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The map label for this gene is fabF [H]

Identifier: 197105023

GI number: 197105023

Start: 1760695

End: 1761975

Strand: Direct

Name: fabF [H]

Synonym: PHZ_c1560

Alternate gene names: 197105023

Gene position: 1760695-1761975 (Clockwise)

Preceding gene: 197105022

Following gene: 197105024

Centisome position: 44.06

GC content: 71.35

Gene sequence:

>1281_bases
ATGCGTCGAGTCGTCGTCACCGGCATCGGCCTCCTGACCCCCCTGGGCCAGGGCACCGAGCACACCTGGAAGCGCATCCT
GGCCGGCGAATCCGGCGCGGCCCGGATCACGGCCTTCGACCCCGCCGACTACGCCTGCCAGGTCGCCTGCGAGGTGCCGA
GGGTCGACGGACGGGGCGGCGGCGGGCCCGACGTGCCCGGCAGCTTCGACCCCGACGCCACCATGTCGGCCAAGGACCGG
CGGCGGGTGGACGACTTCATCCTCTACGCCGTCGCCGCCGCCGACGAGGCGGTGAAGGACGCCGGCTGGACGCCCGAGGA
CGAGGAGAGCCGCGAGCGCACCGGGGTGATGATCGGCTCGGGCATCGGGGGCCTTGGCACCATCGCCGAGACCGCCATCG
AGCTGCACGAGAAGGGCCCGCGCCGGGTCAGCCCCTTCTTCATCCCCTCGGCCCTGATCAACCTGGCCAGCGGCCAGGTC
TCGATCAAGTACGGCTTCAAGGGCCCGAACCACGCCGTCGTCACCGCCTGCGCCACCGGCGCCCACGCGATCGGCGACGC
GGCCCGGCTGATCAAGTACGGTGACGCCGACGTGATGGTCTGCGGCGGGGCCGAGGCCAGCGTGGTGCCGGTGGGCATCG
CCGGCTTCATCGCCTGCCGCGCCATGGCGACGGCGTTCAACGACACGCCCGAGAAGGCCAGCCGTCCCTACGACAAGGAC
CGCGACGGCTTCGTCATGGGCGAGGGCGCGGCCGTCCTGGTGCTGGAGGAGCTGGAGCACGCCAAGGCGCGCGGGGCCAA
GATCTACGCCGAGGTCGCCGGCTACGGCCTCTCGGGCGACGCCTACCACATCACCGCCCCGGTCGAGGACGGCGACGGCG
GCTTCCGGGCCATGAAGGCGGCCCTGAAGGACGCAGGGATGCAGCCGGCCGACGTGGACTACGTCAACGCCCACGGCACC
TCGACCATGGCCGACGGCATCGAGCTGGGCGCCGTCGAGCGCCTGCTGGGCAATTCGGCCCCGGGCAAGGCGATGAGCTC
GACCAAGTCGATGACCGGCCACCTGCTGGGCGCCGCCGGCGCCCTGGAGGCCGCGTTCTCGATCCTGGCCATCCGCGACC
AGATCGCCCCGCCGACCATCAACCTCGACAACCCCGACGTCGAGACCAAGCTGGACCTCGTGCCGCACAAGGCCAAGCCG
ATGAAGATCGACGTGGCCATGTCGAACAGCTTCGGCTTCGGCGGCACGAACGCCTGCGTGATCTTCAAGAAGCCCGCGTG
A

Upstream 100 bases:

>100_bases
GAGCGGCTCGGCGCCTAAGGCGTTCGAATCGCTAGAGAATTCGACCGCCGCGGCTTCCCTTAGACCGGAGACCGCGGCGG
TTTTCGTTTGAGGATCGCCC

Downstream 100 bases:

>100_bases
GCCGCAAGGCCCGCCCCCGCAGCGCGCGCAAGGGAGGCCTCGTCCTCCTGGCCCTGGGCGCGCTCGCGGCCCTGATCGCC
GTCGCGGCCGTCTGGAGCTA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MRRVVVTGIGLLTPLGQGTEHTWKRILAGESGAARITAFDPADYACQVACEVPRVDGRGGGGPDVPGSFDPDATMSAKDR
RRVDDFILYAVAAADEAVKDAGWTPEDEESRERTGVMIGSGIGGLGTIAETAIELHEKGPRRVSPFFIPSALINLASGQV
SIKYGFKGPNHAVVTACATGAHAIGDAARLIKYGDADVMVCGGAEASVVPVGIAGFIACRAMATAFNDTPEKASRPYDKD
RDGFVMGEGAAVLVLEELEHAKARGAKIYAEVAGYGLSGDAYHITAPVEDGDGGFRAMKAALKDAGMQPADVDYVNAHGT
STMADGIELGAVERLLGNSAPGKAMSSTKSMTGHLLGAAGALEAAFSILAIRDQIAPPTINLDNPDVETKLDLVPHKAKP
MKIDVAMSNSFGFGGTNACVIFKKPA

Sequences:

>Translated_426_residues
MRRVVVTGIGLLTPLGQGTEHTWKRILAGESGAARITAFDPADYACQVACEVPRVDGRGGGGPDVPGSFDPDATMSAKDR
RRVDDFILYAVAAADEAVKDAGWTPEDEESRERTGVMIGSGIGGLGTIAETAIELHEKGPRRVSPFFIPSALINLASGQV
SIKYGFKGPNHAVVTACATGAHAIGDAARLIKYGDADVMVCGGAEASVVPVGIAGFIACRAMATAFNDTPEKASRPYDKD
RDGFVMGEGAAVLVLEELEHAKARGAKIYAEVAGYGLSGDAYHITAPVEDGDGGFRAMKAALKDAGMQPADVDYVNAHGT
STMADGIELGAVERLLGNSAPGKAMSSTKSMTGHLLGAAGALEAAFSILAIRDQIAPPTINLDNPDVETKLDLVPHKAKP
MKIDVAMSNSFGFGGTNACVIFKKPA
>Mature_426_residues
MRRVVVTGIGLLTPLGQGTEHTWKRILAGESGAARITAFDPADYACQVACEVPRVDGRGGGGPDVPGSFDPDATMSAKDR
RRVDDFILYAVAAADEAVKDAGWTPEDEESRERTGVMIGSGIGGLGTIAETAIELHEKGPRRVSPFFIPSALINLASGQV
SIKYGFKGPNHAVVTACATGAHAIGDAARLIKYGDADVMVCGGAEASVVPVGIAGFIACRAMATAFNDTPEKASRPYDKD
RDGFVMGEGAAVLVLEELEHAKARGAKIYAEVAGYGLSGDAYHITAPVEDGDGGFRAMKAALKDAGMQPADVDYVNAHGT
STMADGIELGAVERLLGNSAPGKAMSSTKSMTGHLLGAAGALEAAFSILAIRDQIAPPTINLDNPDVETKLDLVPHKAKP
MKIDVAMSNSFGFGGTNACVIFKKPA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=423, Percent_Identity=52.0094562647754, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI223972627, Length=195, Percent_Identity=47.1794871794872, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI41872631, Length=338, Percent_Identity=25.7396449704142, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1787337, Length=425, Percent_Identity=52.7058823529412, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1788663, Length=430, Percent_Identity=35.1162790697674, Blast_Score=242, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=434, Percent_Identity=38.4792626728111, Blast_Score=257, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=42.2641509433962, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI212642053, Length=388, Percent_Identity=26.0309278350515, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=278, Percent_Identity=27.6978417266187, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=454, Percent_Identity=39.647577092511, Blast_Score=308, Evalue=8e-85,
Organism=Drosophila melanogaster, GI24644341, Length=428, Percent_Identity=49.5327102803738, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI221330659, Length=353, Percent_Identity=26.0623229461756, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI19920632, Length=353, Percent_Identity=26.0623229461756, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24581345, Length=341, Percent_Identity=26.099706744868, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44158; Mature: 44158

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGIGLLTPLGQGTEHTWKRILAGESGAARITAFDPADYACQVACEVPRVDGRGG
CCEEEEECCHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCC
GGPDVPGSFDPDATMSAKDRRRVDDFILYAVAAADEAVKDAGWTPEDEESRERTGVMIGS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEC
GIGGLGTIAETAIELHEKGPRRVSPFFIPSALINLASGQVSIKYGFKGPNHAVVTACATG
CCCCHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCC
AHAIGDAARLIKYGDADVMVCGGAEASVVPVGIAGFIACRAMATAFNDTPEKASRPYDKD
CHHHHHHHHHHEECCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
RDGFVMGEGAAVLVLEELEHAKARGAKIYAEVAGYGLSGDAYHITAPVEDGDGGFRAMKA
CCCEEEECCCEEEEEHHHHHHHHCCCEEEEEHHCCCCCCCCEEEEECCCCCCCHHHHHHH
ALKDAGMQPADVDYVNAHGTSTMADGIELGAVERLLGNSAPGKAMSSTKSMTGHLLGAAG
HHHHCCCCCCCCEEEECCCCCHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
ALEAAFSILAIRDQIAPPTINLDNPDVETKLDLVPHKAKPMKIDVAMSNSFGFGGTNACV
HHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCEEE
IFKKPA
EEECCC
>Mature Secondary Structure
MRRVVVTGIGLLTPLGQGTEHTWKRILAGESGAARITAFDPADYACQVACEVPRVDGRGG
CCEEEEECCHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCC
GGPDVPGSFDPDATMSAKDRRRVDDFILYAVAAADEAVKDAGWTPEDEESRERTGVMIGS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEC
GIGGLGTIAETAIELHEKGPRRVSPFFIPSALINLASGQVSIKYGFKGPNHAVVTACATG
CCCCHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCC
AHAIGDAARLIKYGDADVMVCGGAEASVVPVGIAGFIACRAMATAFNDTPEKASRPYDKD
CHHHHHHHHHHEECCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
RDGFVMGEGAAVLVLEELEHAKARGAKIYAEVAGYGLSGDAYHITAPVEDGDGGFRAMKA
CCCEEEECCCEEEEEHHHHHHHHCCCEEEEEHHCCCCCCCCEEEEECCCCCCCHHHHHHH
ALKDAGMQPADVDYVNAHGTSTMADGIELGAVERLLGNSAPGKAMSSTKSMTGHLLGAAG
HHHHCCCCCCCCEEEECCCCCHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
ALEAAFSILAIRDQIAPPTINLDNPDVETKLDLVPHKAKPMKIDVAMSNSFGFGGTNACV
HHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCEEE
IFKKPA
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]