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The map label for this gene is coxB [H]

Identifier: 197105049

GI number: 197105049

Start: 1789000

End: 1789983

Strand: Reverse

Name: coxB [H]

Synonym: PHZ_c1586

Alternate gene names: 197105049

Gene position: 1789983-1789000 (Counterclockwise)

Preceding gene: 197105050

Following gene: 197105048

Centisome position: 44.79

GC content: 75.3

Gene sequence:

>984_bases
ATGTCGCCGCCTACCTCTATACGCTCGACGCTCGCTGAGGCGCTGCGCGGCTGGCCGCCGCCGCCGCTGGACCCGGCCGG
TCCGCACGCGGGGTTGGTGGCGACCCTGAGCTGGGTGCTGTTCGGCATGGCGCTGGCCGTGCTGCTGATGGTCTCCGTCG
CCCTCGTGGTGGCGCTGGCCGGCAAGTCCGAATGGCGGGACAGGCTCGGCCGCGAGTGGCTCATCTGGTCCGCGGGGCTG
GCCCTGCCGATCGTCGTGCTCACCGGCGTCCTCATCTACGGCCTGACCGCCACCCAGGCGCTGTCCCAGGCCCCGCAGCC
GGGCGAGATGCGGGTGCGCGTGACGGGCGAGATGTGGTGGTGGCGCGTGGCCTACCTCGACGCCGAGGGCCGTCCCGCGA
TCCACGACGCCAACGAGCTGCACATCCCCGCCGGCGTCCCCGTCACCCTCGAGCTCGAGGCCGCCGACGTGATCCACAGC
TTCTGGGTGCCGCGCCTGGCCGGCAAGCTCGACATGATCCCCGGCCGGCGCAACATCCTGCGCATCCAGGCCGACCGGCC
GGGCGTCTACGGCGGCCAGTGCGCCGAGTACTGCGGCGGCCCGCACGCCCTGATGGGCTTCGTCGTCGTCGCCCACGCGC
CCGAGGACTTCCAACGCTGGCGCGCCGCGCGCCTCGCGCCGCCTCCCGCCGCCCCCGCAGACGGGCTCGCCGCCCGCGGC
GCCCAGGTCTTCCGCGACAGCGGCTGCGGCGCCTGCCACCGCGTCGCCGGGACCGAGGCCGGCGGCCTCGCCGGGCCCGA
CCTCACCTTCGTCGGCGCCCGCCGCTCGCTGGGCGCGGGCATCCTCGCCAACAACCAGGGCACGCTCGCCGGCTGGGTCG
CCGACAGCCAGGCGATCAAGCCGGGCAACCGCATGCCCGCCTACCGGATGCTGTCCGGCGGCGACCTGCGCGCGCTGGCC
GCCTACCTGGAAAGCCGCCGATGA

Upstream 100 bases:

>100_bases
AACACCGCCGACACCCTGGCGCTGTGGGTGCGCGACGCCCCCGCGCTCTCCCCCGGGACCGGCATGCCCGCCATTCCCCT
CACCGAGCAGGAGGCCCGCG

Downstream 100 bases:

>100_bases
GCTCCGAGACGGGCTTCGACCCGAAGCTCTTCGAGCGCTTCCCCACCCGCGAGCCGCGCCCCGAAGGCGAGTTCGAGACC
CTGAAGCACGTCTGGCGCGC

Product: cytochrome c oxidase, subunit II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II; Oxidase aa(3) subunit 2 [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSPPTSIRSTLAEALRGWPPPPLDPAGPHAGLVATLSWVLFGMALAVLLMVSVALVVALAGKSEWRDRLGREWLIWSAGL
ALPIVVLTGVLIYGLTATQALSQAPQPGEMRVRVTGEMWWWRVAYLDAEGRPAIHDANELHIPAGVPVTLELEAADVIHS
FWVPRLAGKLDMIPGRRNILRIQADRPGVYGGQCAEYCGGPHALMGFVVVAHAPEDFQRWRAARLAPPPAAPADGLAARG
AQVFRDSGCGACHRVAGTEAGGLAGPDLTFVGARRSLGAGILANNQGTLAGWVADSQAIKPGNRMPAYRMLSGGDLRALA
AYLESRR

Sequences:

>Translated_327_residues
MSPPTSIRSTLAEALRGWPPPPLDPAGPHAGLVATLSWVLFGMALAVLLMVSVALVVALAGKSEWRDRLGREWLIWSAGL
ALPIVVLTGVLIYGLTATQALSQAPQPGEMRVRVTGEMWWWRVAYLDAEGRPAIHDANELHIPAGVPVTLELEAADVIHS
FWVPRLAGKLDMIPGRRNILRIQADRPGVYGGQCAEYCGGPHALMGFVVVAHAPEDFQRWRAARLAPPPAAPADGLAARG
AQVFRDSGCGACHRVAGTEAGGLAGPDLTFVGARRSLGAGILANNQGTLAGWVADSQAIKPGNRMPAYRMLSGGDLRALA
AYLESRR
>Mature_326_residues
SPPTSIRSTLAEALRGWPPPPLDPAGPHAGLVATLSWVLFGMALAVLLMVSVALVVALAGKSEWRDRLGREWLIWSAGLA
LPIVVLTGVLIYGLTATQALSQAPQPGEMRVRVTGEMWWWRVAYLDAEGRPAIHDANELHIPAGVPVTLELEAADVIHSF
WVPRLAGKLDMIPGRRNILRIQADRPGVYGGQCAEYCGGPHALMGFVVVAHAPEDFQRWRAARLAPPPAAPADGLAARGA
QVFRDSGCGACHRVAGTEAGGLAGPDLTFVGARRSLGAGILANNQGTLAGWVADSQAIKPGNRMPAYRMLSGGDLRALAA
YLESRR

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cytochrome c domain [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=145, Percent_Identity=30.3448275862069, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1786635, Length=220, Percent_Identity=26.3636363636364, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6226540, Length=170, Percent_Identity=28.2352941176471, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR009056
- InterPro:   IPR003088
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM; PF00034 Cytochrom_C [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 34711; Mature: 34579

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS00078 COX2 ; PS50857 COX2_CUA ; PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPPTSIRSTLAEALRGWPPPPLDPAGPHAGLVATLSWVLFGMALAVLLMVSVALVVALA
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKSEWRDRLGREWLIWSAGLALPIVVLTGVLIYGLTATQALSQAPQPGEMRVRVTGEMWW
CCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEEE
WRVAYLDAEGRPAIHDANELHIPAGVPVTLELEAADVIHSFWVPRLAGKLDMIPGRRNIL
EEEEEECCCCCCCCCCCCCEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEE
RIQADRPGVYGGQCAEYCGGPHALMGFVVVAHAPEDFQRWRAARLAPPPAAPADGLAARG
EEECCCCCCCCCHHHHHHCCHHHHHHHHHEECCCHHHHHHHHHCCCCCCCCCCCCHHHHC
AQVFRDSGCGACHRVAGTEAGGLAGPDLTFVGARRSLGAGILANNQGTLAGWVADSQAIK
HHHHHCCCCCHHHHHCCCCCCCCCCCCEEEEECCHHCCCCEEECCCCCEEEEECCCCCCC
PGNRMPAYRMLSGGDLRALAAYLESRR
CCCCCCCEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SPPTSIRSTLAEALRGWPPPPLDPAGPHAGLVATLSWVLFGMALAVLLMVSVALVVALA
CCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKSEWRDRLGREWLIWSAGLALPIVVLTGVLIYGLTATQALSQAPQPGEMRVRVTGEMWW
CCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEEE
WRVAYLDAEGRPAIHDANELHIPAGVPVTLELEAADVIHSFWVPRLAGKLDMIPGRRNIL
EEEEEECCCCCCCCCCCCCEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEE
RIQADRPGVYGGQCAEYCGGPHALMGFVVVAHAPEDFQRWRAARLAPPPAAPADGLAARG
EEECCCCCCCCCHHHHHHCCHHHHHHHHHEECCCHHHHHHHHHCCCCCCCCCCCCHHHHC
AQVFRDSGCGACHRVAGTEAGGLAGPDLTFVGARRSLGAGILANNQGTLAGWVADSQAIK
HHHHHCCCCCHHHHHCCCCCCCCCCCCEEEEECCHHCCCCEEECCCCCEEEEECCCCCCC
PGNRMPAYRMLSGGDLRALAAYLESRR
CCCCCCCEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]