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The map label for this gene is tyrS [H]

Identifier: 197105298

GI number: 197105298

Start: 2055408

End: 2056664

Strand: Direct

Name: tyrS [H]

Synonym: PHZ_c1835

Alternate gene names: 197105298

Gene position: 2055408-2056664 (Clockwise)

Preceding gene: 197105290

Following gene: 197105299

Centisome position: 51.43

GC content: 69.53

Gene sequence:

>1257_bases
ATGTCCGACCCCGCCTTCAAGTCCGAGTTCCTGAAGACGCTGCAGGCGCGCGGCTACATCCATCAGATCAGCCACCCGCA
GGAACTGGACGAGGCGACCGCCGGCGGCGTGATCGCCGCCTACATCGGCTTCGACGCGACGGCGACTTCGCTGCACGTCG
GCAGCCTGATCCAGATCATGATGCTGCGGCGGCTGCAGCAGGCGGGGCACAAGCCCGTCGTGCTGATGGGCGGCGGGACC
ACCAAGGTCGGCGATCCCAGCGGCCGCGACGAGAGCCGCAAGATGCTCACCGACGCCGATATCGAGCGGAACATCGCCGG
CATCCGGACCGTGTTCGAGAAGTTCCTGACCTTCGGGAACGGGCCCACCGACGCGGTGATGGTCAACAACGACGCGTGGC
TCTCGAAGCTCGGCTACCTGGAGTTCCTGCGGGAGTACGGTCCGCACTTCACCGTCAACCGCATGCTGACCTTCGATTCG
GTGCGCCTGCGGCTCGAGCGCGAACAGCCGCTCACCTTCCTCGAGTTCAACTACATGCTGATGCAGGCCGTGGACTTCCG
GCACCTCAACCGGACCATGGGCGTGCAGCTACAGATGGGCGGCTCGGACCAGTGGGGGAACATCATCAACGGCGTGGAGC
TGGTCCGGCGGATGGACCAGAAGGCCGCCTTCGCACTGACGACGCCGCTGCTGACCACCTCCTCGGGCGCCAAGATGGGC
AAGACCGCTCAGGGCGCCGTGTGGCTGAACGCCGACCTGCTCAGCCCCTACGACTACTGGCAGTTCTGGCGGAACACCGA
GGACGCGGACGTGGGCCGCTTCCTGCGCCTGTTCACCGACCTGCCGCTGGACGAGATCGCGCGGCTGGAGGCGCTGGAGG
GCGCGCAGATCAACGACGCCAAGAAGGTGCTGGCGAACGAGGCCACGCGGATGCTGCACGGCGAGGAGGCCGCGCGGGCC
GCCGAGGCCGCCGCCCGGGCCGCGTTCGAGGAGGGCCGCCTGTCCGGCGACCTGCCGACGCACGAGGTCGCCCGGGCCGA
CCTTGCCGCGGGGATCGCCCTCGCTGCGCTCGCGGCCGACGCGGGGCTCGCTTCCTCGCGGGGCGAGGCCCGGCGCCTGG
CGCAGGGCGGCGGGCTGCGGGTGAACGACGCCCAGGAGACCGACGGCGCGCGCCTCGTCAGCGAGGCCGACCTCGTGGAC
GGCGTCGTGAAGCTCGCCGCGGGCAAGAAGAAGATCGTCCTGGTGAAGCCGGTCTGA

Upstream 100 bases:

>100_bases
GGACGCCGGCCTCCCTGAGCCCCAAGGAGCCGCCATGTCCCTCGAAATCAGCGCCGCGCCCGTGCTAGAGCCCGGCCGTC
CCGAACCTGAGATTCCCGCG

Downstream 100 bases:

>100_bases
GGGAGAGACGAGATGTCGGACGTGATCGAGGGCGCGCCGGCGCCCGACTTCGAGCTGGAGACCGCCGACGGCCCCGTCCG
CCTGTCGGACTTCGCTGGCA

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSDPAFKSEFLKTLQARGYIHQISHPQELDEATAGGVIAAYIGFDATATSLHVGSLIQIMMLRRLQQAGHKPVVLMGGGT
TKVGDPSGRDESRKMLTDADIERNIAGIRTVFEKFLTFGNGPTDAVMVNNDAWLSKLGYLEFLREYGPHFTVNRMLTFDS
VRLRLEREQPLTFLEFNYMLMQAVDFRHLNRTMGVQLQMGGSDQWGNIINGVELVRRMDQKAAFALTTPLLTTSSGAKMG
KTAQGAVWLNADLLSPYDYWQFWRNTEDADVGRFLRLFTDLPLDEIARLEALEGAQINDAKKVLANEATRMLHGEEAARA
AEAAARAAFEEGRLSGDLPTHEVARADLAAGIALAALAADAGLASSRGEARRLAQGGGLRVNDAQETDGARLVSEADLVD
GVVKLAAGKKKIVLVKPV

Sequences:

>Translated_418_residues
MSDPAFKSEFLKTLQARGYIHQISHPQELDEATAGGVIAAYIGFDATATSLHVGSLIQIMMLRRLQQAGHKPVVLMGGGT
TKVGDPSGRDESRKMLTDADIERNIAGIRTVFEKFLTFGNGPTDAVMVNNDAWLSKLGYLEFLREYGPHFTVNRMLTFDS
VRLRLEREQPLTFLEFNYMLMQAVDFRHLNRTMGVQLQMGGSDQWGNIINGVELVRRMDQKAAFALTTPLLTTSSGAKMG
KTAQGAVWLNADLLSPYDYWQFWRNTEDADVGRFLRLFTDLPLDEIARLEALEGAQINDAKKVLANEATRMLHGEEAARA
AEAAARAAFEEGRLSGDLPTHEVARADLAAGIALAALAADAGLASSRGEARRLAQGGGLRVNDAQETDGARLVSEADLVD
GVVKLAAGKKKIVLVKPV
>Mature_417_residues
SDPAFKSEFLKTLQARGYIHQISHPQELDEATAGGVIAAYIGFDATATSLHVGSLIQIMMLRRLQQAGHKPVVLMGGGTT
KVGDPSGRDESRKMLTDADIERNIAGIRTVFEKFLTFGNGPTDAVMVNNDAWLSKLGYLEFLREYGPHFTVNRMLTFDSV
RLRLEREQPLTFLEFNYMLMQAVDFRHLNRTMGVQLQMGGSDQWGNIINGVELVRRMDQKAAFALTTPLLTTSSGAKMGK
TAQGAVWLNADLLSPYDYWQFWRNTEDADVGRFLRLFTDLPLDEIARLEALEGAQINDAKKVLANEATRMLHGEEAARAA
EAAARAAFEEGRLSGDLPTHEVARADLAAGIALAALAADAGLASSRGEARRLAQGGGLRVNDAQETDGARLVSEADLVDG
VVKLAAGKKKIVLVKPV

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=416, Percent_Identity=33.1730769230769, Blast_Score=218, Evalue=6e-57,
Organism=Escherichia coli, GI1787925, Length=419, Percent_Identity=41.2887828162291, Blast_Score=319, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI25145802, Length=433, Percent_Identity=31.8706697459584, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI25145805, Length=320, Percent_Identity=31.5625, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6325160, Length=443, Percent_Identity=32.9571106094808, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI20130383, Length=439, Percent_Identity=34.624145785877, Blast_Score=234, Evalue=9e-62,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45602; Mature: 45470

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPAFKSEFLKTLQARGYIHQISHPQELDEATAGGVIAAYIGFDATATSLHVGSLIQIM
CCCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHH
MLRRLQQAGHKPVVLMGGGTTKVGDPSGRDESRKMLTDADIERNIAGIRTVFEKFLTFGN
HHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPTDAVMVNNDAWLSKLGYLEFLREYGPHFTVNRMLTFDSVRLRLEREQPLTFLEFNYML
CCCCEEEECCHHHHHHHHHHHHHHHHCCCEEEEHEEEEHHHHEEEECCCCCEEEHHHHHH
MQAVDFRHLNRTMGVQLQMGGSDQWGNIINGVELVRRMDQKAAFALTTPLLTTSSGAKMG
HHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCEECCCCCCCC
KTAQGAVWLNADLLSPYDYWQFWRNTEDADVGRFLRLFTDLPLDEIARLEALEGAQINDA
CCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHH
KKVLANEATRMLHGEEAARAAEAAARAAFEEGRLSGDLPTHEVARADLAAGIALAALAAD
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGLASSRGEARRLAQGGGLRVNDAQETDGARLVSEADLVDGVVKLAAGKKKIVLVKPV
CCCCCCCHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure 
SDPAFKSEFLKTLQARGYIHQISHPQELDEATAGGVIAAYIGFDATATSLHVGSLIQIM
CCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHH
MLRRLQQAGHKPVVLMGGGTTKVGDPSGRDESRKMLTDADIERNIAGIRTVFEKFLTFGN
HHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPTDAVMVNNDAWLSKLGYLEFLREYGPHFTVNRMLTFDSVRLRLEREQPLTFLEFNYML
CCCCEEEECCHHHHHHHHHHHHHHHHCCCEEEEHEEEEHHHHEEEECCCCCEEEHHHHHH
MQAVDFRHLNRTMGVQLQMGGSDQWGNIINGVELVRRMDQKAAFALTTPLLTTSSGAKMG
HHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCEECCCCCCCC
KTAQGAVWLNADLLSPYDYWQFWRNTEDADVGRFLRLFTDLPLDEIARLEALEGAQINDA
CCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHH
KKVLANEATRMLHGEEAARAAEAAARAAFEEGRLSGDLPTHEVARADLAAGIALAALAAD
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGLASSRGEARRLAQGGGLRVNDAQETDGARLVSEADLVDGVVKLAAGKKKIVLVKPV
CCCCCCCHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA