Click here to switch to the map view.

The map label for this gene is lpxB [H]

Identifier: 197105229

GI number: 197105229

Start: 1976669

End: 1977847

Strand: Reverse

Name: lpxB [H]

Synonym: PHZ_c1766

Alternate gene names: 197105229

Gene position: 1977847-1976669 (Counterclockwise)

Preceding gene: 197105230

Following gene: 197105226

Centisome position: 49.49

GC content: 73.45

Gene sequence:

>1179_bases
ATGACCGCGGGCCGGCCGCTCACCGTCATGCTGGTGGCCGCCGAGGCCTCCGGCGACGACCGGGGAGCGGGCCTGATGCG
GGCGCTCCGGCGGCGGCTGGGCGAGGGAGTCCGGTTCGTCGGCGTCGGGGGCGAGCGGATGCGGGCCGAGGGGCTGGACA
GCCCGTTCGACATCGCCGAGCTGTCGGTGCTGGGCCTGCTCGAGGGGCTCGCCGCCTATCCGAAGGTGATCCGCCGCGCC
CGCGAAGCCGCCGCCATCGCCGCGCGCGAAAAGCCCGACGTCGCCGTGCTGATCGACTCCTGGGGCTTCACCCTTCGCGT
AGCCCAGCGACTGCGCCGGGCCCGTCCGGGCATGCCGCTCGTGAAGTACGTCGGCCCGCAGGTCTGGGCCTCGCGGCCGG
GCCGGGGGAAGACCACGGCGGCGACCTACGACCACCTGCTGTCGATCCACGCCTTCGACGCGCCGTACTTCGAGGCCGAG
GGCCTGCCGACCACCTTCGTCGGCAACTCGGCCCTGGCGATCGACTTCGGCGGGGCCGATCCGGCCCGCCTGCGCCGGAG
CATCGGCGCAGGGCCTGACGATCCCATCCTCCTGGTGCTGCCCGGCAGCCGCCCGGGCGAGATCCAGCGCGTCCTGCCGG
CGTTCGAGGATGCGGTCCTGCGGCTGAAGGCCGAGCGGCCCGAGCTCCACGTCGTGATCCCCGCCGCGCCGACGGTGGCC
GACATGGTCCGGGCCCGGGTCGCCGGCTGGCCGAACCGCGCGCACGTCGTGGAGGGGGAAGCCGGCAAGCTCGACGCCAT
GAAGGCCGCGACGGTGGCCCTGGCCTGCTCGGGCACGGTGACGACCGAACTGGCGCTGGCGGGCTGTCCGATGGTGGTCG
GCTACAGGCTCGCGCCGCTGACCTATGCGATCCTGAAGCGGCTGATCACCACGAGGTATGTGACGCTGTTCAATATCGCC
GCCGGCGAGGCGGTGGCGCCGGAGCTGCTGCAGGACGACTGCAACGGCCCGGCCCTGGCGCGCGAGGCGGCCTTGCGCCT
GGACGATGCGGATCTGCGCCGCCGGCAGGTCGAGCGGCAGTACGCGGCCCTCGACAAAATGGGACGCGGCGGCCCCGATC
CGAACGAGGCCGCCGCGTCTGCAGTCCTGAAAGTCCTGGAAGGGAAGGGGGCTGCTTAG

Upstream 100 bases:

>100_bases
TGGGCGAGGCGGGGCGGGTCATCGTGCTGGACCGCGAGGCGGTGATCTCGCTGGCCGACGAGCTCGGCGTGTTCATCTTC
GGCGTGGAGCCAGAAGGCCG

Downstream 100 bases:

>100_bases
CCCCGCTTCTCCACCGGCACGTAGTCGCGCTGGGCGGCGCCCGTGTAGAGCTGGCGCGGGCGGCCGATCTTCTGGGACGG
ATCCTCGATCATTTCCTTCC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTAGRPLTVMLVAAEASGDDRGAGLMRALRRRLGEGVRFVGVGGERMRAEGLDSPFDIAELSVLGLLEGLAAYPKVIRRA
REAAAIAAREKPDVAVLIDSWGFTLRVAQRLRRARPGMPLVKYVGPQVWASRPGRGKTTAATYDHLLSIHAFDAPYFEAE
GLPTTFVGNSALAIDFGGADPARLRRSIGAGPDDPILLVLPGSRPGEIQRVLPAFEDAVLRLKAERPELHVVIPAAPTVA
DMVRARVAGWPNRAHVVEGEAGKLDAMKAATVALACSGTVTTELALAGCPMVVGYRLAPLTYAILKRLITTRYVTLFNIA
AGEAVAPELLQDDCNGPALAREAALRLDDADLRRRQVERQYAALDKMGRGGPDPNEAAASAVLKVLEGKGAA

Sequences:

>Translated_392_residues
MTAGRPLTVMLVAAEASGDDRGAGLMRALRRRLGEGVRFVGVGGERMRAEGLDSPFDIAELSVLGLLEGLAAYPKVIRRA
REAAAIAAREKPDVAVLIDSWGFTLRVAQRLRRARPGMPLVKYVGPQVWASRPGRGKTTAATYDHLLSIHAFDAPYFEAE
GLPTTFVGNSALAIDFGGADPARLRRSIGAGPDDPILLVLPGSRPGEIQRVLPAFEDAVLRLKAERPELHVVIPAAPTVA
DMVRARVAGWPNRAHVVEGEAGKLDAMKAATVALACSGTVTTELALAGCPMVVGYRLAPLTYAILKRLITTRYVTLFNIA
AGEAVAPELLQDDCNGPALAREAALRLDDADLRRRQVERQYAALDKMGRGGPDPNEAAASAVLKVLEGKGAA
>Mature_391_residues
TAGRPLTVMLVAAEASGDDRGAGLMRALRRRLGEGVRFVGVGGERMRAEGLDSPFDIAELSVLGLLEGLAAYPKVIRRAR
EAAAIAAREKPDVAVLIDSWGFTLRVAQRLRRARPGMPLVKYVGPQVWASRPGRGKTTAATYDHLLSIHAFDAPYFEAEG
LPTTFVGNSALAIDFGGADPARLRRSIGAGPDDPILLVLPGSRPGEIQRVLPAFEDAVLRLKAERPELHVVIPAAPTVAD
MVRARVAGWPNRAHVVEGEAGKLDAMKAATVALACSGTVTTELALAGCPMVVGYRLAPLTYAILKRLITTRYVTLFNIAA
GEAVAPELLQDDCNGPALAREAALRLDDADLRRRQVERQYAALDKMGRGGPDPNEAAASAVLKVLEGKGAA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=343, Percent_Identity=35.8600583090379, Blast_Score=187, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41640; Mature: 41508

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAGRPLTVMLVAAEASGDDRGAGLMRALRRRLGEGVRFVGVGGERMRAEGLDSPFDIAE
CCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCCCHHH
LSVLGLLEGLAAYPKVIRRAREAAAIAAREKPDVAVLIDSWGFTLRVAQRLRRARPGMPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCH
VKYVGPQVWASRPGRGKTTAATYDHLLSIHAFDAPYFEAEGLPTTFVGNSALAIDFGGAD
HHHCCCHHHCCCCCCCCCHHHHHHHHHEEEECCCCCEECCCCCEEEECCCEEEEEECCCC
PARLRRSIGAGPDDPILLVLPGSRPGEIQRVLPAFEDAVLRLKAERPELHVVIPAAPTVA
HHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCHHH
DMVRARVAGWPNRAHVVEGEAGKLDAMKAATVALACSGTVTTELALAGCPMVVGYRLAPL
HHHHHHHCCCCCCCEEECCCCCCCHHHHHHEEEEEECCCHHHHHHHHCCCHHHHHHHHHH
TYAILKRLITTRYVTLFNIAAGEAVAPELLQDDCNGPALAREAALRLDDADLRRRQVERQ
HHHHHHHHHHHHHHHHEEECCCCHHCHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHH
YAALDKMGRGGPDPNEAAASAVLKVLEGKGAA
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TAGRPLTVMLVAAEASGDDRGAGLMRALRRRLGEGVRFVGVGGERMRAEGLDSPFDIAE
CCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCCCHHH
LSVLGLLEGLAAYPKVIRRAREAAAIAAREKPDVAVLIDSWGFTLRVAQRLRRARPGMPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCH
VKYVGPQVWASRPGRGKTTAATYDHLLSIHAFDAPYFEAEGLPTTFVGNSALAIDFGGAD
HHHCCCHHHCCCCCCCCCHHHHHHHHHEEEECCCCCEECCCCCEEEECCCEEEEEECCCC
PARLRRSIGAGPDDPILLVLPGSRPGEIQRVLPAFEDAVLRLKAERPELHVVIPAAPTVA
HHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCHHH
DMVRARVAGWPNRAHVVEGEAGKLDAMKAATVALACSGTVTTELALAGCPMVVGYRLAPL
HHHHHHHCCCCCCCEEECCCCCCCHHHHHHEEEEEECCCHHHHHHHHCCCHHHHHHHHHH
TYAILKRLITTRYVTLFNIAAGEAVAPELLQDDCNGPALAREAALRLDDADLRRRQVERQ
HHHHHHHHHHHHHHHHEEECCCCHHCHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHH
YAALDKMGRGGPDPNEAAASAVLKVLEGKGAA
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA