAFSIPEGARIAMVEDIVTTGLSSRECVEAIRKAGGNVVVAACIVDRSGGRADPGAPLV
ALARLDVPAYPADQLPPELAAIPIEDPGSRRLKG

Sequences:

>Translated_194_residues
MNTEDVLNEFRGAGALREGHFVLSSGLHSPVFLQKNLVFQYPDRTERLCKALAAKITEAVGPVDLCVSPAVGGIIPGYET
ARHLGCPSVYVEREGGEFKLRRAFSIPEGARIAMVEDIVTTGLSSRECVEAIRKAGGNVVVAACIVDRSGGRADPGAPLV
ALARLDVPAYPADQLPPELAAIPIEDPGSRRLKG
>Mature_194_residues
MNTEDVLNEFRGAGALREGHFVLSSGLHSPVFLQKNLVFQYPDRTERLCKALAAKITEAVGPVDLCVSPAVGGIIPGYET
ARHLGCPSVYVEREGGEFKLRRAFSIPEGARIAMVEDIVTTGLSSRECVEAIRKAGGNVVVAACIVDRSGGRADPGAPLV
ALARLDVPAYPADQLPPELAAIPIEDPGSRRLKG

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_PHEZH (B4RCV1)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002130717.1
- ProteinModelPortal:   B4RCV1
- GeneID:   6791392
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c1877
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- ProtClustDB:   PRK00455
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 20587; Mature: 20587

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 120-120 BINDING 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTEDVLNEFRGAGALREGHFVLSSGLHSPVFLQKNLVFQYPDRTERLCKALAAKITEAV
CCHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEECCEEEECCCHHHHHHHHHHHHHHHHC
GPVDLCVSPAVGGIIPGYETARHLGCPSVYVEREGGEFKLRRAFSIPEGARIAMVEDIVT
CCHHHHHCCCCCCCCCCHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCEEHHHHHHHH
TGLSSRECVEAIRKAGGNVVVAACIVDRSGGRADPGAPLVALARLDVPAYPADQLPPELA
CCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCE
AIPIEDPGSRRLKG
EECCCCCCCCCCCC
>Mature Secondary Structure
MNTEDVLNEFRGAGALREGHFVLSSGLHSPVFLQKNLVFQYPDRTERLCKALAAKITEAV
CCHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEECCEEEECCCHHHHHHHHHHHHHHHHC
GPVDLCVSPAVGGIIPGYETARHLGCPSVYVEREGGEFKLRRAFSIPEGARIAMVEDIVT
CCHHHHHCCCCCCCCCCHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCEEHHHHHHHH
TGLSSRECVEAIRKAGGNVVVAACIVDRSGGRADPGAPLVALARLDVPAYPADQLPPELA
CCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCE
AIPIEDPGSRRLKG
EECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA