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The map label for this gene is hutC [H]

Identifier: 197104950

GI number: 197104950

Start: 1687734

End: 1688468

Strand: Direct

Name: hutC [H]

Synonym: PHZ_c1485

Alternate gene names: 197104950

Gene position: 1687734-1688468 (Clockwise)

Preceding gene: 197104949

Following gene: 197104951

Centisome position: 42.23

GC content: 66.8

Gene sequence:

>735_bases
ATGAATTCGGTGGCCGACCTCACGCTCCACAAGCGGATCCGGTCGGATATCTCCGAGCGGATTCTCTCCGGGGCTTGGCC
CCCGGGTCACCGCATTCCGTACGAACATGAGCTGATGGCGGAATACGGTTGCTCCCGCATGACCGTGAACAAGGCGCTTG
CGCCCCTCGCCGAGGCCGGGCTGATCGAGCGACGGCGCAAGTTTGGAACCTTCGTGGCCCGACCCAAGATCCACTCGGCT
GTCCTCGACATCCCCGATATCCCGACCGAAGTGACGGGGCGCGGCGAGGTCTACGACTACGAGCTGCTGTTTCAGCGGGT
CCGAACAGCGACCCTACGGGAGATGGAGGAGCTTGGCCTTGATCGCTCGGCACAGGTCCTCGTCCTGCGCAGCCTGCACC
GCGCCGCGGGCCGGCCCTTCGCCCTCGAAGAGCGACTGATCAACCTGGAGACCGTTCCGGAGGCGGCCGACGTGGATTTC
GGCGCCACCGCGCCCGGCAGCTGGCTGCTCAGCCATGTCCCATGGACGGAGGCTGAGCACCGGATCAGCGCCGCGAACGT
GCCAAGGGCTGTCGCGACGGCGCTCGGCATCGAACTGATGGCGGCCTGCCTGGTCCTTGAGCGGCGCACGTGGCGAAGCG
CTGACCGGATCACCCACGTCCGTCTGACGTTCCCGGGCGAAGCCTATGACCTCGTGGCCCGCTTCGCACCGCAGGGCGGA
CTATCTGCCAGCTGA

Upstream 100 bases:

>100_bases
CTTCGCTTCCGGCCGCAGCCAAGGACAGCCGGCCGCAAGCTTGATGCGGGCGGCCGCAGGCGTAAGGCTGCGCTCTGCCG
GCGCAATCGGGAGCGAGTCC

Downstream 100 bases:

>100_bases
CGCCTAGCGGTCAGCGGTAGAGGCGTCAGAAGACCTGACGTAGCCTTGAGCGTGTGGCCGAGTTCCTGGCGCGGCAGGAC
CAGATAGGGTCAAGGTGGTT

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MNSVADLTLHKRIRSDISERILSGAWPPGHRIPYEHELMAEYGCSRMTVNKALAPLAEAGLIERRRKFGTFVARPKIHSA
VLDIPDIPTEVTGRGEVYDYELLFQRVRTATLREMEELGLDRSAQVLVLRSLHRAAGRPFALEERLINLETVPEAADVDF
GATAPGSWLLSHVPWTEAEHRISAANVPRAVATALGIELMAACLVLERRTWRSADRITHVRLTFPGEAYDLVARFAPQGG
LSAS

Sequences:

>Translated_244_residues
MNSVADLTLHKRIRSDISERILSGAWPPGHRIPYEHELMAEYGCSRMTVNKALAPLAEAGLIERRRKFGTFVARPKIHSA
VLDIPDIPTEVTGRGEVYDYELLFQRVRTATLREMEELGLDRSAQVLVLRSLHRAAGRPFALEERLINLETVPEAADVDF
GATAPGSWLLSHVPWTEAEHRISAANVPRAVATALGIELMAACLVLERRTWRSADRITHVRLTFPGEAYDLVARFAPQGG
LSAS
>Mature_244_residues
MNSVADLTLHKRIRSDISERILSGAWPPGHRIPYEHELMAEYGCSRMTVNKALAPLAEAGLIERRRKFGTFVARPKIHSA
VLDIPDIPTEVTGRGEVYDYELLFQRVRTATLREMEELGLDRSAQVLVLRSLHRAAGRPFALEERLINLETVPEAADVDF
GATAPGSWLLSHVPWTEAEHRISAANVPRAVATALGIELMAACLVLERRTWRSADRITHVRLTFPGEAYDLVARFAPQGG
LSAS

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27110; Mature: 27110

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50949 HTH_GNTR ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSVADLTLHKRIRSDISERILSGAWPPGHRIPYEHELMAEYGCSRMTVNKALAPLAEAG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
LIERRRKFGTFVARPKIHSAVLDIPDIPTEVTGRGEVYDYELLFQRVRTATLREMEELGL
HHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCC
DRSAQVLVLRSLHRAAGRPFALEERLINLETVPEAADVDFGATAPGSWLLSHVPWTEAEH
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCHHH
RISAANVPRAVATALGIELMAACLVLERRTWRSADRITHVRLTFPGEAYDLVARFAPQGG
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCEEEEEEECCCHHHHHHHHHCCCCC
LSAS
CCCC
>Mature Secondary Structure
MNSVADLTLHKRIRSDISERILSGAWPPGHRIPYEHELMAEYGCSRMTVNKALAPLAEAG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
LIERRRKFGTFVARPKIHSAVLDIPDIPTEVTGRGEVYDYELLFQRVRTATLREMEELGL
HHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCC
DRSAQVLVLRSLHRAAGRPFALEERLINLETVPEAADVDFGATAPGSWLLSHVPWTEAEH
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCHHH
RISAANVPRAVATALGIELMAACLVLERRTWRSADRITHVRLTFPGEAYDLVARFAPQGG
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCEEEEEEECCCHHHHHHHHHCCCCC
LSAS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203754; 2834335 [H]