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The map label for this gene is pcoA [H]

Identifier: 197104941

GI number: 197104941

Start: 1677609

End: 1679543

Strand: Direct

Name: pcoA [H]

Synonym: PHZ_c1476

Alternate gene names: 197104941

Gene position: 1677609-1679543 (Clockwise)

Preceding gene: 197104940

Following gene: 197104942

Centisome position: 41.98

GC content: 67.65

Gene sequence:

>1935_bases
ATGCGACGCCGCCGCGACATCGACCTGGATCGCCGCAAGGTCCTGAAGGGGACCGCCGTCCTTGGGGGCGGCGCCGCGCT
GAGCGCGCTGCTGCCGGCATGGGCGTGGAGCGCGAGCCCTGGCGTCGCTTCGACCTTGCCGACGCTTTCGGGCGAGGAGA
TCAAGCTCACGATCGGCCACACGCCCATCTCCATCGACGGCAAGCGCAGCCACGCCGTGACCATCAACGGCACGGTGCCG
GGCCCGCTGATCCGTCTGAAGGAGGGCCAGAACGTCCGCATCGCGGTCACCAACACGTTGGACGAAGACACCTCGATCCA
CTGGCACGGCCTGCTCGTGCCCTTCCAGATGGACGGCGTGCCGGGGGTCAGCTTCCCGGGCATCAAGCCGGGCGAGACCT
TCGTCTACGAGTTCCCGGTCATCCAGTCGGGCACCTACTGGTACCACAGCCACTCCAGCCTGCAGGAGGCGGAGGGGCAC
TACGCGCCGATCGTCATCGAGCCGGCCAAGCCCGATCCGGTCGCCTACGATCGGGAGCATGTCATCGTGCTCTCCGACCA
CAGCGAGATGCACCCGCACCTGATCTTCAAGCGCCTGAAGCAGATGGGCGGCGTTTTCAATTACCAGCGTCAGACCTTGG
CGGGCCTTCTCGCGGGCAAGGACCAGACCCTTCAGGAGCGGATCGAGTGGGCCAAGATGCTCATGGATCCCACCGACATC
TCCGACGTCACGGGCGCCGTGATGACCTTCCTCGTGAACGGCCACGGCCCGAAGGACAACTGGACGGCGCTGTTCACGCC
CGGCGAGCGCGTGCGCCTGCGCTTCGTCAACGCTGCGGCCCAGATGATCTTCAACGTCCGCATCCCCGGCCTGAAGCTCA
CGGTGGTCGCCGCCGACGGCCAAAACGTACGCCCCGTCGAGGTGGACGAGTTCCAGATCGGCAACGCCGAGACCTACGAC
ATCATCGTCCAGCCCACAGAGGACCGGGCCTACACGCTCGTCTCTGAAGCTATCGACCGCTCCGGCATGGGCCGCGCGAC
GCTCGCCCCGCGGCCGGGCATGAGCGCCCCCGTGCCCCCACTGCGGGAGCGGCCGATCCTGACCATGAAGGACATGGGCA
TGGACATGTCGGCGCACGGGGGACACGGCGCCATGGCCGGCATGGACCACGCCAACATGCCGGGAATGACGCCGGCGCCC
GCCGCGGCCGACCACGCCAACATGCCGGGAATGACGCCGGCGCCCGCCGCGGCCGACCACGCCAACATGCCCGGGATGGA
TCACGCCGCCATGACGGCGATGTCCACTTCGCCCCCGCCTGGGATGGCGCCGCCGCGGGCGAGGGGCTCGGACGTCATGG
GCGACATGGCGGGCATGGACATGAACATGCTGGACTGGTCGAAGGCACCCCAGATCAAGAAGGGGCCGGGCGTGCAGATG
ATCTCGCCCATGCCGATGGATCGCACCGGCGAGGCTGGCCTGGGCCTCGAAAGCGTGGGGCACCGGGTCTTGGTCTACAA
GGACCTGGTGGCCCTGGAGCCGAACCCAGACCCGCGGGCGCCGGAGCGGGCGGTGGAAATCCGCCTGACCGGCAACATGG
AGCGCTTCATGTGGGGCTTCGACGGCTGGAAGTTCAGCGAAGGGCCGCCGCCCTATTCGTTCCGGACAGGCGAGCGCGTG
CGCATCACCCTGGTGAACGACTCGATGATGACCCACCCGATCCACCTGCACGGGCACTTCTTCGAACTCGTGCATGGGCC
TGTCGGTCATCTGCCCCGCAAGCACACGGTCAATGTGGCGCCCGGCGGGAAGGTGAGCTTCGACATCACGGCGGAGGCCG
GCGACTGGGCCTTCCACTGCCACATGCTCTACCACATGCACGCGGGCATGTTCCAAGTGTTCAAGGTGCGCCCGATGCAA
GGAGCGGCGGCATGA

Upstream 100 bases:

>100_bases
ATAGACGCCTGCGCTGCGTATACGTCATCGCAGGCCCTCCCTTGACCCTCCCTACGTGGGAAGCGCTATCCCTCCGCCAA
TGAGGACAGGACAACTTCGT

Downstream 100 bases:

>100_bases
TGCGCCCGGCCCTAATCGCCCTGCTTCCCGCCGCCATCGCGGCGCCCGCGCTGGCGCAGGACCCCCACGCGGGCCACCAG
ATGCCGGCCGCCCCTGCGTC

Product: copper-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MRRRRDIDLDRRKVLKGTAVLGGGAALSALLPAWAWSASPGVASTLPTLSGEEIKLTIGHTPISIDGKRSHAVTINGTVP
GPLIRLKEGQNVRIAVTNTLDEDTSIHWHGLLVPFQMDGVPGVSFPGIKPGETFVYEFPVIQSGTYWYHSHSSLQEAEGH
YAPIVIEPAKPDPVAYDREHVIVLSDHSEMHPHLIFKRLKQMGGVFNYQRQTLAGLLAGKDQTLQERIEWAKMLMDPTDI
SDVTGAVMTFLVNGHGPKDNWTALFTPGERVRLRFVNAAAQMIFNVRIPGLKLTVVAADGQNVRPVEVDEFQIGNAETYD
IIVQPTEDRAYTLVSEAIDRSGMGRATLAPRPGMSAPVPPLRERPILTMKDMGMDMSAHGGHGAMAGMDHANMPGMTPAP
AAADHANMPGMTPAPAAADHANMPGMDHAAMTAMSTSPPPGMAPPRARGSDVMGDMAGMDMNMLDWSKAPQIKKGPGVQM
ISPMPMDRTGEAGLGLESVGHRVLVYKDLVALEPNPDPRAPERAVEIRLTGNMERFMWGFDGWKFSEGPPPYSFRTGERV
RITLVNDSMMTHPIHLHGHFFELVHGPVGHLPRKHTVNVAPGGKVSFDITAEAGDWAFHCHMLYHMHAGMFQVFKVRPMQ
GAAA

Sequences:

>Translated_644_residues
MRRRRDIDLDRRKVLKGTAVLGGGAALSALLPAWAWSASPGVASTLPTLSGEEIKLTIGHTPISIDGKRSHAVTINGTVP
GPLIRLKEGQNVRIAVTNTLDEDTSIHWHGLLVPFQMDGVPGVSFPGIKPGETFVYEFPVIQSGTYWYHSHSSLQEAEGH
YAPIVIEPAKPDPVAYDREHVIVLSDHSEMHPHLIFKRLKQMGGVFNYQRQTLAGLLAGKDQTLQERIEWAKMLMDPTDI
SDVTGAVMTFLVNGHGPKDNWTALFTPGERVRLRFVNAAAQMIFNVRIPGLKLTVVAADGQNVRPVEVDEFQIGNAETYD
IIVQPTEDRAYTLVSEAIDRSGMGRATLAPRPGMSAPVPPLRERPILTMKDMGMDMSAHGGHGAMAGMDHANMPGMTPAP
AAADHANMPGMTPAPAAADHANMPGMDHAAMTAMSTSPPPGMAPPRARGSDVMGDMAGMDMNMLDWSKAPQIKKGPGVQM
ISPMPMDRTGEAGLGLESVGHRVLVYKDLVALEPNPDPRAPERAVEIRLTGNMERFMWGFDGWKFSEGPPPYSFRTGERV
RITLVNDSMMTHPIHLHGHFFELVHGPVGHLPRKHTVNVAPGGKVSFDITAEAGDWAFHCHMLYHMHAGMFQVFKVRPMQ
GAAA
>Mature_644_residues
MRRRRDIDLDRRKVLKGTAVLGGGAALSALLPAWAWSASPGVASTLPTLSGEEIKLTIGHTPISIDGKRSHAVTINGTVP
GPLIRLKEGQNVRIAVTNTLDEDTSIHWHGLLVPFQMDGVPGVSFPGIKPGETFVYEFPVIQSGTYWYHSHSSLQEAEGH
YAPIVIEPAKPDPVAYDREHVIVLSDHSEMHPHLIFKRLKQMGGVFNYQRQTLAGLLAGKDQTLQERIEWAKMLMDPTDI
SDVTGAVMTFLVNGHGPKDNWTALFTPGERVRLRFVNAAAQMIFNVRIPGLKLTVVAADGQNVRPVEVDEFQIGNAETYD
IIVQPTEDRAYTLVSEAIDRSGMGRATLAPRPGMSAPVPPLRERPILTMKDMGMDMSAHGGHGAMAGMDHANMPGMTPAP
AAADHANMPGMTPAPAAADHANMPGMDHAAMTAMSTSPPPGMAPPRARGSDVMGDMAGMDMNMLDWSKAPQIKKGPGVQM
ISPMPMDRTGEAGLGLESVGHRVLVYKDLVALEPNPDPRAPERAVEIRLTGNMERFMWGFDGWKFSEGPPPYSFRTGERV
RITLVNDSMMTHPIHLHGHFFELVHGPVGHLPRKHTVNVAPGGKVSFDITAEAGDWAFHCHMLYHMHAGMFQVFKVRPMQ
GAAA

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=435, Percent_Identity=25.7471264367816, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320714, Length=306, Percent_Identity=25.1633986928105, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321067, Length=367, Percent_Identity=25.3405994550409, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323703, Length=152, Percent_Identity=37.5, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI18859919, Length=274, Percent_Identity=31.021897810219, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585842, Length=297, Percent_Identity=30.6397306397306, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281360167, Length=297, Percent_Identity=30.6397306397306, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI221329998, Length=297, Percent_Identity=30.6397306397306, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI221330000, Length=297, Percent_Identity=30.6397306397306, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24650186, Length=278, Percent_Identity=25.5395683453237, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28574104, Length=302, Percent_Identity=27.4834437086093, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 70122; Mature: 70122

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRRDIDLDRRKVLKGTAVLGGGAALSALLPAWAWSASPGVASTLPTLSGEEIKLTIGH
CCCCCCCCHHHHHHHHCEEEECCHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEEECC
TPISIDGKRSHAVTINGTVPGPLIRLKEGQNVRIAVTNTLDEDTSIHWHGLLVPFQMDGV
CEEEECCCCCEEEEEECCCCCCEEEEECCCEEEEEEEECCCCCCCEEEEEEEEEEEECCC
PGVSFPGIKPGETFVYEFPVIQSGTYWYHSHSSLQEAEGHYAPIVIEPAKPDPVAYDREH
CCCCCCCCCCCCEEEEEECEEECCEEEEECCCCHHHCCCCCCCEEEECCCCCCCCCCCCE
VIVLSDHSEMHPHLIFKRLKQMGGVFNYQRQTLAGLLAGKDQTLQERIEWAKMLMDPTDI
EEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCH
SDVTGAVMTFLVNGHGPKDNWTALFTPGERVRLRFVNAAAQMIFNVRIPGLKLTVVAADG
HHHHHHHHHEEECCCCCCCCCEEEECCCCEEEEEEEEHHEEEEEEEECCCEEEEEEEECC
QNVRPVEVDEFQIGNAETYDIIVQPTEDRAYTLVSEAIDRSGMGRATLAPRPGMSAPVPP
CCCCCEECCCEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCC
LRERPILTMKDMGMDMSAHGGHGAMAGMDHANMPGMTPAPAAADHANMPGMTPAPAAADH
CCCCCEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ANMPGMDHAAMTAMSTSPPPGMAPPRARGSDVMGDMAGMDMNMLDWSKAPQIKKGPGVQM
CCCCCCCHHHHEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCHHCCCCCCCCCCCCCCEE
ISPMPMDRTGEAGLGLESVGHRVLVYKDLVALEPNPDPRAPERAVEIRLTGNMERFMWGF
ECCCCCCCCCCCCCCHHHHCCEEEEEEEEEEECCCCCCCCCCEEEEEEEECCHHHEEEEC
DGWKFSEGPPPYSFRTGERVRITLVNDSMMTHPIHLHGHFFELVHGPVGHLPRKHTVNVA
CCEECCCCCCCCCCCCCCEEEEEEECCCCEECEEEECHHHHHHHCCCHHCCCCCCEEEEC
PGGKVSFDITAEAGDWAFHCHMLYHMHAGMFQVFKVRPMQGAAA
CCCEEEEEEEECCCCEEEEEHHHHHHHCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MRRRRDIDLDRRKVLKGTAVLGGGAALSALLPAWAWSASPGVASTLPTLSGEEIKLTIGH
CCCCCCCCHHHHHHHHCEEEECCHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEEECC
TPISIDGKRSHAVTINGTVPGPLIRLKEGQNVRIAVTNTLDEDTSIHWHGLLVPFQMDGV
CEEEECCCCCEEEEEECCCCCCEEEEECCCEEEEEEEECCCCCCCEEEEEEEEEEEECCC
PGVSFPGIKPGETFVYEFPVIQSGTYWYHSHSSLQEAEGHYAPIVIEPAKPDPVAYDREH
CCCCCCCCCCCCEEEEEECEEECCEEEEECCCCHHHCCCCCCCEEEECCCCCCCCCCCCE
VIVLSDHSEMHPHLIFKRLKQMGGVFNYQRQTLAGLLAGKDQTLQERIEWAKMLMDPTDI
EEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCH
SDVTGAVMTFLVNGHGPKDNWTALFTPGERVRLRFVNAAAQMIFNVRIPGLKLTVVAADG
HHHHHHHHHEEECCCCCCCCCEEEECCCCEEEEEEEEHHEEEEEEEECCCEEEEEEEECC
QNVRPVEVDEFQIGNAETYDIIVQPTEDRAYTLVSEAIDRSGMGRATLAPRPGMSAPVPP
CCCCCEECCCEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCC
LRERPILTMKDMGMDMSAHGGHGAMAGMDHANMPGMTPAPAAADHANMPGMTPAPAAADH
CCCCCEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ANMPGMDHAAMTAMSTSPPPGMAPPRARGSDVMGDMAGMDMNMLDWSKAPQIKKGPGVQM
CCCCCCCHHHHEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCHHCCCCCCCCCCCCCCEE
ISPMPMDRTGEAGLGLESVGHRVLVYKDLVALEPNPDPRAPERAVEIRLTGNMERFMWGF
ECCCCCCCCCCCCCCHHHHCCEEEEEEEEEEECCCCCCCCCCEEEEEEEECCHHHEEEEC
DGWKFSEGPPPYSFRTGERVRITLVNDSMMTHPIHLHGHFFELVHGPVGHLPRKHTVNVA
CCEECCCCCCCCCCCCCCEEEEEEECCCCEECEEEECHHHHHHHCCCHHCCCCCCEEEEC
PGGKVSFDITAEAGDWAFHCHMLYHMHAGMFQVFKVRPMQGAAA
CCCEEEEEEEECCCCEEEEEHHHHHHHCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]