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The map label for this gene is iscS [H]

Identifier: 197105184

GI number: 197105184

Start: 1928707

End: 1929849

Strand: Reverse

Name: iscS [H]

Synonym: PHZ_c1721

Alternate gene names: 197105184

Gene position: 1929849-1928707 (Counterclockwise)

Preceding gene: 197105185

Following gene: 197105183

Centisome position: 48.29

GC content: 73.58

Gene sequence:

>1143_bases
ATGAGTTCGTCCATCTACCTCGACTACAACGCCACCGCCCCGGTGCGCCCGCAGGCGGCGGCCGCTGTGGCCCGCGCCCT
GGAGGTCGGAGGCAATCCGTCGTCGGTCCACGCCGCCGGCCGGGCGGCGCGCGCCATCATGGAATCGGCCCGCGAGAGCA
TCGCCAGGCTGATCGGCGCGCCAGCGCCCGACGTGGTCTTCACCAGCGGCGGCGCCGAAGCCAACAACCTGTGCCTCGAC
AGCGCCGTGGCCGCGGGCTCGCGGCGCCTCATCGTCTCGGCCATCGAGCACGCCACCGTCACCGAGACGGCCAAGGCCTC
GCCGGCCGAGGTGGAATACCTGCCGGTGGGCCGGGACGGCGTCGCCGACCTCGGCTGGCTGCGCGAGCGGCTGGCGGGCT
GGGACGCTGCCGACGGGCGGCCGTTCGTGGCGCTGATGCTGGCCAACAACGAGACCGGAGTGATCCAGCCCATCGCCGAG
GCGGCCGAGATCGTCCACGCCGCCGGGGGCTGGCTGCACGTCGACGCCATCCAGGCGATCGGCAAGATCCCAGTAGATTT
CCAGGCGCTGGGGGCCGACACCCTGACCTTCTCGGGCCACAAGCTGGGCGCGCCGCAGGGCGTGGGCGGCCTGGCCTACG
GAGCCGGGGCGACCCTGGTCCGTCGCCAGCACGGCGGCGGGCACGAACGGGGTCGGCGGGCCGGGACCGAGAACGTGCCG
GGGATCGCGGGCCTGGGCGCCGCCGCCGAGGCGATCCTGACCGCCAACGCCGACTGGTCGCGTCACGCCGCCTGGCGCGA
CGCCGCCGCCGAGCGGCTGAAGTCGGTCGGGGCCGTGGTCATGGGCGAGGGCGCTCCGCGCACGCCCAACACCCTGTGCG
TGGCCACGCCCGGCTGGACGTCGGACTTGCAGCTGATCGCCCTCGATCTGGCCGGGGTGATGGTGAGCGCAGGCTCGGCC
TGCTCGTCGGGCAAGGTGAAGGCGAGCCATGTGCTCGTCGCCATGGACCAGGGCGACCTCGCGTCCTGCGCCATTCGCGT
CAGCGGCGGCTGGAACACCACGGAGGCCGACTGGAACAGGTTCGCCGACGTGTGGTTCGAGGCCTATCAGCGGTTCGCCG
CGCGCCGGAAGGAGGTCGCCTGA

Upstream 100 bases:

>100_bases
ACGACCTCTGGGCCGATCTCGGCCAGCAGATCGAGCATTACCTGGCCTCGGTCACCCTCGCCGACGTGATCGGCGGTCGC
CTCGGAGCCCGCGCCGCCGC

Downstream 100 bases:

>100_bases
TGGCCGCCGTCAAGCAGACCGTCGAGCAGGTCCAGAGTCTCGAGAAGTACAAGCACGGCTTCATCACCGAGATCGACCAG
GAGTTCGCGCCCAAGGGCCT

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSSSIYLDYNATAPVRPQAAAAVARALEVGGNPSSVHAAGRAARAIMESARESIARLIGAPAPDVVFTSGGAEANNLCLD
SAVAAGSRRLIVSAIEHATVTETAKASPAEVEYLPVGRDGVADLGWLRERLAGWDAADGRPFVALMLANNETGVIQPIAE
AAEIVHAAGGWLHVDAIQAIGKIPVDFQALGADTLTFSGHKLGAPQGVGGLAYGAGATLVRRQHGGGHERGRRAGTENVP
GIAGLGAAAEAILTANADWSRHAAWRDAAAERLKSVGAVVMGEGAPRTPNTLCVATPGWTSDLQLIALDLAGVMVSAGSA
CSSGKVKASHVLVAMDQGDLASCAIRVSGGWNTTEADWNRFADVWFEAYQRFAARRKEVA

Sequences:

>Translated_380_residues
MSSSIYLDYNATAPVRPQAAAAVARALEVGGNPSSVHAAGRAARAIMESARESIARLIGAPAPDVVFTSGGAEANNLCLD
SAVAAGSRRLIVSAIEHATVTETAKASPAEVEYLPVGRDGVADLGWLRERLAGWDAADGRPFVALMLANNETGVIQPIAE
AAEIVHAAGGWLHVDAIQAIGKIPVDFQALGADTLTFSGHKLGAPQGVGGLAYGAGATLVRRQHGGGHERGRRAGTENVP
GIAGLGAAAEAILTANADWSRHAAWRDAAAERLKSVGAVVMGEGAPRTPNTLCVATPGWTSDLQLIALDLAGVMVSAGSA
CSSGKVKASHVLVAMDQGDLASCAIRVSGGWNTTEADWNRFADVWFEAYQRFAARRKEVA
>Mature_379_residues
SSSIYLDYNATAPVRPQAAAAVARALEVGGNPSSVHAAGRAARAIMESARESIARLIGAPAPDVVFTSGGAEANNLCLDS
AVAAGSRRLIVSAIEHATVTETAKASPAEVEYLPVGRDGVADLGWLRERLAGWDAADGRPFVALMLANNETGVIQPIAEA
AEIVHAAGGWLHVDAIQAIGKIPVDFQALGADTLTFSGHKLGAPQGVGGLAYGAGATLVRRQHGGGHERGRRAGTENVPG
IAGLGAAAEAILTANADWSRHAAWRDAAAERLKSVGAVVMGEGAPRTPNTLCVATPGWTSDLQLIALDLAGVMVSAGSAC
SSGKVKASHVLVAMDQGDLASCAIRVSGGWNTTEADWNRFADVWFEAYQRFAARRKEVA

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=382, Percent_Identity=35.0785340314136, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI156713448, Length=406, Percent_Identity=33.9901477832512, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI48994898, Length=374, Percent_Identity=37.1657754010695, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1789175, Length=341, Percent_Identity=30.4985337243402, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787970, Length=243, Percent_Identity=31.6872427983539, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25143064, Length=395, Percent_Identity=32.4050632911392, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17533177, Length=321, Percent_Identity=31.4641744548287, Blast_Score=115, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319831, Length=375, Percent_Identity=32.2666666666667, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20129463, Length=384, Percent_Identity=34.6354166666667, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 39122; Mature: 38991

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSIYLDYNATAPVRPQAAAAVARALEVGGNPSSVHAAGRAARAIMESARESIARLIGA
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
PAPDVVFTSGGAEANNLCLDSAVAAGSRRLIVSAIEHATVTETAKASPAEVEYLPVGRDG
CCCCEEEECCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCEEEEECCCCC
VADLGWLRERLAGWDAADGRPFVALMLANNETGVIQPIAEAAEIVHAAGGWLHVDAIQAI
CHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHH
GKIPVDFQALGADTLTFSGHKLGAPQGVGGLAYGAGATLVRRQHGGGHERGRRAGTENVP
CCCCCCHHHCCCCEEEECCCCCCCCCCCCCEEECCCHHEEEECCCCCHHHHHCCCCCCCC
GIAGLGAAAEAILTANADWSRHAAWRDAAAERLKSVGAVVMGEGAPRTPNTLCVATPGWT
CCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEECCCCC
SDLQLIALDLAGVMVSAGSACSSGKVKASHVLVAMDQGDLASCAIRVSGGWNTTEADWNR
CCHHEEHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCCCCHHHHHH
FADVWFEAYQRFAARRKEVA
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSSIYLDYNATAPVRPQAAAAVARALEVGGNPSSVHAAGRAARAIMESARESIARLIGA
CCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
PAPDVVFTSGGAEANNLCLDSAVAAGSRRLIVSAIEHATVTETAKASPAEVEYLPVGRDG
CCCCEEEECCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCEEEEECCCCC
VADLGWLRERLAGWDAADGRPFVALMLANNETGVIQPIAEAAEIVHAAGGWLHVDAIQAI
CHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHH
GKIPVDFQALGADTLTFSGHKLGAPQGVGGLAYGAGATLVRRQHGGGHERGRRAGTENVP
CCCCCCHHHCCCCEEEECCCCCCCCCCCCCEEECCCHHEEEECCCCCHHHHHCCCCCCCC
GIAGLGAAAEAILTANADWSRHAAWRDAAAERLKSVGAVVMGEGAPRTPNTLCVATPGWT
CCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEECCCCC
SDLQLIALDLAGVMVSAGSACSSGKVKASHVLVAMDQGDLASCAIRVSGGWNTTEADWNR
CCHHEEHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCCCCHHHHHH
FADVWFEAYQRFAARRKEVA
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA