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The map label for this gene is rnc

Identifier: 197105333

GI number: 197105333

Start: 2097871

End: 2098587

Strand: Reverse

Name: rnc

Synonym: PHZ_c1870

Alternate gene names: 197105333

Gene position: 2098587-2097871 (Counterclockwise)

Preceding gene: 197105334

Following gene: 197105332

Centisome position: 52.51

GC content: 72.8

Gene sequence:

>717_bases
ATGAACGCCCGTGCGGCCGCCGTCGCCGAACTCGAGCGGCGCATCGGCTACGTCTTCACCGACCGCGACCTGCTGGAACG
GGCGCTGACCCACGCCAGCGTCGGCGACGGCGCCCGCGCCGTGCGTCACAACGAGCGCCTGGAGTTCCTCGGGGACCGGG
TGCTGAACCTGTGCGCCGCCGAGCGGCTGATGGCCCTCGATCCCGACGCCCGCGAGGGCGAGATGAGCCGGCTGCTGGCC
AGCCTCGTGAACTACCATGCCTGCGCCCGGGCGGCGAAGCGGGCCGGCCTGCAGGAGGCGCTGCGCCTGTCGGCCTCGGC
CACCAAGGTCGGCGCGCGCAAGTCCGACGCGGTCCTCGGCGACGCCTGCGAGGCGCTGATCGCGGCGCTCTACATCGACG
GGGGCCTCGAGACCGCCCGCGCGTTCTTCCTCAAGTTCTGGGACGAGGAGTTCGCCAGGCTCGACGAGCCGCGGGCCAAG
GATCCCAAGACCCAGCTCCAGGAGTGGGTGCAGGGCATGGGCCTGCCGTTGCCGACCTACGAGATCGTCTCCCAGGAAGG
GCCGCCGCACGCCCCGTCCTTCACGGTCGAGGTGCAGGTGGCGGGCTTCGGCGCCGAGCGCGGCGAGGGCCGCTCGCGCC
AGGCCGCCGAGAAGGCCGCGGCCCAGTGCATGCTGCTGAAGCGCGAAGGGCCCGAGCCCGGAAAGGTCGGAGAATGA

Upstream 100 bases:

>100_bases
CGTCCTCCTGTCCTGGGAGCCCGAGGCCTCGGTCTTCAAGCCCTGGACCTGGGTGCTCGACGCCCGGCCCAGCCGCTTCT
TCAAGGTCCTGCACTAGTCC

Downstream 100 bases:

>100_bases
GCCGCGCCGGTTTCTGCGCCATCATCGGCGCGCCCAATGCGGGCAAGTCCACCCTGACCAACCGACTGGTCGGGGCCAAG
GTCTCGATCGTCACCCAGAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MNARAAAVAELERRIGYVFTDRDLLERALTHASVGDGARAVRHNERLEFLGDRVLNLCAAERLMALDPDAREGEMSRLLA
SLVNYHACARAAKRAGLQEALRLSASATKVGARKSDAVLGDACEALIAALYIDGGLETARAFFLKFWDEEFARLDEPRAK
DPKTQLQEWVQGMGLPLPTYEIVSQEGPPHAPSFTVEVQVAGFGAERGEGRSRQAAEKAAAQCMLLKREGPEPGKVGE

Sequences:

>Translated_238_residues
MNARAAAVAELERRIGYVFTDRDLLERALTHASVGDGARAVRHNERLEFLGDRVLNLCAAERLMALDPDAREGEMSRLLA
SLVNYHACARAAKRAGLQEALRLSASATKVGARKSDAVLGDACEALIAALYIDGGLETARAFFLKFWDEEFARLDEPRAK
DPKTQLQEWVQGMGLPLPTYEIVSQEGPPHAPSFTVEVQVAGFGAERGEGRSRQAAEKAAAQCMLLKREGPEPGKVGE
>Mature_238_residues
MNARAAAVAELERRIGYVFTDRDLLERALTHASVGDGARAVRHNERLEFLGDRVLNLCAAERLMALDPDAREGEMSRLLA
SLVNYHACARAAKRAGLQEALRLSASATKVGARKSDAVLGDACEALIAALYIDGGLETARAFFLKFWDEEFARLDEPRAK
DPKTQLQEWVQGMGLPLPTYEIVSQEGPPHAPSFTVEVQVAGFGAERGEGRSRQAAEKAAAQCMLLKREGPEPGKVGE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=234, Percent_Identity=36.7521367521368, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI155030234, Length=234, Percent_Identity=36.7521367521368, Blast_Score=118, Evalue=6e-27,
Organism=Escherichia coli, GI1788920, Length=228, Percent_Identity=40.3508771929825, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI193202651, Length=199, Percent_Identity=32.6633165829146, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17506883, Length=199, Percent_Identity=32.6633165829146, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17137682, Length=225, Percent_Identity=30.6666666666667, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_PHEZH (B4RCU4)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002130710.1
- GeneID:   6791385
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c1870
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   CLSK890476
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25888; Mature: 25888

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNARAAAVAELERRIGYVFTDRDLLERALTHASVGDGARAVRHNERLEFLGDRVLNLCAA
CCCHHHHHHHHHHHHCEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ERLMALDPDAREGEMSRLLASLVNYHACARAAKRAGLQEALRLSASATKVGARKSDAVLG
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DACEALIAALYIDGGLETARAFFLKFWDEEFARLDEPRAKDPKTQLQEWVQGMGLPLPTY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHH
EIVSQEGPPHAPSFTVEVQVAGFGAERGEGRSRQAAEKAAAQCMLLKREGPEPGKVGE
HHHCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNARAAAVAELERRIGYVFTDRDLLERALTHASVGDGARAVRHNERLEFLGDRVLNLCAA
CCCHHHHHHHHHHHHCEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ERLMALDPDAREGEMSRLLASLVNYHACARAAKRAGLQEALRLSASATKVGARKSDAVLG
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DACEALIAALYIDGGLETARAFFLKFWDEEFARLDEPRAKDPKTQLQEWVQGMGLPLPTY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHH
EIVSQEGPPHAPSFTVEVQVAGFGAERGEGRSRQAAEKAAAQCMLLKREGPEPGKVGE
HHHCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA