Click here to switch to the map view.

The map label for this gene is accC [H]

Identifier: 197105314

GI number: 197105314

Start: 2073474

End: 2074826

Strand: Direct

Name: accC [H]

Synonym: PHZ_c1851

Alternate gene names: 197105314

Gene position: 2073474-2074826 (Clockwise)

Preceding gene: 197105313

Following gene: 197105315

Centisome position: 51.89

GC content: 68.14

Gene sequence:

>1353_bases
ATGTTCGACAAGATCCTGATCGCCAACCGCGGCGAGATCGCACTCCGCGTCCATCGCGCCTGCAAGGAGATGGGCATCGC
GACCGTCGCGGTGCACTCCGAGGCCGATTCCGGCGCCATGTGGGTGCGGCTGGCGGACGAAAGCGTCTGCATCGGCCCGC
CGCCGGCCGCCAAGAGCTACCTCAACATCCCGGCGATCATCGCCGCGGCCGAGATCACCGGCGCTCAGGCGATCCATCCC
GGCTACGGCTTCCTCTCCGAGAACGCCCGCTTCGCCGAGATCGTGAACGCCCACGGCTTCACCTTCATCGGACCCAAGCC
CGAGCACATCAAGCTGATGGGCGACAAGATCACCGCCAAGCAGGCAGTGAAGGACGCCGGCATCCCGGTCGTGCCCGGCT
CCGACGGGGCGGTGACGACCGAGGAAGAGGCCTTCGCCGCGGCCAAGGCCATCGGCTTCCCGGTCCTCATCAAGGCCGCC
GCGGGCGGCGGCGGGCGCGGCATGAAGGTGGCCCGCAACGAGGAGGAGCTGGTCGAGGCGGTCCAGACCGCCCGGTCCGA
GGCCAAGGCCGCCTTCGGCGACGACGCCATCTACATGGAGCGCTATCTCCAGACCCCGCGGCACATCGAGCTGCAGGTGG
TCGCCGACAGCCACGGCAACGTGGTGCACCTGGGCGAGCGCGACTGCTCGCTGCAGCGCCGTCACCAGAAGGTGCTGGAG
GAGGCCCCCTCCCCGGTCATCGACGCCGCGGCCCGCGAGAAGATCGGCAAGGTCGTGGTCGATGCGGTGCGCGCCATCGG
CTACCTCGGCGTCGGCACCATCGAGTTCCTGTACGAGGACGGCGAGTTCTTCTTCATCGAGATGAATACCCGCCTGCAGG
TGGAGCATCCGGTCACCGAGGCCATCACCGGCATCGACCTGGTGCGCGAGCAGATCCGCATCGCCGCCGGCGAGCCGCTG
TCGTTCCGCCAGGAGGACGTGGTGTTCGAAGGCCACGCCATCGAGTGCCGGATCAACGCCGAAAACCCGAAGACCTTCAC
GCCCTCGCCCGGCCTGGTGACCGATTACCACGCCCCGGGGGGCCTGGGCGTGCGCATGGATAGCGCGCTCTACGCCGGCT
ATTCGATCCCGCCCTACTACGACAGCCTGGTGGGCAAGCTGATCGTCCATGGCCGCGACCGGGAAGAGTGCATCGCCCGC
CTCTGCCGCTGCCTCGGCGAGGTGGTGGTCGGCGGCATCGACACCAACATCCCGCTGTTCCAGGAGCTGCTGGTCAATCC
GGAGATCGTCCGCGGCGACTACAACATCCATTGGCTGGAGCGCTGGATGAAGGCCCAGGCGGAGTCCGCCTAG

Upstream 100 bases:

>100_bases
CCGATCCCCGCCCCGAAGTCGGGCAAGATCGTCGAGATCCTGGTCGAGGACGCCCAGCCGGTGGAGTTCGGCGAGCCGCT
CGCCATCATCGAGTAGGCCG

Downstream 100 bases:

>100_bases
GCCTCGCGCCGCCCCGCCCGCTGCGCTAGGCGTATCGCATGGCGGAGTTCGACGCCCGCGACCTCCTGGACTGCTACGCC
CGCGGGGTGTTCCCCATGGC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MFDKILIANRGEIALRVHRACKEMGIATVAVHSEADSGAMWVRLADESVCIGPPPAAKSYLNIPAIIAAAEITGAQAIHP
GYGFLSENARFAEIVNAHGFTFIGPKPEHIKLMGDKITAKQAVKDAGIPVVPGSDGAVTTEEEAFAAAKAIGFPVLIKAA
AGGGGRGMKVARNEEELVEAVQTARSEAKAAFGDDAIYMERYLQTPRHIELQVVADSHGNVVHLGERDCSLQRRHQKVLE
EAPSPVIDAAAREKIGKVVVDAVRAIGYLGVGTIEFLYEDGEFFFIEMNTRLQVEHPVTEAITGIDLVREQIRIAAGEPL
SFRQEDVVFEGHAIECRINAENPKTFTPSPGLVTDYHAPGGLGVRMDSALYAGYSIPPYYDSLVGKLIVHGRDREECIAR
LCRCLGEVVVGGIDTNIPLFQELLVNPEIVRGDYNIHWLERWMKAQAESA

Sequences:

>Translated_450_residues
MFDKILIANRGEIALRVHRACKEMGIATVAVHSEADSGAMWVRLADESVCIGPPPAAKSYLNIPAIIAAAEITGAQAIHP
GYGFLSENARFAEIVNAHGFTFIGPKPEHIKLMGDKITAKQAVKDAGIPVVPGSDGAVTTEEEAFAAAKAIGFPVLIKAA
AGGGGRGMKVARNEEELVEAVQTARSEAKAAFGDDAIYMERYLQTPRHIELQVVADSHGNVVHLGERDCSLQRRHQKVLE
EAPSPVIDAAAREKIGKVVVDAVRAIGYLGVGTIEFLYEDGEFFFIEMNTRLQVEHPVTEAITGIDLVREQIRIAAGEPL
SFRQEDVVFEGHAIECRINAENPKTFTPSPGLVTDYHAPGGLGVRMDSALYAGYSIPPYYDSLVGKLIVHGRDREECIAR
LCRCLGEVVVGGIDTNIPLFQELLVNPEIVRGDYNIHWLERWMKAQAESA
>Mature_450_residues
MFDKILIANRGEIALRVHRACKEMGIATVAVHSEADSGAMWVRLADESVCIGPPPAAKSYLNIPAIIAAAEITGAQAIHP
GYGFLSENARFAEIVNAHGFTFIGPKPEHIKLMGDKITAKQAVKDAGIPVVPGSDGAVTTEEEAFAAAKAIGFPVLIKAA
AGGGGRGMKVARNEEELVEAVQTARSEAKAAFGDDAIYMERYLQTPRHIELQVVADSHGNVVHLGERDCSLQRRHQKVLE
EAPSPVIDAAAREKIGKVVVDAVRAIGYLGVGTIEFLYEDGEFFFIEMNTRLQVEHPVTEAITGIDLVREQIRIAAGEPL
SFRQEDVVFEGHAIECRINAENPKTFTPSPGLVTDYHAPGGLGVRMDSALYAGYSIPPYYDSLVGKLIVHGRDREECIAR
LCRCLGEVVVGGIDTNIPLFQELLVNPEIVRGDYNIHWLERWMKAQAESA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=50.4524886877828, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=50.4524886877828, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=50.4524886877828, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI116805327, Length=437, Percent_Identity=47.5972540045767, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI106049528, Length=444, Percent_Identity=45.7207207207207, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI106049295, Length=444, Percent_Identity=45.7207207207207, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI106049292, Length=444, Percent_Identity=45.7207207207207, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI38679960, Length=513, Percent_Identity=30.6042884990253, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI38679974, Length=513, Percent_Identity=30.6042884990253, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI38679977, Length=513, Percent_Identity=30.6042884990253, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI38679967, Length=513, Percent_Identity=30.6042884990253, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI38679971, Length=513, Percent_Identity=30.6042884990253, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI134142062, Length=514, Percent_Identity=31.1284046692607, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI18105007, Length=237, Percent_Identity=25.7383966244726, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI170295797, Length=235, Percent_Identity=25.1063829787234, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI21361331, Length=235, Percent_Identity=25.1063829787234, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI169790915, Length=235, Percent_Identity=25.1063829787234, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=61.0738255033557, Blast_Score=549, Evalue=1e-157,
Organism=Escherichia coli, GI1786216, Length=244, Percent_Identity=23.7704918032787, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=47.737556561086, Blast_Score=410, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71987519, Length=433, Percent_Identity=47.3441108545035, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=45.413870246085, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI133931226, Length=488, Percent_Identity=28.4836065573771, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71997168, Length=504, Percent_Identity=26.984126984127, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71997163, Length=504, Percent_Identity=26.984126984127, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI193204318, Length=312, Percent_Identity=23.0769230769231, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=429, Percent_Identity=43.3566433566434, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319695, Length=441, Percent_Identity=44.4444444444444, Blast_Score=341, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=443, Percent_Identity=45.372460496614, Blast_Score=329, Evalue=6e-91,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=28.4883720930233, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323863, Length=476, Percent_Identity=29.2016806722689, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6322331, Length=193, Percent_Identity=25.3886010362694, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281363050, Length=443, Percent_Identity=48.9841986455982, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652224, Length=443, Percent_Identity=48.9841986455982, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652222, Length=443, Percent_Identity=48.9841986455982, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652220, Length=443, Percent_Identity=48.9841986455982, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652218, Length=443, Percent_Identity=48.9841986455982, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652212, Length=443, Percent_Identity=48.9841986455982, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652210, Length=443, Percent_Identity=48.9841986455982, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652214, Length=443, Percent_Identity=48.9841986455982, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI19921944, Length=443, Percent_Identity=48.9841986455982, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652216, Length=443, Percent_Identity=48.9841986455982, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24651757, Length=430, Percent_Identity=46.2790697674419, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24651759, Length=394, Percent_Identity=45.4314720812183, Blast_Score=357, Evalue=9e-99,
Organism=Drosophila melanogaster, GI161076409, Length=507, Percent_Identity=30.3747534516765, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24586458, Length=507, Percent_Identity=30.3747534516765, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI161076407, Length=507, Percent_Identity=30.3747534516765, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24586460, Length=507, Percent_Identity=30.3747534516765, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI45555749, Length=341, Percent_Identity=22.5806451612903, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24642586, Length=341, Percent_Identity=22.5806451612903, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48824; Mature: 48824

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDKILIANRGEIALRVHRACKEMGIATVAVHSEADSGAMWVRLADESVCIGPPPAAKSY
CCCCEEEECCCCEEHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEECCCCCCCHHH
LNIPAIIAAAEITGAQAIHPGYGFLSENARFAEIVNAHGFTFIGPKPEHIKLMGDKITAK
CCCCHHEEEHHHCCCCEECCCCCCCCCCCHHHHHHHCCCEEEECCCCCEEEEECCHHHHH
QAVKDAGIPVVPGSDGAVTTEEEAFAAAKAIGFPVLIKAAAGGGGRGMKVARNEEELVEA
HHHHHCCCEEECCCCCCEECHHHHHHHHHHCCCEEEEEEECCCCCCCCEECCCHHHHHHH
VQTARSEAKAAFGDDAIYMERYLQTPRHIELQVVADSHGNVVHLGERDCSLQRRHQKVLE
HHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPSPVIDAAAREKIGKVVVDAVRAIGYLGVGTIEFLYEDGEFFFIEMNTRLQVEHPVTE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AITGIDLVREQIRIAAGEPLSFRQEDVVFEGHAIECRINAENPKTFTPSPGLVTDYHAPG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEEECCCCCEECCCCCCEEECCCCC
GLGVRMDSALYAGYSIPPYYDSLVGKLIVHGRDREECIARLCRCLGEVVVGGIDTNIPLF
CCCEEECCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
QELLVNPEIVRGDYNIHWLERWMKAQAESA
HHHHCCCEEEECCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFDKILIANRGEIALRVHRACKEMGIATVAVHSEADSGAMWVRLADESVCIGPPPAAKSY
CCCCEEEECCCCEEHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEECCCCCCCHHH
LNIPAIIAAAEITGAQAIHPGYGFLSENARFAEIVNAHGFTFIGPKPEHIKLMGDKITAK
CCCCHHEEEHHHCCCCEECCCCCCCCCCCHHHHHHHCCCEEEECCCCCEEEEECCHHHHH
QAVKDAGIPVVPGSDGAVTTEEEAFAAAKAIGFPVLIKAAAGGGGRGMKVARNEEELVEA
HHHHHCCCEEECCCCCCEECHHHHHHHHHHCCCEEEEEEECCCCCCCCEECCCHHHHHHH
VQTARSEAKAAFGDDAIYMERYLQTPRHIELQVVADSHGNVVHLGERDCSLQRRHQKVLE
HHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPSPVIDAAAREKIGKVVVDAVRAIGYLGVGTIEFLYEDGEFFFIEMNTRLQVEHPVTE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AITGIDLVREQIRIAAGEPLSFRQEDVVFEGHAIECRINAENPKTFTPSPGLVTDYHAPG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEEECCCCCEECCCCCCEEECCCCC
GLGVRMDSALYAGYSIPPYYDSLVGKLIVHGRDREECIARLCRCLGEVVVGGIDTNIPLF
CCCEEECCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
QELLVNPEIVRGDYNIHWLERWMKAQAESA
HHHHCCCEEEECCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]